Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A new device has been developed for microwave coagulation of urinary bladder tumors. Twenty-one patients with urinary bladder tumors were treated by irradiation with microwave energy of 2,450 MHz. Results were obtained as follows: (1) microwave coagulation was performed in 21 patients with transitional cell carcinoma of the urinary bladder. Excluding 4 patients who subsequently received radical cystectomy, 17 patients showed a complete response, although 2 patients subsequently developed recurrences in different parts of the bladder within the following several months. Histological examination of the excised specimen revealed complete eradication of the tumor in 2 patients. In the remaining 2 patients with high-stage tumor (T4), viable tumor cells were noted in the urethra or vaginal wall. (2) Although neither technical difficulties nor severe complications were encountered, transient urinary frequency and calcification of the bladder wall were noted. The results of this study indicate that microwave coagulation may be used in the treatment of both superficial and invasive tumors.
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PMID:Microwave coagulation therapy for urinary bladder tumors. 305 22

Two cases of carcinoma in a diverticulum of the bladder were experienced. The first case was of a 50-year-old male who presented in February, 1981, complaining of asymptomatic microhematuria. The excretory urogram revealed a diverticulum in the left lateral aspect of the bladder which was causing shift of the lower ureter to the median side. The cytology report of voided urine was class III. Diverticulectomy was performed and pathologic findings was a transitional cell carcinoma, grade 1, stage 0. The patient has been free of recurrence for the past 54 months. The second case was of a 67-year-old male with the chief complaint of pollakiuria. Non-papillary tumor in a diverticulum of the bladder was found by cystoscopy and computed tomography. Tumor biopsy and urinary diversion by ileal conduit were performed in the usual manner. The pathologic finding was transitional cell carcinoma of grade 11 malignancy. The patient died of intestinal obstruction on January, 19, 1984, about 15 months after the surgery. The 117 cases of carcinoma in a diverticulum of the bladder we found in the Japanese literature are reviewed briefly.
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PMID:[Primary carcinoma in a diverticulum of the bladder: a report of two cases]. 311 31

A 63-year-old man was admitted with the complaints of macrohematuria, sense of residual urine and urinary frequency. Physical examination revealed an enlarged hard prostate and left scrotal mass. The pathological diagnosis of the needle biopsy specimen of the prostate showed undifferentiated adenocarcinoma. The patient underwent bilateral orchiectomy for hormone therapy of prostatic carcinoma and treatment of suspected left testicular tumor. The histology of testicular tumor revealed metastasis from carcinoma of the prostate. Metastasis of the testis from prostatic carcinoma is rare in spite of the high incidence of the primary tumor. Clinical findings on testicular metastasis from carcinoma of the prostate obtained in 62 cases reported in available literature are reviewed and discussed in detail.
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PMID:[Prostatic carcinoma with metastasis to the testicle: a case report]. 372 49

We have previously reported the clinical effects of NF therapy (NCS + 5-FU) and NFO therapy (NCS + 5-FU + Picibanil) on patients with advanced carcinoma of the digestive organs. In the present study, (NHO therapy (NCS + HCFU + Picibanil) performed in 41 patients and 30 patients were evaluated for its clinical effects. In comparison with NHO, NF and NFO, partial regression (tumor regression exceeding 50%) was noted in 5 of 30 patients (16.7%) on NHO, which was superior to 7.4% on NF, but slightly inferior to 18.8% on NFO. However, six and twelve month survival rate and 50% survival month on NHO therapy were 31.6%, 10.5% and 4.6 months, respectively and they were superior to those of NF and NFO therapy. Though the incidence of the adverse effects by NHO was almost identical with that of NFO and not more frequent than that of NF therapy. Urinary frequency, hot sensation and urgency due to HCFU administration were observed approximately in 10% on NFO therapy. In the three modalities the advantageous clinical effects on patients with hepatic carcinoma irrespective of primary or metastatic were observed.
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PMID:[Combination chemotherapy with neocarzinostatin(NCS), HCFU and picibanil(NHO therapy) for advanced carcinoma of the digestive system--a comparative study with NF, and NFO therapy]. 623 56

Cases of giant vesical diverticula that cause defecation disturbance are very rare. A 67-year-old man with such a condition was admitted to our hospital complaining of pollakiuria , nycturia , retardation, two-phase urination and defecation disturbance which began about 7 years earlier. A goose-egg-sized tumor touched above the hen-egg-sized prostate and the tumor disappeared after urination. X-ray examinations revealed that defecation disturbance was caused when the sigmoid colon was oppressed by the giant diverticulum. After diverticulectomy and prostatectomy the vesical symptoms and defecation disturbance completely subsided.
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PMID:[A case of giant vesical diverticula causing defecation disturbance]. 642 98

Although sclerosing lipogranuloma is relatively rare, it is of special interest to urologists because the majority of the cases occur in the genital and urinary tracts. A 49-year-old man complained of urinary frequency and lower abdominal pain. IVP examination revealed compression and irregularity of dome of bladder. CT scan showed giant abnormal mass upper dome of bladder. The tumor and part of the bladder which was adhered to it were excised. Histological findings were necrosis of the fat cells with liberation of fat droplets into the intercellular spaces. There were giant cells clinging to fatty masses and small fat vacuoles in them. Essentially sclerosing lipogranuloma is a disease affecting the fat cells which for some unknown reason undergo a degenerative type of change which results in rupture of the cells with liberation of free fat droplets into the surrounding intercellular spaces and then reaction around. Complete surgical excision is the treatment of choice. Otherwise the lesion recurs.
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PMID:[A case of sclerosing lipogranuloma]. 652 47

