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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A new method has been developed allowing the introduction of the argon laser beam into the water-filled bladder using normal operation cystoscopes. The energy is applicated to the bladder by means of a light conductor which is placed into the bladder through the working channel of an operation cystoscope. Treating large tumors of the bladder we laser the resection bed after electroresection (TUR). The sole use of laser therapy on large tumors of the bladder is not to be recommended because of the uncertainty of their total destruction. On the other hand, the sole laser coagulation of small relapses of tumor up to the size of raspberries restricted to the mucous membrane seems to be more effective than electroresection. The advantage of laser treatment is the absence of electric power flow through the tissue which avoids muscle convulsions of the bladder and electric power leakage. Besides of this, laser therapy being painless allows treatment without anesthesia. So far 68 patients with tumors of the bladder have been treated by transurethral laser therapy combined with electroresection (TUR). The aim of transurethral laser therapy is the reduction of recidivity of bladder tumors.
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PMID:[Value of transurethral laser therapy in the treatment of bladder carcinoma]. 8 60

Two hundred patients with obstructing esophagogastric malignancy were treated with positioning of a plastic prosthesis. With the aid of a small caliber fiberendoscope and a pusher tube, the prosthesis was positioned under continuous visual control, using only local anesthesia. Seventy-seven patients had esophageal carcinoma, 25 had pulmonary carcinoma obstructing the esophagus, and 98 had gastric carcinoma. Of the latter, 21 had extensive stomach involvement and 8 had local tumor recurrence after esophagojejunostomy. A bronchoesophageal fistula was present in 17 patients. Complications were bleeding (3), perforation (16) with only one death, and obstruction either due to food impaction (13), tumor overgrowth (17), or reflux esophagitis (5); the latter two conditions were corrected by changing the tube in all cases. Tube migration occurred frequently, but could be prevented by adapting the shape of the prosthesis. The procedure was performed as ultimate palliation in patients unfit for surgical insertion and had a low mortality rate of 2%. In general, there was marked improvement in the quality of life.
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PMID:Palliative treatment of obstructing esophagogastric malignancy by endoscopic positioning of a plastic prosthesis. 9 Jun 32

Local X-ray irradiation of a transplantable rat tumour in a single dose of 3000 R increased significantly the extracellular space of this tumor as estimated by the plasma-tissue equilibration of 51Cr-EDTA, while the plasma and red blood cell volume as estimated with 125I-labeled albumin and 59Fe-labelled erythrocytes after sacrifice by bleeding under ether anaesthesia were unchanged. These results combined signified a decreased cell volume of cells, excluding red blood cells.
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PMID:Vascular and extravascular spaces in a transplantable rat tumour after local X-ray irradiation. 13 9

Two 8-month-old and two 4-month-old male beagle dogs received 250 ml of 150 microgram/ml solution of N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG) and 2% Tween 60 mixed with a pellet diet twice a day for 8 months as the same methods used for mongrel dogs in our first report [Juntendo Medical Jouranl 19, 579-583 (1973)]. Gastric carcinomas with distant lymph nodes metastases occurred in three beagle dogs except for one died from anesthesia at the endoscopy. Metastases to the liver were observed in two beagles. In the most long-lived beagles, peritonitis carcinomatosa with ascites and metastases to the liver, lungs, bones, and skin were found. Main gastric tumors were located at the subcardia in two dogs (elevated tumor in dog No. 6, ulcerated tumor in dog No. 8), but in dog No 7 at the angulus (ulcerated tumor). Histologically, carcinomas were composed of poorly differentiated adenocarcinoma, signet-ring cell carcinoma, tubular adenocarcinoma, and undifferentiated adenocarcinoma. In all of three dogs which developed adenocarcinoma of the stomach, Stewart's criteria were completely satisifed. Using our methods the target organ is limited only to the stomach, without any sarcomatous lesion of the intestines.
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PMID:Adenocarcinomas of the stomach induced in beagle dogs by oral administration of N-ethyl-N'-nitro-N-nitrosoguanidine. 14 26

Two cases of carinal tumor managed by resection and primary anastomosis are presented. Their course is discussed and a description of an anesthetic technique which obviates the need for cardiopulmonary bypass is presented. The principles of carinal surgery are discussed, emphasizing expert anesthesia and resection line control by frozen-tissue examination.
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PMID:Carinal resection. A report of two cases and a description of the anesthetic technique. 17 35

