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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Neurogenic tumors in the neck region are relatively infrequent with the exception of those involving the cranial nerves. A case of a ganglioneuroma or neurofibroma involving the nerve root of C4, C5 interspace is reported. The tumor appeared as a mass within the neck with a slight amount of pain in the shoulder and upper arm upon palpation. Surgical exploration revealed a mass superficial to the foramen and erosion of the foramen. Roentgenograms taken in the region demonstrated an extradural mass that was subsequently removed by laminectomy. Postoperatively, the patient did quite well. Surgical excision is the treatment of choice. Preservation of the nerve should be accomplished if at all possible.
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PMID:Ganglioneuroma of the C4, C5 interspace. 50 22

An adenocarcinoma of the second portion of the duodenum in a 26-year-old male is presented. The patient was suffering from pain in the epigastrium. Immunofluorescent studies revealed that it consisted almost exclusively of cells with a distincly positive somatostatin-like immunoreactivity. Ultrastructurally, the cytoplasm of the tumor cells had numerous large round granules (about 400 micrometers) with variable electron density. Most of these cells closely resembled the D cells normally seen in the duodenum and the islets of the pancreas, although a few argyrophil cells could be demonstrated by light microscopy. Radioimmunoassay of extracts of the tumor revealed a large amount of somatostatin (2260 pg/mg); substance P and VIP were detected also. Somatostatinoma has been known to occur in the pancreas, but this seems to be the first somatostatinoma found in the intestine.
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PMID:Somatostatinoma of the duodenum. 50 96

A diagnosis of vertebral multiple myeloma, based on radiographic evidence of osteolytic lesions and the finding of monoclonal paraprotein and large numbers of plasma cells in bone marrow biopsies, was made in a mature Doberman Pinscher. The abnormal serum paraprotein was a cryoglobulin of the immunoglobulin A class. Neurologic signs associated with the tumor included pain, progressive pelvic limb paresis, and paraplegia that developed during a 6-week period.
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PMID:Neurologic complications of IgA multiple myeloma associated with cryoglobulinemia in a dog. 51 33

Sixteen cases of colorectal adenocarcinoma in patients 30 years of age and younger were treated at the University of Virginia Medical Center between 1957 and 1977. Ten patients (63%) were black, and seven patients (44%) were black females. The high incidence of this tumor in young blacks in our patient population appears to be a recent development, becoming clinically manifested since 1965. Pain was the major presenting symptom, and bleeding was a constant finding in the patients with rectosigmoid lesions. Eighty-six percent had metastases at the time of diagnosis despite a short duration of symptoms. Five-year survival in 11 patients with mucinous adenocarcinoma was 18%, while the three patients with well-differentiated glandular carcinoma had a 5-year survival of 33%. Material was unavailable for histologic review in two cases. Fourteen of 16 patients eventually died of their carcinoma, and one patient died of malignant lymphoma. Additional factors which correlated with length of survival were resectability, extent of bowel wall invasion, and the presence of lymph node capsular invasion. Nodal capsular invasion is an especially sensitive marker for short-term survival and has not been previously reported in colonic tumors.
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PMID:Colorectal carcinoma in the first three decades of life. 53 61

This paper is based on 21 patients with metastases of the choroid from extraocular tumors, observed over a period of 25 years (1952--1977) at Erlangen University Eye Clinic. Approximately 70% of these relatively rare metastases of the choroid are caused by cancer of the breast. Ophthalmoscopically, they are usually localized to the left of the posterior pole and are yellowish. In about 20% of the cases both eyes are affected. Since breast cancer is the most frequent cause of the primary tumor, women in the 40 to 60 age group are the most common sufferers. On the other hand, it is worth mentioning that in 2 cases the metastases were the first signs of any type of malignancy. Typical is the relatively flat, shell-like growth. In cytological specimens the portion of the retina covering the tumor normally shows no evidence of cystic degenerative change, in contrast to malignant melanoma. In view of the short average life expectancy of about 9 months, therapy should consist in preserving the eye and thus some degree of vision. Radiotherapy, chemotherapy or cytostatic therapy whould be tried. Enucleation is only indicated where there is severe pain, secondary glaucoma, amaurosis or if it is impossible to differentiate from a malignant melanoma.
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PMID:[Tumor metastases of the choroid: clinical picture and histology (author's transl)]. 54 92

