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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A transplantable, metastasizing prostatic adenocarcinoma (Tumor I) in Lobund Wistar rats was examined for activity and distribution of five hydrolytic enzymes and for ability to accumulate radioactive zinc. The results suggest that the tumor had arisen in the ventral lobe of the prostate and that its growth was not affected by orchiectomy, adrenalectomy, or replacement treatment with exogenous androgen or corticosteroids. The androgen independency of the tumor was further shown by the low uptake of 3H-testosterone, in contrast to the high uptake in the ventral prostate. Tumor growth was retarded by Cytoxan but not by 5-fluorouracil, Estracyt, or streptozotocin, three agents clinically effective in the treatment of some patients with prostatic cancer resistant to endocrine therapy. It is concluded that this tumor in Lobund Wistar rats may be an adequate model for human prostatic cancers resistant to the agents mentioned above.
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PMID:A rat prostatic adenocarcinoma as a model for the human disease. 44 85

It was shown that tumor growth is intensifying as a result of tumor cell implantation not only in early sensitization of BCG-vaccinated organism (see previously published data) but at the later period as well. Cyclophosphan removed this effect whereas desensitization carried out against the background of cyclophosphan action restored it. The data on the relationship between tuberculin allergy and the state of immunological defence reactions of the body suggest the possibility of stimulation of tumor growth as well as of its inhibition.
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PMID:[Resistance of BCG-vaccinated body to tumor growth after administration of cyclophosphamide and desensitization]. 45 26

An endodermal sinus tumor (endodermal germ cell carcinoma) was diagnosed in a 1-year-old girl in the vagina after hemorrhage; the tumor was completely removed by radical abdominal surgery. Postoperative polychemotherapy was performed for two years with Actinomycin D, Adriamycin, Vincristin, and Cyclophosphamide. The infant is now tumor-free for 26 months, showing almost normal somatic and psychic development. The characteristic histological patterns and clinical course of this strongly malignant tumor are demonstrated, based on 25 published case reports of endodermal sinus tumors in the vagina of little girls (aged 5-26 months). This neoplasm in early infancy has to be separated from the clear-cell adenocarcinoma of the vagina which occurs after puberty in adolescent girls and young women, and is induced by stilbestrol therapy to the mother during early pregnancy.
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PMID:Endodermal germ cell carcinoma (endodermal sinus tumor) of the vagina in infant girls. 47 68

Changes in susceptibility to treatment with Cytoxan, methotrexate, 5-fluorouracil, and Adriamycin, single or in combination, have been studied during the initial and progressive stages of s.c. and pulmonary (via tail vein injection) growth of two transplanted syngeneic C3H/He mammary carcinomas. One tumor was fast growing, reaching a size of 3 mm from a 1-mm s.c. implant in 7 days; the second tumor would grow to the same size in 30 days. The tumor with the slower growth rate was more susceptible to drug treatment, manifested by delayed growth as well as by prevented growth. The slower-growing tumor also remained susceptible longer, when treatment was delayed, than did the faster-growing tumor. Pulmonary growth was more often prevented by drug treatment than was s.c. growth. Tumor implants s.c. which had reached palpable size could be reduced temporarily to impalpable size by effective drug treatment but were rarely cured. The importance of early treatment relative to the time of tumor implantation was indicated when early treatment with a single drug proved more effective than did delayed treatment with a more potent combination of drugs.
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PMID:Effects of combination drug therapy on the subcutaneous and pulmonary growth of a slow and a fast-growing C3H/He mammary carcinoma. 49 77

Nb rat autonomous prostatic adenocarcinomas were transplanted into several groups of synergeneic Nb rats. Chemotherapy using 5-fluorouracil, methotrexate, Adriamycin, and cyclophosphamide was evaluated. Significance was seen with the use of these agents with varying doses. Cyclophosphamide and 5-fluorouracil treated animals had complete tumor regression whereas Adriamycin and methotrexate treated animals had cessation of tumor volume increase in some groups after chemotherapy; however, neither agent causes complete tumor regression.
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PMID:Therapeutic manipulation of Nb rat prostatic adenocarcinomas: chemotherapeutic evaluation of autonomous tumors. 50 Mar 17

