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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

During a 3 year period 572 high-resolution sonograms were carried out in the follow-up examinations of 348 patients who had been treated for ENT malignancy. Our experiences in routine application of this diagnostic method are described and illustrated by typical sonograms. Ultrasound findings of complications (chylous cysts, seromas, granulomas, fistulae) are demonstrated and the value and limitations of sonography in detecting lymph node metastases and primary recurrences are pointed out. In spite of the high accuracy of this method, it is not possible to differentiate between lymph nodes which are invaded by tumour and those with non-specific lymph adenopathy by echographic criteria only. We used ultrasound for follow-up studies on patients treated by irradiation or chemotherapy. Finally, sonography provided additional information on the exact site and size of the tumor. Real-time sonography is not time-consuming and can be applied without any special preparation of the patient. It has therefore become a satisfactory diagnostic method in the follow-up of patients who have undergone treatment of malignant tumors.
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PMID:[Role of sonography in post-therapeutic control of tumors of the head and neck area]. 331 77

Isolated surgical approaches to tumor treatment have largely reached a point beyond which prospects appear to be unpromising. The search for more promising therapeutic approaches, therefore, has become a compelling challenge. Surgico-adjuvant tumour chemotherapy has been more thoroughly studied than anything else in that direction. The underlying theoretical concept seems to be persuasive, though clinical results have so far stayed below expectations. Secured prolongation of life, following this therapy, has so far proved to be probable only for cases of osteosarcoma, mammary carcinoma with high risk of recurrence, testicular tumours, and neurogenic tumours. Neo-adjuvant chemotherapy seems to work well in cases of ENT tumours. Model studies into Lewis-Lung carcinoma have shown that therapeutic effects cannot be guaranteed unless a sensitised tumour is treated with an effective preparation. This is likely to add to the long-range importance of the individual aspects relating to surgico-adjuvant tumour chemotherapy. Methods have been and continue to be developed for that purpose. Yet, all of them need to be methodologically improved. At present, waiting for such improvement, surgico-adjuvant tumour chemotherapy should be used only within the framework of controlled clinical studies.
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PMID:[Adjuvant chemotherapy in cancer surgery]. 332 55

New techniques in tumor diagnosis allow us to improve and to refine the surgical procedure of partial laryngectomy. The first aim remains the radical tumor resection. After that we postulate a better functional surgery. Improvements were also realized using surgical voice restoration during and after laryngectomy. Technique and results are described with the use of voice prosthesis and tracheostoma valves for non-sign language speech. The treatment of laryngeal cancer today means cooperation between radiotherapy, oncology and ENT-surgery. Therefore the discussion of new developments in ENT-tumor surgery is of interest.
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PMID:[New aspects in the therapy of laryngeal tumors from the surgeon's viewpoint]. 362 66

The concept for surgical removal of facial skin neoplasms consists of three components: Sufficient preoperative clinical diagnosis; complete tumor removal; Adequate functional and esthetic reconstruction. For achieving proper diagnosis the collaboration with the dermatologist is highly recommended. The ENT examining microscope allows for better visualisation of structural characteristics. Excisional biopsy should be preferred whenever possible. Out of 97 basal cell carcinomas 25% secondary or thirdly neoplasms have been found. In 81 basal cell carcinomas the visible extent, the real tumor extent in the specimen after fixation and the total excisional area are compared. According to these measurements the following safety margins seem to be recommendable: For small solid or solid-cystic superficial basal cell carcinomas 3-5 mm, for the sclerodermiform or partially undifferentiated basal cell carcinoma 10-20 mm and for basal cell carcinomas involving the bone more than 20 mm. Excising a spinocellular carcinoma a safety margin of at least half of the maximal diameter has proved to be sufficient. The close collaboration with the histopathologist resulted in our department in a simplified economic and safe microscopically controlled excision. The rate of recurrences of 97 basal cell carcinomas was 6.6%. The question of prophylactic lymph-node dissection in combination with the excision of spinocellular carcinomas is discussed.
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PMID:[Oncosurgical treatment principles in basalioma and spinocellular carcinoma of the facial skin]. 379 57

