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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Giant cell tumor of the bone (GCT) is a relatively uncommon tumor. It is characterized by the presence of multinucleated giant cells. GCT is a primary benign tumor but may evolve into a malignant tumor, usually after irradiation. We report a rare case of osteosarcoma arising ten years after the primary surgery for GCT without radiation. A 45-year-old woman presented with severe right knee pain after suffering contusion. Roentgenogram revealed a bone tumor in the lateral femoral condyle of the right knee. Histopathological examination demonstrated the features of GCT, and treatment consisted of curettage and bone grafting. Four months after the operation, multiple lung metastases of GCT occurred, which were treated by partial lobectomy. Ten years after the primary treatment, severe knee pain recurred. Roentgenogram and magnetic resonance imaging (MRI) demonstrated a destructive lesion in the lateral condyle of the right knee. Histopathological examination demonstrated a lacy pattern of osteoids and abnormal mitoses in the aggregated atypical mononuclear cells, indicating osteosarcoma. Despite above-knee amputation and chemotherapy, scapular and lung metastases developed and the patient died five months after above knee amputation. One may question whether the primary GCT contained some malignant cells. However, given the aggressiveness of the malignant tumor, this is unlikely. The recurrence of pain and aggravation of bone destruction many years after the primary treatment suggest malignant transformation of GCT.
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PMID:Osteosarcoma arising from giant cell tumor of bone ten years after primary surgery: a case report and review of the literature. 1643 39

Hemangiomas arising from tendon and tendon sheath are rarely reported, and may be confused with other lesions of tendons. In this case report, a 19-year-old woman was diagnosed with a cavernous hemangioma originating in the left gracilis tendon and tendon sheath. When her symptoms initially developed, MRI did not delineate the lesion due to the relatively small size of the tumor. Nine years after the onset of the patient's complaints of knee pain and swelling, the tumor was adequately diagnosed on physical examination and MRI, and was resected with complete relief of symptoms.
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PMID:Persistent popliteal pain derived from cavernous hemangioma involving gracilis tendon and tendon sheath. 1644 98

A pregnant patient in the first trimester presented with acute onset knee pain and effusion. As the clinical status was mimicking septic arthritis, surgery was performed. Arthroscopy demonstrated a local synovial tumor and excision was performed with arthrotomy. Microscopic evaluation revealed localized pigmented villonodular synovitis. Due to the presence of necrosis and hematoma in the tumor, we hypothesize that, that torsion or bleeding of the tumor in the presence of physiological pregnancy- related metabolic changes might have been the cause of acute presentation.
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PMID:Localized pigmented villonodular synovitis of the knee: acute onset in pregnancy. 1670 12

This report describes a rare intra-articular synovial lipoma of the knee joint which developed in a 66-year-old female. The patient suffered from sudden knee pain and a catching or slight interruption of normal motion of the left knee and then noticed the tumor. The tumor was located in the lateral recess of the knee joint and showed a signal intensity similar to subcutaneous fat on T1 and T2()-weighted magnetic resonance images. The arthroscopy revealed a smooth, globular, yellowish, encapsulated tumor extending into the lateral recess from the surface of the lateral condyle and the tumor was totally excised under arthroscopic guidance. Histologic examination of the specimen revealed a tumor composed of mature adipose cells covered by a thin fibrous layer of varying thickness and normal synovial lining cells. The diagnosis was intra-articular synovial lipoma. Intra-articular synovial lipomas should be distinguished from other similar lipomatoid conditions such as Hoffa disease and villous lipomatous proliferation of the synovial membrane (lipoma arborescens). Intra-articular synovial lipoma should be considered in the differential diagnoses when examining a patient with sudden knee pain, and a catching or locking knee.
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PMID:Intra-articular synovial lipoma of the knee joint (located in the lateral recess): a case report and review of the literature. 1712 64

Glomus tumors are rare benign tumors distinguished clinically by their small size and ability to cause extreme pain. These lesions are usually found beneath the fingernails. Atypical locations of the tumor are difficult to diagnose, especially when the lesion is situated in a deep anatomic structure. We describe a 33-year-old man with glomus tumor beneath the plica synovialis in the knee. He had experienced right knee pain for 10 years which increased with movements of the knee. There was a point of tenderness on palpation at the lateral aspect of the knee. CT scan with arthrography showed a small mass on the lateral femoral condyle in the joint space. It was seen retrospectively in MRI. Arthroscopy demonstrated the soft tissue mass beneath the plica synovialis. We made a separate incision and removed it completely. An immediate disappearance of the pain was observed after surgery. Histology was the glomus tumor of the vascular type. The tumor seemed to be stimulated by the plica synovitis or the lateral joint capsule and it caused pain on motion similar to meniscal tear. There has been no recurrence for 3 years after surgery.
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PMID:Glomus tumor beneath the plica synovialis in the knee: a case report. 1724 Jan 52

