Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 12-year-old, premenarchal girl with hirsutism and virilization of nine months' duration was found to have highly elevated serum testosterone and a radiologic evaluation suggestive of bilaterally enlarged ovaries with a solid left ovarian mass. Serum gonadotropins were normal, with an LH:FSH ratio of 2:1. Exploratory laparotomy showed bilaterally enlarged polycystic ovaries, confirmed by wedge biopsies. No ovarian tumor was found. Oral contraceptives decreased the total serum testosterone to the normal female levels within three months. This was one of the youngest reported patients with primary polycystic ovary syndrome.
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PMID:Primary polycystic ovary syndrome in a premenarchal girl. A case report. 392 38

Data are presented concerning a case of female pseudohermaphroditism of unknown etiology. The child was born with labioscrotal fusion and clitoromegaly. From the age of 5 to the age of 25 there was no clinical evidence of a hormonal abnormality. At the age of 25 the patient presented with masculinization and Cushing's syndrome, and a left adrenal tumor was removed. The patient was restudied at the age of 29, when 21-hydroxylase deficiency was excluded. Other types of congenital adrenal hyperplasia are considered unlikely. The possible relationship between the ambiguous genitalia present at birth and the virilizing tumor diagnosed at the age of 25 is analyzed.
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PMID:Female pseudohermaphroditism with adrenal cortical tumor in adulthood. 398 37

A report is given on the rare case of a hormonactive Leydig cell-tumor in a 52-year-old patient. In spite of virilization symptoms of many years' standing, it was only because of multiple troubles with a great uterus myomatosus that she was admitted to the hospital. An ovarian tumor existing at the same time, turned out to be histologically a mere hilus cell-tumor with a strong nucleus polymorphy. In consideration of the danger of a malignant degeneration (borderline case), the patient was included in our tumor follow-up control programme.
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PMID:[Leydig cell tumor with pronounced virilization]. 401 45

Virilization in pregnancy has been reported with various ovarian neoplasms. Presented is a case of maternal virilization resulting from an unclassified sex-cord stromal neoplasm.
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PMID:Maternal virilization in pregnancy due to an unclassified sex-cord stromal neoplasm. 401 50

Results of measurement of urinary steroid metabolite profile using gas chromatographic analysis in eight patients with adrenocortical tumors, i.e. 3 adenomas with Cushing's Syndrome, one adenoma with virilization, one adenoma without clinical manifestations, one carcinoma with Cushing's syndrome and virilization, one carcinoma with Cushing's syndrome and feminization, and one carcinoma without endocrinological symptoms, are reported. A unique pattern dominated by 5 beta and 11 beta-hydroxy steroid metabolites was confirmed in five patients with Cushing's syndrome consisting of three cases with adenomas and two with carcinomas. Excessive 3 alpha, 17 alpha, 21-trihydroxy-5 beta-pregnan-20-one (tetrahydro-11-deoxycortisol, THS) and delta 5-pregnene-3 beta, 11 alpha, 20 alpha-triol (delta 5-pregnenetriol) values were found in all three carcinomas including a nonfunctional carcinoma. These findings would strongly suggest the tumor to be a carcinoma, although excessive excretion of THS and delta 5-pregnenetriol was detected in one patient with a large adenoma associated with virilization. One patient with carcinoma was responsive to ACTH stimulation while the remainder show almost no response to exogenous ACTH. Urinary steroid profiling using gas chromatographic analysis, especially the values for THS and delta 5-pregnenetriol, appears to be a useful method to use in detecting these steroid metabolic characteristics in patients with adrenocortical carcinoma.
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PMID:Measurement of urinary steroid profile in patients with adrenal tumor as a screening method for carcinoma. 401 73

A Leydig (Hilus)-cell tumor of the ovary was diagnosed in a 54-year-old woman with severe hirsutism and virilization. This case is unique in that it was diagnosed in a postmenopausal female 24 years after ovarian irradiation for sterilization, and the tumor was successfully localized preoperatively using 131I-19-iodocholesterol scintigraphy. This nuclear scanning technique may be of use in documenting the biologic activity of ovarian masses and in localizing functioning ovarian tumors which are too small to palpate or to localize by other means.
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PMID:Leydig-cell tumor of the ovary: visualization using 131I-19-iodocholesterol scintigraphy. 404 8