Piracetam and Pyrithioxin, drugs affecting the central nervous system, prolonged survival times in rats with the 3-MC sarcoma. Tumor remissions were observed in several male animals. We were able to achieve a high survival rate without metastasis after surgical removal of the tumors. The remission rate could be increased 6-fold when Piracetam was combined with Cyclophosphamid. In this group male and female animals reacted in the same manner. When used prophylactically, Piracetam proved to be more effective than Pyrithioxin. The effectiveness of Piracetam depended on the onset of treatment. Tumor remission was significant 28 weeks following 3-MC injection when 3-MC and Piracetam were given simultaneously. A remarkable increase of the tumor rate ensued when medication was discontinued. The tumor rate decreased to less than 50% 36 weeks following 3-MC injection if treatment was started 8 weeks following 3-MC application. The latter applied only to Piracetam and not to Pyrithioxin. In the EEG of rats the diminished amplitude induced by 3-MC could be fully compensated by 100 mg/kg Piracetam. All animals treated in this manner for 7 months remained tumor-free.
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PMID:[Antineoplastic activity of drugs affecting the central nervous system against chemically induced tumors in the rat (author's transl)]. 50 Jul 65

The response of 6 human colorectal tumour xenografts to 7 cytotoxic agents have been established. Tumour responses have been quantified by growth inhibition, and the time taken for 3H-thymidine fractional incorporation (TFI) to recover to the control value after treatment. The chemosensitivity of each tumour line to a spectrum of agents was individual, and no pattern of response which would allow prediction of individual agent efficacy was apparent. Cyclophosphamide, methyl-CCNU and 5-fluorouracil produced marked growth inhibition in individual tumour lines, whereas actinomycin-D, cis-dichlorodiammine platinum, doxorubicin and pentamethylmelamine showed little activity. Data presented agree with clinical evaluation for single-agent therapy. The uptake and incorporation of radiolabelled 5-fluorouracil into 4 tumour lines is reported. No marked differences between 3 FU-insensitive lines and 1 sensitive line have been observed.
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PMID:Evaluation of single-agent therapy in human colorectal tumour xenografts. 65 10

Cyclophosphamide given to rats 2 or 5 days after an injection of Yoshida ascites sarcoma cured approximately the same proportion of animals, but the resistance to a subsequent tumor challenge was found only in rats treated with the drug 5 days after tumor injection.
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PMID:The timing of cyclophosphamide therapy in tumor-bearing rats affects the resistance to tumor challenge in survivors. 73 20

Cure following surgery of bladder cancer is limited by recurrence of the original tumor or by the development of new primary tumors. TCC of the bladder induced in C3H/HeJ mice by FANFT closely resemble their human counterpart and have been used to evaluate the effect of chemotherapy and/or BCG on the induction and growth of these tumors. Three hundred five mice were divided into a control group of 30 and 11 treatment groups of 25. Therapy was initiated at 5 and 7 months after FANFT. The first tumors in this system are observed at 8 months with an expected incidence of 70-90% by 11 months. Therapy consisted of: 1) BCG; 2) cyclophosphamide; 3) cyclophosphamide + BCG; 4) cyclophosphamide + 5-FU; 5) cyclophosphamide + adriamycin; and 6) adriamycin. All mice were killed after 11 months on FANFT. Bladders were wieghed and the tumors were staged. Tumor incidence was reduced by only two regimens: adriamycin and cyclophosphamide + adriamycin. Cyclophosphamide significantly reduced subsequent tumor volume compared with the control group, with the effect being more pronounced in mice beginning treatment at 5 months. The combination regimens were superior to cyclophosphamide alone. BCG did not potentiate the antitumor action of cyclophosphamide and, when used alone, actually enhanced tumor growth (P less than 0.025). The use of BCG immunotherapy should be cautioned, but the effectiveness of the antineoplastic drugs suggests their use in clinical trials in patients with bladder cancer.
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PMID:Effectiveness of long-term chemotherapy and/or BCG on murine bladder cancer. 74 88

The author presented results of BCG and Corynebacterium parvum treatment of the transplantable mouse FANFT bladder tumor carried in the host's leg. A comparison was made of the results of treatment with BCG alone and C. parvum alone or either used in conjunction with Cytoxan upon effectiveness in increasing animal survival and retarding tumor growth.
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PMID:A bladder tumor model response to immunotherapy. 74 89


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