Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A study has been made of 79 children from zero to seven years of age admitted to hospital with fever of unknown origin (F.U.O.) of more than two weeks duration. Children in whom fever was not clinically observed after one week of hospitalization are not included. In 50 cases (63.2%), it was possible to establish a definitive diagnosis within the first fornight of admission. The most frequent cause of fever was that of infection, found in 51 children (64.5%), tuberculosis and urinary infections predominating with ten cases each. In another ten children neoplastic disease was diagnosed (mostly leucosis), and there was colagenosis in seven cases (8.8%). In another seven children, the etiology was not established. Mortality rate was 7.5%. Clinical history and exploration were of main importance in the orientation of the diagnoses. The findings of this study suggest that in all children presenting F.U.O., apart from hospitalization of at least one week, a very thorough anamnesis and clinical exploration are most important in establishing the diagnosis, along with a more or less aggressive approach to the problem according to the findings.
 ...
PMID:[Fever of unknown origin in children (author's transl)]. 72 2

The author presents a case of metastatic hepatoma diagnosed at autopsy. The patient's liver had been nearly entirely replaced, and there were diffuse microscopic pulmonary metastases. Chest x-ray was normal at the time of gallium imaging for fever of unknown origin. Gallium imaging revealed a normal-appearing liver and mild, diffuse, bilateral increased uptake in the lungs. A CT scan 3 weeks before autopsy showed relatively minimal abnormality of the liver with a few areas of inhomogeneity and mild enhancement with contrast. Ultrasound-guided aspiration and liver biopsy were negative for tumor or infection. No case report or description of microscopic lung metastases from hepatoma seen with gallium was discovered in a recent literature search.
 ...
PMID:Visualization of microscopic metastatic hepatoma to lung on gallium scintigraphy. 131 20

Clinicopathological analysis was performed in 19 patients diagnosed clinically with malignant histiocytosis. Ultimately, 9 patients died and 10 are still alive. All 19 had fever of unknown origin. Among the 10 surviving patients, 6 recovered with only supportive therapy such as antibiotic treatment. One recovered with steroid therapy and 2 with VP (vincristine and prednisolone) therapy. Complications due to immunodeficiency were detected in one surviving patient and 2 who died. All 9 patients who died had anemia, and 8 had thrombocytopenia. However, among survivors, only one had anemia and only 2 had thrombocytopenia. Chromosomal abnormality was detected in one patient who died. Histiocytic cells were classified morphologically into 3 types: immature, intermediate and mature. In 4 patients who died, histiocytic cells were immature, but in 4 others mature histiocytic cells were detected. In 5 of the 10 surviving patients, histiocytic cells were of the immature type. Immuno-histochemical analysis of the origin of histiocytic cells in 8 deceased patients showed T-zone histiocytes in one, T cells in one, monocyte phagocytic system (MPS) in 5, and histiocytes of unknown origin in one. Thus, malignant histiocytosis is a heterogenous entity including reactive histiocytic disorder, lymphocytic neoplasm and true histiocytic neoplasm. In histiocyte proliferative disorders, red blood cell counts and platelet counts are useful for assessing prognosis, while cytological findings only confuse this evaluation.
 ...
PMID:[Evaluation of clinical features, cytopathological findings and prognosis of histiocyte proliferative disorders]. 140 58

We report a case of fibromatosis, soft tissue tumors that are benign histologically, but exhibit behavior intermediate between benign and malignant diseases. Mesenteric fibromatosis grows vigorously without a general inflammatory reaction, and its symptoms are the result of obstruction and/or compression of the intestine. However, in our case, the general inflammatory reactions of fever and C-reactive protein (CRP) elevation was present at an early stage. Because this inflammatory reaction disappeared after surgical resection, it may have been induced by some inflammatory factors produced in the tumor, such as those produced in inflammatory fibrous histiocytoma. We found that computed tomography was useful in the detection of the cause of fever of unknown origin, and suggest that it should be recommended in cases of long-lasting unexplainable fever.
 ...
PMID:Mesenteric fibromatosis presenting as fever of unknown origin. 141 13

The patient was a 76-year-old female who had been referred to our hospital because of fever of unknown origin on October 15, 1987. On admission, the body temperature was 38.6 degrees C and atonic palsy of the left upper limb was noted. Abnormal laboratory findings included CRP5+, an increase in LDH, Hb 7.9 g/dl. The cause of the fever could not be identified. The fever did not respond to various treatment. The patient developed DIC in late October and died on November 5. In autopsy histological examination revealed tumor cells in the vessels of the generalized organs. A diagnosis of neoplastic angioendotheliosis (NAE) and immunohistologically B lymphoma was made. We reviewed the literature on 37 Japanese cases of NAE. The cases, consisting of 19 males and 18 females, were aged 37-87 years with a median value of 60 years. The symptoms observed during the course were most frequently mental or neurological symptoms and fever, and rash was uncommon. Laboratory findings were non-specific and biopsy was needed for definitive diagnosis. By autopsy, lesions were noted more frequently in the brain, kidneys, and lungs, and the findings in the skin were indeterminate. These observations suggest that when NAE should be considered, kidney, lung or skin biopsy should be performed for definitive diagnosis.
 ...
PMID:[Clinicopathological review of Japanese cases with neoplastic angioendotheliosis]. 143 52

