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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The patient, a 25-year-old woman, complained of epigastralgia. Her physical examination and routine laboratory data were unremarkable, though an upper G-I series and a gastro-endoscopy demonstrated a small sessile polypoid lesion at the posterior wall of the gastric body. An endoscopic biopsy specimen taken from the polyp revealed a typical carcinoid tumor. The patient underwent a wedge resection of the stomach and a sampling was taken of the regional lymph node around the left gastric vessels. Histologically, although the carcinoid tumor was 5 mm in diameter and limited to within the submucosal layer, it showed lymphatic and venous invasion into the submucosal layer and had metastasized to one of the regional lymph nodes around the left gastric vessels. Therefore, a total gastrectomy with an extended lymph node dissection was performed and no other metastatic lesion was uncovered. Of the reported cases with a gastric carcinoid thus far, none with a tumor size of less than 5 mm has evidenced metastasis. This case suggests that even cases of a minute gastric carcinoid should be treated by radical gastrectomy and extended lymph node dissection.
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PMID:[A minute, solitary carcinoid of the stomach with a lymph node metastasis--a case report]. 339 63

A case of a 78-year old woman, complaining of epigastralgia, is reported. A series of gastrointestinal examinations revealed a small, elevated lesion with a central depression in the antrum. Since a fiberoptic biopsy had shown a Group V classification, a partial gastrectomy was performed. Tumor nodules, judged to be metastatic, were noticed in the liver and regional lymph nodes. Histologic scrutiny disclosed a keratinizing tumor that measured 1.0 X 0.9 cm in diameter and was largely a squamous cell carcinoma with a small focus indicating an adenocarcinoma. This tumor was confined to the muco-submucosal layers with prominent vascular permeation. No adenocarcinomatous components were found in the metastatic foci. The patient died eight months after operation. In light of our experience, together with what has been found in a review of the literature, we feel that a squamous carcinoma and an adenosquamous carcinoma of the stomach to be more aggressive than an ordinary adenocarcinoma and keeping this point in mind, they should be considered differentiated from an adenoacanthoma.
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PMID:[A case of small squamous cell carcinoma with a grading of IIa + IIc, an early gastric cancer type]. 340 55

Rhabdomyosarcoma (RMS) of the hepatobiliary system is extremely rare in adults. To our knowledge only three cases have been reported in the literature, all involving the gallbladder. The present case concerns a 40-year-old woman who presented with epigastric pain and obstructive jaundice and was found to have a fusiform, submucosal neoplasm in the common bile duct. Histologically, the tumor presented a diagnostic problem due to a predominant sclerotic growth pattern suggesting an epithelial tumor. Extensive sampling revealed a focal alveolar growth pattern with rhabdomyoblasts, although cross striations were not seen. Electron microscopy failed to demonstrate the characteristic thick myofilaments and/or Z-band material. The diagnosis was supported by strongly positive immunohistochemical staining for myoglobin and desmin; the keratin stain was negative. A subsequent supraclavicular metastasis showed the typical histology of an alveolar RMS. The histologic features of the primary tumor suggest that RMS in this location may be underrecognized due to regional similarities to either primary or metastatic infiltrating carcinomas.
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PMID:Rhabdomyosarcoma of the common bile duct in an adult. 351 54

An endocrine cell carcinoma of the extrahepatic bile duct in a 79-year-old man is described. The patient had complaints of jaundice and epigastric pain due to a small tumor located at the confluence of the common hepatic duct with the cystic duct. Microscopically, the tumor showed a well differentiated tubular adenocarcinoma and was confined to the mucosa. Numerous tumor cells showed argyrophil and/or argentaffin reactions. Immunoperoxidase staining revealed that the tumor tissue contained somatostatin-, gastrin-and serotonin-immunoreactive cells. From these findings the tumor was diagnosed as endocrine cell carcinoma. Four years later he remains well without any evidence of recurrence or metastasis. The histogenesis of endocrine cells in the biliary tract is briefly discussed.
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PMID:Endocrine cell carcinoma of extrahepatic bile duct. 352 8

