Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 14-year-old boy had a protracted illness characterized by bilateral tenderness and weakness of the extremities; the illness was considered to be a connective tissue disease similar to polymyositis. Not until nine months later, when the patient had new cardiac murmurs, pulmonary edema, and then a cerebrovascular accident, was the true nature of his illness suspected. The diagnosis of left atrial myxoma with the triad of constitutional, obstructive, and embolic effects was confirmed by echocardiographic studies and cardiac catheterization. The tumor was successfully removed.
 ...
PMID:Atrial myxoma mimicking a collagen disorder. 42 37

A case of clivus chondroma was presented in detail with a review of twenty-four cases reported in Japan. A twenty-eight-year-old house wife was admitted to hospital with complaints of muscle weakness and numbness on the right side of the body. Neurological examination revealed the right hemiparesis and hemihypesthesia. Cranial nerve palsies were also disclosed on the right Vth and the left IXth, Xth and XIth nerves. Craniograms showed a ring-like calcified shadow localized in the clival region without definite bone destruction. Roentgenograms disclosed many well-demarcated radioluscent areas in the phalanges of both hands and feet. The marked separation between the basilar artery and the clivus was demonstrated on vertebal angiograms and pneumoventriculograms. CT scan showed an irregularly shaped low density area localized on the clivus, which turned out to be enhanced following contrast infusion. The tumor was partially removed by the subtemporal approach, and was histologically chondroma. The patient was discharged, gaining adequate muscle strength after operations.
 ...
PMID:[An operated case of clivus chondroma (author's transl)]. 44 May 27

A 6-year-old girl was transfered to our hospital because of continuing pleocytosis, and detection of the squamous cells and cholesterin crystals in the CSF. Neurological examination on admission revealed no remarkable disorders, except for weakness of anal sphincter. X-ray examination of the spine showed a deformity of the sacral vertebra. Myelography revealed a pre-sacral cystic tumor, which was connected with spinal CSF cavity at cul-de-sac of the spinal canal by a narrow fistula. The tumor was totally removed and no meningitic sign appeared in postoperative course. Histological examination diagnosed it as a typical epidermoid tumor. Attention should be payed to the location, size, structure and clinical course in this particular case.
 ...
PMID:[Pre-sacral epidermoid cyst communicating with spinal CSF cavity (author's transl)]. 45 Jan 95

The first symptoms of the disease encountered in 30 patients were paresthesia, constant dull headaches and a feeling of numbness of the face or its half. Eventually weakness, atrophia of the masticatory muscles, a drop or absence of the corneal reflexes and cerebral and focal symptoms super vened (the symptoms depended upon the direction of the neurinoma growth). Signs of hypertension were seen in 17 cases. There was also a protein-cell dissociation: 0.5--7% of protein in pleocytosis 6/3--68/3. The craniograms showed a destruction of the ground of the middle cranial cavity in 24 cases, while in 23 cases there was a destruction of the pyramidal apex. Antiographic studies demonstrated a displacement of the carotid siphon medially (18 cases), forward (8 cases) or behind (5 cases). The tumor vascular network was detected in 5 patients. The diagnosis of neurinomas of Gasser's node requires a comprehensive summarization of the clinical and x-ray findings.
 ...
PMID:[Clinical diagnosis of neurinomas of Gasser's ganglion]. 45 90

The case of a 47-year-old man who died one month after a history of paroxysmal occipital headaches, vertigo, vomiting, weakness, and sweating is presented. The death was due to a pontine softening caused by a subintimal dissecting aneurysm of the two vertebral, the basilar and the right posterior inferior cerebellar arteries. No etiological factor of the illness could be found. The clinical signs resembled those of a flap-valve tumor of the IIIrd ventricle.
 ...
PMID:Intracranial dissecting aneurysm. Report of a case. 49 12

A study is presented of 14 patients with hyperparathyroid crisis treated at the Massachusetts General Hospital between 1964 and 1978. These patients showed diverse clinical manifestations that were indistinguishable from those in patients with pseudohyperparathyroidism. Their symptoms varied from progressive fatigue, malaise, and weakness to those related to the gastrointestinal and urinary tracts. The one biochemical alteration commonly found among these patients was the rapid increase in the serum calcium. There was a concomitant rise in the BUN in 50% of the patients and in the creatinine in 80%. The diagnosis was established by an elevated immunoreactive parathyroid hormone (PTH) level in all eight patients (100%) who had the radioimmunoassay; by the presence of subperiosteal resorption of the phalanges in six of the eight patients (75%); and in three of four patients (75%) by the loss of the lamina dura of the teeth. The 12 patients who had surgery all survived; the two who did not died. Thirteen patients (93%) had a neoplasm--an adenoma in 12 and a carcinoma in one. One patient had hyperplasia (7%). Nine patients (64%) received hypocalcemic drug therapy. The serum calcium temporarily fell to 12 mg/100 ml in five patients (56%) but failed to budge in four (44%). Simultaneous treatment with saline infusion, furosemide and with hypocalcemic drugs over a prolonged period compounded the difficulty at operation by increasing interstitial edema. Our findings from this study show prompt surgical intervention as the ideal treatment for hyperparathyroid crisis, preferably, within 72 hours of the acute onset of symptoms.
 ...
PMID:Hyperparathyroid crisis: clinical and pathologic studies of 14 patients. 51 79

