Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effects of beta-FNA, a highly selective and irreversible mu opioid receptor antagonist, in altering tumor response in A/Jax mice inoculated with S20Y cells were determined. Inoculation of neuroblastoma cells in control subjects resulted in 100% tumor incidence within 16 days, and mean and median survival times of 36 and 35 days, respectively, following tumor inoculation. Tumor incidence and survival times were comparable to controls for mice given chronic injections of 2 mg/kg and 10 mg/kg beta-FNA every 48 h beginning 2 days after tumor inoculation. Tumor growth was subnormal in the 10 mg/kg beta-FNA group. Both dosages of beta-FNA were found to block morphine-induced analgesia for 48 h. These results suggest that, in and by themselves, mu receptors selectively antagonized by beta-FNA do not play an important role in neuro-oncogenic events.
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PMID:beta-Funaltrexamine (beta-FNA) and neural tumor response in mice. 405 12

The relationship between the pharmacological properties of an opioid antagonist, naltrexone (NTX), and tumor response was studied in mice with transplanted neuroblastoma (NB). Animals receiving 0.1 mg/kg NTX every 6 hr, which blocked morphine-induced analgesia for 24 hr each day, had a 100% tumor incidence, no deviation in time before tumor appearance, and a 17% decrease from control values in total survival time. In contrast, once daily injections of either 0.1 mg/kg NTX or 0.4 mg/kg NTX (the equivalent of 0.1 mg/kg given 4 times daily), which blocked morphine-induced analgesia for less than 10 hr each day, resulted in a tumor incidence of 20% and 60%, respectively, delays in time prior to tumor appearance of 90% and 65%, respectively, and an increased total survival time of 10% and 24%, respectively, for tumor-bearing mice relative to control levels. Inoculation of NB in control animals resulted in 100% tumor appearance within 16 days and a mean survival time of 36 days. These results show that tumorigenic events are dictated by the duration of opiate receptor blockade rather than the dosage of opiate antagonist, and provide compelling evidence that endogenous opioid systems play a crucial role in neuro-oncogenic expression.
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PMID:Duration of opiate receptor blockade determines tumorigenic response in mice with neuroblastoma: a role for endogenous opioid systems in cancer. 608 62

Electrical stimulation of the periaqueductal gray of the rat's midbrain analgesia leads to an increase in the number of artificial pulmonary metastases from the Walker 256 tumor. In an effort to investigate the influence of the pain suppression system and its associated peptides on this phenomenon, we activated the pain suppression system directly from the Nucleus of the Raphe Magnus, a non-opioid subsystem. After inducing analgesia by direct injection of beta-endorphin on the Nucleus of the Raphe Magnus, we noted an increase in the number of artificial pulmonary metastases. This result could be blocked by pretreatment with naloxone. If the Nucleus of the Raphe Magnus was activated by electrical stimulation sufficient to induce analgesia, the metastatic effect was still present but markedly attenuated.
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PMID:Beta-endorphin injected into the nucleus of the raphe magnus facilitates metastatic tumor growth. 608

Hysteroscopy has become a standard investigational and therapeutic tool in gynecology. Many office procedures done with the hysteroscope can be performed without analgesia or anesthesia. With the use of the hysteroscope lost IUDs can be identified, and the entire uterine cavity can be inspected easily in a matter of minutes. The special features of the microcolpohysteroscope permit contact hysteroscopy to be performed at the squamocolumnar junction regardless of its location, thus offering advantages over traditional colposcopy. The diagnostic and therapeutic applications of hysteroscopy are many and range from visualizing neoplasia to examining the fetus in utero.
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PMID:Hysteroscopy. 619 74

22 gynecological patients suffering from considerable tumor pain in an advanced carcinoma stage had a continuous peridural anaesthesia. 18 patients reported a very good and 4 patients a sufficient analgesia. The average morphine dose per day was 14 mg. The indwelling catheters remained on an average 27 days in site. Side effects, which could be related to the morphine PDA, occurred in one case.
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PMID:[Peridural morphine analgesia for the control of tumor-induced pain in gynecologic cancer patients]. 620 73

Exposure to stress has been associated with alterations in both immune function and tumor development in man and laboratory animals. In the present study, we investigated the effect of a particular type of inescapable footshock stress, known to cause an opioid mediated form of analgesia, on survival time of female Fischer 344 rats injected with a mammary ascites tumor. Rats subjected to inescapable footshock manifested an enhanced tumor growth indicated by a decreased survival time and decreased percent survival. This tumor enhancing effect of stress was prevented by the opiate antagonist, naltrexone, suggesting a role for endogenous opioid peptides in this process. In the absence of stress, naltrexone did not affect tumor growth.
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PMID:Apparent involvement of opioid peptides in stress-induced enhancement of tumor growth. 668 24

