Gene/Protein Disease Symptom Drug Enzyme Compound
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 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The article analyses the findings of clinical and X-ray examination in 39 patients in two types of growth of neurinoma of the gasserian ganglion: with localization within the boundaries of the middle cranial fossa (22) and with the formation of tumor nodes in the middle and posterior cranial fossae (17). The first symptoms of the disease were paresthesia or numbness and continuous pain mostly in the zone innervated by the 1st--2nd pair of the trigeminal nerve, absence of corneal reflexes, high lumbar cerebrospinal fluid pressure, and protein-cellular dissociation in the cerebrospinal fluid. The craniograms revealed destruction of the floor of the middle cranial fossa with involvement of the walls of the f. ovale, spinosum et lacerum and the apex of the pyramid of the temporal bone. Carotid angiography demonstrated typical displacement of the carotid siphon to the midline, to the front, or to the back. The middle cerebral artery was moderately displaced upward and an arched art. chorioidea, anterior was noted. Growth of the neurinoma into the posterior cranial fossa was attended with displacement and deformity of a. basilaris et cerebellaris superior and the veins of the posterior cranial fossa. The ventriculograms showed compression of the inferior horn of the lateral ventricle and moderate compression of the caudal parts of the fourth ventricle and aqueduct of Sylvius. Comprehensive generalization of all the findings gained from examination of the patient is necessary in determining the topics and type of the growth of a neurinoma of the gasserian ganglion.
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PMID:[Diagnosis of neurinomas of the Gasserian ganglion]. 30 54

A fully documented series of thirty nine cases of epiphyseal chondroblastoma is described. This is a remarkable series because of the rarity of this tumour. There is a slight predilection for the male sex. The age most affected is ten to twenty years. The tumour progresses slowly and joint involvement and pain are slight. The commonest site is the proximal epiphysis of the humerus, followed by the epiphyses of the knee. The classical appearances are of a clearly defined area of osteolysis, central or eccentric, with foci of calcification, in the epiphyseal or apophyseal regions, and often transgressing the epiphyseal cartilage. We have never observed involvement of the opposite bone in the affected joint. In four of our thirty nine cases the neoplasm invaded the point and/or soft tissues. The differential diagnosis, especially in localisations at the knee, is with giant cell tumour. The tumour is slow growing and the prognosis is always good. We have never seen malignant transformations or so-called "benign" pulmonary metastases. The few recurrences in this series (five out of thirty nine) were all cured by a second operation. Curettage and grafting is the operation of choice.
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PMID:Epiphyseal chondroblastoma (a study of 39 cases). 34 74

The potential for using CT to diagnose orbital lesions is clearly demonstrated in this chapter. The patients discussed were all suffering from proptosis and had other complaints such as visual disturbances, pain, or ophthalmoplegia. CT is superior to ultrasonography in its ability to reproduce anatomical structures, including the retroocular space, bony walls of the orbit, and extraorbital regions, such as ethmoid sinuses and the cranial cavity. Such reproduction helps distinguish lesions arising within the orbit from those invading the orbit from outside. CT not only defines the extent of a lesion but also provides information about the physical properties of the tissue. The remarkable difference on CT between proptosis caused by thyrotoxic disease and that caused by intraorbital tumor or pseudotumor is a striking example of the way in which CT may contribute to more accurate diagnosis.
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PMID:Computerized tomography of the orbit. 34 4

Roentgenograms of a 46-year-old Caucasian man with progressive swelling and pain at the base of the thumb who had been treated for arthritis showed an enlargement of the trapezium. The entire bone and surrounding ligaments were removed and an iliac bone graft was used to fuse the trapezoid to the first metacarpal. Sections of the tumor were diagnosed as chondrosarcoma. No recurrence is apparent 3 years after excision.
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PMID:Chondrosarcoma of the trapezium: a case report. 35 Sep 48

The therapeutic effect of carminomycin was studied in clinic at different treatment schemes with respect to 14 children and juvenile patients with osteogenic sarcoma. Pronounced local effect evident from disappearance of the pain and in some cases decrease of the metastatic tumor were noted in the patients with metastases of the osteogenic sarcoma to the bones or relapses of the primary tumor. Subjective improvement and objective effect were observed respectively in 90 and 53 per cent of the patients with metastases into the lungs and pronounced lung symptomatology.
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PMID:[Use of carminomycin on children and adolescents with osteogenic sarcoma]. 37 20