The differential diagnosis of anteromedial knee pain is extensive and can be associated with meniscal tear, medial collateral ligament sprain, or pes anserinus bursitis. An association between knee pain and a peripheral nerve sheath tumor has rarely been reported. The authors describe the case of a 44-year-old man with a saphenous nerve schwannoma who presented with vague pain in the medial aspect of his knee mimicking the clinical presentation of a meniscal tear.
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PMID:Knee pain in saphenous nerve schwannoma: case report. 1761 2

The localized nodular synovitis is a benign proliferative synovial tumor manifesting as an intra-articular solitary nodule. We report a case of localized nodular synovitis at the infrapatellar fat pad of the knee which presented as a vague symptom of anterior knee pain. An arthroscopic excision of the lesion relieved the anterior knee pain and there has been no evidence of recurrence. Although the localized nodular synovitis shares some common histologic features with the pigmented villonodular synovitis without villous fronds, hemorrhage, or hemosiderin deposit, it is important to make a distinction between the two entities because their clinical presentations differ greatly, as do their responses to treatment. This rare tumorous lesion should be included in the differential diagnosis of common clinical symptom of anterior knee pain.
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PMID:Localized nodular synovitis of the knee presenting as anterior knee pain: a case report. 1766 8

Desmoplastic small round cell tumor (DSRCT) is a rare malignant neoplasm typically involving the abdominal cavity of a young male. Extra-abdominal occurrence of this tumor is very rare. We report a 10-year-old girl with primary DSRCT arising within the left femur. The patient presented with knee pain, and radiological findings were strongly suggestive of osteogenic sarcoma. In addition to the typical microscopic appearance and immunophenotype, RT-PCR demonstrated the chimeric transcript of EWS-WT1, which is diagnostic of DSRCT. Pulmonary metastases were present at initial staging studies, but no abdominal or pelvic lesion was present. Despite chemotherapy and complete tumor excision, the patient developed progressive lung and bone metastases and died 3 years after initial presentation. This is the second reported case of primary DSRCT of bone with genetic confirmation.
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PMID:Primary desmoplastic small round cell tumor of the femur. 1847 May 11

We present four cases of glomus tumors presenting as knee pain. All cases were treated by surgical excision of the tumor. All patients made an immediate recovery with return to full normal function. The presentation of this is unique in that the patient has exquisite pain and tenderness when the area affected is palpated. Occasionally, local infiltration or an ischaemia test can assist with diagnosis. To our knowledge, this is the largest case series in the literature.
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PMID:Glomus tumor and knee pain: a report of four cases. 1913 62

Although osteosarcoma is the most common primary malignancy of bone, it has only been reported to arise from the patella in a handful of cases. Telangiectatic osteosarcoma accounts for <5% of all osteosarcomas, and it is distinguished histologically by spaces, often blood filled, separated by septa containing highly malignant cells and radiographically by a predominately lytic and/or expansile component. Telangiectatic osteosarcoma can be radiologically confused with aneurysmal bone cyst or giant cell tumor. A 22-year-old otherwise healthy man presented with increasing pain, swelling, and limited flexion of the right knee after failing physical therapy for anterior knee pain. Standard anteroposterior and lateral radiographs demonstrated a diffuse destructive process involving the majority of the patella (including loss of the inferior patellar cortex) and a lytic lesion of the proximal tibia. Apparent osteoid matrix was visible in the soft tissue extension along the inferior pole of the patella. A computed tomography scan of the chest showed 2 pulmonary nodules consistent with metastatic disease. Evaluation of core needle biopsy showed osteosarcoma with telangiectatic features. Given that the majority of the tumor involved the patella/extensor mechanism, it was clear that the tumor originated in the patella. This case presents the first published report of a telangiectatic osteosarcoma arising from the patella.
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PMID:Telangiectatic osteosarcoma of the patella. 1929 11


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