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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A syringomatous adenoma of the nipple is a benign locally infiltrating neoplasm histologically similar to the syringoma of the skin. Morphologically similar lesions have been described as adenoma of the nipple or florid papillomatosis. Patient was a 33 year old woman who was admitted with a history of bloody nipple discharge from her right breast. With a clinical impression of Paget's disease explorative mastectomy was performed. Microscopically typical tubular and duct like structures with syringomatoid features were present throughout the stroma of the nipple.
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PMID:Syringomatous adenoma of nipple--a case report. 326 85

A case of squamous cell breast carcinoma is presented. The patient was 31-year old woman with a complaint of a right breast mass. The tumor was found to measure 7.0 x 8.0 cm without any inflammatory signs, and was associated with a bloody nipple discharge. Lymph-node metastases of the ipsilateral axillary and supraclavicular nodes were noted, and metastasis to the fifth lumbar vertebrae also was seen. Because of a diagnosis graded T4bN3M1, stage IV, an extended radical mastectomy was performed. Histologically, the major portion of this tumor consisted of a squamous cell carcinoma with a minimal component of adenocarcinoma and accompanying keratinization. The patient died of this cancer 5 months after the operation.
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PMID:[A case of squamous cell carcinoma of the breast]. 328 78

A 74-year old female presented a giant tumor and serosanguineous nipple discharge from the left breast. The tumor was first recognized 26 years ago, and untreated. The resected breast contained several cysts and some small white nodules. Some of the cysts contained intracystic tumors. Histologically, the tumor consisted of a mixture of papillotubular carcinoma and intraductal papilloma. This case seems to represent a malignant change in intraductal papilloma from its long clinical course and by the microscopic findings. Review of this case seems to warrant clinical attention to the possibility that benign intraductal papilloma may transform itself into malignancy after many years.
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PMID:[A case of breast carcinoma, possibly the result of malignant transformation of an intraductal papilloma in a 26-year period]. 356 Apr 52

A case of non-invasive secretory carcinoma of the breast is reported. The patient was a 33-year-old Japanese woman who complained of abnormal nipple discharge from the right breast. Although physical and radiological examinations failed to find any abnormal nodular lesions in the breast, a cytological examination revealed signet-ring-like atypical cells in the smears of nipple discharge. Radical mastectomy with axillary lymph nodes dissection was performed. No nodular lesions were macroscopically observed. However, intraductal proliferation of atypical cells was microscopically found in the excised breast. Diastase-resistant PAS-positive mucus was observed in the tumor-cell-forming-lumina and in the cytoplasm of tumor cells. No metastases were observed in the axillary lymph nodes.
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PMID:[Non-invasive secretory carcinoma of the breast]. 359 81

Between 1 January 1974 and 30 June 1984, 1,003 specimens obtained from the breast were submitted for cytologic evaluation to the Department of Pathology at the Waterbury Hospital Health Center. Eighty-eight per cent were obtained by fine needle aspiration of a palpable mass; the remainder were smears of nipple discharges. Precytologic and postcytologic clinical data were available for 80 per cent of the specimens. In the fine needle aspiration group, there were 219 instances of proved carcinomas; 79 per cent of these had either positive or suspicious cytologic findings. Seventy-five per cent of the patients with positive cytologic results underwent mastectomy without prior histologic confirmation of the needle aspiration and all were confirmed as malignant growths. There were 41 false-negative aspirates which were reviewed in detail. The cytologic slides of 24 of the 41 false-negative aspirates were available for re-evaluation by a second, independent cytopathologist. Only one was thought to have been misread initially; the remainder appeared to have been falsely negative for technical reasons related to aspiration or fixation technique or tumor size less than 1 centimeter. There was one false-positive finding in a patient who was found to have fat necrosis at biopsy. Results of nipple discharge cytology were less accurate. Positive or suspicious cytology was found in only five of 11 proved instances of carcinomas. There was one false-positive and five false-negative results in this group. We conclude that needle aspiration of palpable masses of the breast is an accurate, cost effective procedure which is readily adaptable to a community hospital, provided that a pathologist with an interest in cytology is available.
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PMID:Aspiration of the breast and nipple discharge cytology. 377 19

