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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The tumor-suppressor protein p53 is over-expressed in a large fraction of squamous-cell carcinomas of the larynx (LSCCs). p53 overexpression is dependent upon the synthesis of mutated versions of the protein and has been associated with the malignant progression of certain tumor types. In order to examine the prognostic value of p53 immunodetection in LSCCs, we performed a retrospective analysis on a selected series of tumors, using the PAb 1801 and CM1 antibodies. No significant difference in the frequency of p53 over-expression was observed between tumors from patients with early relapse (67%) and those who had been disease-free for more than 5 years (84%). The lack of correlation of p53 immunoreactivity with clinical stage and differentiation grade of LSCCs, together with the coordinated expression of p53 in primary tumors and the corresponding lymph-node metastases, indicate that p53 over-expression is probably unrelated to the biological aggressiveness of these tumors. In addition, the detection of p53 immunostaining in pre-invasive areas as well as in preneoplastic lesions suggests that p53 abnormalities probably constitute a very early event in LSCC development.
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PMID:p53 over-expression is an early event in the development of human squamous-cell carcinoma of the larynx: genetic and prognostic implications. 152 6

Why are tumors more frequent in the elderly? Is there a difference in tumor aggressiveness with advancing age? Should treatment be different for the older patient? Experimental biologists have demonstrated that the process of cancer development takes time, and this may be the major explanation for the appearance of the disease late in life. In many tumor models in lower species, it is apparent that tumor growth and spread is less in older animals and this may also be demonstrable in certain human settings. Finally, tumors are not rendered more resistant to treatment by age. However, age is associated with slight reductions in certain organ functions, and these deficiencies might be magnified by comorbid conditions. Cancer treatments, especially chemotherapy, may, therefore, be more toxic in the older patient.
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PMID:Geriatric correlates of experimental tumor biology. 153 38

Tumor grade and stage are two of the strongest predictors for indolent versus aggressive clinical course in bladder cancer. To identify age-related trends in tumor aggressiveness the authors investigated the relationships of age with grade and stage. Pathologic specimens were obtained for 89% (527 of 590) of new bladder cancer cases among men older than 50 years of age reported to the state tumor registry in Wisconsin for 1988. Tumors were grouped as low grade (G1, G2) or high grade (G3), and as superficial (Ta) or invasive (greater than or equal to T1), according to the TNM system. This analysis included 485 transitional cell carcinomas (TCC) for which the authors determined stage-stratified and grade-stratified odds ratios for men 50 through 64 years of age and older than 65 years of age. Men older than 65 years of age with superficial TCC were more than three times as likely to have a high-grade malignancy than men 50 through 64 years of age (P = 0.01); the odds ratio was 3.44 (95% CI = 1.28, 9.26). A relationship was not apparent for invasive TCC. Age and stage were weakly associated for low-grade and high-grade TCC that may be due, in part, to the strong correlation of stage with grade as a prognostic indicator. These data suggest that men in older age groups are at increased risk for superficial bladder cancer of high grade, which portends an aggressive clinical course.
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PMID:Age as a predictor of an aggressive clinical course for superficial bladder cancer in men. 154 Aug 82

Clinically, cytometric DNA (ploidy and proliferative fraction) analysis is primarily used in the determination of tumor prognosis. This determination has a clinical impact primarily in low stage tumors where therapeutic options are available, rather than in higher stage tumors that will be treated the same independent of their ploidy or proliferative fraction. In general, the best available data indicate that for most tumors aneuploidy is an indicator of more aggressiveness. Ploidy analysis is independent of other prognostic indicators in many tumors and is the most significant prognostic indicator in some. More recent data suggest that proliferative fraction, the percentage of tumor cells in the S-phase of the cell cycle, may be as important an indicator of tumor prognosis as simple presence of aneuploidy. However, the poor interlaboratory reproducibility of S-phase measurements as currently performed limits the general applicability of this measurement in the management of patients.
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PMID:Cytometric DNA analysis in the management of cancer. Clinical and laboratory considerations. 154 Aug 94

