Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

With the aim of exterminating small (up to 3--4 cm. in diameter), single or multiple subcutaneous fat tumors (lipoma etc.) the author suggests to use transcutaneous injections of solutions possessing necrotizing properties (10% calcium chloride, 96% alcohol, formalin) into the tumor instead of its surgical removal. The injection should be done under local anesthesia, slowly, the amount of solution not exceeding 0.5--1 of the volume of the tumor. The necrotherapy has been used for 4 years upon 14 patients (32 tumors); besides, the author made 12 self-injections. In 3 cases a repeated injection was required. There were no complications or recurrences.
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PMID:[Method of injection necrotherapy of benign tumors of the subcutaneous cellular tissue]. 69 78

Serum cholinesterase activity was determined in 30 female patients anaesthetized with enflurane for excision of lump in the breast. In all 30 patients biopsy of the tumor was negative for carcinoma. Blood samples were taken before induction of anaesthesia, at the end of the operation and 24 hours after the operation. Enzymatic determinations were performed by the Boerhinger cholinesterase kit. Enzyme levels were found sufficiently high at the end of the operation and returned to the preoperative levels 24 hours post-operatively.
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PMID:Serum cholinesterase activity following enflurane anaesthesia. 72 26

Cancer of the nose is very common and lesions seen by reconstructive surgeons are often recurrent and extensive. Surgical removal of cancer of the nasal skin can usually be accomplished under local anesthesia, and in most instances frozen section histologic examination should be used to confirm the adequacy of excision. The location and three dimensional extent of the tumor will dictate the choices of repair or reconstruction as well as the timing thereof. Very small lesions can be excised with primary closure; other well circumscribed tumors can be excised and the defect closed with an appropriate nasal flap. In our experience most nasal skin cancers have been managed by excision and full-thickness skin grafting. We have found the skin of the neck and that of the preauricular region to provide the best skin cover except in the upper third of the nose where upper eyelid skin provides excellent coverage. We have used composite grafts from the ear to replace up to two-thirds of an alar rim. Nasolabial, cheek, and midline forehead flaps are useful in a variety of instances, but usually when less than one-half of the nose has been excised. We have been pleased, in most instances, with the Converse scalping flap for near total, subtotal, and extensive three-dimensional lower nasal defects. (Transverse superficial temporal artery pedicle flaps can be successfully used to reconstruct large nasal defects with adjacent cheek loss.) We have rarely used distant flaps. Regardless of what regional pedicle flap has been transferred to the nose, subsequent revisions of a relatively minor nature will nearly always enhance the result. Patients who have undergone extended total nasectomies are probably best managed with a prosthesis, as prognosis is often guarded and flap reconstruction may be quite unsatisfactory. In our experience, defects in lining and support can usually be repaired with local nasal tissue.
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PMID:Cancer of the nose: ablation and repair. 78 30

A female Perodicticus potto developed a subcutaneous spherical mass on the medial aspect of the inguinal area. The anesthesia, surgical removal, and aftercare were described. The tumor was described grossly and histologically. It was determined to be a myeloliposarcoma. The tumor has not recurred after 14 mo.
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PMID:Myeloliposarcoma in a potto (Perodicticus potto): a case report. 82 Sep 22

The ability of leukocytes to kill tumor cells appears central to the defense against neoplastic growth. The authors determined the effect of thiopental on this phenomenon in vitro by incubating 51Cr-labelled YAAC-1 tumor cells obtained from the peritoneal cavities of syngeneic A/JAX white mice with immune leukocytes from the peritoneal cavities of allogeneic C57/black mice. Tumor-cell death was quantitated by the amount of 51Cr released into the medium following tumor-cell lysis. Thiopental, in concentrations used during routine anesthesia, inhibited tumor-cell killing in a dose-related manner. Inhibition of cytotoxicity ranged from 8.6 per cent at 2.8 x 10(-5) M thiopental to 38.1 per cent at 8.5 x 10(-5) M thiopental. Moreover, this inhibitory effect was additive to that previously demonstrated with halothane, and was related to the duration of exposure to the anesthetic. It is postulated that thiopental and other anesthetics contribute to the inhibition of leukocyte responsiveness observed in patients with malignancies who have undergone surgical procedures.
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PMID:Thiopental inhibition of tumor immunity. 83 52

A study was made of 201 asymptomatic women over age 40 (range, 40-74 years) who underwent uterine sounding and endometrial screening by the negative-pressure jet irrigation technique, without anesthesia, in private gynecologists' offices. Introduction of the irrigator was accomplished in 88 percent of these patients. In 97 percent of the successful irrigations, the specimens obtained were satisfactory for cytologic and histologic diagnosis of neoplasia. No occult endometrial carcinomas were discovered. The factors which interfered with endometrial screening by these methods are analyzed. Cervical stenosis prevented endometrial irrigation in 13 of the 24 unsuccessful attempts. Acceptance by the patients was high, in that 74.2 percent reported slight or no discomfort and only 4.7 percent complained of severe discomfort. Although 12.5 percent experienced pelvic cramping after irrigation, no other significant side effects were observed. The results of this investigation indicate the feasibility of using the endometrial irrigation technique for massive screening studies of asymptomatic women who are at risk for the development of endometrial carcinoma.
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PMID:Endometrial screening of asymptomatic women by irrigation technique in the private gynecology office. 83 42

