Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Twenty rats with implanted liver tumor were studied. Following baseline angiography, the hepatic artery was embolized with Gelfoam powder or ethanol (n = 12) while the controls (n = 8) did not undergo embolization. Postmortem Microfil perfusion was performed in all livers. Filling of tumor lakes from the portal vein was seen more often in embolized animals than in controls, indicating the potential role of the portal venous system in the supply of dearterialized hepatic tumors. We discuss the possible clinical implication of our results.
 ...
PMID:Blood supply of experimental liver tumors after intraarterial embolization with gelfoam powder and absolute ethanol. 649 67

Embolization and detached balloon occlusion by the femoral route were performed in 45 cases: 19 cases of meningiomas, 5 of scalp arteriovenous malformations (AVMs), 4 of dural AVMs, 6 of cerebral AVMs, 8 of facial angiomas and 3 of carotid cavernous sinus fistulas (CCFs); and favorable results were attained. In meningiomas, there is only a short interval between the embolization and the removal of tumor (we usually perform the embolization a couple of days before the removal), and we use Gelfoam as embolus material. We aim at central tumor embolization with small emboli. The embolization reduced bleeding in removing the tumors, simplifying the surgical procedure, and 12 of 19 cases required no blood transfusion. Almost all cases of scalp AVMs, dural AVMs and facial angiomas could most probably be cured only by the embolization without surgery. Gelfoam was the first choice, because it would probably dissolve, and also because it would be relatively safe even if pulmonary embolism might occur as a result of probable passage of its emboli onto the venous side. In recanalized cases, the embolization was performed again with Ivalon, a permanent embolus material. The most important of this procedure is to inject the emboli of the suitable size for each case together with a suitable contrast material at as low a rate as possible under the image intensifier. Embolization by the injection pressure should never be tried, but the emboli be allowed to be carried only on the blood flow to the distal side. And the embolization should be discontinued at the stage when the contrast material has stagnated. CCFs are very good indications for the detached balloon occlusion, while this technic proved to serve for no more than occluding the feeding vessels in cerebral AVMs; in other words, it is indicated in a rather limited range of AVMs. We have encountered no severe complications in any of the cases treated by the embolization and detached balloon occlusion.
 ...
PMID:[Embolization and detached balloon occlusion by the femoral route in craniofacial lesions]. 662 83

The operative and histopathological findings in 31 cases of intracranial meningioma after preoperative embolization with Gelfoam and/or lyophilized dura mater are reported. Removal of the tumor after embolization was facilitated in those meningiomas fed exclusively or mainly by branches of the external carotid artery (29 of 31). Large areas of tumor necrosis were never seen on histopathological examination, even when suggested by large regions of decreased density on the postembolization computed tomographic scan. Preoperative embolization of the feeding vessels arising from the external carotid artery system has proven to be a useful adjunct before the resection of intracranial meningiomas.
 ...
PMID:Preoperative embolization of intracranial meningiomas. 662 40

Polyvinyl alcohol foam (Ivalon) particles were used in arterial embolization of abdominal neoplasms for tumor devascularization. The Ivalon particles are available in two sizes: small (0.25-0.59 mm) and large (0.60-1.0 mm). Twenty-five tumor embolizations in 22 patients (16 hepatic neoplasms, five renal carcinomas, one lumbar metastasis) were performed during a 4 month period. Occlusion of the embolized artery was documented by angiography in 24 procedures and by surgery in the remaining one. The postembolization syndrome was the same as that following Gelfoam embolization. Ivalon particles compared with Gelfoam cubes are advantageous in: (1) being easier to use; (2) reaching smaller arteries; and (3) causing more permanent occlusion.
 ...
PMID:Ivalon embolization in abdominal neoplasms. 678 67

Vascular occlusion is described using microemboli of a predetermined size for the treatment of neoplastic conditions with a "capillary barrier." Particulated microemboli of either 40--60 micron Gelfoam powder or 200--1,000 micron polyvinyl alcohol foam (PVA) are best. Fluid embolic agents such as silicone fluid are used in lesions without a capillary barrier. The radiographic, pathologic, and clinical results in three patients are described in detail. Microembolization is useful in the treatment of neoplastic conditions for it produces tumor necrosis in addition to hemostasis.
 ...
PMID:Microembolization techniques of vascular occlusion: radiologic, pathologic, and clinical correlation. 678 61

