Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We report 5 cases of human anisakiasis revealed respectively by an acute intestinal obstruction due to multiple small bowel stenosis, an acute inflammatory ileitis simulating appendicitis, ulcer type epigastralgia, purulent peritonitis and a latent small bowel tumor. Diagnosis was established in 4 cases on microscopic analysis of bowel specimens (eosinophilic granulomas and/or parasitic fragments) and in 1 case at gastroscopy. Serodiagnosis was positive in 2 of 4 cases and the consumption undercooked fishes was found in 4. In small samples we estimated the infestation (1 to 50 parasites) by anisakis larvae of 3 fish species: 80 p. 100 for herrings, 63 p. 100 for mackerels and 100 p. 100 for whitings. This work emphasizes the role of anisakiasis as a source of digestive symptoms and intestinal eosinophilic granuloma.
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PMID:[Human anisakiasis: 5 cases in northern France]. 395 15

A 65-year-old man with superficial esophageal cancer associated with gastric wall metastasis is presented. He had suffered from epigastralgia and dysphagia for two months. X-Ray and endoscopic examination revealed esophageal erosion at the right wall of the lower esophagus and a large gastric submucosal tumor at the lesser curvature of the upper and middle stomach. Resection of the lower esophagus and total gastrectomy were performed. Histologically, the erosion of the lower esophagus was moderately differentiated squamous cell carcinoma invading as deep as the submucosal tissue and the tumor of the stomach was metastasis of the esophageal cancer. Intramural metastasis of esophageal cancer was discussed.
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PMID:[A case of superficial esophageal cancer with metastasis to the gastric wall]. 405 68

A case of multiple liver adenomatosis in a 24-year-old woman who had taken sequential (Norquential) and combined (Stediril) oral contraceptives is recounted, and 11 other published cases are summarized. The patient was hospitalized for severe epigastric pain radiating to the scapular region, suggesting liver tumor, and becoming generalized, suggesting hemoperitoneum. During laparotomy a ruptured subcapsular hematoma, a tumor 6 cm in diameter, and multiple yellow spots 2-5 cm were found. Histologically the hepatocytes contained intracellular and intravesicular fat deposits; affected cells were located in nodules but not encapsulated. Liver function was normal. 1 month later the right liver was removed, and the patient was released in 15 days. Of the 11 published cases all were isolated adenomas; 4 were simple, 3 complicated, and 3 fatal.
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PMID:[Hepatic adenomatosis and oral contraceptives. Surgical aspects]. 447 18

A 21-year-old woman presented with a 12-month history of epigastric pain, and for 3 months she had noticed a mass in the right hypochondrium. She had taken 'Norinyl-1' (norethisterone 1 mg and mestranol 50 mcg) for 5 years. She smoked 20 cigarettes a day but drank little alcohol. Physical examination revealed irregular hard hepatomegaly 10 cm below the right costal margin. Hepatitis B surface antigen was not detected in the serum and alpha fetoprotein levels were normal ( 10 M.R.C. units). A liver scan showed a large space-occupying lesion in the right lobe of the liver, and liver biopsy revealed a cholangicarcinoma with striking fibrous reaction. Multiple shadows consistent with metastases were present on chest X-ray, but no bony deposits were found on radiological skeletal survey or bone scan. The serum calcium was persistently high (2.74-2.92 mmol/l) but fell on prednisolone therapy. Serum parathyroid hormone levels were normal. A causal relation between oral contraceptives and hepatic adenoma is now generally accepted, and several patients with hepatocellular carcinoma have also been reported. We have been able to find only 1 previous report of cholangiocarcinoma in a young female taking oral contraceptives, and there is 1 report of this tumor in a man taking high doses of anabolic steroids for refractory anemia. This tumor has its peak incidence in the 6th decade and is very rare in the 3rd decade. The association with hypercalcemia due to pseudohyperparathyroidism is well recognized. In only some cases are parathyroid hormone levels raised, and the cause of the pseudohypercalcemia in our patient is unknown.
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PMID:Cholangiocarcinoma and oral contraceptives. 610 61

The patient was a 60-year-old Japanese male. He complained of epigastralgia and right chest pain of 4 month's duration, and general malaise, nausea and vomiting of 2 month's duration. Physical examination revealed on the right third rib a tender mass with a diameter of 2 cm and hepatomegaly with a multi-nodular surface and red palms. There were no signs of carcinoid syndrome, such as cutaneous flushing. Laboratory examinations disclosed certain biochemical alterations; alkaline phosphatase 810 IU/l, gamma-glutamyl transpeptidase (gamma-GTP) 2090 IU/l, carcinoembryonic antigen (CEA) 23.5 ng/ml and alpha-fetoprotein (AFP) 6,800 ng/ml. Both HBs-Ag and HBs-Ab were negative. The patient died in a uremic state, with rapid increases of jaundice and ascites. Autopsy revealed gastric carcinoid with extensive metastases to the liver and the bone marrow. Tumor cells showed argyrophilia but not argentaffinity. Immunofluorescence specific for AFP was positive in the hepatocytes, particularly those adjacent to the metastatic tumor cells but not in the tumor cells, either primary or secondary. 79 cases reported in Japan of serum AFP-positive malignant tumor other than hepatocellular carcinoma and certain other malignancies of germ cell origin are reviewed and discussed.
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PMID:Serum alpha-fetoprotein-positive gastric carcinoid with liver metastasis. 616 67

