Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 3 Fr. single lumen balloon catheter was successfully introduced for arterial infusion chemotherapy by percutaneous transfemoral arterial insertion. This balloon catheter was used combined with 6.3 Fr. outer catheter coaxially. After placing the catheter into the target artery, the balloon catheter was ruptured by injecting 1 ml contrast medium. On the other hand the balloon was made as a leak balloon catheter by a small needle puncture before use. Some merits of this system were as follows: Transarterial infusion chemotherapy can be followed immediately after making a diagnosis by transfemoral angiography. At the time of rupturing the balloon, we can see the area that must be infused under the conventional fluoroscopy. In the case of leak balloon catheter no blood regurgitation through the catheter was occurred during the procedure because of elasticity of the rubber. In 40 patients having liver tumor we performed this method combined with continuous infusion of 5-fluorouracil for 3 to 5 weeks and also once a week intra-arterial administration of mitomycin C and adriamycin. In some patients hyperthermia therapy was also carried out for the purpose of potentiation of cellular chemosensitivity by low temperature hyperthermia. The result of this therapy was as follows: CR; 10.3%, PR; 20.7%, NC; 63.9% and PD; 5.1%. No serious complications were encountered in our series except for some minor arterial troubles caused by catheter tip.
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PMID:[Percutaneous transfemoral arterial placement of 3 Fr. balloon infusion catheter for infusion chemotherapy of liver tumors]. 234 95

The echocardiographic findings of two unusual cases of malignant uterine tumors that invaded the heart are reported. A woman previously operated on for invasive cervical carcinoma had multiple embolic phenomena and evidence of obstruction to mitral flow. An echocardiogram showed a mass in the left atrium that reached the mitral valve ring. The tumor was implanted in a pulmonary vein and was removed with no complications. Cell type indicated metastatic carcinoma of the cervix. In the second case the patient had a large abdominal mass and precordial manifestations of obstruction and regurgitation of the tricuspid valve. An echocardiogram showed that a mass emanating from the inferior vena cava filled the right atrium and part of the right ventricle. The trajectory of the tumor was followed to its origin in an ovarian vein by tomography. The entire tumor was removed and identified as endometrial stromal sarcoma. An increase in operations with or without radiation therapy for malignant tumors has augmented the frequency of metastatic invasion of the heart; intracavitary extension tends to results from embolization or propagation along great veins. This is the first report of a uterine carcinoma reaching the heart by way of the pulmonary veins and of invasion of the heart by endometrial stromal sarcoma, both with successful excision.
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PMID:Intracardiac extension of malignant uterine tumors. Echocardiographic detection and successful surgical resection. 235 26

PGE1 has a beneficial effect on cardiac failure with mitral valve regurgitation by decreasing the "after load". An 82-year-old female had a total cystectomy of a bladder tumor. The preoperative standard 12 lead electrocardiogram showed atrial fibrillation and incomplete right bundle branch block. The preoperative echocardiogram showed regurgitation of both mitral valve and tricuspid valve. Under heavy premedication, we intubated with fentanyl and pancuronium bromide, maintained anesthesia with enflurane. After incision, both pulmonary artery pressure and pulmonary capillary wedge pressure increased, and cardiac index decreased. Continuous injection of 100ng.kg-1.min-1 PGE1 made pulmonary artery pressure and pulmonary capillary wedge pressure to decrease, and cardiac index to increase. PaO2, however, decreased apparently. PGE1 was effective for cardiac failure with mitral valve regurgitation associated with pulmonary hypertension. But attention must be given to the decrease in PaO2.
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PMID:[The use of PGE1 in an elderly patient with mitral valve regurgitation during general anesthesia]. 270 14

Between 1982 and 1985, 83 patients with hypopharyngeal or extensive laryngeal cancers underwent pharyngoesophagectomy (48 patients), circumferential pharyngectomy (8 patients), and partial pharyngectomy (27 patients), depending on the site and extent of tumor involvement. The resultant hypopharyngeal defects were reconstructed with gastric transposition, a tubed pectoralis major myocutaneous flap, and a pectoralis major flap patch, respectively. There were three hospital deaths in the gastric transposition group (6 percent) and none in both pectoralis major flap groups. The leakage rate was 8.3 percent in the gastric transposition group, 25 percent in the tubed pectoralis major flap group, and 3.7 percent in the pectoralis major flap patch group. Stricture was avoided with the interdigitation technique used at the tubed-flap-to-esophagus anastomosis, although the fistula rate was high. The overall complication rate was higher with gastric transposition. Although swallowing was satisfactory in all three groups, 42 percent of the patients with gastric transposition experienced regurgitation. Over a follow-up period of 16 to 50 months the local recurrence rate was 5 percent, and the actuarial survival rate was 55 percent at 24 months.
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PMID:Reconstruction of hypopharyngeal defects in cancer surgery: do we have a choice? 366 40

