Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Silicone foam containing BLM and implanted in the cavity resulting from the resection of a tumor seemed to act against any tumor cells remaining in the resection site in microscopic amounts by slowly releasing this carcinostatic agent. The silicone foam is molded in precise accordance with the shape of the wound surface as it foams and hardens, leaving no space between the material and the wound surface. The carcinostatic agent released can, therefore, act on the entire surface of the wound, and the implantation also has a hemostatic effect. High tissue concentrations of the agent can be maintained for a long time due to the slow-release properties of the silicone foam. Systemic side effects of the procedure seem to be negligible. Local recurrence of cancer was observed in 11 (33.4%) of our 32 patients. Three-year survival was seen in 1 (50%) of the 2 patients with T2 lesions, 11 (68.7%) of the 16 with T3 lesions and 4 (66.6%) of the 6 with T4 lesions.
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PMID:Slow-release local chemotherapeutic regimen for maxillary sinus cancer. 242 45

The combined antitumor effects of local hyperthermia and a simultaneous injection of bleomycin suspended in sesame oil (BLM-sesame oil) into the proper hepatic artery were studied in a model of liver cancer in rabbits. Fourteen days after inoculation of VX2 carcinoma into the left anterior lobe, 107 rabbits were used for the experiments. Local hyperthermia of 43-47 degrees C for 20 minutes was administered directly to the liver tumor via a 915 MHz microwave. In a preliminary study, administration of sesame oil alone into the proper hepatic artery led to a peripheral hepatic artery embolization, as evidenced by microangiography, and to the inhibition of tumor growth. The tumor-bearing rabbits were placed into groups of six. The first group was treated with hyperthermia, the second with a saline solution of bleomycin given intra-arterially, the third with a combination of hyperthermia and a saline solution of bleomycin given intra-arterially, the fourth with BLM-sesame oil given intra-arterially, the fifth with a combination of hyperthermia and sesame oil given intra-arterially, and the sixth with a combination of hyperthermia and BLM-sesame oil given intra-arterially. Consequently, the concomitant application of hyperthermia and intra-arterial injection of sesame oil led to a prominent inhibition of tumor growth, as compared with each modality alone (P less than 0.001). The most significant effect was obtained in the case of a combination of hyperthermia and BLM-sesame oil, as compared with a combination of hyperthermia and sesame oil (P less than 0.001). Local hyperthermia concurrent with the blockage of blood flow supplying the tumor led to a prominent inhibition of tumor growth, and addition of bleomycin to this regimen had an even greater antitumor effect. Thus, a combination of hyperthermia and chemoembolization with BLM-sesame oil is an effective treatment for liver cancer, at least in rabbits.
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PMID:Destruction of VX2 tumor in rabbits by hyperthermia plus bleomycin suspended in sesame oil. 242 62

The patient was a 65-year-old male who came to our hospital with a complaint of dysphagia. He was admitted to hospital following a diagnosis of combined tumor in the esophagus and stomach as revealed by X-ray fluoroscopy. For preoperative chemotherapy, he was given oral administration of BLM-polyacrylate pasta, 30 mg/day for 25 days and 15 mg/day for 5 days, up to a total dose of 825 mg. This regimen successfully reduced the tumor in the esophageal area. No signs of pulmonary dysfunction, changes in blood cell count and blood chemistry of any other abnormalities in his general status were seen as side-effects of the BLM-polyacrylate pasta. Thoracic-esophagectomy and total gastrectomy were performed on November 7, 1983. He has been maintaining a good quality of life without any signs of recurrence of the tumor for the last two years and six months after the operation. The esophageal tumor was identified as moderately differentiated squamous cell carcinoma with A0N0M0Pl0 and grade of invasion "mp", while the gastric tumor was moderately differentiated adenocarcinoma with H0P0S0N0 and invasion grade "m" in the early stage of IIa + IIc type.
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PMID:[A case report of concurrent esophageal and gastric double cancer successfully treated by surgery and the effectiveness of the oral administration of polyacrylate pasta (PANA kayaku) and bleomycin oil in esophageal carcinoma]. 243 May 26