Sexual ambiguity at birth in a girl usually suggests congenital adrenal hyperplasia. After exclusion of this diagnosis, we thought of an isolated abnormal state. It was only when the girl was 14 months old that the diagnosis of adrenocortical tumor with signs of virilism was stated. The difficulties of this diagnosis and the therapeutical possibilities of such cases are discussed.
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PMID:[Virilizing adrenal cortical tumor in children. Apropos of a neonatal case]. 408 May 3

This is a complete outlined summary of menstrual disorders of puberty. First diagnostic procedures are suggested, such as history, evaluation of degree of pubertal development, and gynecologic, neurologic, and psychiatric exam, with temperature curve, vaginal smear, basal and stimulated hormone tests, and chromosome studies as required. Common but probably not pathologic complaints include dysmenorrhea (rule out ovarian cyst, endometriosis, congenital malformation); menstrual irregularity (rule out Stein-Levinthal syndrome); menometrorrhagia (rule out Willebrand's syndrome and vaginal or uterine tumor). Primary amenorrhea, if not simply late development, could be due to ovarian dysgenesis, Turner's syndrome, sellar tumor, olfactory-genital syndrome, testicular feminization syndrome, or malformation of the vagina or uterus. Amenorrhea with virilization may be of adrenal or ovarian origin, distinguished by whether urinary ketosteroids are elevated after adrenal inhibition or after ovarian stimulation. Secondary amenorrhea may possibly be related to hypothyroidism, adrenal androgens, pregnancy, or psychogenic causes. If urinary gonadotropins are high, ovarian tumor, primitive ovarian insufficiency, or gonadal dysgenesis may be suspected; of if gonadotropins are low, primitive hypothalamic syndrome, tumor, or iatrogenic causes may be considered as causes of secondary amenorrhea.
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PMID:[Menstrual disorders at puberty]. 484 92

In normal females, androstenedione from both the adrenal cortex and ovary, as a result of peripheral conversion, is the source of the majority of biologically active testosterone in the circulation. The control of the secretion of precursor steroid and androgenic hormone (testosterone) in females is not clear at this time. There are a number of possibilities to explain various types of hirsutism and virilization. The presence of true virilization indicates a significant disorder and requires complete investigation. The presence of increased amounts of 17-ketosteroids in the urine implicates the adrenal cortex as a source of the pathologic manifestations. The suppressibility of elevated 17-ketosteroids with cortisol analogues aids in distinguishing between adrenal hyperplasia and autonomous neoplasm of the adrenal cortex. By far the most common entity in this area is simple hirsutism without virilization. Although our knowledge of this disorder is quite incomplete, conservative management is indicated. Further progress in this field is rapidly occurring. An informed clinician can do an adequate job of diagnosis and treatment with the clinical and laboratory tools generally available.
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PMID:Hirsutism and virilization. 604 95

Endocrine studies were made on 4 women with ovarian Sertoli-Leydig cell tumors of varying degrees of differentiation. Clinically, all 4 patients showed evidence of increased androgen production, manifested by either hirsutism or virilization. The calculated ratios of steroid hormones between the affected ovarian venous values and peripheral values for testosterone (T), androstenedione (A), and dehydroepiandrosterone (DHEA) in 3 patients, were 1.4-18.6, 4.2-24.4, and 3.7-10.0, respectively. The peripheral levels of the hormones before salpingo-oophorectomy in all the patients were T: 0.97-45.0 ng/ml; A: 2.92-114.0 ng/ml; and DHEA: 13.0-20.9 ng/ml. In the 3 juvenile patients, elevated basal levels of LH and normal or subnormal levels of FSH (high LH:FSH ratio) were found. In a 12-year-old patient with 1,900 g tumor composed predominantly of Sertoli cells with lipid storage, the peripheral serum levels of T and estradiol (E2) were 114 ng/ml and 1890 pg/ml, respectively. The present data suggest that: 1) androblastomas have a biosynthetic capacity for androgen, estrogen, or both in which both the delta 5 and delta 4 pathways are involved, and 2) little correlation exists between the endocrine function and cellular composition of the tumors or their degree of differentiation.
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PMID:Endocrine studies on ovarian androblastomas (Sertoli-Leydig tumors). 609 78


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