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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We report a case of renal cell carcinoma with pulmonary metastases treated with recombinant alpha interferon and subsequently presenting as congestive heart failure due to a dilated cardiomyopathy. A 66-year-old man presented himself to the department of internal medicine at our hospital with a complaint of persistent cough with sputum on August 27, 1988. Ultrasonogram, computed tomography and angiography showed a right renal cell carcinoma and chest x-ray films disclosed bilateral multiple nodular shadows, probably representing metastases of the renal tumor. After being transferred to our department, the patient underwent the ligation of the right renal artery and vein and the postoperative treatment with recombinant alpha interferon, achieving a complete response for pulmonary metastases and a partial response for the primary region. On February 14, 1990 the patient was admitted to our hospital with a complaint of dyspnea to be diagnosed as congestive heart failure due to dilated cardiomyopathy. The interferon therapy was suspected to have caused the heart disease, and four months after discontinuation of interferon therapy the heart failure symptoms had improved, but hypokinesis of the cardiac wall still persisted. To our knowledge, this may be the first case of alpha interferon-related cardiomyopathy in Japan.
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PMID:[Dilated cardiomyopathy following alpha interferon therapy of renal tumor with pulmonary metastases: a case report]. 141 58

Endobronchial neoplastic disease is rarely encountered in patients under 20 years of age. The great majority of these lesions are carcinoids or mucoepidermoid carcinoma. Symptoms are secondary to bronchial irritation and manifest as recurrent pneumonitis, hemoptysis, persistent cough, reactive airway disease, and chest pain. Early bronchoscopy reliably enables identification and may prevent harmful sequelae resulting from delay in diagnosis. Retrospective data from four cases collected from the Tumor Registry in the Southern California Kaiser Permanente Medical Group is presented and a review of the literature is discussed.
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PMID:Endobronchial carcinoid and mucoepidermoid carcinoma in children. 200 93

A 54-year-old woman, who had received left radical mastectomy 12 years previously, was admitted with persistent cough and hemoptysis. Plain chest X-ray film showed no abnormality but fiberoptic bronchoscopy revealed that a polypoid lesion occluded the right truncus and the surrounding bronchial mucosa was firm and edematous. Biopsy specimen demonstrated adenocarcinoma. Right middle and lower sleeve bilobectomy was performed. The tumor occupied mainly the outer and submucosal layer of the bronchial wall. Histologically, this tumor showed scirrhous adenocarcinoma with the same pathologic appearance as the primary breast lesion. It is considered that endobronchial metastasis from breast carcinoma is not particularly uncommon, therefore any patient with a past history of breast cancer and respiratory symptoms should undergo fiberoptic bronchoscopy, particularly when the chest X-ray is normal or shows non-specific changes.
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PMID:[A resected case of endobronchial metastasis from breast carcinoma]. 221 19

The authors report a case of primary bronchial malignant melanoma, occurring in a 34-year-old woman presenting with persistent cough. At bronchoscopic examination, a polypoid mass was found to occlude the left mainstem bronchus. Biopsies showed a malignant epithelioid tumor resembling an atypical carcinoid. Histochemistry, electron microscopic study, and immunohistochemistry confirmed the diagnosis of melanoma. Physical examination and additional clinical history to exclude other possible primary sites were negative. The patient underwent thoracotomy with left pneumonectomy. Nineteen months after resection she was found to have a histologically similar tumor involving her left adrenal gland. Review of the literature shows that melanoma of the lower respiratory tract has been reported only in adults and has a tendency to present as a central polypoid growth that may be responsive to surgical resection.
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PMID:Primary malignant melanoma of the lower respiratory tract. Report of a case and literature review. 223 29

We experienced a surgical case of large Hodgkin's lymphoma of the thymus. An 18 year-old male who had been complaining of a persistent cough was admitted to our hospital. Chest X-ray film showed an anterosuperior mediastinal tumor. But there was no superficial lymphadenopathy and hepatosplenomegaly. He received a surgical extirpation of the tumor approached by median sternotomy. The tumor expanded to the whole antero superior mediastinal region, which was 18.5 X 15 X 5.5 cm in size, surrounding the trachea and main branch of aortic arch and veins. The tumor directly invaded the bilateral pleura and left innominate vein, so these regions were resected with the tumor. The left innominate vein was reconstructed with a PTFE graft. The pathological diagnosis was Hodgkin's lymphoma nodular sclerosis type by LSG classification. A post operative course was uneventful.
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PMID:[A surgical case of Hodgkin's lymphoma originated from thymus]. 232 91

