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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Chondroblastomas are highly destructive tumors that are derived from immature cartilage cells. The occurrence of this tumor in the temporal bone or skull base is uncommon. Approximately 70 cases have previously been reported, several of which have involved the temporomandibular joint (TMJ). We report here the case of a 67-year-old woman who presented with right-sided mixed hearing loss, a right external auditory canal mass, ear fullness, otalgia, blood-stained otorrhea, and pain around the TMJ, associated with difficulty in opening the mouth. CT and MRI revealed a mass involving the TMJ, infratemporal fossa, and pterygopalatine fossa. The patient underwent tumor resection via an infratemporal fossa approach type B. Gross total tumor removal was achieved, with no facial nerve paralysis or other complications observed after surgery. No recurrence or residual tumors were observed on CT and MRI, even after 7.5 years of follow-up. We conclude that temporal bone chondroblastomas are extremely rare and aggressive, but the outcome after appropriate surgical treatment is favorable. From the review, it may be particularly important to deal with tumors that involve the TMJ, which could affect the long-term outcomes, as well as tumor recurrence.
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PMID:Chondroblastoma of the temporal bone. 2150 72

Giant cell tumors of the head and neck are rare. We describe the case of a 50-year-old man who presented with otalgia and eustachian tube dysfunction. After his symptoms persisted despite aggressive medical management, further investigation revealed the presence of a firmness in his left parotid tail. Computed tomography identified a heterogeneously enhancing mass in the left masticator space. The tumor was removed surgically, and it was diagnosed on histopathology as a giant cell tumor. The patient recovered uneventfully and was closely followed for signs of recurrence. To the best of our knowledge, ours is the first reported case of a giant cell tumor in the masticator space. We review the literature on giant cell tumors of the head and neck, with particular attention given to cases involving the temporomandibular joint.
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PMID:Giant cell tumor of the masticator space: case report and literature review. 2210 28

Pleomorphic adenoma (PA) is the most common benign tumor of the major and minor salivary glands, but rarely found in the nasopharynx. A PA originating from the left lateral wall of the nasopharynx was found in a 52-year-old female who presented with nasal obstruction, left-side otalgia, aural fullness, tinnitus and subjective hearing loss. It was successfully removed by transnasal endoscopic surgery (TES) and navigator system assessed our location, due to the proximity of critical anatomic structures such as the left internal carotid. We believe that the TES for primary and recurrent nasopharyngeal benign tumors is feasible and safe in properly selected patients, due to superior functional and cosmetic results and a low complication rate. Tumor characteristics and location should be taken into account when selecting cases for the right procedure for this lesions; transnasal endoscopic surgery is safe and preferable, carrying less potential morbidity compared to open procedures.
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PMID:Transnasal endoscopic resection of a nasopharyngeal pleomorphic adenoma: a rare case report. 2247 9

Middle ear adenoma is a rare disease that arises from the mucosa of the middle ear. Only a few cases of associated facial nerve paralysis have been reported. Facial nerve involvement is most likely related to nerve compression rather than tumor invasion of the nerve. We describe a case of a huge middle ear adenoma in a 63-year-old man. He presented with a 1-month history of right-sided otalgia, otorrhea, and facial palsy; he also had a 10-year history of right-sided hearing loss. A tympanomastoidectomy was performed. Intraoperatively, the tumor was found to fill the middle ear cavity as well as the entire diameter of the external auditory canal. The tumor had eroded the wall of the facial canal at the second genu, and it was tightly adherent to the epineurium. Focal inflammation around the tumor was observed at the exposed facial nerve. The tumor was removed and the facial nerve was decompressed. Immediately after surgery, the patient's aural symptoms resolved. The final pathology evaluation established the diagnosis of a middle ear adenoma. At the 3-year follow-up, the ear cavity was completely healed and facial nerve function was improved.
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PMID:Huge middle ear adenoma with delayed facial nerve paralysis. 2271 94

Primary cancers of the external auditory canal (EAC) are rare and most are squamous cell carcinomas. We report the case of a 78-year-old man who visited our institution with a 5-month history of right-side intermittent otalgia and ear fullness. Otoscopic examination showed a bulging mass arising from the superior and posterior aspects of the right EAC, and incision biopsy confirmed the lesion as adenoid cystic carcinoma (ACC). Lateral temporal bone resection in conjunction with total parotidectomy and neck dissection was subsequently performed. Postoperative adjuvant radiotherapy was administered and no recurrence was noted at a 26-month follow-up. We review the medical literature on the topic and suggest that early diagnosis is still the best option for successful treatment of this neoplasm. ACC arising in the EAC must be removed using radical procedures to increase the chance of local control. Subsequent metastasis that tends to develop in the lungs and regional lymph nodes is best evaluated regularly using computed tomography examination.
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PMID:Adenoid cystic carcinoma of the external auditory canal. 2272 26