Acute abdominal pain is the presenting manifestation in approximately 30% of all patients with Willms' tumor. In a small proportion of these patients this pain is significant enough to engender a diagnosis of an acute surgical abdomen. Six of 38 patients with Wilms' tumors treated between the years 1965 and 1975 at the Shands Teaching Hospital of the University of Florida Medical Center have had significant pain. Our experience with these patients emphasizes the importance of thoroughly palpating the abdomen of any child with a suspected acute surgical condition, following induction of anesthesia and prior to initiating the operation. In the absence of any evidence of an acute surgical problem at the time of the exploratory laparotomy, it is also imperative that a careful intra-abdominal examination be performed to exclude the presence of conditions, such as Wilms tumor of the kidney, that may occasionally present in this manner.
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PMID:Wilms' tumor with acute abdominal pain. 19 3

Seven cases of biopsy-proved juvenile nasopharyngeal angiofibroma are presented. All patients were males. Examination under anesthesia and tomography and angiography were very rewarding in determining the full extent of tumor. Selective carotid angiography revealed a characteristic early arterial phase with reticulated vessels, and a homogeneous blush continuing into the venous phase without early draining veins. The tumor has a strong predilection for young males. Chromosomal studies and estimation of 17-ketosteroids in 4 patients were normal. None of the patients demonstrated sexual underdevelopment. All were treated by external radiotherapy with 3000 rads in 15 fractions in three weeks with good results. There were no undue side effects.
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PMID:Juvenile nasopharyngeal angiofibroma. A report of seven cases. 20 2

Percutaneous transhepatic portal vein catheterization and transfemoral portal and caval catheterizations were performed under local anesthesia in five patients with symptoms of organic hypoglycemia. During the investigation, results of pancreatic phlebography revealed the pancreatic venous anatomy. Blood obtained from the celiac artery, caval branches and pancreatic veins was assayed for insulin by two different radioimmunoassay methods. Pathologically high, pancreatic arteriovenous insulin differences in two patients with insulinomas and in two patients with islet cell hyperplasia. In one of the patients with an insulinoma, one of the assays failed to detect the tumor insulin. This inconsistency still remains unexplained. Angiography revealed a pancreatic abnormality in only two patients. During operation, two of the tumors were found upon palpation and inspection. Pancreatic resections were performed according to the findings of pathologic hormone differences in all five patients. Immunocytochemistry revealed that three of the patients had insulin-producing tumors and two had local islet cell hyperplasia. Catheterizations performed two months postoperatively confirmed the radicality of the operation in all patients, with the possible exception of one patient. In one patient, a recurrance was detected by catheterization ten months postoperatively.
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PMID:Localization of insulinomas and islet cell hyperplasias by pancreatic vein catheterization and insulin assay. 20 62

Twenty-six cases of ultrasonically guided percutaneous fine-needle aspiration biopsies of abdominal masses are reported. Included are masses in the pancreas, retroperitoneum, liver, kidney, and pelvis. Aspiration biopsies accurately diagnosed or excluded malignancy in 21 patients (81%). The procedure, performed under local anesthesia, is rapid, simple and almost painless. No complications occurred; specifically, there was no hemorrhage, peritonitis, or spread of tumor along the needle tract.
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PMID:Ultrasound guided fine-needle aspiration biopsy of abdominal masses. 21 38

Normal rat thyroid membranes adsorb neurotoxicity when incubated with purified tetanus toxin. Membranes from a rat thyroid tumor with a thyrotropin receptor defect adsorb very little neurotoxicity when similarly evaluated. This inability of the tumor membranes to adsorb neurotoxicity is correlated with a defect in their ability to bind both 125I-labeled tetanus toxin and [125I]iodothyrotropin. The effect of tetanus toxin on the release of radioiodine from the thyroids of appropriately prepared mice has been measured by adapting methods used for the bioassay of thyrotropin. One minimum lethal dose of tetanus toxin given sc caused a significant release of radioiodine into the blood of mice 48 h after injection. In mice subjected to the stress of prior bleedings or anesthesia, the release of radioiodine from the thyroid by tetanus toxin was accelerated, i.e., the increase in blood radioiodine could be measured 24 h after injection. These results again suggest that tetanus toxin may interact with thyrotropin receptors on thyroid plasma membranes. The "sympathetic overactivity syndrome" seen in some patients with tetanus and the syndrome characterized as "thyroid storm" in patients with Graves' disease are discussed as they may relate to these observations.
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PMID:Tetanus toxin interactions with the thyroid: decreased toxin binding to membranes from a thyroid tumor with a thyrotropin receptor defect and in vivo stimulation of thyroid function. 21 3


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