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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Three cases of gastrointestinal bleeding caused by secondary renal carcinoma are presented. Hemorrhage occurred secondary to invasion of bowel anatomically related to the primary tumor. Bleeding can best be controlled by excision of tumor and involved intestine. Surgery is justified by the unpredictable prognosis for renal carcinoma with secondary disease.
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PMID:Recurrent renal carcinoma causing intestinal hemorrhage. 30 14

Intrinsic body defences against cancer depend on cells of the lymphatic and reticulo-endothelial systems, the T-lymphocytes playing a central role in the immunological rejection of tumor. The mononuclear cell infiltrate in tumor tissue is largely composed of immunocytes of the T-lymphocyte series. A heavy concentration of lymphocytes in stroma of bladder tissue affected with cancer appears to indicate a good prognosis. After removal of the primary tumor, recurrences are noted only after a relatively long interval, infiltration of the tumor into bladder muscle being hindered by immunocyte activity. It is clear, from comparison with dinitrochlorbenzol skin testing, that the extent of lymphocyte infiltration in tumor tissue is a measure of the cellular immune status of a patient with cancer.
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PMID:[Influence of T-lymphocytes in bladder cancer on appearance and infiltration of recurrences (author's transl)]. 30 5

Three hundred and two female breast carcinomas were assessed histologically with special attention focused on the nuclear grade of the tumor, the stromal lymphocyte reaction and the morphology of the paracortical areas of the regional lymph nodes. These morphologic parameters were correlated with the 5-year survival data of the patients. Nuclear grade of the primary tumor was directly positively related to the 5-year survival as was the paracortical activity of the regional lymph nodes. The paracortical activity was inversely related to the frequency of nodal metastases which were a sign of poor prognosis. The value of the morphology of the regional lymph node paracortex in evaluating the criteria of host resistance in association with breast carcinoma is emphasized.
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PMID:Paracortical activity in the lymph nodes draining female breast carcinoma. 31 1

Spleen cells of C57BL/6J mice bearing a poorly immunogenic syngeneic tumor T241 have been shown to suppress the mitogen-induced proliferative responses of normal spleen cells. However, no suppressive effect of these cells was observed on the generation of cytotoxic cells following immunization in vitro against H-2 histocompatibility antigens. The suppressor activity disappeared rapidly after the removal of the primary tumor. Spleen cells of tumor-bearing mice also suppressed the mitogen-induced stimulation of normal spleen cells of mice of different H-2 loci. Removal of phagocytic cells with carbonyl iron treatment had very little effect on the suppressor activity. Suppressor activity was enhanced following fractionation of cells through nylon wool columns. The suppressor population was found to resist anti-immunoglobulin serum and complement treatment, but treatment with anti-thymocyte serum and complement drastically reduced the suppressor activity. These results indicate that cells with suppressor activity have characteristics of T-lymphocytes.
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PMID:Presence of suppressor cells in spleens of mice bearing a weakly immunogenic syngeneic tumor. 31 43

The case of a six year old girl with metastatic (or primarily multifocal) osteogenic sarcoma is reported, which was treated with chemotherapy only. Within 15 months--the primary tumor regressed and at least a transient inactivation has resulted until now;--the pulmonary metastases showed no progression;--an osteoplastic destruction of the sacrum has completely regressed. At the time of report (15 months after initiation of treatment) neither on X-ray controls nor on bone scan signs of tumor regrowth are evident. The child is without any complaints and the leg has no loss of function.
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PMID:[Course of metastatic osteogenic sarcoma treated with chemotherapy only (author's transl)]. 31 74