Extensive lower limb paresis developed in three patients with terminal cancer following internal iliac (hypogastric) artery embolization. This procedure was carried out for control of hemorrhage in two of the patients and for reduction of the bulk of metastatic tumor in another. The embolic materials used resulted in extensive obliteration of small and large vessels of the posterior and anterior divisions of the internal iliac artery. The paresis is attributed to the resulting ischemia of the sciatic and femoral nerves; previous radiotherapy may also have been a contributing factor. To reduce the incidence of paralysis, identification of the bleeding vessels and selective embolization are recommended. If this cannot be achieved, and the catheter lies in the main stem, it is recommended that the emboli should not be smaller than Gelfoam pledgets (1 X 1 X 10 mm) to preserve the peripheral circulation and lessen the risk of complication.
 ...
PMID:Paresis following internal iliac artery embolization. 684 68

A patient presented with mediastinal metastases from renal adenocarcinoma. Palliative therapy included Gelfoam and steel coil embolization of the right renal artery. Six weeks later he was found to have developed severe hypertension. Arteriogram revealed collateral vessels which supplied the tumor; the renal vein renin activity was four times higher on the right than on the left. We suspect that infarction of the kidney was not complete because of collateral arterial supply, and renin-dependent hypertension was the result. Thus, it may be hazardous to embolize large hypernephromas without subsequent nephrectomy.
 ...
PMID:Hypertension with renal carcinoma. An effect of arterial embolization. 685 May 39

Ivalon particles were used for 80 hepatic artery embolizations in 50 patients who had either primary or metastatic hepatic neoplasms. Ten patients died within 1-5 months and the remaining 40 patients were still alive. The post-hepatic embolization syndrome was identical to that following Gelfoam embolization. Follow-up hepatic angiography in 20 patients revealed tumor response to embolization in 17 patients. Ivalon particles were easier to use and caused more peripheral and persistent occlusion than Gelfoam. The results suggest that Ivalon particles were safe and feasible for hepatic artery embolization.
 ...
PMID:Therapeutic Ivalon embolization of hepatic tumors. 697 33

The therapeutic arterial embolization in the case of renal cell carcinoma using microencapsulated mitomycin C (MMC) was investigated by an angiographic evaluation in comparison with nonencapsulated MMC. The Gelfoam embolization supplemented with nonencapsulated MMC could not necessarily prevent the recanalization and collateral circulation, while the Gelfoam embolization supplemented with microencapsulated MMC completely or considerably eliminated the revascularization with a distinct advantage in this degree. Moreover, peripheral blood MMC level after the embolization using microencapsulated MMC was reduced to 39 per cent of that after nonencapsulated MMC infusion. The result was consistent with the previous experiments, indicating that the transcatheter infusion of microencapsulated MMC is the therapeutic arterial embolization of the tumor-supplying vessels together with regional anticancer chemotherapy. Further clinical application to various malignancies is in progress.
 ...
PMID:Evaluation of therapeutic arterial embolization in renal cell carcinoma using microencapsulated mitomycin C. 722 18

Seventy-two hepatic artery embolizations were performed in 47 patients to treat hepatic neoplasms. Hepatic artery embolization creates tumor devascularization, but the portal flow prevents infarction of liver parenchyma because of the single vascular supply from the hepatic artery to a neoplasm, in contrast to the dual vascular supply to the liver parenchyma. Indications for the use of hepatic artery embolization are failure of chemotherapy, either systemic or intra-arterial infusion, vascular anomalies requiring combined lobar embolization and lobar infusion, and lack of effective treatment. Three types of embolization were performed: peripheral embolization using Gelfoam, proximal embolization using coils, and combined peripheral and proximal embolization. The complications after embolization were pain, fever, and transient liver function changes. No death or hepatic abscess occurred. The median survival duration of the group was 11.5 months from the time of embolization. Hepatic artery embolization is an effective treatment of hepatic neoplasm.
 ...
PMID:Hepatic artery embolization in the treatment of hepatic neoplasms. 724 43


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>