Two cases of facial nerve neurinoma (VII-Nm) were reported. The first case is a 41-year-old man who had 16 years of history of slowly progressive right facial palsy and hearing disturbance. The tumor originated in horizontal portion of the right facial nerve, and extended epidurally into the middle cranial fossa, as well as medially along the facial canal to the C-P angle. The second case is a 55-year-old man with 16 years of history of progressive right facial palsy which was followed by hearing disturbance. The tumor was found in the vertical portion of the right facial nerve, expanding in the petrous bone. Both tumors were removed surgically. 116 VII-Nm were reported in the literature including our 2 cases. Most were reported in the ENT field, and only 11 cases in the neurosurgical field. Facial palsy or hearing disturbance is the initial symptom, depending on the site of origin in the facial nerve. VII-Nm can originate in any part of the facial nerve. The most common part of origin is the vertical portion where the tumor tends to expand locally, but it may extend extracranially along the facial canal. The tumor which originates in the tympanic portion tends to extend into the middle ear cavity. The tumor originating in the horizontal portion extends to the epidural space in the middle cranial fossa and/or medially along the facial canal. VII-Nm in the cisternal portion of the facial nerve extends to the posterior cranial fossa and produces the signs of C-P angle tumor. Unlike the acoustic neurinoma, VII-Nm is associated with marked facial palsy.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Facial nerve neurinoma--report of 2 cases]. 399 Sep 6

Hematoporphyrin derivative-photoradiation therapy (HPD-PRT) of human malignancy has been performed on 267 tumor sites in 50 patients. Tumor response has been assayed at 24 hours and one month following treatment with 625-635 nm light from an argon laser-pumped dye laser. The majority of tumors treated were dermal breast cancer recurrences (21 cases), local recurrence of ENT squamous cell carcinomas (16 cases), and ENT cutaneous metastases of squamous cell carcinomas (9 cases). A 30-day favorable response was judged to be either complete regression of the tumor or reduction of tumor diameter by greater than 50%. The above categories of tumors had a combined favorable response of 81%. Appropriate dosimetry is discussed.
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PMID:Laser photoradiation therapy of cancer following hematoporphyrin sensitization. 621 88

The number of severely disabled with official acknowledgement is nowadays estimated at over four million and is going to mount to six or seven million shortly. In the future that means an additional activity for the ENT-specialist concerning the medical opinion handling the law of severely disabled. In this study registration procedure, course of law and questions in giving the medical opinion (signs of old age, hearing impairment, disequilirium, neoplasm) are described. Also findings and results of 38 medical opinions for social courts are described.
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PMID:[Expert testimony according to the law on the severely disabled]. 621 78

Unexplained osteomalacia may be the result of various neoplasma including ENT tumors. The mechanism of this oncogenic osteomalacia is uncertain, but it may result from a tumor-induced alteration in vitamin-D metabolism or from a direct phosphaturic action of a tumor product. Thorough ENT evaluation of patients presenting with unexplained osteomalacia is indicated, as successful tumor excision can lead to cure.
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PMID:Nasopharyngeal angiofibroma presenting as adult osteomalacia: case report and review of the literature. 631 23

Twenty-six patients with known primary tumors were treated surgically for pulmonary metastases between 1951 and 1979. The metastases were diagnosed more often (58% of cases) by routine radiological examinations than because of thoracic symptoms. While diagnosis of the primary tumor and the metastases was simultaneous in three cases, the average lapse of time between the two diagnoses was 5 years and 1 month in the other cases. In four cases, it was 10 years or more. Lung X-rays showed single tumors more often than multiple tumors (12%). Broncho-fibroscopy was usually normal, but a preoperative biopsy showed the metastatic nature of the tumor in 5 cases. Ablation was by lobectomy (42%), pneumonectomy (23%) or atypical resection (27%). The hospital mortality rate was 7.6%. The survival rate at 1, 3 and 5 years (71%, 39%, and 17%) is identical to that of primitive bronchial tumors, and seems to be influenced by certain factors, such as the locus of the primitive tumor (with a particularly bad prognosis for ENT tumors), the lapse of time between the diagnoses of the primary and secondary tumors, the fact that there is one, rather than several, metastases, or that the metastases are monolateral rather than bilateral, and, finally, the limited nature of the exeresis. These factors prompt regular, systematic and prolonged radiological monitoring in search of further pulmonary metastases.
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PMID:[Surgical treatment of pulmonary metastases. Apropos of 26 cases]. 632 Mar 80

Five year survival rate of 168 cases of cancer in the cervical esophagus with extension to the hypopharynx, which had been treated in ENT department of Keio University during the past 13 years, was shown to be as low as 28%. Factors responsible for this poor result were delineated from standpoints such as local recurrence, node metastasis, distant metastasis, skip lesions, double lesions and so on. Preoperative combination of chemo-radiotherapy was evaluated histopathologically, and the results indicated that macroscopic reduction of tumor in the cavity does not always correspond with histologic improvement. The author stressed the demerit of preoperative radiotherapy and proposed a trial of induction chemotherapy, radical excision with primary reconstruction and postoperative combination of immuno-chemo-radio-therapy.
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PMID:[Cancer of the cervical esophagus with extension to hypopharynx: its behavior and treatment]. 650 95


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