A five-year-old boy was admitted, complaining of a persistent cough. Chest film showed a smooth round mass in right mediastinal region and deformity of 6th rib. CT studies revealed the presence of a well-defined mass with low density. Pulmonary arteriography demonstrated hypovascularity in right pulmonary field. Preoperative diagnosis was a benign neurogenic tumor originated from intercostal nerve located at the posterior mediastinum. At operation, a large round smooth mass was found adhered to chest wall and, in part, parietal pleura, and it was removed completely. The sixth rib with deformity was also resected partly. The specimen measured 9.5 x 5.0 x 4.0 cm and weighed 175 g. Histopathological findings demonstrated that the tumor proved to be ganglioneuroma.
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PMID:A surgical case of giant mediastinal tumor in a child associated with rib deformity. 248 37

A 66-year-old woman was admitted to hospital because of a persistent cough and hemoptysis. Her chest X-ray showed a coin lesion in the S10 area of her right lung. The tumor was resected and its histologic features showed it to be a so-called carcinosarcoma of the lung.
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PMID:[A case of so-called carcinosarcoma of the lung]. 260 9

We present our experience with 18 bronchial carcinoids, two of those being of atypical histology. Mean age is 44 years, without sex preponderance. Clinical symptoms are poorly specific, with persistent cough and recurrent pneumonia as most frequent features. Carcinoid syndrome was seen in one patient. In 4 patients, the carcinoid tumor was an incidental finding on routine chest X-Ray film. Lack of pathognomonic clinical signs explains the considerable delay in diagnosis, with a mean of 10 months of clinical evAluation. Radiographic patterns are atelectatic lobe consolidation, a solitary coin lesion or a transparent lung field. All patients were submitted to bronchoscopic evaluation and only two endoscopic explorations remained negative, because of their peripheral localizations. In all other cases, there was a typical appearance of "cherry red adenoma". Mediastinal extension was present in 2 cases, while extrathoracic metastases were never found. Whenever possible, surgical resection was performed (16 cases). Two patients got endoscopic extirpation of their tumor. There is one postoperative hospital death. This study was done to gain a better understanding of clinical, diagnostic and pathologic features of bronchial carcinoid tumors, and their implications in terms of therapy and prognosis. The authors discuss clinical, diagnostic and therapeutic aspects of bronchial carcinoids as well as their microscopic appearance and relationship with oat cell carcinoma.
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PMID:[Carcinoid tumors of the bronchi. Our experience of these during the last 10 years, with a review of the literature]. 267 50

A patient with a giant leiomyoma of the esophagus (1235 g) presented with persistent cough, intermittent fever, nocturnal pyrosis, and intermittent dysphagia for solid foods. Reconstruction after extirpation of the distal esophagus, the tumor, and the proximal stomach involved a Collis gastroplasty and a Nissen fundoplication using stapling technique. This combination of operations after resection was used to assure the best functional result possible in a young man with benign disease.
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PMID:Giant leiomyoma of the esophagus. 663 58

A rare case of a patient with non-insulin-dependent diabetes mellitus (NIDDM) with small cell lung cancer, initially diagnosed as pyogenic vertebral osteomyelitis, was reported. A 40-year-old male patient was diagnosed with NIDDM about 3 years earlier, but he did not receive any treatment. Then, a two-month history of high fever, persistent cough and back pain developed. Chest X-ray film showed a lung infiltrate with a small cavity in the upper portion of the left lung. Computed tomography and magnetic resonance imaging of the chest revealed a tumor mass shadow with osteoclasia along the bodies of the 6th and 7th thoracic vertebral bone. Staphylococcus aureus infection was confirmed by arterial blood culture. Administration of antibiotics resulted in the disappearance of the left lung infiltrate and a slight reduction of the tumor mass in the thoracic vertebral bone, suggesting pyogenic vertebral osteomyelitis as an unusual complication of NIDDM. However, as the tumor mass still remained, needle biopsy for the mass lesion was performed, resulting in the diagnosis of metastasis of small cell carcinoma from the left lung. Gene aberration in this lung disease has been reported recently, and its correlation with NIDDM which may also be induced by genetic abnormality is an interesting question that remains to be resolved.
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PMID:[A rare case of a diabetic patient with small cell lung cancer, initially diagnosed as pyogenic vertebral osteomyelitis]. 775 Jun 28


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