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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We present a case report of primary hepatocellular carcinoma with tumor thrombus extending into the right atrium complicated by pulmonary embolism. A 49-year-old man was admitted to our hospital for searching a cause of thrombus in the right atrium. The patient complained of shortness of breath and oedema of the lower extremities. He had a history of hepatitis B. Abdominal sonography and computed tomography revealed a tumor of the liver. A needle biopsy confirmed the diagnosis of hepatocellular carcinoma. Magnetic resonance showed a tumor thrombus also in the inferior vena cava. The diagnosis of pulmonary embolism was confirmed by pulmonary perfusion scintigraphy. This case stresses that clinicians should include hepatocellular carcinoma among the possible causes of intracardiac thrombus and pulmonary embolism.
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PMID:[A case of primary hepatocellular carcinoma with tumor thrombus in the right atrium and massive pulmonary embolism]. 875 55

A case of a giant atypical carcinoid tumor is discussed. The tumor occurred in a 33-year-old man who presented with pleuritic chest pain and shortness of breath. Details of his preoperative evaluation, metastatic work-up, and use of tumor embolization are described. The operative procedure and use of cardiopulmonary support to achieve appropriate margins are described as well. Review of the literature and pathologic characteristics of carcinoid tumors and atypical carcinoid tumors are discussed.
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PMID:Giant carcinoid tumor of the lung. 906 21

Five cases of yolk sac tumor of the anterior mediastinum associated with prominent thymic cystic changes are presented. The patients were five men between the ages of 17 and 22 years (mean, 19.5 yr). Clinically, four patients presented with symptoms of chest pain and shortness of breath, whereas the fifth was asymptomatic: his tumor was discovered during a routine physical examination. None of the patients had a history of previous tumor elsewhere. Grossly, the tumors were described as cystic lesions measuring between 8 and 12 cm in greatest dimension. Histologically, the tumors showed prominent cystic changes reminiscent of those observed in acquired multilocular thymic cysts, i.e., the presence of cystic cavities lined by squamous epithelium with prominent inflammatory changes, lymphoid hyperplasia, cholesterol cleft granulomas, and remnants of thymic tissue in the walls of the cysts. In addition, there was a neoplastic cellular proliferation composed of small cells with scant cytoplasm, round nuclei, and inconspicuous nucleoli adopting a reticular pattern of growth and, in some areas, embedded in abundant myxoid stroma. Numerous intra- and extracellular hyaline globules, as well as Schiller-Duval bodies, could also be identified. Immunohistochemical studies showed positive reaction with alpha-fetoprotein antibodies in the tumor cells. Follow-up information obtained in these patients showed that all had died of tumor 1 to 3 years after initial diagnosis. The present cases document another unusual but distinctive growth pattern of yolk sac tumor in the mediastinum and highlight the importance of proper sampling of cystic lesions in this location.
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PMID:Mediastinal yolk sac tumors associated with prominent multilocular cystic changes of thymic epithelium: a clinicopathologic and immunohistochemical study of five cases. 926 22

Primary choriocarcinoma of the anterior mediastinum is by far the rarest and most controversial form of extragonadal germ cell tumor. A clinicopathologic study of eight primary mediastinal neoplasms bearing the histopathologic and immunohistochemical features of choriocarcinoma is presented. The patients were all men between the ages of 21 and 63 years (mean, 42 years). Clinical symptoms included shortness of breath, chest pain, cough, and superior vena cava syndrome; one patient also had gynecomastia. All patients presented with large anterior mediastinal masses on chest radiographs that measured an average of 10 cm in greatest diameter. Grossly, the tumors were described as large, soft, extensively hemorrhagic, and with foci of necrosis. Histologically, they were characterized by a dual cell population composed of cytotrophoblastic cells with uniform, round nuclei, clear cytoplasm, and prominent nucleoli admixed with large, multinucleated syncytiotrophoblastic cells with bizarre nuclei, prominent nucleoli, and abundant eosinophilic cytoplasm. Immunohistochemically, the tumors were notable for strong keratin and beta-human chorionic gonadotropin (HCG) positivity. Seven patients presented at the time of diagnosis with thoracic and extrathoracic (liver, adrenal, kidney, and spleen) metastases. In one case, the tumor was entirely confined to the mediastinum. All patients died over a period of 1 to 2 months. Complete autopsies were performed in all cases; none of the patients showed evidence of a testicular tumor or scar after thorough examination of the testes on serial sectioning. The present cases demonstrate the widespread distribution of germ cells in the human body and lend further support to the existence of primary extragonadal choriocarcinoma arising in the thymic region.
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PMID:Primary mediastinal choriocarcinomas: a clinicopathologic and immunohistochemical study of eight cases. 929 76