The antitumor effects of transnodal cancer chemotherapy were studied using rat models. After inoculation of AH-66 tumor cells into the iliac lymph nodes (target lymph node), emulsionized bleomycin (BLM emulsion) or BLM water solution was injected into an intact popliteal lymph node and chronological changes in BLM levels in the target lymph node were measured. In the target lymph node of the iliac lymph node, the level of BLM emulsion continuously was greater than 2 micrograms/g for 9 hours after the injection, while the level of BLM water solution decreased rapidly. The antitumor effects were quantitatively estimated in the tumor of the target lymph node. The ratio of necrotic area in the BLM-emulsion-treated group was significantly greater than that in the emulsion- or saline-treated groups. Survival rate in rats treated with BLM emulsion was significantly higher than that in control groups and was slightly higher than that in the group given BLM water solution iv. The concentration of BLM in the serum and lung in case of transnodal administration of BLM was much lower than that in rats given an iv administration of BLM water solution. These findings suggest that transnodal administration of BLM emulsion is an effective and safe treatment for metastatic lymph nodes, at least in rats.
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PMID:Transnodal cancer chemotherapy for metastatic lymph nodes in rats. 243 25

The strong antitumor resistance was induced after the complete cure of a KMT-17 fibrosarcoma in WKA rats treated with bleomycin (BLM, 5 mg/kg/day, ip, for 5 days from Day 8). This suggests that immune responses of the hosts may participate in the therapeutic effects of BLM. The immune responses against the tumor associated antigens (TAA) of KMT-17 tumor cells were examined by assaying the cytotoxic T lymphocyte (CTL) activity of spleen cells after a mixed lymphocyte tumor culture (MLTC). The non-treated tumor-bearing rats showed slight responses on Day 5 and the responses reached the peak on Day 8. On Day 11, however, the responses could not be detected further. On the other hand, the responses were restored and augmented in the BLM-treated rats. The responses could be detected on the next day after the end of BLM treatment (Day 13) and were able to maintain for at least one month. Furthermore, the augmentation of T cell-mediated responses against TAA in BLM-treated rats was found to be due to the elimination of suppressor T cell activity appearing in the course of tumor progression. The T cell-fraction of spleen cells obtained from non-treated tumor-bearing rats inhibited the responses of hyperimmune rats, while the fraction obtained from BLM-treated tumor-bearing and normal rats did not. The antigen presenting cell (APC) activity of macrophages involved in T cell responses was not altered significantly by the tumor growth or BLM treatment. Moreover, macrophages of non-treated tumor-bearing rats did not show any suppressor activity on the T cell responses. The antitumor activity of CTL generating after the MLTC was detected not only by the in vitro 51Cr release assay but also by the in vivo tumor neutralizing assay (Winn's assay).
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PMID:[Enhancement of T cell-mediated immune responses in KMT-17-bearing rats by treatment with bleomycin]. 244 Jul 89

Bleomycin, with was discovered by H. Umezawa et al., is being used throughout the world of its clinically proved effect on tumors such as squamous epithelical carcinoma, malignant lymphoma etc. Elucidation on the mechanism of its effect has advanced to a molecular level, and it is believed that the agent cuts a DNA chain via a ferrum chelate [active type of BLM-Fe(III) chelate]. The heterologous dosage forms (oleosu, ointment) were developed for exerting a long-lasting at local tumor sites. And moreover, the assessment of derivatives to obtain increase the antitumor effect and reduce side effects provided clues leading to the development of Peplomycin. The essential clinical applications of this agent involve its combined with other carcinostatics and combination therapy with surgery and radiation. Many regimens have been studied in order to increase its anti-tumor effect in each field of application. There is the characteristic feature of side effects on bleomycin, which has no myelotoxicity but has fibroid lung as dose limiting toxicity. So it is necessary for the agent to be used carefully in order to reduce this pulmonary toxicity. Selection of cases, method of administration, method of early diagnosis and treatment of side effects should also be taken into consideration.
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PMID:[Bleomycin]. 244 96

