Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

SMS 201-995 was administered to 40 acromegalic patients, in a multicentric study. Some of the results have been analyzed from 37 patients who remained under a long term treatment. Clinical improvement was noted in most patients, especially as concerns soft tissue swelling, sweating, headache. Digestive adverse effects were noted, leading to the drop-out from the protocol (in 4 patients) or in most patients to a slight discomfort related to increasing doses. There was an effect for all the doses used (300, 600, 900, 1500 micrograms in 3 subcutaneous injections per day), compared with pretreatment values, if we consider the mean GH value of each cycle obtained under the different dosages. The highest dose was most effective than the lowest in some cases. However in most patients the 300 micrograms dose was efficient. We could not obtain normalization of GH secretion. However 22/37 patients could reach a good score as concerns the number of GH values less than 5 micrograms/l, during circadian evaluations. In 5/37 patients, the antisecretory effect was insufficient (mean GH above 50% of the pretreatment level). Reduction in tumor volume was highly significant (more than 50%) in 2/11 patients. In conclusion, this study shows the efficacy of SMS 201-995 in improving clinical signs and symptoms of acromegaly, and GH hypersecretion in approximately 80% of the patients. General and metabolic tolerance are rather good. Some points concerning tolerance remain to be investigated.
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PMID:[Effect of repeated injections of sandostatine, with increasing doses, in the treatment of 40 acromegalics. French Group for the study of Sandostatine in Acromegaly]. 305 76

Tarsal coalition refers to the condition that exists when there is absent or restricted movement between two or more of the bones of the hindfoot. The usual cause of the restricted movement is a congenital abnormality with a fibrous (syndesmosis), cartilagenous (synchondrosis), or bony (synostosis) union between the adjoining involved bones. The commonest site of these congenital anomalous attachments are reported in the literature as being located at the calcaneonavicular, the talocalcaneal, and, less commonly, the talonavicular areas. Limited movement in the hindfoot can also result from trauma, arthritis, tumor, or injury involving those joints in the foot. The congenital form may often go unrecognized until such time as a twist or sprain of the ankle or foot leads to its diagnosis. On the other hand, the condition may go unrecognized as a cause for chronic pain or discomfort in the hindfoot or ankle. In this article, a series of 13 feet in 11 patients with this condition that have been noted in the sports medicine clinic at the University of Arizona Health Sciences Center during the past 8 years is described. A detailed historical, clinical, and biomechanical account is also included.
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PMID:Tarsal coalition: a review of the literature and presentation of 13 cases. 306 63

Colonoscopy is a superior diagnostic tool for the detection of cancer of the colon. Its limitations include that it is not always available and there is a great deal of discomfort for the patient. It should therefore be used as effectively as possible. The goal of this retrolective cohort study was to analyze the usefulness of colonoscopy, especially by relating it to the subsequent therapeutic impact. Indication-related groups included "rectal bleeding," "other symptoms suggestive of malignancy," and "follow-up." In 714 patients selected as a result of admission to the proctological unit of our surgical clinic, a carcinoma was discovered in 9% and an adenoma in 13.4%. Patients with rectal bleeding were found to benefit most from colonoscopy since active therapeutic management followed in 56% of the cases. On comparison, there was a direct therapeutic impact in only 10% of the colonoscopies performed for follow-up. Identification of additional factors such as mucosal proliferation markers may help to improve the efficiency of endoscopy by more specifically designating the populations at risk for colonic neoplasia.
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PMID:Usefulness and limitations of colonoscopy in a proctological clinic. 313 73

Pleural effusions are resistant to standard therapy, which causes discomfort and can require prolonged hospitalization. As an alternative, pleuroperitoneal shunting for pleural effusions of various etiologies was evaluated. We implanted 36 shunts in 29 patients. Two patients had bilateral shunts and five had shunt revisions. The effusion was related to a malignancy in 22 patients, postoperative chylothorax in two patients, and other causes in five patients. Therapeutic thoracentesis had been attempted in 28 patients, and eight had had chest tube placement previously with attempted sclerosis. Seven patients had a trapped lung syndrome. There was no operative mortality. All patients were deemed ready for discharge from the hospital if they had recovered from the operation within 48 hours. Five patients had poor results, either because of a moribund status or their refusal or inability to pump the shunt. Of the remaining 24 patients, four had good results with temporary improvement, and excellent results were achieved in 20 patients (83.3%), who experienced symptomatic relief and stabilization or regression of pleural effusion until the time of their death. Patients with chylothorax experienced complete resolution. The 14 patients with malignant effusions had a median survival of 4 months, and there were no instances of peritoneal tumor seeding. In conclusion, pleuroperitoneal shunting is an alternative therapy for pleural effusions that requires a limited hospitalization only, is associated with minimal and short-term discomfort, achieves excellent results in properly selected patients, and is the only viable therapy when lung expansion cannot be achieved.
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PMID:Pleuro-peritoneal shunting. Alternative therapy for pleural effusions. 317 32

This is the report of a 27-year old woman with a symptomatic leiomyoma of the left kidney. Symptoms consisted of a mild discomfort at the left flank and a walking difficulty. A left radical nephrectomy was performed. The tumor measured 15 cm in its largest diameter and was composed of elongated cells which demonstrated positive reactivity with anti-desmin and anti-actin antisera and negative reactivity for S-100 protein and cytokeratins. Histologic differential diagnosis is with other spindle cell renal tumors such as leiomyosarcoma, mesoblastic nephroma, angiomyolipoma, fibroma, schwannoma and sarcomatoid renal cell carcinoma.
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PMID:Leiomyoma of the kidney. 318 48

