Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0027651 (
tumor
)
685,946
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Robust CD8
+
T cell memory is essential for long-term protective immunity but is often compromised in cancer, where T cell exhaustion leads to
loss of memory
precursors. Immunotherapy via checkpoint blockade may not effectively reverse this defect, potentially underlying disease relapse. Here we report that mice with a CD8
+
T cell-restricted neuropilin-1 (NRP1) deletion exhibited substantially enhanced protection from
tumor
rechallenge and sensitivity to anti-PD1 immunotherapy, despite unchanged primary tumor growth. Mechanistically, NRP1 cell-intrinsically limited the self-renewal of the CD44
+
PD1
+
TCF1
+
TIM3
-
progenitor exhausted T cells, which was associated with their reduced ability to induce c-Jun/AP-1 expression on T cell receptor restimulation, a mechanism that may contribute to terminal T cell exhaustion at the cost of memory differentiation in wild-type
tumor
-bearing hosts. These data indicate that blockade of NRP1, a unique 'immune memory checkpoint', may promote the development of long-lived
tumor
-specific T
mem
that are essential for durable antitumor immunity.
...
PMID:Neuropilin-1 is a T cell memory checkpoint limiting long-term antitumor immunity. 3272 88
<< Previous
1
2
3
4
5
6
7