Considerable progress has been made in the past few years in the field of intrauterine contraception. IUDs are not as effective as oral contraception (OC); their side effects and complications, however, are less serious than those from OC. IUD complications include: 1) uterine pain, in about 10-20% of IUD wearers; 2) bleeding, the most common complaint; 3) dysmenorrhea; 4) uterine perforation, the most serious but also the rarest complication; 5) pelvic infection; 6) necessity of removal in 10-20% of wearers for a variety of medical reasons; 7) expulsion, in about 1-13% of wearers. It must also be remembered that, however seldom, pregnancy can occur with IUD in situ, and that 1-10% of these pregnancies are ectopic. Absolute contraindications to the use of an IUD are pelvic infection, uterine cavity malformation, serious menstruation disorders, possibility of initial pregnancy or of malignant genital neoplasia, and, above all, nulliparity.
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PMID:[Principal complications and contraindications in the use of mechanical contraceptives]. 38

(MPA) Medroxyprogesterone acetate when employed at high doses (5001000 mg/day intramuscularly) can produce objective remission with improved survival in about 30% of postmenopausal women with advanced breast cancer resistant to cytotoxic drugs and endocrine therapies. When administered to women not previously treated with chemotherapy, the objective remission response rate reached 40%. From available evidence, high dose MPA can be considered a useful agent in the treatment of advanced breast cancer in postmenopausal women with soft tissue, pulmonary, pleural, or osseous involvement even when patients have become refractory to prior hormone and cytotoxic therapies. Early results suggest that the response rate can be increased in patients with estrogen-and/or progesterone-positive receptors. It is noteworthy that in a study conducted on postmenopausal women resistant to cytotoxic and/or hormonal drugs, the median duration of survival was 13.5 months, while CRs and PRs did not reach the median at 24 months after beginning MPA treatment. High dose MPA is essentially devoid of major side effects. Relief of pain, increase in appetite, and body weight, and sense of wellbeing are characteristic features of the improved quality of life under MPA treatment. However, a gluteal abscess (from 2-20% dose-related) is the most frequent side effect. A promising area for future studies is combined therapy using hormonal and cytotoxic agents or alternating sequential combinations. Well-designed studies are needed to develop means for increasing the complete response rate and therefore survival. Recent studies of combined chemotherapy and hormonal (MPA) therapy have yielded objective tumor regressions of 53-80% with an increased rate of complete remissions and duration of response. (Author's modified)
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PMID:High-dose medroxyprogesterone acetate (MPA) treatment in advanced breast cancer. A review. 39 Jul 98

An overview of the current status of various aspects of spinal metastasis, including pathology, diagnosis, and management is presented. The cell type of the tumor, particularly with reference to its radiosensitivity, seems to be positively correlated with treatment outcome, regardless of the treatment modality. Because pretreatment neurological status also seems to influence prognosis, early identification of spinal involvement in patients at risk is important; therefore, a high index of suspicion in patients known to have cancer is necessary. The most useful warning of impending spinal cord or nerve root compression is spinal or radicular pain, which usually precedes neurological deficit by days to years. An aggressive diagnostic evaluation of pain symptoms is therefore warranted; this should include plain spine films and, in questionable cases, radioisotope bone scan. Myelography should also be considered in any cancer patient with persistent spinal or radicular pain, even in the absence of neurological deficit and certainly if there is any neurological impairment. Therapeutically, radiation and surgery continue as the mainstays of management, whereas steroids and chemotherapy serve as adjuvants. The guidelines for management recommended in this paper are to be viewed as tentative because the ideal treatment for spinal metastasis has not been established. The proposed guidelines are based on an analysis of retrospective studies that suggest that radiotherapy should be the primary mode of treatment and that surgery should be reserved for situations in which radiotherapy fails or where there is bony compression or spinal instability. Cases are presented to illustrate the application of these guidelines. (Neurosurgery, 5: 726--746, 1979).
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PMID:Spinal metastasis: current status and recommended guidelines for management. 39 32

Twenty-seven patients have been operated on for total replacement of the temporomandibular joint because of ankylosis due to trauma, arthritis, neoplasm, infection, or pain. One prosthesis had to be taken out because of gross infection due to Staphylococcus albus, 2 more were removed for pain and dislocation of the prosthesis, and 1 was removed because of erosion through the skin. The remaining 23 had no complications.
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PMID:Total prosthetic replacement of the temporomandibular joint. 42 Apr 87

The cases of 70 consecutive patients having a transsphenoidal hypophysectomy for metastatic carcinoma of the breast or prostate are reviewed. In half of the patients with cancer of the breast an objective remission was obtained. In 30 percent of the patients with cancer of the prostate there were objective signs of tumor regression and in 75 percent there was relief of pain. The operative mortality was 1.4 percent and the morbidity of the procedure was gratifyingly small. There is some indication that hypophysectomy may be preferred to adrenalectomy in patients with hormone-responsive metastatic mammary cancer.
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PMID:Transsphenoidal hypophysectomy in the treatment of metastatic breast and prostate carcinoma. 42


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