A case of acquired pulmonic stenosis is described. The only symptoms reported by the patient, a seemingly healthy woman, were minor chest discomfort and mild dyspnea upon exertion for the last six month. Cardiac catheterization revealed stenoses of both the right and left pulmonary arteries. Magnetic resonance imaging revealed a mediastinal tumor mass that almost totally compressed the right main pulmonary artery and also encroached upon the left pulmonary artery. Histologically the tumor was a malignant teratoma. The subsequent course of treatment was complicated by cardiac tamponade. With regression of the tumor during therapy the signs of pulmonic stenosis disappeared. In cases with acquired pulmonic stenosis an underlying mediastinal tumor has to be considered.
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PMID:[Peripheral pulmonary stenosis: initial manifestation of a malignant teratoma]. 319 81

Traditionally, sonographically guided percutaneous needle biopsy has been used for the biopsy of large, superficial, and cystic masses. Today, however, many think that small, solid masses also can be biopsied accurately. Real-time sonographically guided biopsies of 126 consecutive solid masses that were less than or equal to 3.0-cm in diameter (less than or equal to 1.0 cm, 24; 1.1-2.0 cm, 42; 2.1-3.0 cm, 60) were performed to diagnose primary or secondary neoplasm. These masses were located in a variety of anatomic regions (abdomen, 92; neck, 31; breast, two; extremity, one). Clear visualization of the biopsy needle was accomplished by continuous real-time monitoring of the needle's position, primarily by using linear, phased-array transducers, large-caliber needles (18- to 19-gauge, when possible), and an echogenic screw stylet inserted coaxially within the biopsy needle. The correct cytologic/histologic diagnosis was established in 91% of the masses (less than or equal to 1.0 cm, 79%; 1.1-2.0 cm, 88%; 2.1-3.0 cm, 98%). No complications other than mild, localized discomfort were encountered. Our experience suggests that sonographically guided biopsy is a highly accurate and safe procedure that can be used to establish the diagnosis in solid masses that are 3.0 cm or less in diameter if proper techniques are used to clearly visualize the biopsy needle.
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PMID:Sonographically guided percutaneous biopsy of small (3 cm or less) masses. 328 65

The neuroradiological stereotactic examinations provide indispensable information to localize many intracranial lesions: the data obtained by the CT-Scan are complementary of the stereotactic ones. The transfer of the routine CT-Scan transverse axial slices into the Talairach stereotactic system needs a precise definition of the inclination of the plan of the slices and a correct evaluation of the mean magnification factor. The inclination of the slices is appreciated using the bony, vascular and ventricular landmarks clearly identified on the CT-Scan and stereoscopic stereotactic images. We compared the spatial "reconstructed" CT-Scan data with the histopathological findings obtained by serial stereotactic biopsies in 48 tumor patients. The error varied from 1.5 to 4.6% (m: 2.7 +/- 1.2) on the sagittal plane; from 1.3 to 10% (m: 5.8 +/- 3.4) on the transversal plane; from 2.5 to 4.3% (m: 3.5 +/- 0.7) on the axial plane. The mean global error was 3.7% +/- 2.3. The CT-Scan directly performed under stereotactic conditions (acrylic frame) seems to be the more useful procedure. Nevertheless considering the good precision obtained with our methodology applied to the Talairach's system, we consider it suitable when: a) the gantry of the CT-Scan apparatus is too narrow for the acrylic frame; b) the exploitation of previous CT-Scan examinations is necessary; c) patient refuses the discomfort of the acrylic frame.
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PMID:[Value and technic of translating the data from x-ray computed tomography into the stereotaxic coordinates of the Talairach system]. 329 40

A 42-year-old patient with hemophilia A developed acute left hypochondrial pain 8 days postnephrolithotomy. A colloidal scan indicated multiple hematomas, and conservative management was given. Postoperatively, recurrent discomfort necessitated splenectomy. Multiple space-occupying lesions were found, and the histology was that of a large, noncleaved lymphoma. Contiguous spread outside of the capsule was evident, but abdominal nodes and liver appeared normal. Chemotherapy was administered, with evidence of tumor response, but refractoriness supervened, and the patient died 4 months after the diagnosis. Space-occupying lesions in a hemophiliac are generally ascribed to hematomas. The exposure of this population to the human immunodeficiency virus (HIV) should raise the consideration of a non-Hodgkin lymphoma in any situation where rapid clinical resolution of a hematoma is not occurring.
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PMID:Intrasplenic lymphoma resembling multiple hematomas in a hemophiliac. 340 37

Cystadenoma of the pancreas is a rare tumor, which usually occurs in young women. In this paper, 8 patients are reported. The common clinical symptom was upper abdominal mass or discomfort. The tumor was located by ultrasonography and CT scan. Impression and displacement of the duodenum and stomach were showed by barium meal examination of the upper gastrointestinal tract. Macroscopically, the tumor was encapsulated. Its section showed cystic and multilocular structures. Microscopically, the tumor cells were in papillary arrangement. Six of these 8 patients were misdiagnosed as pseudocyst of the pancreas and cystojejunostomy was performed. Three of 6 underwent malignant change, which was finally diagnosed by fine needle aspiration cytology. This tumor, even after malignant change, is prone to local invasion and less likely towards distant metastasis. Resection, including pancreatoduodenectomy, is the best treatment.
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PMID:[Cystadenoma of the pancreas]. 345 32


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