Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 32-year-old woman with a contraceptive history of use of combination contraceptives (Oviston, Non-Ovlon) between 1966 and 1979 (with a 1-year interruption), followed by radical hysterectomy in 1979, complained of dull right upper quadrant pain, nausea, vomiting, and fatigue in 1980. Among various diagnostic studies performed only cholecystography and cholangiography demonstrated clear areas in the gallbladder assumed to be stones. Cholecystectomy performed in 1981 showed chronic inflammation of the gallbladder without stones. The undersurface of the liver revealed a greyish tumor (3 cm in diameter). Frozen section demonstrated mature hepatocellular adenoma. Wedge excision of the tumor and cholecystectomy were performed without complications. CAT-scan follow-up showed no residual pathology. Additional literature search reports 58 cases in western European and American journals. Diagnosis of these benign tumors is difficult because the symptoms are vague. The main complication is intraabdominal hemorrhage necessitating emergency lobectomy. Ligation of a branch of the hepatic artery is done in case of inoperability. CAT-scan and ultrasonography with selective angiography are the best procedures to ascertain the diagnosis. Needle biopsy is contraindicated because of the risk of hemorrhage.
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PMID:[Hepatocellular adenoma following long-term intake of ovulation inhibitors]. 630 51

We report a case of primary hepatic leiomyosarcoma in a 70 years old woman presenting with hepatomegaly, right upper quadrant pain and impairement of general status. A left hemihepatectomy was undertaken revealing a single tumor of 7 cm in diameter in the left hepatic lobe. An immunohistochemycal study was performed indicating the smooth muscle nature of the tumor. The patient died 6 months later without evidence of active tumoral disease. This is the 28th report on primary leiomyosarcoma of the liver in the world literature.
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PMID:[Primary leiomyosarcoma of the liver]. 774 10

Anomalous junction of the pancreaticobiliary duct (AJPB) is a rare, congenital anatomic abnormality of the biliary system and is thought to be associated with a high risk of developing carcinoma of the gallbladder. We have had two cases of AJPB-associated gallbladder carcinoma in the past four years. Case 1: a 42-year-old female complaining of right upper quadrant pain was found in an abdominal sonogram to have irregular thickening of the gallbladder wall. Endoscopic retrograde cholangiopancreaticography revealed an abnormally elongated common channel; an abdominal CT scan and celiac angiogram showed a gallbladder tumor with invasion to the liver base. Case 2: a 36-year-old female presented with right upper quadrant pain and a palpable mass. A gallbladder tumor was found in an abdominal sonogram. Intraoperative cholangiography showed an abnormally elongated junction of the pancreaticobiliary duct. In these two cases, adenocarcinoma of the gallbladder was proven by pathology after surgical excision. Since AJPB and bladder carcinoma are both rare, the coexistence of these two diseases indicates that patients with AJPB have a high risk of developing gallbladder carcinoma. It is suggested that patients with AJPB should be closely followed. A prophylactic cholecystectomy may be indicated in some cases because of the high risk of developing gallbladder carcinoma.
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PMID:Anomalous junction of pancreaticobiliary duct with carcinoma of the gallbladder: report of two cases. 810 48

Early detection of hepatic lymphoma involvement is of prime importance, as it affects the choice of treatment and the prognosis. However, clinical recognition of these lesions at the time of initial staging or during the course of the disease is difficult because infiltration by lymphoma is usually diffuse rather than focal. We describe a 64-year-old man with a previous history of peripheral T-cell lymphoma involving the lung, skin and inguinal lymph nodes. After six months of chemotherapy resulting in a complete clinical remission, he suffered from an intermittent fever and right upper quadrant pain one week prior to admission. Abdominal ultrasonography and computed tomography disclosed a 6.0 x 5.7 cm heterogeneous mass in the liver. The serum alfafetoprotein level was within the normal limits and an indirect hemagglutinin titer for ameba was negative. The patient was initially treated for a liver abscess until a liver biopsy showed malignant lymphoma. Chemotherapy was initiated and the tumor was remarkable reduced in size, with a final dimension of 2.3 x 2.2 cm before discharge. radiologic patterns of hepatic lymphoma and its differential diagnosis are discussed in this report.
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PMID:Hepatic lymphoma mimicking liver abscess: report of a case and review of the literature. 810 81

A 38-year-old woman developed right upper quadrant pain due to a mass in the left lobe of the liver. The tumor was resected along with segment 3 of the left lobe. Histologic examination and immunochemistry supported a diagnosis of benign schwannoma. No metastatic disease was present, and the patient has been well for more than 18 months after surgery without recurrence. This is the first reported case of successful resection of a schwannoma of the liver in a patient without von Recklinghausen's disease.
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PMID:Resection of primary schwannoma of the liver not associated with neurofibromatosis. 825 Jul 15

