Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Renal cell carcinoma (Grawitz tumor, hypernephroma), may metastasize to the head and neck region at different stages of its evolution. The authors present a case of a 79 year old woman who consulted for otalgia, deafness, and tinnitus. A polyp in the external auditory canal proved to be a metastasis of a renal carcinoma. The patient underwent a nephrectomy eight years previously and had no problems since. The data on otolaryngological metastasis of this tumor as well as its pathogenesis are reviewed.
 ...
PMID:[Metastasis of a hypernephrome to the ear]. 713 34

A 61-year-old Caucasian man presented with otalgia, dysarthria, and weight loss. Neurological examination revealed palatal hypomotility, and weakness of the facial and tongue muscles. Magnetic resonance imaging of the head demonstrated the presence of a soft tissue mass in the clivus. Histologic examination of resected tumor disclosed well-differentiated thyroid follicles that invaded the local osseous tissues. Physical examination and radioiodine images of the thyroid gland were normal. The serum thyroglobulin concentration was markedly elevated (1011 ng/mL). A 0.9-cm well-differentiated benign-appearing left thyroid lobe follicular neoplasm with a thick fibrous capsule was found following diagnostic thyroidectomy. This report illustrates that clinically significant distant metastases can arise from occult follicular thyroid neoplasms that, according to standard histologic criteria, are benign. The presence of a thick fibrous capsule, even in the absence of vascular or capsular invasion, may identify follicular neoplasms that have metastatic potential.
 ...
PMID:Metastatic follicular thyroid carcinoma masquerading as a chordoma. 758 Feb 71

Malignant otitis externa is a necrotizing infection of the external ear canal and surrounding soft tissue and bone, usually caused by Pseudomonas aeruginosa. The infection classically occurs in diabetic patients, however recently, several patients with the acquired immunodeficiency syndrome (AIDS) have been reported to have malignant otitis externa. A patient with AIDS who had malignant otitis externa with skull base osteomyelitis is presented and reported cases in patients with AIDS are reviewed. Predisposing factors include immunologic abnormalities (notably neutropenia), dermatitis, medications, neoplasm, and iatrogenic procedures, e.g., ear lavage. Treatment of malignant otitis externa has traditionally included anti-pseudomonal cephalosporins/penicillins and aminoglycosides for prolonged durations. Recently, ciprofloxacin has been shown to be effective as an oral regimen. With the increasing number of patients with AIDS being seen in the outpatient clinics, the diagnosis of malignant otitis externa should be considered in any patient with persistent ear pain or otorrhea who does not respond to conventional treatment for external otitis.
 ...
PMID:Malignant otitis externa in AIDS patients: case report and review of the literature. 780 99

A 38-year-old woman presented with otalgia and facial pain. She was found to have a tumour involving the right maxillary sinus and pterygopalatine fossa. Exclusively composed of a myxoid population of spindle and stellate cells within a mucosubstance-rich matrix, it was originally interpreted as a mesenchymal neoplasm. However, immunophenotypic characterization revealed a pure population of salivary-type myoepithelial cells with cytoplasmic co-expression of cytokeratin, vimentin, muscle-specific actin, S-100 protein and glial fibrillary acidic protein. Sinonasal myxoid myoepithelial neoplasia is exceedingly rare and represents a potential diagnostic pitfall.
 ...
PMID:Salivary-type myxoid myoepithelioma of the sinonasal tract: a potential diagnostic pitfall. 822 49

It is evident that carcinomas of the upper aerodigestive tract are increasing. Unfortunately advanced tumor stages prevail when patients enter clinical treatment. The causes for delayed tumor diagnosis are manifold, they can be "organ-, tumor-, patient- and doctor-related". Only by means of a complete and thorough examination, employing both an endoscope and a microscope, as well as by consequent histological classification of visible proliferations of uncertain dignity, an adequate diagnosis and treatment of pre- and early cancer stages can be accomplished. The organ-specific characteristics and organ-independent common features are described with respect to early cancer diagnosis. By presenting the diagnostic and therapeutic procedures applied to early cancer stages, the relative merits of smear cytology and histology (cup forceps vs excision biopsy) are discussed. Ultimately, the detection of clinically occult primary tumors is dealt with by referring to a number of principal signs such as nodes in the neck, secondary otalgia, etc. The possibilities of early detection of neck metastases are pointed out and the importance of panendoscopy for early diagnosis of simultaneous secondary tumors is emphasized. In conclusion, the consequences for improved early cancer diagnosis are presented in detail.
 ...
PMID:[Early detection of cancer in the upper aerodigestive tract. Part I]. 837 84

The first case report is an undifferentiated squamous cell carcinoma of the ear. This patient complained with pain and discharging ear, which led us to practice a TC followed by an attico-antrotomy. The pathologist could detect in the removed tissue the neoplasm in its early evolutive stages. In the other case the earache and the suppuration suggested at first a carcinoma. In spite of the TAC and MR exams the surgery that followed was not confirmative of the tumor presence.
 ...
PMID:[The value of the computer tomography (CT) and magnetic resonance (MR) in tumors of the ear]. 848 86