Fifty patients with gastric leiomyosarcoma seen at M.D. Anderson Hospital between 1957 and 1978 were reviewed. Symptoms included weakness, gastrointestinal bleeding, and epigastric pain. An upper abdominal mass or tenderness was the most frequent physical finding. Laparotomy was performed in all patients, with gastric resection in 86%, and resection for cure in 68%. Survival after distal subtotal gastric resection (mean: 62 months) was longer than after proximal subtotal (30 months) or wedge resection (46 months). The five-year survival was 19% for all patients, and 32% for those operated on for cure. A favorable prognosis was predicted by mild atypia or few mitoses (grade 1). No differences in survival were demonstrated between patients with tumors of different cell types (epithelioid, spindle, or pleomorphic). No lymph node in any patient contained metastatic tumor, suggesting a lymph node dissection need not be performed. Commonly, tumor spread was to liver or lungs or by direct invasion of contiguous tissue or organ. Radiotherapy and chemotherapy are of limited value in treating unresectable disease. If possible, both the primary lesion and recurrent tumor should be widely resected.
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PMID:Gastric leiomyosarcoma: clinical and pathological review of fifty patients. 617 74

Pancreas divisum was demonstrated in 22 of 500 consecutive ERCP (4.4%). Among patients with otherwise normal ERCP, pancreas divisum was found in 12.8%. In contrast, only 1.8% of patients with other pathology in the ERCP exhibited pancreas divisum (p less than 0.001). In relation to the clinical indication, pancreas divisum was found in 13.3% of patients with suspected or proven pancreatitis, in 1.9% of patients with suspicion of biliary tract disease (p less than 0.001), in 1.9% of patients with suspicion of pancreatic cancer (p less than 0,05) and in 4.4% of patients with epigastric pain of undetermined origin (p greater than 0.05). In 14 patients pancreas divisum was the only pathological finding in a thorough clinical and gastrointestinal workup; 6 of the 14 patients had had typical episodes of pancreatitis, in 6 other patients there was clinical and biochemical evidence of pancreatic disease (mainly pain and hyperenzymemia), and the last 2 cases had chronic epigastric pain without biochemical abnormalities. In 2 patients of this series the pancreas divisum was misinterpreted morphologically (sonography, autopsy) as tumor of the head of the pancreas. Based upon our experience and the literature, the following practical conclusions can be drawn: 1. Pancreas divisum may cause typical episodes of acute (relapsing) pancreatitis. 2. In patients with chronic epigastric pain associated with hyperenzymemia but without typical acute pancreatitis, pancreas divisum may be the cause. 3. Morphologically pancreas divisum may mimic a pancreatic tumor (sonography, computer-tomography, autopsy).
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PMID:[Clinical significance of pancreas divisum]. 618 82

A 67-year-old man with complaints of general malaise and epigastralgia was admitted to our hospital for further examination. Upper GI series and endoscopy showed advanced cancer, Borrmann type II; biopsy specimens revealed pathological pictures of malignancy. The serum alpha-fetoprotein values were remarkably high (473,000 ng/dl); the liver scintigram revealed a space-occupying lesion in the right lobe and the abdominal CT-scan showed ascites and lymphadenopathy of the abdominal para-aortic region. Therefore, double cancer of the stomach and the liver was suspected. The patient died in a state of hepatic coma with a rapid increase of jaundice, ascites and right pleural effusion at 3 weeks after admission despite the anti-cancer treatment. Autopsy revealed embryonal carcinoma with yolk sac tumor elements of stomach origin, extensive metastasis to the liver, lung, peritoneum, and portal vein. The peroxidase anti-peroxidase technique revealed that primary and secondary tumor cells produced alpha-fetoprotein.
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PMID:[A case of alpha-fetoprotein producing embryonal carcinoma of the stomach]. 619 22

We review eight cases of early gastric cancer which occurred in five female and three male patients. In seven patients the main complaint was epigastric pain and in one melena. In seven of the eight cases, endoscopic diagnosis was established on the first examination and confirmed by biopsy. Types of early gastric cancer observed were: type I, one case; IIa, one case; IIc three cases: III, two cases and type III + IIc, one case. In five cases the neoplasia was located in the antrum, two in the pre-pyloric region, two along the greater curvature and one in the anterior wall. Three cases were located in the body of the stomach, two in the lower third of the lesser curvature and one in the upper third of the greater curvature. From the histopathologic standpoint four cases were differentiated adenocarcinomas, three undifferentiated adenocarcinomas and one case mucus carcinoma. In no case did we encounter regional lymph node metastases. Postoperative survival rates at the present time varies between one and five years.
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PMID:Evaluation of eight cases of early gastric cancer. 629 47

A case of duodenal somatostatinoma is reported. The patient, a 54-year-old male, had complained of an epigastric pain due to gastric ulcer and a duodenal polyp was unexpectedly found at a gastrectomy. The polyp showed basically tubular adenocarcinoma, with negative argyrophil and argentaffin reactions. By an indirect immunofluorescent examination almost all of the tumor cells were revealed as somatostatin-immunoreactive. Big somatostatin was also positive. Radioimmunoassay of the tumor indicated 6400 pg of somatostatin-like immunoreactivity per milligram of wet tissue. This seems to be the second case of duodenal somatostatinoma, following the case reported by us previously.
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PMID:Duodenal somatostatinoma. Immunohistopathology and review of literature. 630 Dec 8


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