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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 12-year-old boy was investigated for knee pain and contractures, and was found to have an intraspinal tumor of a lumbar nerve root and a tumor in the tectal region, both low-grade astrocytomas. We postulated that the tectal region astrocytoma metastasized to the lumbar intraspinal region. After surgery, the child underwent focal irradiation to the posterior fossa supplemented by craniospinal irradiation and a boost dose to the region of the lumbar spinal tumor. A low-grade astrocytoma rarely presents as spinal metastasis. This case may represent the first of a primary tectal low-grade astrocytoma manifesting as a symptomatic spinal mass.
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PMID:Low-grade astrocytoma of the tectal region as an unusual cause of knee pain: case report. 194 46

Evaluation of a limping child requires careful consideration and a basic knowledge of potential problems affecting the child. The most important point is not to miss or delay diagnosis of the septic hip. This is truly an orthopedic emergency. Complaints of knee pain should not throw the physician off the track of a diagnosis of hip disease. It is also important to be aware of how the medical history affects the musculoskeletal system. Many causes of limp are best analyzed by repeat examination and stepwise laboratory and radiographic evaluation. One should realize that a painful limp can be caused by something as mundane as a thorn in the heel or as serious as a tumor of the spine: Be suspicious.
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PMID:The limping child. 200 30

Tumors are rare causes of knee symptoms in children but must be considered in the differential diagnosis of pediatric knee pain in order to avoid errors in treatment that could result in loss of limb or even life. Experience with 199 bone and soft-tissue tumors about the knee in children are reviewed. The majority of lesions were benign bone tumors (n = 101), with osteocartilaginous exostoses, nonossifying fibromas, and chondroblastomas predominating. Malignant bone tumors (n = 59) were less frequent, and osteosarcoma (n = 48) was by far the most common sarcoma. Soft-tissue lesions (n = 31) were much less frequent and included rhabdomyosarcoma, synovial sarcoma, fibrosarcoma, and desmoid tumors. A careful history, physical examination, and review of roentgenograms are essential to avoid errors in diagnosis. Malignant tumors require roentgenograms and laboratory studies in sequence to stage the patient. A properly performed biopsy established the diagnosis in most instances. Popliteal cysts, stress fractures, infection, myositis ossificans, histiocytosis, and other lesions can mimic tumors and delay correct diagnosis.
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PMID:Tumors about the knee in children. 218 35

A 64-year-old man with right knee pain had uptake of Tc-99m MDP in the area as well as in the greater trochanter. Both sites were shown to contain osteogenic sarcoma. There was resection of the bone. Eight months later, radiogallium uptake was avid in the nearby soft tissue, indicating tumor spread.
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PMID:Multifocal osteogenic sarcoma in the seventh decade. 345 63

An 18-year-old man suffered four years of undiagnosed knee pain until a CAT scan revealed an epiphyseal osteoid osteoma of the tibia located subchondrally, just medial to the proximal tibiofibular joint. A nidus in this location is not easily accessible, and its proximity to the joint surface raised concerns about damage to the tibial plateau. To facilitate excision of the tumor, cadaveric dissections were performed to develop a limited posterior approach to the proximal, lateral portion of the tibia. The CAT scan was used to calculate the precise dimensions of the tumor and its relation to the posterior tibial cortex and the proximal tibiofibular joint. With the use of the exposure developed in the laboratory and the calculations derived from the CAT scan, the tumor could be excised by removing a single block of bone 15 mm3. Intraoperative radiographs confirmed the presence of the nidus within the excised block of bone. This case report reaffirms the frequent difficulties and tardiness in diagnosing osteoid osteomas and the need to include these tumors in the differential diagnosis of knee pain and epiphyseal lesions. Before CAT scans were used, the working diagnoses were torn meniscus, juvenile rheumatoid arthritis, and bone hemangiomatosis.
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PMID:Limited posterolateral surgical approach to the knee for excision of osteoid osteoma. 365 82

A case of chronic knee pain of rare etiology is reported. Conventional radiographs excluded any articular pathology but ultrasound images showed features typical of a transsonic type tumor. Pathologic examination was necessary to establish the diagnosis, the tumor being an Antoni type A schwannoma.
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PMID:[Knee pain of rare etiology]. 647 Oct 13

