Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 60-year-old man was admitted with anosmia, memory disturbance and disorientation in 1971. He was diagnosed the left olfactory groove meningioma and received the removal of the tumor after ligation of the left external carotid artery. Over the following two years he was admitted again with progressive memory disturbance and mental disorder in Aug. '73. Physical examination disclosed no abnormalities except for slight hypertention. His CSF pressure was 120 mm H2O and pneumoencephalograms showed marked dilatation of the lateral ventricles. Right carotid angiography revealed the right olfactory groove meningioma which was receiving a rich circulation from the branches of right ophthalmic artery. And right selective external arteriography showed an arteriovenous communication between the occipital artery and the transverse sinus. Contrast medium flowed to the left transverse sinus. Left internal carotid arteriography showed an anomalous arteriovenous communication between the tentorial branch (Bernasconi-Cassinari artery) of the internal carotid artery and sigmoid sinus. Further left vertebral arteriography revealed another arteriovenous communication between the left occipital artery anastomosed with vertebral artery and the transverse sinus. An operation for the right olfactory groove meningioma was made in Sep. '73. Some considerations on the pathogenesis of developement of these arteriovenous communications were discussed.
 ...
PMID:[A case of arteriovenous communication between external and internal carotid arteries and the sinus after removal of the meningioma (author's transl)]. 123 33

We encountered a rare case of subfrontal schwannoma. A 55-year-old woman had received resection of a left frontal tumor because of hyposmia, at the age of 28 years. On June 10, 1989, she was admitted with the chief complaint of progressive contraction of visual field. Neurologic examination revealed anosmia, impaired vision and concentric contraction of visual field. Fundoscopy showed optic atrophy. CT examination demonstrated a calcified mass of mixed density which was occupying her nasal cavity, ethmoid sinus and anterior skull base. The lesion was enhanced with contrast medium. MRI clearly depicted the extension of the lesion and a low signal intensity area in the left frontal lobe as a postoperative scar. Angiography showed hypovascularity. The tumor was totally removed by bifrontal craniotomy on August 22, 1989. Infiltration into the brain or compression of the optic nerve was not detected. The dura on the cranial base side was damaged and lost by infiltration of the tumor, normal olfactory bulb was not able to be identified, and the cribriform plate was broken. The anterior skull base was reconstituted by covering the dural defect with cadaveric dura and the bony defect with a pericranium. HE staining showed Antoni A&B types of schwannoma. Postoperative course was uneventful. In this case, it is most likely that a remnant of the tumor resected when she was 28 years old had developed subfrontal schwannoma a long time after the operation, although the histological type at that time was unknown. It is also possible that a primary tumor in the nasal cavity or paranasal sinus may have extended into the cranium.(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:[A case of subfrontal schwannoma]. 144 94

A 51-year-old male patient presented with right-sided swelling of the neck and a 2-year history of decreasing olfaction that had culminated in complete anosmia. CT and MRI showed a calcified ethmoid tumor and destruction of the lamina cribrosa extending into the anterior fossa and frontal lobes. Contrast material demonstrated marked enhancement on the CT and MRI. Bilateral angiography of the external and internal carotid arteries failed to show tumor vascularity typical for an esthesioneuroblastoma but rendered an olfactory meningioma unlikely. Histological findings of cervical lymph nodes removed during neck dissection showed infiltration by an esthesioneuroblastoma (Kadish C classification). Tumor calcifications in these neoplasms are generally well seen on CT and--while not specific--may suggest the diagnosis. CT and MRI are the most sensitive methods of demonstrating local tumor growth, metastasis and bone destruction.
 ...
PMID:[Cervical lymph node metastasis as a primary manifestation of esthesioneuroblastoma]. 149 71

An unusual case of a giant prolactinoma extending to the nasopharynx and nasal cavity is presented. A 35-year-old man admitted for nasal obstruction and visual disturbances was found to have bilateral anosmia, right homonymous hemianopsia, and a right hemiparesis. The serum prolactin level was 13,300 ng/mL. Radiological examination revealed a large mass invading the skull base and extending into the suprasellar region and the left frontal lobe superiorly and into the nasopharynx inferiorly. Subtotal removal was done through a bilateral orbitofrontal craniotomy, which was followed by radiotherapy and bromocriptine administration. Immunohistochemical analysis confirmed a prolactinoma. The rarity of such a tumor, its location and extension, and the usefulness of magnetic resonance imaging and immunohistochemistry are stressed. Pertinent literature is reviewed.
 ...
PMID:Giant basal prolactinoma extending into the nasal cavity. 159 40

Foster Kennedy syndrome is a very rare syndrome which includes ipsilateral optic atrophy and central scotoma, anosmia, contralateral papilledema, and, occasionally, ipsilateral proptosis. A large frontal lobe, olfactory groove, or medial third sphenoidal wing tumor, usually a meningioma, creates this syndrome. In this report, the author presents a case of metastatic cerebral tumor with Foster Kennedy syndrome but without frontal lobe or anterior cranial fossa involvement.
 ...
PMID:A case of Foster Kennedy syndrome without frontal lobe or anterior cranial fossa involvement. 163 28