A 74-year-old woman presented with severe right ear pain associated with bleeding of 2 months' duration and vertigo. She was otherwise fit and well apart from arthritis. On examination there was dried blood overlying the right ear drum and very mild inflammation of the canal but no obvious acute infection. The dried blood was removed in subsequent clinic visits. The ear drum was intact and there was no evidence of infection. However, the patient still had persistent pain in the right ear. A diagnosis of referred otalgia was made. Nose, throat, neck, temporo-mandibular joint, oral examination and flexible nasoendoscopic examination were normal. She underwent MRI of her neck which revealed a right supraglottic mass. Laryngoscopy was performed. Intra-operative findings revealed a smooth right supraglottic mass, which was thought to be an internal laryngocoele. The laryngocoele was de-roofed. The histology specimen showed no evidence of neoplasia.
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PMID:Internal laryngocoele and referred otalgia. 2279 79

External auditory canal (EAC) carcinomas are frequently misdiagnosed. The aim of this study was to conduct a review of misdiagnosed cases and analyze the factors involved. This study was a retrospective assessment. Eighteen of 44 EAC carcinoma cases seen at the Eye and ENT Hospital were misdiagnosed. All medical records were retrospectively analyzed for the age, sex, presenting symptoms, type of misdiagnosis, computed tomographic (CT) or magnetic resonance imaging (MRI) findings, stage of the cancer, surgical approach, histopathological examination, adjunctive therapy (postoperative radiotherapy) and outcomes of treatment. Six cases were misdiagnosed as otitis media, five cases were misdiagnosed as otitis externa, and two cases were misdiagnosed as external auditory canal cholesteatomas. Other misdiagnoses were stenosis of the EAC, ear neuralgia, furuncle of the EAC, benign neoplasm of the EAC and pre-auricular fistula. Our analyses suggest that a biopsy should be conducted to obtain a histopathological diagnosis if an EAC carcinoma is suspected, in case otitis media or otitis externa does not respond to routine anti-bacterials. Head and neck MRI should be used to explore the involvement of soft tissues. Patients with bloody ear discharge and otalgia, particularly with temporal bone erosion seen in a CT scan, are highly likely to have a malignant carcinoma of the temporal bone.
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PMID:The misdiagnosis of external auditory canal carcinoma. 2292 89

Squamous cell carcinoma of the temporal bone and external auditory canal is a rare tumor with a reported incidence of between 1 to 6 cases per million population per year. Because squamous cell carcinoma of the temporal bone and auditory canal is so rare, developing an adequate tumor staging system and treatment has been difficult. We present a case of squamous cell carcinoma of the external auditory canal in 65-year-old Hispanic female who presented with a 6-month history of right ear pain, 3-month history of serosanguineous right ear drainage, and symptoms of facial paralysis. Due to the extensive spread of her tumor into the middle ear at the time of diagnosis, her tumor was deemed unresectable and she received palliative chemotherapy and radiation therapy and was sent to Alice Hospice and died several weeks later.
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PMID:Squamous cell carcinoma of the external auditory canal: a case report. 2293 70

Leukoplakia means a " White Patch", and is defined as a white patch or plaque on the mu-cosa that cannot be rubbed off and is not ascribable to any other condition(Fig. 1). Many patients come to the O.P.D. with presentation of white patch, ulcer, excessive salivation, trismus, increased sensitivity to chilies and burning sensation, dysphagia, otalgia and ultimately growth. Advanced countries have attained sophistication in oncopathy (like tumor marker, tumor antibodies). But we are still in search of an efficient screening method by which the cytologist can point accurately towards the nature of the disease within a few hours. That is why a correlative study of clinical picture and cytohistopathological findings had been studied in 74 cases in last three years, which were clinically diagnosed as leukoplakia in the out patient department of ENT in M.L.B. Medical College. Jhansi. In oral malignancy, it is extremely desirable that a correct and reliable method is adopted for early diagnosis and treatment, which can be instituted at a stage when the chances for cure are definitely greater.
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PMID:Leukoplakia: A correlative study of clinical picture and cytohistopathology. 2311 17

A 46-year-old man presented with persistent right otalgia and hearing loss. Exam was significant for a mildly tender retromandibular mass with intact nonerythematous overlying skin. Computerized tomography with intravenous contrast of the neck revealed 2 relatively well circumscribed masses in the right parotid gland. Although 1 lesion was suspected to be a necrotic lymph node, histologic analysis after superficial parotidectomy demonstrated 2 unique salivary gland tumors. Diagnoses of both sebaceous lymphadenoma and membranous basal cell adenoma were rendered. The occurrence of unique, synchronous, ipsilateral salivary gland tumors is distinctly unusual and this combination of parotid gland neoplasms has not previously been documented. In this report, we present the case with its management, followed by a discussion of the histopathologic nature of each tumor including the possible overlap between these two entities.
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PMID:Synchronous ipsilateral sebaceous lymphadenoma and membranous basal cell adenoma of the parotid. 2331 37


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