Different activation energy for heat cell killing is observed between ranges of temperatures at above and below 43 degrees C, i.e. ca. 150 and 360 kcal/mol, respectively, resulting in the different concept and mode of application in clinical heating for oncotherapy. Cell phase response to heat is characterized in more thermosensitivity of S-phase cells rather than G2, M and G1 phases, while less radiosensitive of S-phase. Reduced partial Oxygen tension (pO2), nutrition and pH as the cell-extrinsic circumstances result in enhanced thermosensitivity, respectively. Not synthesis but cellular content of heat shock proteins (HSPs) as part of physiological stress proteins, which are produced by the cells principally after and occasionally even during the sublethal heating with the contrary reduction of the other proteogeneses or otherwise which are produced constitutively, concern development of thermotolerance. Among the combined thermotherapy with anticancer drug(s), that with MMC or BLM showed interactive, or more than additive, cell killing effect, while that with ADR occasionally showed less than additive effect up to the modality of the combination. Benzaldehyde showed no appreciable cytotoxicity at 37 degrees C while enhanced thermosensitivity and inhibited development of thermotolerance. Study on therapeutic ratio in in vitro cells enables that effect of each of the above-mentioned extrinsic factors on the cellular thermosensitivity is investigated independently, while study on that in vivo may not distinguish the effect of the each factor since those are given by a single cause of inadequate vascularization of tumor tissue rather than the normal counter part.
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PMID:[Fundamentals of thermochemotherapy of cancer]. 244 3

Induction chemotherapy is now frequently included in therapeutic protocol for carcinoma of oral cavity and oropharynx. Frequency of objective responses and predictive factors for favorable responses to therapy were evaluated in 135 patients. In 45% of cases an objective tumoral regression was noted (with 6% total regression). Combined CDDP-5 FU produced responses in 65% of cases, whereas the combinations of CDDP-BLM-VCR-MTX and of CDDP-BLM-VDS produced values of 35 and 41% respectively. Small tumors (T1, T2) regressed better during chemotherapy than extensive tumors (T3, T4) (16 and 34% respectively). The tumor implantation site was a predictive factor: tumors of the tonsillar region not extending to base of tongue regressed in 74% of cases as against 35% for lesions of base of tongue. In contrast, histologic type and degree of glandular involvement were not important predictive factors. These findings suggest that induction chemotherapy for carcinoma of oropharynx or oral cavity is feasible and that predictive factors of response to treatment are size and site of tumor and type of chemotherapy.
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PMID:[Induction chemotherapy of carcinomas of the oral cavity and oropharynx. Feasibility study, levels and factors of response to treatment. Apropos of 135 cases]. 244 63

The controlled release behaviour of bleomycin hydrochloride microcapsules was investigated by an in vitro dissolution method and an in vivo antitumour test. Bleomycin hydrochloride microcapsules prepared using the highest cooling rate exhibited sustained release characteristics and its release rate obeyed a nearly zero order release kinetics. Microcapsules containing bleomycin hydrochloride were locally injected into the solid tumour of uterine cervix carcinoma bearing nude mice. Tumour growth was markedly inhibited by treatment using bleomycin hydrochloride microcapsules compared to the control group and the group receiving direct local administration of bleomycin hydrochloride. No significant differences in the changes of body weight after treatment were found between the control group and the treated group. These results suggest that controlled release microcapsules may be applicable as a drug carrier for delivery of antitumour agents in cancer chemotherapy.
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PMID:An experimental study of the antitumour effect of bleomycin hydrochloride microcapsules. 246 54

From 1977 to 1988, 61 patients have received radical treatment for a carcinoma of the mobile tongue. Fifty-nine of these patients were treated in association with a BLM (or PEP), and 26 patients with external irradiation. The local tumor control rate at two years was 77%, and subsequent lymph node metastasis was 25%. The five year cumulative survival rate was 55% and the main causes of death were found to be regional node metastases and other related diseases particularly. The determinate survival for TxN0 tumors was 83%. Six percent and 26% had radio-osteonecrosis and soft tissue necrosis respectively and three patients required surgery.
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PMID:[Interstitial irradiation of carcinoma of the tongue]. 246 8


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