A rare case of acromegaly with radiculomyelopathy due to spinal canal stenosis is reported. A long history of acromegalic deformity was seen on this 55 years old acupuncture therapist for the last 18 years, while he had developed unusually increased appetite, profuse perspiration and gained weight. Fifteen years ago, acromegalic tendency became prominent and was accompanied by low back and knee pain. In 1974 CB-154 was administered in several occasions beside 4000 rads irradiation to the sella. After radiation therapy was completed his outlook was somewhat improved, although low back pain was aggravated and associated with atrophy of the left lower extremity. The neurological examination at admission in 1980 revealed acromegalic feature, increased DTRs on both upper and lower extremities, dysesthesia of feet and atrophy of the leg muscles in general, mainly due to diffuse atrophy. Patient bended knees due to pain and unable to walk. He had radiating pain in the postero-lateral aspect of the left lower extremity and some dysesthesia of feet, although no specific root lesion was identifiable. Spinal roentgenograms disclosed diffuse ossification of anterior and posterior longitudinal ligaments, and marked spondylotic changes. Although the low back pain was impending complaint of the patient, the hypophyseal tumor was advised to remove and transsphenoidal hypophyseal adenomectomy was performed. A good amount of softend tumor tissue was removed however, adenoma found markedly fibrotic. Low back pain and knee were decreased gradually, but intermittent claudication was evident. Acromegaly in association with spinal canal stenosis were reviewed in literature, and the relationship of growth hormone and therapeutic problems were discussed.
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PMID:[Acromegaly and spinal canal stenosis]. 666 55

The authors reported a case of a 56-year-old man with lung cancer which secreted human growth hormone (hGH). On admission, he had clubbed fingers and gonalgia without complaining cough or sputum. Serological examination revealed a high level of hGH which was 22.7 ng/ml (normal < 1.46). Right upper lobectomy was performed in February, 1994. It returned to the normal level after resection of the tumor. Gonalgia was improved but he still had clubbed fingers after operation. Histological examination of the tumor shows poorly differentiated adenocarcinoma with no evidence of lymph node metastasis. Immunohistochemical study showed that a group of the tumor cells demonstrated a specific reaction for anti-hGH antibody.
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PMID:[A case of human growth hormone (h-GH)-producing adenocarcinoma of the lung]. 760 9

Lateral crypta synovial crush syndrome is often confused with lateral meniscus injury. Thirteen cases were reported in this paper. Of them, eleven cases had pain at the lateral of their knees which were flexed from twenty degrees to eighty degrees. One patient had knee pain in erect position and other one on walking. Local tenderness at lateral tibial plateau of knee existed in all cases and small nodule could be palpated at tenderness point in ten cases. Ten cases were examined by arthroscope. Synovial neoplasm or abnormal synovial fold was discovered in lateral crypta of knee which could be pushed into joint space at flexed twenty degrees to eighty degrees. After removing them, symptom disappeared. Three cases were cured by nodule block therapy. The block therapy of injection of prednisolonum was available for not only diagnosis, but also treatment. The indication of arthroscope is that effect of block therapye is unsatisfactory. That all cases occurred on the lateral side might be related to the diffierence in anotomic structure.
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PMID:[Diagnosis and treatment of lateral crypta synovial crush syndrome of knee]. 873 87

Osteoid osteoma is a primary, benign, bone tumor with a typical X-ray appearance. The diagnosis is usually straightforward when it involves the long bones of the leg. However it may occur in unusual locations, such as in flat and cancellous bones. The following case demonstrates the difficulty in diagnosing it in an extremely rare site. A 25-year-old woman with long-standing anterior, right knee pain had had 3 interventions: 2 diagnostic arthroscopies and a distal, femoral biopsy. Since there had been no improvement in her condition, the diagnosis of osteoid osteoma of the patella was suggested, supported by recent X-ray and scintigraphic findings. This rare condition was confirmed by biopsy of the upper pole of the patella, a procedure that was followed by complete recovery. 6 years later, she is now completely free of pain and has no clinical or X-ray evidence of recurrence. Review of the literature revealed only 5 previously reported cases of osteoid osteoma of the patella. All were diagnosed relatively late and in 1 the tumor was diagnosed only after total patellectomy. Diagnosis of these rare cases that mimic much more common causes of patello-femoral pain demands a high index of suspicion.
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PMID:[Osteoid osteoma of the patella]. 915 14


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