100 Nigerian women were entered into a prospective study of spontaneous occurring nipple discharge over a seven year period. The patients consisted of 25 study group patients and three groups of 25 patients comprising the controls. In the study group, seven types of nipple discharge were identified, namely: bloody (40%), watery (4%), and milky (4%). Intraductal papilloma and other benign breast disease were the cause of nipple discharge in 23 of 25 (88%) study group patients. Only 28% of breast cancer patients in control group A, 16% of bloody or serosanguineous and 16% of benign breast tumor patients of control group B presented with nipple discharge. Nipple discharge was an incidental finding in 16% of normal control group C patients. Thus Nigerian women are more likely to seek medical intervention for bloody and serosanguineous discharge. Surgical management remains the optimal management for nipple discharge.
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PMID:Nonpuerperal nipple discharge in Nigerian women. 381 Aug 44

Abnormal nipple discharge is rare, constituting only 3-5% of mammary consultation. In the present paper 267 patients with primary nipple discharge operated on at Institut Gustave-Roussay (IGR) in Villejuif, France, between January 1, 1960 and December, 1974 were evaluated. In all cases, the nipple discharge was symptomatic, spontaneous, and represented the primary reason for the patient's consultation. During the same period 1,145 cases of nipple discharge were treated at IGR. Of the 1,145 cases with symptomatic nipple discharge, 267 patients (23%) required surgical intervention. Among these, fibrocystic disease and duct ectasia were the leading causes of nipple discharge occurring in 42% of surgical specimens. Twenty one per cent of the patients had carcinoma and 35% were found to have intraductal papilloma. The overall incidence of malignancy, however, was 4.8% among the 1,145 women with nipple discharge. On the average, patients with nipple discharge due to malignancy were ten years older than those with benign lesions (Table 2). Approximately 25% of patients with malignant discharge and 5% with benign discharge have associated tumor. Over 60% of the patients with both discharge and a mass had malignancy.
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PMID:Nipple discharge from the breast. 627 58

In order to investigate the cytologic characteristics of breast carcinoma in nipple discharge, 190 histologically proven cases of various breast lesions from 2,723 samples of nipple discharge were studied. The general criteria of malignancy as described for other organs applied also to the breast carcinoma cells. However, the breast carcinoma cells were generally smaller and less pleomorphic than those arising from other organs. In addition to the malignant features of individual tumor cells, the presence of a spherical cell cluster with a smooth rim was also an important finding suggestive of malignancy. The diagnostic rate of breast carcinoma increased significantly when the 190 cases were reexamined on the basis of the findings of this study.
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PMID:Cytologic diagnosis of breast carcinoma with nipple discharge: special significance of the spherical cell cluster. 693 79

A milky discharge may be of a benign endocrine nature, drug induced or secondary to a pituitary lesion. A clear or bloody discharge may be functional or related to benign or malignant breast lesions. Carcinoma is a very unusual cause of nipple discharge in the absence of a palpable mass or an abnormal mammogram. A unilateral bloody discharge without evidence of a tumor may stem from a benign intraductal papilloma. Careful follow-up evaluations are sufficient for a persistent nipple discharge, after serious pituitary and breast disorders have been ruled out.
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PMID:Nipple discharge. 719 28

To compare the specific information provided by ultrasound (US) and galactography and to appreciate the clinical applicability of US as a primary diagnostic method for breast tumors associated with nipple discharge, a comparative study of each method in 15 patients with ductal tumors of the breast was performed. To evaluate the smallest anatomical unit of the lactiferous system demonstrable by US, 30 patients with normal lactating breasts were examined prospectively. The smallest anatomical ductal unit that could be evaluated with US in the normal lactating breast was the terminal duct lobular unit (TDLU). US is superior to galactography in detecting masses smaller than 0.5 cm or lesions involving multiple ducts. Galactography is better for visualizing the duct system and detecting calcification. In conclusion, US serves as a primary noninvasive diagnostic tool in patients with clinically suspicious breast tumor associated with bloody nipple discharge, but galactography also should be done in specific circumstances.
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PMID:Breast tumors associated with nipple discharge. Correlation of findings on galactography and sonography. 755 30


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