Children with malignant disease have an increased risk for bacterial infections. We investigated a possible correlation between septic episodes and decreased IgG subclass levels in 63 patients. At diagnosis 13 of 50 children showed decreased IgG subclass levels: 10x IgG4, 2x IgG1, and 1x IgG3 + IgG4 were reduced. Bone marrow infiltration by tumor cells did not increase the frequency of subclass reductions (4/25 with, 9/25 without bone marrow infiltration). The time course of subclass levels was followed during 37 febrile episodes (mainly fever of unknown origin, septicemia, pneumonia) of 23 children under cytostatic therapy. 6 patients showed transient low IgG subclasses: 2x IgG4, 1x IgG1, 1x IgG3, 1x IgG2 + IgG4, and 1x IgG1 + IgG3 + IgG4. Children with decreased IgG subclass levels appeared to occur more independently of leucopenia. In general, febrile episodes in children with subclass decreases did not last a longer period and did not occur more frequently than in children without IgG subclass deficiencies. In conclusion, the determination of IgG subclasses in cancer children at diagnosis or during chemotherapy did not add substantial information of prognostic or therapeutic relevance.
 ...
PMID:[The IgG subclass level in children and adolescents with malignant diseases]. 151 65

A 58-year-old female was admitted to our hospital with a complaint of anterior chest tumor, fever of unknown origin and anemia. Chest X-ray films and chest CT scans revealed a large tumor in the anterior mediastinum, there were strong inflammatory reactions in laboratory studies. The tumor was resected with a part of the rt anterior chest wall. The partial resection of the upper and middle lobe of the rt lung and the pericardium which were invaded of the tumor were performed. Postoperative course was uneventful and body temperature went down. Inflammatory reaction and anemia got also improved. In histological findings, both rounded histiocyte-like and spindled fibroblast-like tumor cells were arranged in a random or haphazard fashion and showed a storiform pattern. And there was a collection of xanthoma-like foamy cells and invasive inflammatory cells. So the histological diagnosis was inflammatory type of MFH. As far as we investigated, this case was the 23rd mediastinal MFH in the world literature.
 ...
PMID:[Inflammatory type of malignant fibrous histiocytoma in the anterior mediastinum--a case report]. 164 47

A 78-year-old man visited our department for macroscopic hematuria in June, 1989. On the basis of the diagnosis of tumor of the bladder and right afunctional kidney, total right nephro-uretero-cystectomy and skin grafting of the left ureter were performed on August 2. The patient continued to have fever of unknown origin postoperatively. Repeat laparotomy, which was performed for rectal fistula on August 25, revealed that the abdominal wall, colon, small intestine and mesenterium adhered to one another, producing a mass and that two sites in the rectum were perforated. A part of the small intestine was excised, the perforated sites were sutured, and an artificial anus was created at the transverse colon. Since the patient had intermittent fever and continued to complain of abdominal pain after creation of the artificial anus, nosotropic therapy was continued. However, the patient died from cardiac insufficiency on October 10. Erosion and ulcer were histologically observed over a wide range in the excised small intestine. In addition there was a defect in one area of the small intestine, penetrating the tunca muscularis propria, in which many cytomegalovirus (CMV) inclusion bodies were observed. CMV inclusion bodies were also detected in the bladder with re-examination of specimens from the excised bladder. From these findings, it appears that endogenetic CMV may have been reactivated in the present case.
 ...
PMID:[A case of cytomegalovirus infection that caused gastrointestinal perforation after surgery for cancer of the bladder]. 166 62

Between the 1st of January 1985 and the 31st of december 1989 101 patients were admitted for fever. Their data were analysed retrospectively. The patients were divided into three groups according to the diagnostic procedures. 32 patients belonged to the first group. The causes of their fever were diagnosed within 24 hours by simple clinical and laboratory means. The second group held 42 patients whose diagnosis were made within one week after detailed laboratory and clinical examinations. The third group (21 patients) fulfilled the criteria of FUO (Fever of Unknown Origin), and the authors analyse this group of patients. Most of the FUO group, 11 patients were diagnosed as infectious origin, 1 tumor, 4 autoimmune. In three cases the diagnosis remained unknown. Authors conclude that patients coming to hospital with fever should deserve more attention of specialist infectologists.
 ...
PMID:[Differential diagnosis in patients with fever at the department for infectious diseases of a county hospital]. 173 45

Cardiac myxoma is the commonest primary cardiac tumor, however, the incidence of right atrial myxoma is very rare. We reported a 71-year-old man with a right atrial myxoma, whose main complaint was fever of unknown origin. Definite diagnosis was confirmed by echocardiography and cineangiocardiography. Venacavogram revealed huge mass which occupied greater part of right atrial cavity. Coronary angiogram revealed the feeding artery arising from left coronary circumflex artery and the sign of hypervascularity. Open heart surgery was performed, and a 4.9 x 4.0 x 3.8 cm tumor was found in the right atrial cavity. Pathological examination showed the findings of myxoma. Postoperative clinical course was uneventful.
 ...
PMID:Right atrial myxoma with hypervascularity demonstrated by selective coronary angiography. 184 57


1 2 3 4 5 6 7 8 9 10 Next >>