Four cases of primary hepatoid yolk sac tumors of the anterior mediastinum are described. The patients were all men between the ages of 26 and 40 years (median 33). Clinically, they all presented with a history of shortness of breath and chest pain of several weeks' duration. None of the patients had a history of germ cell tumor elsewhere or evidence of any hepatic abnormality. Grossly, all the tumors were described as large mediastinal masses that impinged on adjacent structures. Histologically, they were characterized by sheets of medium-sized, round to polygonal neoplastic cells with moderate amounts of eosinophilic cytoplasm and round to oval nuclei with prominent nucleoli. The cellular proliferation was homogeneous and displayed moderate cellular atypia and scattered mitotic activity. All the tumors showed focally the presence of more conventional areas of yolk sac tumor, with islands of tumor cells showing a reticular pattern of growth admixed with scattered intra- and extracellular hyaline globules and occasional Schiller-Duval bodies. Immunohistochemical studies showed strong positivity of the tumor cells for alpha-fetoprotein in both components of the lesions. Follow-up information was available in three patients, all of whom developed lung metastases within a year after initial diagnosis. Two of these patients died of tumor within the same period, whereas a third patient has been lost to follow-up. The present cases illustrate an unusual histologic pattern of yolk sac tumor in the mediastinum and highlight the importance of considering this tumor in the differential diagnosis of lesions showing a hepatoid pattern of growth in the mediastinal area.
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PMID:Hepatoid yolk sac tumors of the mediastinum: a clinicopathologic and immunohistochemical study of four cases. 988 15

Bronchioloalveolar carcinoma is characterized pathologically by a pulmonary neoplasm showing lepidic growth. More than half of all patients with bronchioloalveolar carcinoma are asymptomatic. The most frequent symptoms and signs are cough, sputum, shortness of breath, weight loss, hemoptysis, and fever. Bronchorrhea is unusual and a late manifestation. Nonmucinous bronchioloalveolar carcinoma tends to be more localized and has a lower frequency of bronchogenic spread than mucinous bronchioloalveolar carcinoma. Bronchioloalveolar carcinoma appears radiographically as a single nodule, segmental or lobar consolidation, or diffuse nodules. At computed tomography (CT), the single nodular form appears as a peripheral nodule or localized ground-glass attenuation with or without consolidation, frequently associated with bubblelike areas of low attenuation and open bronchus signs. The lobar consolidative form may demonstrate the CT angiogram and open bronchus signs. The diffuse nodular form appears as multiple nodules or areas of ground-glass attenuation or consolidation. The single nodular form has a better prognosis than the others but may show false-negative results for malignancy at 2-(fluorine-18) fluoro-2-deoxy-D-glucose positron emission tomography.
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PMID:Bronchioloalveolar carcinoma: clinical, histopathologic, and radiologic findings. 939 50

A 74-year-old man presented with shortness of breath and vague chest pain. A chest roentgenogram showed subtotal atelectasis of the upper lobe of the left lung and a CT scan revealed an occlusion of the bronchus of the upper lobe of the left lung by an intraluminal tumor. A well-circumscribed yellow tumor obstructing the bronchus of the upper lobe of the left lung was seen by fiberoptic bronchoscopy. Biopsies revealed mature fat tissue and small areas with bone consistent with the diagnosis of an endobronchial predominantly lipomatous hamartoma.
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PMID:Endobronchial lipomatous hamartoma: a rare cause of bronchial occlusion. 944 Jun 4

A 68-year-old man presented to another hospital with progressive shortness of breath, dry cough, and systemic edema. A chest X-ray, echocardiogram, and chest CT showed a mediastinal mass and massive pericardial effusion. His symptoms improved after the treatment for heart failure. The pericardial effusion was bloody. In that, malignant cell wasn't proved. Thoracotomy was performed to diagnose the mediastinal tumor and to extirpate it. Pathological diagnosis after operation was thymoma with direct invasion to pericardium and tunica externa of aorta. Thymomas are routinely asymptomatic for prolonged periods of time. Symptomatic pericardial tamponade as initial manifestation due to a thymoma with a massive pericardial effusion is uncommon.
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PMID:[Invasive thymoma with pericardial tamponade as initial manifestation]. 945 8

Adrenocortical carcinoma is a rare tumor which can extend into the right heart via the inferior vena cava. We describe a case of a 26-year-old woman who had progressive shortness of breath, intermittent chest pain, and peripheral edema. A two-dimensional echocardiogram on hospital admission showed a large multinodular mass in the right atrium which extended into the inferior vena cava. Further studies showed that this mass was adrenocortical carcinoma. An echocardiogram performed 3 weeks before admission was completely normal. It appears that an adrenocortical carcinoma is capable of rapid growth up the inferior vena cava and into the right atrium.
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PMID:Rapid extension of left adrenocortical carcinoma into the right atrium. 948 78

We report a case of lipomatous hypertrophy of the interatrial septum in a patient with a recent syncopal episode and shortness of breath. Preoperative transesophageal echocardiography demonstrated a large tumor protruding from the interatrial septum. In addition, the patient was found to have significant coronary artery disease and a right internal carotid artery stenosis. The patient underwent successful resection of the mass with septal reconstruction, aortocoronary bypass, and right carotid endarterectomy. Histology of the mass was consistent with lipomatous hypertrophy.
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PMID:Surgical treatment of lipomatous hypertrophy of the interatrial septum. 964 8


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