Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 28-year-old man presented with epigastric pain and obstructive jaundice associated with a histologically and immunologically unusual variant of carcinoid tumor involving the ampulla of Vater. The tumor contained abundant psammoma bodies and exhibited immunoreactivity only for somatostatin. Immunoperoxidase studies for insulin, glucagon, vasoactive intestinal peptide, calcitonin, serotonin, and ACTH had negative results. In contrast to most somatostatinomas of pancreatic origin, clinically this ampullary somatostatinoma was not accompanied by features of the somatostatinoma syndrome. A literature review of the clinical and hormonal features in reported cases of gastrointestinal and pancreatic somatostatinomas is presented.
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PMID:Ampullary somatostatinoma: psammomatous variant of gastrointestinal carcinoid tumor--an immunohistochemical and ultrastructural study. Report of a case and review of the literature. 631 1

A 16-yr-old man with Burkitt's lymphoma presented with 1 mo of epigastric pain and was found at endoscopy to have gastric ulcers with nodular borders and a duodenal mass lesion. Laparotomy revealed a large pelvic mass and tumor involvement of the stomach, small bowel, and retroperitoneal lymph nodes. Presentation with gastroduodenal disease is unusual, and the endoscopic features of Burkitt's lymphoma have not been previously reported. Gastrointestinal involvement with Burkitt's lymphoma is reviewed, and characteristics of the North American and African varieties are contrasted.
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PMID:Burkitt's lymphoma presenting with gastroduodenal involvement. Endoscopic description and review of the literature. 634 58

Through X-ray and endoscopic examination of stomach, a 77 year-old man, who complained of epigastralgia, he was diagnosed to have Borrmann III type gastric carcinoma on the antrum. The gastric biopsy specimen obtained from the tumor revealed to be well differentiated adenocarcinoma. Since the patient refused receiving surgical treatment, a combined administration of futraful and uracil (UFT therapy) was performed. 4 weeks after receiving UFT therapy, the patient became less aware of subjective symptom and the gastrofiberscopic picture showed smaller mass lesion compared to that of prior to the treatment. 8 weeks later, the tumor was remarkable reducing its size. When compared 14 cases of gastric carcinoma receiving UFT therapy with 26 cases receiving Futraful therapy (FT therapy), the UFT group responded more effectively than the FT group. In the UFT therapy, complete (CR) and partial response (PR) were obtained in 4 of 13 cases of gastric carcinoma with an effective rate of 30.8% according to the response criteria proposed by the Koyama-Saitoh group and with a Karnofsky scale of IA or better in 6 (42.8%) of 14 cases. On the other hand, in the FT therapy CR and PR were obtained in 5 of 26 cases with that of 19.2%, while a Karnofsky scale of IA or better was achieved in 6 (23.1%). As for 3 cases of PR in the UFT therapy the microscopic view of the biopsy specimen from gastric carcinoma showed well differentiated adenocarcinoma, which responded to the UFT therapy remarkably 4-5 weeks after receiving UFT therapy.
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PMID:[Case of Borrmann III stomach cancer effectively treated by UFT therapy (co-administration of uracil and futraful)]. 640

A 51-year-old man with extramedullary plasmacytoma of the stomach is presented. He complained of epigastralgia. Barium meal revealed 2 submucosal tumors in the gastric body. Laboratory investigations showed neither hypergammaglobulinemia nor proteinuria. Bone X-ray examinations were not remarkable. There was tumor invasion to the pancreas and metastasis to the perigastric lymph nodes. Proximal gastrectomy was performed, and the patient died 5.5 years after the operation. Histologically, the proliferation of atypical plasma cells with eccentric nuclei was seen. Those cells invaded all layers of the stomach. The tumor cells were pyroninophilic and contained Russel bodies. Immunohistochemical study using the immunoperoxidase technique demonstrated IgG and lambda-light chains in the tumor cells.
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PMID:[A case of extramedullary plasmacytoma of the stomach]. 642 3

An autopsy case of "Malignant lymphoma, small non-cleaved, non-Burkitt's type" with hypercalcemia is presented. A 57-year-old Japanese man suffering from epigastralgia and "retroperitoneal tumor" for nine months was found at autopsy to have two large tumor masses in the retroperitoneum and pelvic cavity. Tumor cell infiltration into the liver, spleen, both kidneys, and both adrenal glands was observed on microscopic examination. The tumor cells were lymphoid cells with the characteristics of "Malignant lymphoma, small non-cleaved, non-Burkitt's type". The importance of recognizing non-Burkitt's type is pointed out. The cause of the presence of hypercalcemia is also discussed.
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PMID:Malignant lymphoma, small non-cleaved, non-Burkitt's type. 652 81