A rare case of neuroendocrine carcinoma arising from the nasal cavity is reported. A 57-year-old female, who had been complaining of anosmia for 8 years, was admitted to the otolaryngological department because an intranasal tumor was found. Then, removal of the tumor and radiotherapy was carried out. After these procedures, the patient suffered from a high fever and CSF rhinorrhea. At this stage, our neurosurgical department was consulted. CT scan revealed a partially calcified low density mass with a slight enhancement effect at the left frontal base. Under the diagnosis of intracranial invasion by intranasal neuroendocrine carcinoma, the patient was operated on. Through bifrontal craniotomy and a combination of extra- and intradural approach, the tumor was excised. After that, the dura and the skull base were reconstructed. On histological examination, the tumor was found to consist of NSE positive cells forming some glandular structures. Electron microscopic study disclosed neurosecretory granules in the cytoplasmic process. These findings are typical of neuroendocrine carcinoma and compatible to those of the intranasal tumor previously removed. Neuroendocrine carcinoma is rare in itself and there have been reported only two cases of its invasion of the skull base. The clinical features, diagnostic procedures, pathological findings, and treatment of this tumor are discussed in this report.
 ...
PMID:[Intracranial invasion of neuroendocrine carcinoma: a case report]. 238 25

A 58-year-old male was admitted following an episode of unconsciousness. Nine years prior to this, he had undergone surgery and radiation therapy for a nasal tumor. Subsequently, he had undergone surgical excision of recurrent nasal tumors and metastases to the cervical lymph nodes. The final pathological diagnosis was paraganglioma. On admission, he had no neurological deficit other than anosmia. Laboratory studies showed no abnormalities in urinary concentrations of vanillylmandelic acid or catecholamines. Computed tomography (CT) demonstrated a calcified, heterogeneously enhanced mass in the anterior ethmoid sinus and bilateral frontal fossa. Cerebral angiography revealed a mesh-like tumor stain. Through a bifrontal craniotomy the intracranial tumor was totally removed. It was hypervascular and clearly demarcated from the surrounding cerebral tissue. The pathological diagnosis was paraganglioma without malignant features. Radiation therapy was administrated postoperatively at a total dose of 5060 rads, and follow-up CT showed regression of the ethmoid sinus tumor. As of 2 years postoperatively, the tumor has not recurred.
 ...
PMID:[Nasal cavity paraganglioma with intracranial extension. Case report]. 247 3

The ultrastructure of pinealocytes was studied in rats with 7,12-dimethylbenz(a)anthracene-induced mammary tumors which were subjected to experimental manipulations known as enhancers of pineal actions (anosmia, underfeeding or cold exposure). In these animals we found: (I)--more nuclei with deep nuclear invaginations; (II)--a large number of cytoplasmic organelles, including lipid droplets, myeloid bodies, synaptic ribbons and lysosomes; (III)--numerous degenerative changes. In general, we found an increase in structural features related to pineal photoneuroendocrine activity. Our results indicate that pineal-dependent inhibition of neoplastic growth induced by these experimental manipulations, previously reported, can be mediated through an increase in pineal metabolic activity.
 ...
PMID:Pineal gland in rats with 7,12-dimethylbenz(a)anthracene-induced mammary tumors subjected to manipulations known as enhancers of pineal actions. 252 Apr 60

A rare case of ectopic meningioma of the ethmoid sinus is reported. A 57 year-old male patient was admitted with complaints of anosmia and headache. Computed tomography revealed a relatively high-density mass in the bilateral ethmoid and sphenoid sinuses. The mass was markedly enhanced after intravenous administration of contrast medium. The cerebral angiography showed tumor stains fed by bilateral internal and external carotid arteries with right side dominance. The tumor in the ethmoidal sinus was removed by otolaryngologists at first and then the tumor in the sphenoid sinus was removed using sublabial transseptal sphenotomy. The histological examination resulted in a diagnosis of transitional meningioma with psammoma bodies. The tumor in this case is suspected to have originated from heterotopic meningocytes or meningocytes accompanying the perineural sheath of the olfactory nerve.
 ...
PMID:[Ectopic meningioma of the ethmoid sinus: case report and a review of the literature]. 265 55

Female rats were subjected to superior cervical ganglionectomy (Gx), blinding and anosmia (BAs) or combined procedures (BAsGx). Onset and growth of dimethylbenz(a)anthracene (DBMA)-induced mammary tumors was studied in these animals and compared to tumorigenesis in intact control rats. Carcinostatic effects were present in all surgically altered animals, as evidenced by a trend toward reduced tumor incidence, reduced final tumor mass, and a significant reduction in mean number of tumors in Gx and BAsGx rats, and increased regression of tumors in BAs rats compared to intact group. Reduced tumorigenesis was paralleled by a trend toward either an increase (BAs) or a decrease (Gx and BAsGx) in the activity of pineal hydroxyindole-O-methyltransferase (HIOMT) compared to intact group. In addition, BAs and BAsGx animals showed a significant reduction in body weight. These results suggest that Gx reduces mammary tumorigenesis in both sighted and BAs rats. They further confirm the findings of others on reduced mammary tumorigenesis in BAs rats. Possible involvement of multiple carcinostatic mechanisms in different animal models is discussed.
 ...
PMID:Induction and growth of mammary tumors after superior cervical ganglionectomy in sighted and blinded-anosmic rats. 308 98


1 2 3 4 5 6 7 8 Next >>