A 47-year-old woman with left ear pain and hearing loss was diagnosed with a glomus jugulare tumor for which she received radiation therapy as the primary treatment. Over a period of 20 years, she developed temporal bone necrosis, brain stem calcifications, local tumor recurrence, and eventually metastases to her lungs and sacrum. This case underscores the often indolent nature of glomus jugulare tumors, the late sequelae of radiation therapy for benign intracranial tumors, and the potential of these tumors to metastasize. This patient's history suggests that aggressive surgical resection should be considered early for such tumors, particularly because radiation treatment does not ablate the tumor. This is only the second reported case of a glomus jugulare tumor metastatic to the sacrum.
 ...
PMID:Glomus jugulare tumor metastatic to the sacrum after high-dose radiation therapy: case report. 855 22

The TNM staging system for head and neck cancer is based on the morphologic description of the tumor and disregards the clinical condition of the patient. Cancer symptoms were evaluated as a biologic index of disease to improve survival estimates. The medical records of 1010 patients receiving initial cancer treatment between 1980 and 1991 were retrospectively reviewed. The mean survival duration was 62 months for the entire population. By use of SAS statistical software (SAS Institute, Cary, NC), 48 symptom variables were screened by univariate analysis, and 23 of these variables were selected for entry into a Cox proportional hazards model on the basis of survival duration. Dysphagia, otalgia, neck lump, and weight loss were identified as independent predictors of survival duration (P < 0.01). A composite symptom-severity staging system was created on the basis of the 4 symptoms. Mean survival duration (95% CI) by symptom-severity stage was as follows: none, 74 months (70 to 79 months); mild, 56 months (51 to 61 months); moderate, 40 months (33 to 47 months); and severe, 31 months (22 to 41 months) (chi 2 = 30.8, P = 0.0001). Survival duration by TNM stage was as follows: I, 89 months (82 to 95 months); II, 71 months (65 to 78 months); III, 53 months (47 to 59 months); and IV, 42 months (37 to 47 months) (chi 2 = 56.2, P = 0.0001). When symptom-severity stage was entered in a proportional-hazards model along with TNM stage, comorbidity, age, and alcohol use, all 5 variables were independently predictive of survival duration (risk ratio: symptom severity 1.28, TNM 1.33, comorbidity 1.80, age 1.47, alcohol use 1.09). Appropriately defined symptom variables contain important prognostic information, which is independent of the TNM system. Therefore symptoms provide an index of biologic behavior in head and neck cancer.
 ...
PMID:Symptoms as an index of biologic behavior in head and neck cancer. 1006 42

Middle ear adenocarcinoma is a very rare, locally invasive neoplasm assumed to arise from the middle ear mucosa. Although endolymphatic sac tumor (aggressive papillary middle ear tumor) and jugulotympanic paraganglioma may show brain invasion, intracranial extension of histologically confirmed middle ear adenocarcinoma has not been previously reported. The authors describe a 53-year-old man who suffered from otalgia and tinnitus for more than 10 years and from neurological deficits for 1 year due to a large temporal bone tumor that invaded the temporal lobe. A combined neurosurgical and otolaryngological resection was performed. Pathological analysis revealed a low-grade adenocarcinoma of a mixed epithelial-neuroendocrine phenotype, which showed a close histological similarity to, and topographical relationship with, middle ear epithelium. The authors conclude that middle ear adenocarcinoma belongs to the spectrum of extracranial tumors that have possible local extension to the brain.
 ...
PMID:Middle ear adenocarcinoma with intracranial extension. Case report. 1006 29

We reported a retrospective review of the clinical records for a 64 year old male patient with bilateral middle ear squamous cell carcinoma (MESCC), and for the five other patients with MESCC treated at our institution during the last 20 years. The patient with bilateral MESCC has survived and remained tumor free for more than 1.5 years after extended radical resection of the secondary tumor combined with intra-arterial and systemic chemotherapy, radiotherapy and immunotherapy. Four patients with unilateral MESCC were treated with multidisciplinary treatment (induction chemotherapy, surgery and radiotherapy), and the remaining patient was treated with radiotherapy and mastoidectomy. Five of the six patients are alive with no evidence of disease. The patient treated with radiotherapy and radical mastoidectomy died of local recurrence 3 years after diagnosis. We suggest that MESCC should be considered when refractory granulation, long-standing otorrhea, otalgia and facial paralysis are observed. Multidisciplinary treatment, including intra-arterial chemotherapy and en bloc resection of the temporal tumor is useful for the treatment of MESCC and will improve the prognosis of patients with this disease.
 ...
PMID:Bilateral middle ear squamous cell carcinoma and clinical review of an additional 5 cases of middle ear carcinomas. 1007 54


<< Previous 1 2 3 4 5 6 7 8 Next >>