Biliary cystadenocarcinoma is a rare malignancy, and only one preoperatively perforated case was recorded among 36 cases documented in the literature. A 48-year-old female was admitted with chief complaints of right epigastralgia and a right upper abdominal mass. CT scan revealed a well-defined low density area with calcification in the right hepatic lobe. On postcontrast CT, the septa and an internal papillary projection were well enhanced. Angiography demonstrated displacement and stretching of the right hepatic artery encircling a hypovascular lesion with some tumor stain and pooling. At laparotomy, a child-head size multilocular cyst was found in the right hepatic lobe; cyst excision was performed. Pathological analysis showed both benign cystadenoma and cystadenocarcinoma, suggesting a transition from the benign to the malignant state. At 17 months after the procedure, the patient is in good condition.
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PMID:[A case of perforated biliary cystadenocarcinoma]. 670 Jan 20

The study group consisted of 35 patients with early gastric cancer, 16 of whom were admitted for preoperative immunotherapy. Ten to 40 K.E. of OK-432 was injected intralesionally by endoscope, and then gastrectomy was performed. After the intralesional injection, fever, nausea, vomiting and epigastralgia occurred. In cancer lesion and regional lymph node, histological findings from OK-432 treated group were compared to those of the control group. Lymphoid cell infiltration at cancer lesion was marked in OK-432 treated group, and degenerated cancer cells were found in 3 cases. On the other hand, lymphoid follicles showed a marked statistical increase in OK-432 treated group. Also the cases with marked lymphoid follicle showed increased numbers of peripheral blood lymphocyte. From the results, intralesional injection of OK-432 may confirm the tumor-associated antigenicity and serves as a useful method to potentiate the specific and/or non-specific immunity in regional lymph nodes.
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PMID:[Endoscopic preoperative intralesional injection of OK-432 in early gastric cancer]. 672 7

Forty-nine cases of young adults with carcinoma of the stomach were reviewed. The occurrence of this tumor had a percentage rate of 2.7 of the total of 1767 Japanese patients with stomach carcinoma, with a male to female ratio of 1.0:0.88. The most common complaint observed was epigastric pain (45.7%). In the majority of patients, the period from the onset of symptoms to the time of diagnosis was over two years (49%). Thirty-nine out of 49 patients had resection of the stomach and a consequent operation was curative in 55.1% of them. The overall 5-year survival rate was 26.8%. However, the 5-year survival rate for the curative operation was 42.6% particularly in early gastric carcinoma without any serosal invasion and no patients died from carcinoma of the stomach. These results indicate that early diagnosis is very important to improve the curing rate of this disease in young adults.
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PMID:Gastric carcinoma in young adults in Japan. 716 84

Fifty-eight coelio-splanchnic nerve blocks by alcoholisation were done for thirty-two patients at the regional Center of the Fight against Cancer at Montpellier for persistent neoplastic pain of the pancreatico-solar type. In 15 cases (46,6 p. cent), the pancreatico-solar syndrome is the initial sign of a primitive or secondary supra-mesocolic cancer. In 12 cases, the hyperalgic syndrome discloses the extension or recidive of the tumor. According to etiologies, the illnesses were as follows: --pancreatic neoplasias I or II: 13 cases, --hepato-biliary lesions I or II: 11 cases, --peritoneal carcinosis: 4 cases, --invasion of retro-peritoneal nodes: 4 cases. Epigastric pain irradiating to the left para-vertebral area are resistant to analgesias; 95 p. cent of these patients received morphinic drugs for several days, if not weeks. The splanchnic nerves were reached by a posterior high lumbar injection according to the Kappis and Labat technic. A block with 2 p. cent lidocaine is immediately followed by alcoholisation by 99,8 p. cent ethanol. According to patient status, the blocks to the left and right were done at once or at several visits. The block by lidocaine gives immediate analgesia thereby indicating the proper placement of the injection. The coeliac alcoholisation assures the neurolysis of the splanchnic nerves. The antalgic effect lasts a variable time, averaging 42 days (varying from 2 to 240 days). The antalgic action always allows the discontinuation of morphinic drugs and increases the efficacy of minor analgesics, if necessary. All the same, 18/25 received morphine during their last few days before death.
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PMID:[Splanchnic nerve blocks by alcoholisation in pancreatico-solar hyperalgia of tumoral origin (author's transl)]. 730 43

A 62 year-old man was admitted with the chief complaint of a epigastric pain and difficulty of swallowing. Examination of the upper gastrointestinal tract revealed a calcified mass causing a smooth filling defect at the lesser curvature of the cardia. At laparotomy, a localized tumor was detected beneath the serosa of the stomach. The excised tumor was 4 x 4 x 1.6 cm and the pathological diagnosis was calcified leiomyoma probably due to cytoplasmic degeneration. In this paper, details of the case are described and the related literature is reviewed.
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PMID:Calcified gastric leiomyoma--a case report. 732 39


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