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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The sonograms of 26 patients (19 adults and seven children) with pathologically proven diagnoses of primary adrenocortical carcinoma were evaluated. Clinical corroboration was obtained in all cases. The size of the lesions ranged from 3 to 22 cm. The five smaller lesions (3-6 cm) showed a homogeneous echo pattern, similar to renal cortical echogenicity. The 21 larger lesions varied in echo texture, having a heterogeneous appearance with focal or scattered echopenic or echogenic zones representing areas of tumor necrosis, hemorrhage, and/or, rarely (19%), calcification. Even the largest lesions were fairly well delineated, often with a lobulated border. Few (7/26 or 27%) showed a surrounding echogenic thin capsulelike rim. All five small lesions showed clinical evidence of endocrine activity. Larger lesions were hormonally active less often (9/21 or 43%). Twelve patients (46%) showed no sign of endocrine activity and presented with symptoms such as fever, weight loss, abdominal discomfort, abdominal mass, hematuria, and hypertension. In the pediatric and adolescent age group (0-16 years), all tumors were hormonally active, while only seven (37%) of tumors in the adult population (17-69 years) were hormonally active. Unfortunately no echo pattern was characteristic enough to allow differentiation of adrenal adenoma from carcinoma. Smaller lesions are more likely to be benign, and larger lesions with areas of necrosis, hemorrhage, and calcification are more likely to be malignant.
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PMID:Primary adrenocortical carcinoma: sonographic evaluation with clinical and pathologic correlation in 26 patients. 355 25

A 24-year-old white woman presented with abdominal discomfort associated with a firm, nonpulsatile hepatic mass. Radiological examination, which included radionuclide liver scan, abdominal ultrasonography, computed tomography, and hepatic angiography, demonstrated a large, globular, multilocular cyst arising from the left lobe of the liver. A left hepatic lobectomy was performed, and gross examination of the specimen confirmed the cystic nature of the lesion. Histologically, the multiple locules were lined by a single layer of tall cuboidal to columnar cells, which were comparable to those of native biliary tract epithelium. There was little evidence of cellular pleomorphism, and invasion into the underlying mesenchymal stroma was not present. A diagnosis of intrahepatic biliary cystadenoma was made. The clinical, radiological, and pathological findings of this neoplasm are presented and its differential diagnosis discussed.
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PMID:Intrahepatic biliary cystadenoma. Clinical, radiological, and pathological findings. 373 80

We report two patients with a colo-ovarian fistula which produced a granulomatous oophoritis. Both patients presented with an adnexal mass and abdominal discomfort; in each case the preoperative diagnosis was a probable neoplasm. The patients underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy; the colo-ovarian fistula was not recognized intraoperatively in either case. Both patients required reoperation in the early postoperative period because of the development of a colovaginal and a colocutaneous fistula, respectively. Intraoperative recognition of colo-ovarian fistula is important for the selection of the appropriate surgical procedure. The differential diagnosis of granulomatous oophoritis is discussed.
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PMID:Colo-ovarian fistula: a report of two cases. 380 43

A 47 year-old male presented with increased stool frequency, abdominal discomfort and weight loss. Two sonographers found independently a "mass" in the region of the head of the pancreas. 8 years before the patient had had a Billroth-II-surgery. Laparatomy revealed a chronic periduodenitis as sonographic substratum. Therefore, basing on sporadic reports, an anamnestic finding of a Billroth-II-surgery should be kept in mind in differential diagnosis of a tumor of the head of the pancreas when employing sonography as a diagnostic tool.
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PMID:[Chronic periduodenitis as a sonographic mass in the region of the pancreas head]. 390 25

During a 10-yr period starting January 1973, 123 patients with a carcinoma at the head of the pancreas underwent endoscopic retrograde cholangiopancreatography at our hospital. Analysis of their case histories revealed that the early complaints of pancreatic head carcinoma are rather nonspecific--sudden onset of diabetes mellitus (33.3%), weight loss (80.5%), tiredness and malaise (42.3%), change in bowel habits (41.5%), and upper abdominal discomfort (22.0%)--and that jaundice (88.6%) and classic pain (70.7%) are late symptoms. The diagnostic accuracy of endoscopic retrograde cholangiopancreatography (92.7%) was much higher than that of computed tomography (58.5%) and echography (54.4%). The patients were divided according to the maximal tumor diameter into three groups: group 1, tumor diameter ranging between 2.5 and 4.0 cm; group 2, tumor diameter ranging between 4.5 and 6.0 cm; and group 3, tumor diameter ranging between 7.0 and 15.0 cm. The tumor diameter did not correlate with the degree of differentiation. Extension of the tumor, vascular involvement, and metastases were evaluated for the several tumor diameters. The tumor was, in principle, operable in 77% of group 1 patients; in 24% of group 2 patients; and in 9% of group 3 patients. Tumors less than 3 cm in diameter were always resectable; tumors greater than 8 cm in diameter were seldom (9%) resectable. A curative resection was performed in 22.0% of the patients. The 4-yr survival of these patients was 44% as opposed to no survivors among the patients who had received only palliative or symptomatic treatment. During the decade, there was a tendency toward the diagnosis of smaller tumors (mean tumor diameter decreased from 9.0 +/- 1.7 to 5.4 +/- 2.8 cm) with a higher chance of resectability (from 25% to 44%).
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PMID:Carcinoma of the head of the pancreas. Therapeutic implications of endoscopic retrograde cholangiopancreatography findings. 620 85