Within a 2-year period, 2 cases of extremely rare occurence of simultaneous intra- and extrauterine pregnancy were observed in a Frankfurt-Oder clinic. In the 1st case the 33-year-old patient had had an IUD for 3 years. In the 2nd case the 40-year-old patient had suffered adnexitis after interuptio. Variations in egg-transport speed, stopping of the egg at a tubal obstacle, or digression of the egg are mentioned as possible causes for double pregnancy. Swelling of the tubal pregnancy due to nidation of the 1st intrauterine egg is also suggested. Incidence of tubal pregnancies is higher with IUDs or after adnexitis or adnex operations. Diagnosis in such cases is extremely difficult, and there is always a danger that the 2nd pregnancy may be overlooked because extrauterine pregnancy symptoms are so acute. If the uterus is abnormally enlarged or breakthrough bleeding does not occur after adnexectomy or removal of the corpus luteum graviditatis, or if there are positive pregnancy tests after Postoperative Day 14, intrauterine pregnancy should be suspected. If interupptio of intrauterine pregnancy has been performed, extrauterine pregnancy may be suspected if an adnex tumor is discovered, bleeding remains slight, or the immunological pregnancy test remains positive after 14 postpartum days. Thus it is recommended that preabortion examinations include tests for adnex tumors; thorough examinations may be carried out with anesthesia. Dismissal examinations should also be meticulously performed, and there should be careful ambulatory follow-up supervision of the patient.
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PMID:[2 cases of simultaneous intra- and extrauterine pregnancy]. 84 1

The conditions for the success of surgical interventions within the chiasmal region are careful preparation of the patient, ideal general anesthesia, precise surgical technique especially improved by the use of the microscope and bipolar coagulation. The surgical results also depend on the age of the patient, on his general condition, on the volume of the tumoral lesion and on the extent and kind of implication of the vascular and nervous structures of this region. The lesions are classified into extraparenchymatous lesions, intraparenchymatous lesions, giant aneurysms and inflammatory lesions. The extensive extraparenchymatous lesions represent the most important group: they comprise the pituitary adenomas, the cranio-pharyngiomas, the meningiomas and finally rarer tumors like the chordomas, or other tumors of the sphenoid. In these regions the choice of access is extremely important: transphenoidal, subfrontal intracranial or mixed. Among the intraparenchymatous lesions one has to mention first of all the gliomas of the chiasm and then the ectopic pinealomas. The giant aneurysm in older persons is improved the symptomatology by ligation of the internal carotid. The inflammatory arachnoidal lesions of the chiasm (specific or nonspecific) generally profit from an intervention aiming to disconnect the adhesions. X-ray therapy represents very often an indispensable component of the surgical treatment of the tumoral lesions. Apart from death the complications are postoperative infection, aggravation of the neuro-ophthalmological symptoms, the neuro-psychological consequences and the endocrinological and hypothalamic complications. Early diagnosis represents the best means to diminish the importance of the complications. An alternative complication is the tumor recurrence.
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PMID:[Neurosurgery of chiasma syndromes (author's transl)]. 85 83

An aged gray stallion was examined because of fullminating posterior paresis, bladder paralysis, and perineal anesthesia. Lower motor neuron dysfunction was detected at the lumbosacral level of the spinal cord, and cerebrospinal fluid was yellow. After brief supportive treatment, the horse died. Necropsy revealed a single epidural melanoma at L5-6. The absence of cutaneous melanotic growth, absence of organ involvement, and extensive vertebral remodeling indicated the neoplasm to have been primary and to have been present for an extended period. Neurologic dysfunction was acute and progressive, as a result of spinal cord compression by the neoplasm.
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PMID:Epidural melanoma causing posterior paresis in a horse. 87 44

150 cases of prostate cancer treated with estrogens at the Urology clinic of the Hotel-Dieu from 1963 to 1974 are presented. The men ranged in age from 50 to 91; the majority were 60-69 years. Their clinical stages were 29% Stage 1, no perceptible mass; 43% Stage 2, nodule felt on rectal exam; 13% Stage 3, tumor extended outside the prostate but not metastases, normal prostatic phosphatases; and 15% Stage 4, elevated prostatic phasphatases and metastases. Diagnosis was by urinary symptoms in Stage 2 or above, rectal palpation, and puncture biopsy under local anesthesia. Estrogen treatment consisted of diethylstilbestrol, stilbelstrol diphosphate or TACE (Chlorotraianisene), or estradiol. Estrogen side effects were loss of libido after 1 month, gynecomastia, and nausea. Other treatments included prostatectomy in Stages 1 and 2, cobalt in 5 cases, castration in 3 cases, 1 endo-uretral resection, and 1 hypophysectomy. 50% died in 1 year and 16% were lost to follow up and presumed dead in 1 year; the mean survival of the others was 3 years. Estrogen therapy improved symptoms and reversed tumor growth temporarily in hormone-dependent cancers, but these tumors all escape hormone control eventually.
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PMID:[Course of prostate cancer under estrogen therapy]. 87 31


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