Prognostic factors such as T-cell markers, peripheral WBC and age at diagnosis in ALL, or B-cell markers and site of primary tumor in NHL, are used today for important therapeutic decisions. Immunologic markers are said to be the most important. A survey of 7 ALL patients diagnosed in the period 1977 to 1978 shows that 4 are in continuous remission, including 3 for more than 3 years to date (2 despite a high initial WBC). These 3 had received only standard ALL treatment. Of 7 NHL cases diagnosed in 1977/1978, 4 had abdominal primaries (3 of the B-cell type). Of 2 children with mediastinal tumors, one (with a T-cell tumor) has been disease-free for 16 months, as also the patient with a cervical reticulum cell sarcoma. These 3 patients are under intensive high dose chemotherapy. These few cases show that prognostic factors are only of relative importance and need not involve a pessimistic attitude towards treatment.
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PMID:[The prognostic value of immunologic markers in juvenile acute lymphatic leukemias and non-Hodgkin lymphomas]. 31 64

A case of metastic choriocarcinoma after term pregnancy, with tumor localization in the kidney of a hydropic stillborn infant, is presented. The primary tumor was found in a scraping four weeks after delivery. The identity and nature of the malignant growth in mother and child were substantiated by identical immunohistochemical patterns for gonadotropin activity. Because of a positive Kleihauer test it was assumed that massive feto-maternal transfusion had caused the hydrops and intrauterine death. Now, four and a half months after starting methotrexate therapy, the mother seems to be free of tumor. Plasma human chorionic gonadotropin titers have decreased to normal.
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PMID:Choriocarcinoma in mother and child, identified by immunoenzyme histochemistry. 32 Aug 62

In 93 reported cases of metastatic basal cell carcinoma (BCC), 76 had spread through lymphatics or blood vessels. Two more cases are presented, bringing the total to 78. Metastasis to regional lymph nodes was the most frequent, followed in frequency by lungs, bones, and other organs. The size of the primary tumor, its site, its resistance to x-ray therapy, and the effects of radiation appeared to contribute to the occurrence of metastasis. However, in an appreciable number of cases, tumor dissemination was related to incomplete excision followed by immediate wound closure, particularly by grafting. It is recommended that wound grafting be delayed for at least six months after excision or large or recurrent BCC in order to assure complete removal.
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PMID:Metastatic basal cell carcinoma: review, pathogenesis, and report of two cases. 33 91

A metastasis from a bronchial carcinoid tumor presented as an isolated breast mass in a 58-year-old female. A review of the English literature revealed four cases of metastatic carcinoid to the breast that presented as an isolated breast mass. In each case, radical mastectomy was performed after the lesion had been interpreted clinically and pathologically as a primary carcinoma. When the primary tumor was excised, all cases had either regional lymph node or liver involvement. A mass was the usual presenting sign of the metastatic deposit. No metastasis was reported to be greater than 2 cm in diameter. No axillary lymph nodes were reported to contain tumor. Frozen section preparations may not be adequate to differentiate a primary carcinoma of the breast from a metastatic carcinoid tumor, thereby necessitating permanent sections, special stains, review of previously resected neoplasms, or electron microscopy. The first mammogram of a metastatic carcinoid to the breast is reported with this case.
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PMID:Breast metastasis: an unusual manifestation of a malignant carcinoid tumor. 33 42

Cancer of the lip occurs in about 90 percent at the lower lip arising in the vermilion mucosa. In tumor stage I the type of repair depends on the size of the primary tumor. Small tumors are best treated by a simple full-thickness W-excision with direct closure, occasionally combined with vermilionectomy. The simple W-excision is the most common procedure in lip cancer (65%). After excision of greater tumors, repair may be performed by cross lip flap of the Estlander-Abbe type or by the fan-flap of the Gillies type. Large defects are closed with Dieffenbach's or Burow's flap. The Burow's technique give better cosmetic and functional results than the Dieffenbach's method. Also in comparison to the cross lip flaps Burow's technique advantages. The orificium of the mouth remains wide, the lateral angle is not distorted and the tumor may be removed with a broad margin in the normal tissue. Therefore, the Burow's technique is frequently applied (30%) displacing the other methods(is less than 5%). At least the practice of two techniques may be sufficient in dermato-surgery, the W-excision with or without vermilionectomy; and the Burow's technique with its modifications.
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PMID:[Lip carcinoma and its surgical treatment]. 35 Aug 6


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