During a 2-year period, three young Chinese women in Taiwan were found to have a rare pancreatic tumor known as solid and papillary neoplasm of the pancreas. They had a large abdominal mass, found either incidentally or because of abdominal discomfort. Endoscopic retrograde cholangiopancreatography was useful in localizing the tumor. Grossly, the tumors all appeared well circumscribed with focal or extensive cystic change and hemorrhage. Microscopically, they were composed of small uniform eosinophilic cells forming papillary, microcystic, and solid structures with extensive hemorrhage resulting in necrosis and formation of cholesterol granulomas. No carcinoembryonic antigen was demonstrated by the immunoperoxidase method. None of these three patients experienced recurrence more than 2 years after surgery. Even the one who received only drainage and cyst-jejunostomy has been doing well. Long survival or even cure can be expected, but the accumulated experiences indicate that this neoplasm should be regarded as a low-grade, potentially malignant tumor. One of the patients developed diabetes mellitus postoperatively.
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PMID:Solid and papillary neoplasm of the pancreas. Report of three cases from Taiwan. 646 70

A 56-year-old man was hospitalized with the complaint of upper abdominal discomfort. A gastrointestinal series revealed a filling defect in the body of the stomach. Under the diagnosis of gastric cancer, total gastrectomy was performed. Borrmann III type cancer measuring 5 X 4 cm, extending to the antrum and the upper portion of the body of the stomach, was identified in the body. Histologically, most of the tumor consisted of squamous cell carcinoma. Adenocarcinoma and a small nest of squamous metaplasia were observed at the peripheral wall of this tumor. The pathological diagnosis was adenosquamous carcinoma. In some regional lymph nodes, metastasis of adenocarcinoma was observed.
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PMID:[Primary adenosquamous carcinoma of the stomach--a case report]. 651 26

A phase II study of ip 5-FU was performed in 14 patients with ovarian cancer who were refractory to systemic chemotherapy including prior iv 5-FU in 12 of the patients. 5-FU was administered via a semipermanent Tenckhoff peritoneal dialysis catheter. The starting concentration of 5-FU in the dialysate was 4 mM. The patients received eight consecutive 2-L exchanges, each of 4-hour duration, for a total of 36 hours including time for instillation and drainage. Treatment courses were repeated every 2 weeks for six cycles or until disease progression occurred. A total of 69 cycles of ip 5-FU were administered to 14 patients. There was one complete response to therapy documented by second-look laparotomy. While the response rate was only 7%, in seven of eight (88%) patients with small volume disease (tumor masses less than 2.0 cm in diameter), there was no evidence for disease progression while receiving ip 5-FU therapy. In this phase II trial, the major toxic effect of ip 5-FU was abdominal pain. While there were no cases of documented bacterial peritonitis, all of the patients experienced some degree of abdominal discomfort while receiving therapy. Fifty percent of the patients had severe abdominal pain with at least one cycle of therapy. Other toxic effects included myelosuppression, mucositis, nausea and vomiting, and skin rash. The results of this study indicate that ip 5-FU should be further evaluated in patients with ovarian cancer who have a small volume of disease and who have not had prior therapy with 5-FU.
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PMID:Phase II trial of 5-FU administered Ip to patients with refractory ovarian cancer. 652 96

The approach to the integrated diagnosis of the patient with biliary tract diseases is reviewed as a basis for the appropriate treatment, taking into account the functional disturbances and the organic elements including malformation, inflammation, infection, gallstone and neoplasia. The role of impaired emptying of the gallbladder is emphasized. This condition may give origin to inflammation of the gallbladder is emphasized. This condition may give origin to inflammation of the gallbladder which is caused by the irritative action of concentrated bile acids as a consequence of the stagnated bile in the gallbladder with poor emptying. Other consequences of bile stagnation in the gallbladder is gallstone formation and biliary infection by bacterias. Thus, increase of gallbladder emptying and of bile production are advised in the treatment of biliary diseases. Such two effects can be obtained by the diet using adequate amounts of vegetables, oils and eggs and by drugs such as choleretics. A new choleretic drug-the cicloxilic acid-was used in 102 patients, 48 out of them with gallstone and 54 without lithiasis. The following three actions of this drug were recorded: a decrease of gastrointestinal gaseousness; a decrease of abdominal discomfort and soreness, and a mild laxative effect with stool of less consistency.
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PMID:[Treatment of bile duct diseases. Dyskinesias. Chronic inflammation]. 675

A case of choriocarcinoma responding well to cis-diamminedichloroplatinum (CDDP) was reported. A 24-year-old male was admitted to our hospital with chief complaints of upper abdominal discomfort and gynecomastia. Physical findings on admission included solid tumors in the upper abdomen and bilateral inguinal regions. The chest X-ray picture showed numerous coin lesions, and abdominal ultrasound examination revealed a widespread metastasis in the retroperitoneum. Blood chemical analysis pointed out the high levels of LH, HCG, and beta-subunit of HCG. The pathological diagnosis of the biopsied inguinal mass was choriocarcinoma. The patient was treated with CDDP, vincristine and bleomycin according to the protocol of Einhorn. After three courses of this therapy, serum HCG level was normalized and pulmonary metastatic lesions were diminished, although abdominal ultrasound examination showed remnants of the decreased tumor masses. The patient was transferred to the urological department for further cytoreductive therapy.
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PMID:[Case of choriocarcinoma of a probable testicular origin with a good response to cis-diamminedichloroplatinum (CDDP)]. 689 89


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