Naltrexone, an opiate antagonist, had both stimulatory and inhibitory effects, depending on the dosage, on the growth of S20Y neuroblastoma in A/Jax mice. Daily injections of 0.1 milligram of naltrexone per kilogram of body weight, which blocked morphine-induced analgesia for 4 to 6 hours per day, resulted in a 33 percent tumor incidence, a 98 percent delay in the time before tumor appearance, and a 36 percent increase in survival time. Neuroblastoma-inoculated mice receiving 10 milligrams of naltrexone per kilogram, which blocked morphine-induced analgesia for 24 hours per day, had a 100 percent tumor incidence, a 27 percent reduction in the time before tumor appearance, and a 19 percent decrease in survival time. Inoculation of neuroblastoma cells in control subjects resulted in 100 percent tumor incidence within 29 days. These results show that naltrexone can modulate tumor response and suggest a role for the endorphin-opiate receptor system in neuro-oncogenic events.
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PMID:Naltrexone modulates tumor response in mice with neuroblastoma. 686 37

Fifty-eight coelio-splanchnic nerve blocks by alcoholisation were done for thirty-two patients at the regional Center of the Fight against Cancer at Montpellier for persistent neoplastic pain of the pancreatico-solar type. In 15 cases (46,6 p. cent), the pancreatico-solar syndrome is the initial sign of a primitive or secondary supra-mesocolic cancer. In 12 cases, the hyperalgic syndrome discloses the extension or recidive of the tumor. According to etiologies, the illnesses were as follows: --pancreatic neoplasias I or II: 13 cases, --hepato-biliary lesions I or II: 11 cases, --peritoneal carcinosis: 4 cases, --invasion of retro-peritoneal nodes: 4 cases. Epigastric pain irradiating to the left para-vertebral area are resistant to analgesias; 95 p. cent of these patients received morphinic drugs for several days, if not weeks. The splanchnic nerves were reached by a posterior high lumbar injection according to the Kappis and Labat technic. A block with 2 p. cent lidocaine is immediately followed by alcoholisation by 99,8 p. cent ethanol. According to patient status, the blocks to the left and right were done at once or at several visits. The block by lidocaine gives immediate analgesia thereby indicating the proper placement of the injection. The coeliac alcoholisation assures the neurolysis of the splanchnic nerves. The antalgic effect lasts a variable time, averaging 42 days (varying from 2 to 240 days). The antalgic action always allows the discontinuation of morphinic drugs and increases the efficacy of minor analgesics, if necessary. All the same, 18/25 received morphine during their last few days before death.
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PMID:[Splanchnic nerve blocks by alcoholisation in pancreatico-solar hyperalgia of tumoral origin (author's transl)]. 730 43

New laparoscopic instrumentation coupled with standard surgical techniques allows one to perform procedures previously thought impossible via the laparoscope. This report reviews the natural history, the indications for resection, and the technique of laparoscopic resection of hepatic hemangiomata. Two women, 24 and 62 years of age, were first seen with abdominal pain. A diagnosis of hemangioma was made in each case, and both lesions were removed laparoscopically. Operative blood loss was 200 cc in each case, and neither patient required transfusion. Diets were started on the first postoperative day (POD), and the patients were discharged on the second and fourth PODs without narcotic analgesia. If the size and location of the tumor are favorable, laparoscopic resection of liver hemangiomata can be performed safely. Blood loss comparable to that of open procedures and a quicker recovery support an endosurgical approach to resection of liver hemangiomata in selected cases.
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PMID:Laparoscopic resection of two liver hemangiomata. 755 Dec 79

The influence of adrenalin on the pharmacokinetics of lidocaine given interpleurally to 10 patients with pancreatic neoplasia was studied. Five patients received an interpleural dose of lidocaine (200 mg; control group), and 5 patients received an interpleural dose of lidocaine (200 mg) plus adrenalin (1:200,000). Plasma and cerebrospinal fluid (CSF) levels of lidocaine were measured before and at specified times (up to 8 hours) after the dose. The analytical technique was radioimmunoassay; and plasma and CSF data were assessed using noncompartmental analysis. The drug was quickly absorbed into the plasma in the control group (Cmax = 2.76 +/- 0.10 microgram/mL at 0.33 +/- 0.14 hours after administration); whereas drug access to CSF was decreased and occurred slowly (Cmax = 0.32 +/- 0.07 microgram/mL at 1.66 +/- 1.35 hours). The drug was eliminated more quickly from plasma than from CSF, with half-lives of 1.71 +/- 0.43 hours and 3.86 +/- 1.27 hours, respectively. The simultaneous administration of adrenalin delayed absorption (tmax = 0.91 +/- 0.52 hours). The drug elimination half-lives in plasma and CSF of this group increased to 3.22 +/- 1.22 hours and 8.71 +/- 3.28 hours, respectively. The duration of the analgesia, evaluated as the time until the patient needed another dose, increased from 8.2 +/- 1.5 hours in the control group to 9.7 +/- 1.3 hours in the group that received adrenalin. From these results the levels that would be reached on a multiple-dose regimen (D = 200 mg, tau = 8 hours) were predicted.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:The influence of adrenalin on the pharmacokinetics of interpleurally administered lidocaine in patients with pancreatic neoplasia. 765 Feb 34


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