Despite recent renewed interest in the detection of tricuspid valve regurgitation by echocardiographic and Doppler techniques, little morphologic information is available on dysfunctioning tricuspid valves. This report describes 45 necropsy patients with clinical and morphologic evidence of pure (no element of stenosis) tricuspid regurgitation and provides morphometric observations (anular circumference, leaflet area) of the tricuspid valve useful in determining the etiology of pure tricuspid regurgitation. Of 45 patients, 24 (53%) had pure tricuspid regurgitation resulting from an anatomically abnormal valve (prolapse in 7, papillary muscle dysfunction in 6, rheumatic disease in 5, Ebstein's anomaly in 3, infective endocarditis in 2, carcinoid tumor in 1), and 21 (47%) had an anatomically normal valve with systolic pulmonary artery hypertension (cor pulmonale in 12, mitral stenosis in 9). Anular circumference was dilated (greater than 12 cm) in patients with various causes of pulmonary hypertension, floppy valve and Ebstein's tricuspid anomaly. Leaflet area was increased in floppy valve and Ebstein's anomaly. Of the 45 patients, 24 had pulmonary systolic artery pressure measurements available for correlation with tricuspid valve morphology. Pulmonary artery pressures accurately predicted morphologically normal from abnormal valves in 16 patients (89%). Morphologic overlap occurred in six patients with pulmonary pressures of 41 to 54 mm Hg. Of these six, the additional knowledge of normal or dilated anular circumference correctly separated valves with normal and abnormal leaflets.
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PMID:Etiology of pure tricuspid regurgitation based on anular circumference and leaflet area: analysis of 45 necropsy patients with clinical and morphologic evidence of pure tricuspid regurgitation. 395 62

Palliative surgical treatment of malignant oesophago-gastric strictures has been disappointing. Resections in an advanced tumor stage are heroic interventions with a high mortality rate. Alimentary fistulas do not release from annoying saliva regurgitation but unnecessarily mutilate the terminal patient. The positioning of a tube under endoscopic control into the constricting neoplasma has the following advantages: 1. deglutition and saliva drainage are restored; 2. morbidity- and mortality rate is low; 3. duration of hospitalization is brief (1-2 days).
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PMID:[Endoscopic tube implantation for the palliative treatment of malignant stenoses in the esophago-gastric region]. 619 30

Forty patients with malignant cardioesophageal obstruction were treated by fiberoptic intubation. Their ages ranged from 38 to 84 years. Eight patients had bronchoesophageal fistula, 9 had tumor relapse after radiation therapy, and 5 had hiatal hernia. In 7 with severe or total stenosis, diathermic resection was used with no morbidity or mortality. Complications were hemorrhage, 2; regurgitation, 2; atelectasis, 1; tube migration, 1; and bronchoesophageal fistula, 1, for a total of 17.5%. The procedure mortality was 2.5%. Actual survival time after intubation was 37.5% at 12 months. It was demonstrated that a new antireflux prosthesis, designed for endoscopic insertion, diminished morbidity and avoids mortality due to regurgitation; we would therefore recommend to be used in patients not otherwise amenable to surgery or radiotherapy, with cancer of the cardia, lower esophagus or lesions beyond 24 mm from the incisors associated with hiatal hernia.
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PMID:Endoscopic palliative treatment of esophageal and cardial cancer: a new antireflux prosthesis. A study of 40 cases. 619 63

A case report is presented of a 64-year-old female with a very large pedunculated lipoma in the esophagus. These lipomas are relatively uncommon and in spite of their large size may cause very few symptoms. Often they are first recognized after regurgitation of the tumor mass in the mouth which may, in some cases, lead to asphyxia and death. Because of the danger of asphyxia, therapy by excision of the tumor soon after diagnosis appears to be essential. A classification of benign esophageal tumors is given and the role of radiology in diagnosis described.
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PMID:Lipoma of the esophagus. 656 95

We describe a 63-year-old woman with a large sessile left atrial myxoma and coexisting mitral valve stenosis and regurgitation. The diagnosis of a left atrial tumor was confirmed by echocardiography and coronary angiography. This case reveals the rare finding of tumor vascularity originating from both the right coronary artery and left circumflex artery.
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PMID:Angiographic demonstration of tumor vascularity in left atrial myxoma: a case report. 669 44

Benign pedunculated intraluminal tumor of the esophagus is extremely rare. Although the correct diagnosis of this tumor is difficult, it should be extirpated early because, if untreated, it may result in death of the patient by progressive emaciation, bleeding from erosions, or acute airway obstruction. We present a case rescued from suffocation caused by regurgitation of a giant esophageal tumor. In the discussion on the difficulty of diagnosis, the necessity of repeated examination is emphasized. The classification of benign esophageal tumors is also discussed.
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PMID:Benign pedunculated intraluminal tumor of the esophagus. 707 29


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