Clinical study of HCFU for head and neck cancer was performed HCFU at a daily dose of 600 to 900 mg. Was orally administered to 30 patients, including 5 patients with metastases. The primary sites of cancer were: larynx 9 cases, mesopharynx 6 cases, hypopharynx 5 cases, maxilla 5 cases, nasopharynx 3 cases, parotid gland and floor of the mouth one each. All of them were squamous cell carcinoma except a case presenting parotid lesion caused by adenocarcinoma. In 7 cases receiving the single therapy of HCFU for one month, a positive response was presented in one out of 7. Twenty-three cases treated HCFU in combination with radiation, 11 showed complete response (CR: over 90% decrease of tumor size), 6 showed partial response (PR: over 50% decrease), 3 showed minor response (MR: over 25% decrease), and 3 were diagnosed as no change (NC). Positive responses evaluated as PR or above obtained at the mean cumulative dose of 25.7 Gy and HCFU 15972 mg. Four cases receiving HCFU in adjuvant chemotherapy were studied only for clinical toxicity. Clinical toxicities of HCFU in 30 patients were presented in transient pollakiuria (7 cases), neurotoxic effect (2), eruption and diarrhea (one each). Symptoms similar to anemia and unconsciousness caused by the intake of alcohol were found in 6 patients. Although positive effect of HCFU was observed only in one case being administered singly, it presented better results in more cases when administered in combination with radiation. The combination therapy also made the lesions respond faster than by radiation therapy only. Intake of any alcohol is not advisable.
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PMID:[Clinical study of HCFU and radiation therapy for head and neck cancer]. 688 99

Thirty-seven patients were enrolled in a randomized prospective study to compare standard surgical therapy for superficial bladder cancer to standard therapy plus bacillus Calmette-Guerin (BCG). Side effects of BCG have been tolerated well and include dysuria in 95 per cent of the patients, urinary frequency in 83 per cent, hematuria in 39 per cent, fever in 22 per cent and nausea in 22 per cent. Of 19 control patients 8 (42 per cent) had recurrent tumors in the followup period, compared to 3 of 18 patients (17 per cent) treated with BCG. One patient treated wih BCG had 2 recurrences, yielding a recurrence rate of 22 per cent in the group receiving BCG compared to 42 per cent in controls. When the incidence of recurrent tumors in matched intervals before and after entry into the protocol is compared, no change in the rate of tumor recurrence (p equals 0.726 chi-square) occurred in controls, whereas tumor recurrences were reduced significantly in the group treated with BCG (p equals 0.010 chi-square). The reduction in tumor recurrence in patients treated with BCG compared to controls is statistically significant (p equals 0.029 chi-square). Of 4 patients who presented with new bladder tumors remain free of tumor after BCG therapy, while 2 of 5 comparable control patients developed recurrent tumors. Intravesical and percutaneous BCG immunotherapy appears to decrease the rate of tumor recurrence in patients followed for 1 year.
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PMID:Bacillus Calmette-Guerin immunotherapy of superficial bladder cancer. 699 13

A phase II study of a new fluoropyrimidine antitumor agent, carmofur (HCFU) fine granules, was performed in 24 institutions. The eligibility of patients and the criteria of response evaluation were based on the "Japanese Criteria for Evaluation of Clinical Effects of Cancer Chemotherapy on Solid Tumors." Out of 119 patients entered in the study, 65 patients were evaluable: 63 patients among them had measurable or evaluable lesions. Positive responses better than PR (Partial Response) were obtained in five (17.9%) out of 28 patients with gastric cancer, four (36.4%) out of 11 patients with colorectal cancer and five (45.5%) out of 11 patients with breast cancer. The total positive response rate was 22.2%. Optimal doses for the clinical use were ranged from 9 to 18mg/kg, and the median duration of PR was 19.6 weeks. In addition to the similar gastrointestinal toxicities observed in other fluoropyrimidines, hot sensation, pollakiuria and frequent defecation were seen in 12.4%, 10.1% and 3.4% of patients, respectively.
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PMID:[Phase II study of carmofur (HCFU) fine granules]. 718 33

A 72-year-old female patient presented to our clinic with the chief complaint of gross hematuria and urinary frequency on September 6, 1990. Cystoscopic examination revealed a thumb's head size nonpapillary tumor. The tumor was located adjacent to the orifice of the left ureter. Histological findings of the tumor by transurethral resection (TUR) indicated transitional cell carcinoma with partial signet ring cell carcinoma. No other malignant findings in any other organs including the gastrointestinal tract were noted. Total cystectomy was performed and Indiana pouch was constructed. Histopathological staging was pT1 N0 M0. The patient died of multiple metastasis of the signet ring cell carcinoma on June 22, 1992. This is the thirty-second case of signet ring cell carcinoma of urinary bladder reported in the medical literature in Japan. We investigated 19 alive or unknown cases as follow up and briefly discussed the treatment and outcome of the primary signet ring cell carcinoma of the urinary bladder. The outcome appeared to be somewhat better than previous reports. Total cystectomies were performed in 18 of the 32 cases (56.3%). As noted in past reports, the treatment of our patient consisted of total cystectomy. Twenty-two patients died of signet ring cell carcinoma. Recurrence to the pelvic area was observed in 18 of the 22 (81.8%) patients who died. Because of this high rate of recurrence, we recommend a thorough assessment of the pelvic area of the patients diagnosed with signet ring cell carcinoma of urinary bladder.
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PMID:[A case of primary signet ring cell carcinoma of urinary bladder]. 786 66


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