A rate case was reported in which a brain tumor was also found in a patient who had an intracranial arteriovenous malformation and a cerebral aneurysm separately. A 56-year-old man was admitted with motor weakness and repeated convulsions in the left lower limb. Preoperative right and left carotid angiograms showed an arteriovenous malformation in the left parietal region and a left internal carotid artery aneurysm, but both the carotid angiograms and brain scintigrams could reveal no brain tumor. After the radical operation for these two lesions, pneumoencephalography, right serial carotid angiography and brain scintigraphy were performed, demonstrating a right parasagittal tumor. The tumor was totally removed and histological findings were fibrous meningioma.
 ...
PMID:[The association of intracranial meningioma with arteriovenous malformation and aneurysm (author's transl)]. 55 38

This is the 28th case report of jugular foramen neurinoma in the world. A 24-year-old man was admitted to our hospital with complaints of dizziness and impaired balance. Neurological examination revealed IX, XI and XII cranial nerves and cerebellar involvements, e.g., Brun's-Cushing nystagmus, curtain sign on the left, weakness of the left sternocleidomastoid muscle and deviation of the tongue to the left, accompanied with atrophy. Choked discs and other signs of increased intracranial pressure were not recognized. There were no cerebellar symptoms except impaired balance and nystagmus. Lateral view of vertebral angiography showed that the posterior inferior cerebellar artery was displaced backward and upward, the basilar artery was imposed to the clivus, and the superior cerebellar artery was elevated. A-P view of vertebral angiography showed that the posterior inferior cerebellar artery was displaced to the left. Enlargement of the left jugular foramen was revealed especially by tomograms of horizontal section at the level of 0.3 cm below the external acoustic meatus and 0.5 cm behind the external acoustic meatus. The jugular foramen margins were smooth and somewhat sclerotic. We confirmed the diagnosis of the jugular foramen neurinoma on the left. Suboccipital craniectomy confirmed a huge tumor which covered the left jugular foramen and the bulk of which was in the cisterna magna. These findings were supposed to explain that the patient did not show increased intracranial pressure. The tumor was encapsuled with smooth and thin capsule. This tumor was totally removed and the postoperative course was uneventful. Histological diagnosis was neurinoma. We consider that this tumor arose on the IXth or XIth cranial nerve.
 ...
PMID:[Intracranial neurinoma of jugular foramen--report of a case and reference, its clinical manifestations (author's transl)]. 55 40

Three cases of tethered cord syndrome are presented with reference of reported literatures. This syndrome is usually associated with spina bifida occulta and cutaneous manifestation such as subcutaneous tumor, skin dimple, hairy patch, and neavus. Presented symptoms are various progressive neurological deficits involving weakness and/or sensory disturbance of lower limbs, bowel and/or bladder dysfunction, leg and/or low back pain, and orthopedic pathological conditions such as scoliosis and/or foot deformities. Properly performed myelography is the only method of preoperative confirmation of this syndrome. As the surgical release of the tethered spinal cord is effective for these various symptoms except for foot deformity, early investigation and early surgery are recommended.
 ...
PMID:[Tethered cord syndrome--our three cases and the review of the literature (author's transl)]. 66 74

A review of the otoneurologic findings in 500 patients with facial paralysis revealed their importance for diagnosis, prognosis, and understanding the pathophysiology of Bell's palsy. Diagnosis. The presence of simultaneous bilateral palsy, facial paralysis associated with lateral rectus palsy, slowly progressive facial weakness with or without hyperkinesis, and facial paralysis that showed no recovery after six months excluded Bell's palsy from the diagnosis. Ipsilateral recurrent palsies were another indication to suspect an underlying cause, since a tumor of the facial nerve caused the paralysis in 30% of the patients with this finding. Signs such as intact forehead movement, alterations in facial sensation, and corneal hypesthesia--although often associated with lesions in the cerebral cortex, cerebellopontine angle, or internal auditory canal--were also found in patients with Bell's palsy. Prognosis. A spontaneous complete recovery following Bell's palsy occurs in about 70% of the patients; but in the presence of a dry eye or dysacousis, the prognosis for a complete recovery drops 10 and 25%, respectively. Pathophysiology. It is proposed that the wide range of neurologic findings associated with Bell's palsy is due to a viral polyneuropathy. This is a disorder that primarily involves sensory nerves, and the facial motor deficit results from involvement of the sensory fibers carried with the facial nerve within the fallopian canal.
 ...
PMID:Facial palsy: interpretation of neurologic findings. 67 68


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>