Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An 18-year-old male preferred to our clinic with hemoptysis, cough, dyspnea and stridor. A wide-based polypoid tumor that was localized at the right wall of the distal trachea was observed over 3 cm from the carina by flexible bronchoscope. Computerized tomography showed an intraluminal soft tissue density mass in the trachea. Though right thoracotomy, a tracheal resection that contains three rings of the trachea with malignant lesion was performed. Pathologic examination reported a tracheal mucoepidermoid carcinoma. The patient is alive without recurrence three years after surgery.
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PMID:[A rare tracheal malignant tumor: mucoepidermoid carcinoma (a case report)]. 1514 78

Aberrant right subclavian artery (ARSA) is the most common anomaly of the aortic arch. We present the successful use of endoscopic ultrasonography (EUS) in the diagnosis of ARSA. A 65-year-old woman was admitted because of dyspnoea and inspiratory stridor. Bronchoscopy revealed a subglottic tracheal stenosis. To exclude an underlying malignancy, endoscopy was performed showing an oesophageal impression, which subsequently was identified as ARSA by EUS. Computed tomography excluded neoplasm and confirmed the diagnosis of ARSA. After laser resection of subglottic tissue the stridor resolved and could therefore not be attributed to the co-existence of ARSA. In most cases the ARSA crosses between the oesophagus and the spine from the descending aortic arch to the right and may seldom cause dysphagia due to oesophageal compression. Diagnosis is usually based upon computed tomography or magnetic resonance imaging, whereas angiography is only rarely needed. Endoscopic ultrasonography offers a convenient alternative diagnostic tool and can be performed even as a bedside examination. The diagnosis can be easily assessed in all patients referred for EUS of the upper gastrointestinal tract for any reason. Especially in patients undergoing invasive procedures in the upper thorax or neck, knowledge of an abnormal course of the great vessels is important. Arteria lusoria is often found by chance. EUS is a simple and excellent tool for assessing the diagnosis and usually does not require confirmation through other investigation methods.
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PMID:[Impact of endoscopic ultrasonography in the diagnosis of aberrant right subclavian artery: a case report]. 1530 May 5

A 28-year-old primigravida at 35 weeks gestation with acute onset of dyspnoea and stridor due to an intrathoracic neoplasm required semi-urgent caesarean section to allow diagnosis and treatment. Her inability to lie supine precluded regional anaesthesia. She underwent awake fibreoptic oral intubation followed by general anaesthesia. This was complicated by desaturation, high airway pressures, unilateral lung collapse, venous congestion and unexpected blood loss due to an undiagnosed placenta praevia.
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PMID:Awake fibreoptic intubation, airway compression and lung collapse in a parturient: anaesthetic and intensive care management. 1532 Nov 59

We reviewed the diagnosis, complications and treatment of congenital laryngeal stridor (CLS), in 97 patients who consulted our clinic between 1991 and 2001. The 97 patients were diagnosed with laryngeal malacia (32%), vocal cord paralysis and laryngeal stenosis (22%), a neoplastic disease like hemagioma and papilloma (11%), or cystic disease (7%). The cases with vocal cord paralysis, laryngeal stenosis or laryngeal cysts were usually diagnosed within 2 months of birth based on severe dyspnea. Two of the 31 cases of laryngeal malacia and 2 of the 22 cases of vocal cord paralysis were associated with neuromuscular disorders. Three patients suffered from vocal cord paralysis complicated by laryngeal stenosis. Thirty-three of the 97 cases required a tracheostomy; these 33 cases included the one case of laryngeal papilloma (100%), 9 of the 10 cases of hemangioma (90%), and 18 of the 24 cases of laryngeal stenosis (75%). Since any disorders of the upper airway can potentially induce stridor, establishing an accurate diagnosis is sometimes difficult when stridor is the only presenting symptom. Hence, information on associated symptoms and the past history of the subject is particularly important for an accurate diagnosis. In addition, decisions regarding the course of treatment course require adequate consideration of possible complications.
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PMID:[Congenital laryngeal stridor]. 1534 96

Primary extranasopharyngeal angiofibroma is very rare. To date, approximately 60 cases have been reported in the English literature. Only 1 case was confined to the posterior wall of hypopharynx. In August 2000, a 68-year-old man presented with a 6-month history of progressive foreign-body sensation in the throat and intermittent inspiratory stridor. Endoscopic examination of the larynx and pharynx revealed a nonpulsatile, pink-grayish, polypoid mass arising from the posterior pharyngeal wall of the left hypopharynx. Under general anesthesia, this tumor mass was subsequently removed by the endoscopic CO2 laser. The histologic diagnosis was an angiofibroma. Three-year follow-up found no evidence of tumor recurrence or post-operative complications.
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PMID:Angiofibroma of the hypopharynx. 1551 Sep 37