A 68 year old woman with primary hepatic leiomyosarcoma, impairement of general status and right upper quadrant pain was diagnosed with liver tumor by sonography, CT scan and nuclear magnetic resonance imaging. Angiograms showed a hypervascular tumor. The patient was treated by hepatic transplantation but died 15 days after operation. The diagnosis of leiomyosarcoma was established by immunohistochemical and ultrastructural studies; the primary nature was confirmed by necropsy. Diagnostic and therapeutic features of primary hepatic leiomyosarcoma--the 19th case reported in the literature--are discussed.
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PMID:[Leiomyosarcoma of the liver: a case treated by transplantation]. 833 Jun 97

A rare case of double primary tumors of the liver is reported. A 69-year-old male presented with fever and right upper quadrant pain. On admission blood culture grew Salmonella group B. Laboratory data showed leucocytosis, mild elevation of aspartate aminotransferase, alanine aminotransferase and sugar, positive-HBsAg, and normal range CEA and AFP. Abdominal sonography disclosed a well demarcated solid mass and another cystic lesion with a ragged wall in the left lobe of liver. Abdominal CT revealed a mixed density solid mass in the medial segment, and laterally located cystic mass with internal septa. A preoperative diagnosis of double tumors of the left lobe of the liver was made and the patient underwent a left hepatic lobectomy. Hepatocellular carcinoma and cystadenocarcinoma were diagnosed by histopathological examination. The patient has been well without tumor recurrence after one and a half year's follow-up.
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PMID:Double primary tumors of the liver. 838 67

The case of a 68-yr-old woman with a rare type of Alonso-Lej's type III choledochal cyst (choledochocele) is described. This patient was admitted to the hospital because of right upper quadrant pain. Endoscopy revealed a bulge of the papilla of Vater resembling a submucosal tumor. Endoscopic retrograde cholangiopancreatography demonstrated cystic dilation of the terminal portion of the common bile duct. In addition, small stones were located in the gallbladder, the common bile duct, and the cystic lesion. Cholecystectomy, resection of the cystic lesion, and papilloplasty were performed. Histologically, the interior wall of the cyst was lined with biliary mucosa and demonstrated no evidence of malignancy. We reviewed 63 reported cases of choledochocele in Japan and 65 reported cases in the English literature. The clinical features of choledochoceles were similar in both groups, and they were associated with a minimal risk of malignant degeneration. These findings may have important implications for treatment.
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PMID:Choledochocele-containing stones. 863 54

We present a case of 70-year-old female patient who was admitted due to progressive jaundice. Our clinical impression of cholangiocarcinoma (Klatskin tumor), was confirmed by ultrasound, abdominal CT scan, and percutaneous transhepatic cholangiography. Two self-expanding metallic stents were placed in both intrahepatic ducts through a single transhepatic tract. After successful biliary stenting, the jaundice subsided and she was discharged as improved. However, progressive right upper quadrant pain was noted a few days after discharge and persisted for about 5 months, thus the was readmitted. During admission, she was febrile, exhibiting leukocytosis, with clinical signs of impending septic shock. Gallbladder empyema with hilar cholangiocarcinoma were diagnosed. Percutaneous transhepatic cholecystotomy and drainage (PTCCD) was done to alleviate the symptoms and cholecystectomy was performed thereafter. Pathologic report was compatible with xanthogranulomatous cholecystitis. Post-operative recovery was fair at follow-up examination.
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PMID:Xanthogranulomatous cholecystitis: a complication of metallic biliary stent placement. 868 48

A 46-year-old man presented with right upper quadrant pain with a clinical suspicion of cholelithiasis and was referred for an abdominal ultrasound (US). On US evaluation, the liver and gallbladder were normal. Incidentally noted a homogeneous, well demarcated, hyperechoic, 5-cm mass in the inferior portion of the spleen. A subsequent Tc-99m labeled RBC scan showed a 5-cm photopenic area in the inferior portion of the spleen on perfusion and early blood pool images. Subsequent filling in on delayed images with slightly increased uptake relative to surrounding splenic tissue was seen on the final images (85 min). Splenic hemangiomas are rare neoplasms, although they still represent the most common primary neoplasm of the spleen. The incidence of splenic hemangiomas ranges from 0.03-14% in autopsy studies.
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PMID:Three-phase Tc-99m labeled RBC scintigraphy of a splenic hemangioma. 906 68


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