A case of pancreatic cancer with liver metastasis is reported, in which chemotherapy had a marked effect, with the responses clearly documented. The patient was a 59-year-old male who experienced epigastric pain in February 1985, upper gastrointestinal X-ray examination revealing extragastric compression by the pancreas. He visited the National Cancer Center Hospital, Tokyo, in April 1985 and the diagnosis of pancreatic cancer with liver metastasis was made using the imaging procedures of ultrasonography, computed tomograph scanning and endoscopic retrograde cholangiopancreatography as well as by biochemical and serological tests. At the time a 5 cm tumor was palpable in the middle upper abdomen. The patient was treated with Cis-diaminedichloro platinum, tegafur, and 5-fluorouracil, successively, and the abdominal tumor gradually diminished, finally becoming impalpable. The response was evaluated as one of partial responses (PR) by ultrasonography, and the improvement substantiated by computed tomography and tumor markers.
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PMID:A case of pancreatic cancer with liver metastasis which responded to chemotherapy. 356 Apr 66

Although common in Japan, early gastric cancer is rarely seen in Western countries and generally accounts for only 7 to 10 percent of all gastric malignancies. Eleven patients with early gastric cancer seen over a 10 year period have been reviewed for clinical and pathologic features, method of diagnosis, treatment, and prognosis. The symptoms usually consisted of vague epigastric pain or dyspepsia, but anorexia, weight loss, anemia, and hypoalbuminemia were not commonly seen. Barium meal examination was not helpful in the diagnosis in 50 percent of the patients. The diagnosis was made by endoscopic biopsy of abnormal areas of the stomach, although in 6 of 11 patients, there was no macroscopic suspicion of malignancy. All patients were treated by surgical resection. The tumor was confined to the mucosa in five patients and had infiltrated the submucosa in six patients. The lymph nodes were free of tumor in every patient. At last follow-up, seven patients had survived more than 5 years after operation and were well, although recurrent tumors developed in two patients 3 and 4 years postoperatively but were detected early by endoscopic surveillance. Early gastric cancer has a good prognosis after surgical resection, but the symptoms are vague and the diagnostic tests can be misleading. A vigorous approach to investigation, treatment, and follow-up is necessary to achieve satisfactory results.
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PMID:Diagnostic and prognostic problems in early gastric cancer. 367

A rare autopsy case of clear cell carcinoma of the pancreas developing in a 71-year-old Japanese male is described. He complained of epigastralgia and back pain and was clinically diagnosed as having primary pancreatic cancer. After death due to disseminated metastasis and cachexy, autopsy revealed pancreatic clear cell carcinoma metastasizing to various organs including the lungs (lymphoangiosis carcinomatosa). The tumor was almost entirely composed of clear cells with cytoplasm weakly positive for PAS and alcian blue, and negative for Sudan III stains. Histological differential diagnosis from the clear cell carcinoma of other organs, especially that of kidney, is also mentioned.
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PMID:Clear cell carcinoma of the pancreas. 368 32

Primary pancreatic hydatidosis is exceptional. Only 12 cases have been reported in Spain up to 1982. In large series of patients with hydatidosis, pancreatic involvement occurs in 0.25% of cases. We describe a 55-yr-old man who was admitted to the hospital because of fever, epigastric pain, and abdominal mass. Endoscopy, upper gastrointestinal series, and computerized tomography revealed a fistula between the duodenum and the pancreatic tumor. At surgical exploration, a primary infected hydatid cyst in the head of the pancreas communicating with the duodenum was encountered. The cyst was removed and drained. We have been unable to find in the literature a review of this form of presentation of pancreatic hydatidosis.
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PMID:Hydatid cyst of the head of the pancreas with spontaneous fistula to the duodenum. 368 7

Biopsy of the uterine cervix from a 46-year-old woman who suffered from epigastric pain and weight loss showed metastatic adenocarcinoma. The primary site of the tumor was the stomach. At laparotomy, disseminated adenocarcinoma on the peritoneum and Krukenberg's tumor in the right ovary were found. A palliative partial gastrectomy, resection of the right ovary, and postoperative chemotherapy were performed. The possible mechanism of metastasis of extragenital cancer to the uterus is discussed.
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PMID:Gastric cancer diagnosed by biopsy of the uterine cervix. 379 31

The authors report the case of a 74 year-old woman who was hospitalized for severe abdominal pain. The patient had epigastralgia for many years. Biology revealed hyperamylasemia and computerized tomodensitometry showed that the pancreas head was enlarged. At retrograde wirsungography a short stenosis was visible in the pancreatic duct, 2 cm from the papilla. This was considered to be a tumor and surgery was performed. Histological sections of the pancreatic head showed strictly intraductal carcinoma "de novo" or associated with ductal epithelial hyperplasia. Although very rare, in situ carcinoma should be considered when clinical features are unexplained in order to perform radical surgery.
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PMID:[Intra-epithelial carcinoma of the pancreas. Study of a case and review of the literature]. 380 27


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