To set the basis for a precise assessment of new therapeutic approaches, the prognosis of patients with colorectal cancer should be evaluated with the highest precision. The recent discovery, in tumor cells, of somatically acquired genetic alterations believed to be instrumental in tumor behavior may provide new independent prognostic factors. In the present study, the usual prognostic factors and a set of genetic alterations, i.e., Ki-ras mutations, DNA content, and allelic losses on chromosome 17p, 18q, 5q, and 1p, were investigated in 109 colorectal carcinomas. Univariate analysis for correlation with 5-year survival showed the following significant associations: histological staging (P less than 0.00001), preoperative serum carcinoembryonic antigen concentration (P less than 0.002), DNA content (P less than 0.009), and allelic loss on the short arm of chromosome 17 (P less than 0.002) and 1 (P less than 0.03). In multivariate analysis, only histological staging and allelic loss on the short arm of chromosome 17 were found to be independently associated with shorter survival (P less than 0.0001 and P less than 0.004, respectively). Loss of 17p alleles in colorectal carcinoma thus appears to be a marker of tumor aggressiveness. Its monitoring may lead to an improved classification of patients when adjuvant chemotherapy is considered.
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PMID:Survival and acquired genetic alterations in colorectal cancer. 155 51

Digital rectal examination and transrectal ultrasound was used to evaluate the clinical status of 125 men previously treated for prostate carcinoma by definitive radiation. Transrectal ultrasound-guided biopsy of a hypoechoic lesion was performed on all 125 men, with 71.2% of them found to have persistent carcinoma. These irradiated carcinomas exhibited increased tumor aggressiveness by both histologic (Gleason score) and biologic (DNA ploidy) parameters. Following radiation therapy 30.6% of pretreatment diploid tumors were found to be aneuploid after treatment. Similarly, there was a 24% increase in the number of poorly differentiated (Gleason score 8 to 10) tumors following radiation therapy. A number of patients with persistent carcinoma postradiation therapy, but with clinically localized disease, may be "cured" by subsequent surgery. Salvage radical prostatectomy found localized cancer in 16 of 20 patients (80%). The use of transrectal ultrasound for early detection and staging was crucial for patient selection for definitive salvage therapy.
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PMID:Histologic changes of irradiated prostatic carcinoma diagnosed by transrectal ultrasound. 156 34

The authors briefly illustrate some biological and epidemiologic characteristics of the malignant urologic tumors; then they describe the modalities of metastasizing underlining that this process is determined not only by hematic and lymphatic dissemination but also by sequential and complex events "metastatic fall", involving multiple guest-tumor intersections to the organotropism of the neoplastic cells and to their intrinsic aggressiveness and to the histological type of tumor. Afterwards the authors analytically analyze the most important malignant neoplasms of the urogenital apparatus either as clinical importance or as statistic incidence.
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PMID:[Clinical and prognostic significance of metastases]. 157 May 22

Quantitative morphometric analyses of the nuclear shape have been successfully used with prostatic carcinoma to predict tumor metastatic potential and provide the most sensitive indicator of tumor aggressiveness in the individual case. We have studied the nuclear morphometric characteristics of 22 patients with T1 and T2 squamous cell carcinoma of the floor of the mouth to see if a correlation existed between lack of nuclear roundness and presence of cervical metastatic disease. A significant difference was identified between the morphology of cancer cell nuclei and normal squamous epithelium. Nuclear morphology could not be used to distinguish between patients with cervical node-negative and node-positive disease. Some patients both with and without cervical metastases who are long-term survivors had nuclear roundness scores in the highest range, reflecting greatest variation from normal.
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PMID:Nuclear morphometry for prediction of metastatic potential in early squamous cell carcinoma of the floor of the mouth. 157 Nov 29

MISC of the cervix is a potentially fatal disease if not properly classified and treated. Strict criteria for diagnosis are required to provide appropriate therapy. It is recommended that a radical approach be considered for those patients in whom the depth of invasion of the carcinoma is greater than 3 mm on cone biopsy and in all cases where vascular invasion is demonstrated. Confluency may not of itself be a reason for more radical therapy but is an indicator of the aggressiveness of the tumor. Vascular invasion is seen more frequently with increased depth of invasion but may be found with minimal infiltration and has a serious connotation. Further refinement of the definition of MISC of the cervix appears to be needed.
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PMID:20 year follow-up on microinvasive squamous carcinoma of the cervix. 158 92

A cytogenetically detectable form of gene amplification, presumably oncogene amplification, double minute chromosomes, has been found in 11 out of 45 specimens (24%) of moderately and poorly differentiated, deeply infiltrating transitional cell carcinoma of the bladder and ureter. None of the 75 low-grade low-stage tumors contained this karyotypic anomaly. It is obvious that double minutes are not a rare and sporadic phenomenon in this type of tumors; additionally there is strong evidence that they are involved in tumor progression, i.e. they are associated with tumor aggressiveness and unfavorable prognosis.
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PMID:Cytogenetic evidence of gene amplification in urothelial cancer--a possible mechanism of tumor invasiveness. 158 12


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