A seven-month-old male presented with a one month history of an enlarging left neck mass and worsening inspiratory stridor. Upon excision of the mass, pathologic examination was consistent with embryonal rhabdomyosarcoma (RMS). Preoperative imaging and intraoperative exploration were consistent with tumor replacing the left lobe of the thyroid. No cases of either anterior neck rhabdomyosarcoma or thyroid rhabdomyosarcoma have been explicitly described in the literature. The distinction between the two malignancies becomes important when considering prognosis and treatment protocols.
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PMID:Rhabdomyosarcoma presenting as an anterior neck mass and possible thyroid malignancy in a seven-month-old. 1565 63

Venous thromboembolic disease has an estimated annual incidence of one in 1000 people. However, thrombosis of the superior mediastinum and neck veins is less frequent and it is usually due to direct trauma to the neck by intravenous catheters, drug abusers or neck dissection surgery. Local or distant malignancy (Trousseau's syndrome) is also an important cause. Thrombosis of the superior mediastinal and internal jugular veins is rarely a cause of primary referral to the otolaryngologist. On these rare occasions, it can present as a painful neck mass, but may also present with stridor, dysphonia or dysphagia. The four patients presented here illustrate different ways of presentation. Different imaging techniques such as ultrasound, computed tomography (CT) scan, magnetic resonance imaging (MRI) and venogram, will produce a diagnosis of thrombosis, occasionally with a mass, but only a biopsy will confirm or rule-out malignancy. Spontaneous thrombophlebitis can be the first manifestation of an occult neoplasm and any investigation into venous thrombosis must include a thorough general examination and follow up.
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PMID:Superior mediastinal and internal jugular venous thrombosis presenting to the otolaryngologist. 1580 64

Inflammatory myofibroblastic tumor is extremely rare in the larynx and can mimic a malignant process. We present the case of a 62-year-old male who required tracheotomy due to rapidly progressive stridor. Laryngoscopy showed an exophytic, occlusive tumor located in the right true vocal cord. CT showed an expansive mass measuring 2 x2 x1.3 cm3 and occupying the anterior commissure, with glottic progression to the right true vocal cord. The tumor was completely resected with a CO2 laser via a transoral approach. Histologic examination demonstrated extensive ulceration with the presence of granulation tissue. The specimen was mainly composed of spindle cells arranged in a fasciculated pattern with a myxoid background and focal hyalinization. Immunohistochemical studies revealed positivity of spindle cells to vimentin, muscle-specific actin and smooth muscle actin. The patient showed no evidence of disease 24 months after surgery.
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PMID:Inflammatory myofibroblastic tumor in the larynx: clinicopathologic features and histogenesis. 1588 Sep 56

About 2 years after right lower lobectomy for anadenocarcinoma in the right lung, an 80-year-old man had a reccurent tumor in tracheocarinal lymph nodes. Although concurrent chemoradiotherapy was performed, there was no change (NC) and the tumor grew back slowly. He was admitted to our hospital with exertional dyspnea and stridor 2 years later. The bronchoscopic microwave coagulation therapy was performed in the right main bronchus. After potassium titanyl phosphate (KTP) laser therapy had been performed in the tracheocarinal lumen, an expandable metallic stent was performed. The postopertive course was uneventful.
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PMID:[Microwave coagulation therapy with potassium titanyl phosphate (KTP) laser therapy for airway stenosis from a recurrent tracheocarinal tumor]. 1610 65

A 75-year-old woman who complained of cough at night and stridor on exertion was admitted for examination of a possible tracheal tumor. Chest radiography and CT showed an intratracheal calcification. Bronchoscopic examination revealed a lobulated tumor on the anterior wall of the trachea, 6 cm below the vocal cord. The tumor was covered with tracheal epithelium. Microscopic findings of the transtracheal biopsy specimen revealed the tumor to be composed of bone tissues covered with normal tracheal epithelium. No cartilage, smooth muscle, or fats tissue were detected, and so a diagnosis of intratracheal osteoma was made. After Nd-YAG laser therapy, the size of the tumor decreased, and clinical findings improved. During periodical follow up after discharge, the residual tumor was expectorated at home on coughing. Histological examination confirmed the tumor to be osteoma. An intratracheal osteoma is very rare, and this case is the first case reported in Japan.
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PMID:[A case of intratracheal osteoma]. 1628 94


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