Angiosarcoma of the intima is a very rare tumor. The authors report a case which involved early metastases to the periphery of the leg. Cramping pain, circumscribed clusters of cells, and gangrene appear to be characteristic and should be kept in mind, as this condition imitates occlusive arteriosclerotic disease.
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PMID:Angiosarcoma of the superficial femoral artery with distal embolization. 55 6

Six patients who originally received radiotherapy for Hodgkin's disease or primary gastric lymphoma developed radiation injury of the stomach requiring surgical management. Only two of these patients had evidence of gastric neoplastic involvement at the time of treatment. Experience with these patients leads us to draw the following conclusions: (1) Symptoms of radiation injury mimic those of recurrent neoplastic disease. (2) The effects of radiation are progressive and may be resistant to medical management. (3) The indications for surgical management include perforation, hemorrhage, obstruction, intractable pain, fistula formation, and inability to rule out recurrence. (4) Parenteral hyperalimentation can be an important adjunct in preparing debilitated patients for operation. (5) Gastric resection with gastrojejunostomy is the preferred operation. (6) Frozen section examination can be useful in determining the proper level of resection.
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PMID:Gastric complications after radiotherapy for Hodgkin's disease and other lymphomas. 57 92

In November 1975 a 28-year-old woman with 2 children was hospitalized with severe pain from a liver mass in the right lobe detected by liver scan. She had taken oral contraceptives (OCs) containing mestranol off and on for 91 months. Her blood showed an elevated SGOT (50 mU/ml) and elevated alkaline phosphatase (159 mU/ml). After an ultrasonic abdominal sound, an arteriogram, a liver scan, and a liver panel, the abdomen was explored. The liver was twice normal size, congested, soft, and spongy, more vascular than normal, and mottled. There was a large thickening, but no tumor. Drains were placed and the abdomen was closed. The diagnosis was a liver hematoma secondary to hepatic vein thrombosis. No therapy was provided but withdrawal of OCs. 10 months later, the liver had returned to normal size and was quite firm, and the hemogram was normal. This case shows that hepatic vein thrombosis as well as liver neoplasm must be considered in the diagnosis of young women with a liver mass and a history of OC use. Inferior venocavography and hepatic venography should be included in the initial evaluation of such women to avoid unnecessary exploration, and would have prevented it in this case.
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PMID:Hematoma of liver: a lesion-mimicking hepatic neoplasm. 59 56

Presented are three cases of hemangiomas of skeletal muscle in which the presenting symptom was pain. Examination revealed almost spot tenderness at the site of the tumor, but no masses were palpable. Treatment was exicision. Results of surgery usually are good, although local recurrence can follow incomplete resection, as it did in one of our cases.
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PMID:Hemangiomas of the striated muscle. 59 92

A retrospective review of 329 cases of adenocarcinoma of the pancreas and 31 adenocarcinomas of the ampulla and and common bile duct seen between the years 1929 and 1973 was carried out. The most common complaints for carcinoma of the pancreas were pain, weight loss, and jaundice in that order of frequency; while jaundice was the most common complaint with periampullary lesions. The most common procedure carried out was a gastric and/or biliary bypass. Thirty-five patients underwent pancreatoduodenectomy. The survival of this latter group was longer and better than those undergoing bypass and in 40% of patients with ampullary carcinoma a cure was effected. Patients undergoing bypass did not live longer than patients undergoing simple exploratory laparotomy. Duration of symptoms and location of tumor within the pancreas (excluding ampullary tumors) did not appear significantly to alter the prognosis. In view of our experience it is felt that pancreatoduodenectomy should be undertaken whenever the tumor is deemed resectable as this provides the only chance for cure and the best palliation.
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PMID:Carcinoma of the pancreas and periampullary region: a 41 year experience. 60 75


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