Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Review of the world literature revealed 16 cases of intraoral rhabdomyomas. Thirteen additional cases of intraoral rhabdomyomas from the files of the Armed Forces Institute of Pathology are reported. The neoplasm occurred principally in adults (mean age 56 years), and the male-female ratio was greater than 2:1. The majority of cases occurred in the floor of the mouth, followed by the soft palate, tongue, and buccal mucosa. Recurrences occurred in four (30 percent) cases, and there was one multiple recurrence. One residual tumor, the result of incomplete surgical removal was noted. Although these tumors have a characteristic microscopic appearance, they were frequently misinterpreted. The size, clinical presentation, and growth pattern of these tumors may reflect their ultimate behavior and prognosis.
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PMID:Intraoral rhabdomyomas. 29 57

Fifteen patients with cancer involving the temporal bone have been considered for radical surgical treatment by partial resection of the temporal bone during the past 12 years. All but one had undergone previous treatment by local surgery and/or irradiation. Two patients proved to be inoperable at surgical exploration. Three types of partial resection of the temporal bone and described to encompass disease involving the concha, the mastoid and squamous areas of the temporal bone, the ear canal, the middle ear, and the parotid gland. Closure of the surgical defect has been achieved in five cases using the residual pinna, in four cases with scalp flaps, and in five cases with a deltopectoral flap. Complications have been surprisingly few, with only one postoperative death. In one case communicating hydrocephalus persisted until death from residual disease many months later. Minor repair failure occurred in two patients. No attempt has been made to restore facial nerve function by grafting procedures. Long-term survival has been disappointing; however, it is considered that such radical surgery remains justified in selected cases for relief of the pain and disfigurement caused by chronic ulcerating neoplastic disease.
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PMID:Temporal bone resection for cancer. 29 6

A subpopulation of human lymphocytes bearing receptors for the Fe portion of IgG causes lysis of nucleated target cells in the presence of antibody. The reaction is known as antibody-dependent cellular cytotoxicity (ADCC) and the effector cells have been called killer (K) cells. We have measured K cell activity quantitatively in the peripheral blood of cancer patients using 51Cr labeled murine mastocytoma target cells and hyperimmune rabbit antimastocytoma antibody. ADCC was the same in males and females, was not affected by eating, smoking or the presence of infections, but was decreased in those over 65 years, during pregnancy, and in those with cachexia, or severe sepsis associated with nonmalignant diseases. It was normal in those with cancers being treated for cure and in those with benign diseases, but was decreased in those with advanced cancers. Operation did not produce a significant change in those who were not immunodepressed; in those who were immunodepressed before operation it caused a significant decrease maximal by the fifth day with recovery by the 15th day. Radiotherapy caused a decrease in K cell activity, maximal at 4 weeks, that persisted for 12 weeks with recovery after that time in those who did not have residual tumor. The values did not return to normal in those who had persistent tumor or distant metastases.
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PMID:Effect of operation and radiotherapy on antibody-dependent cellular cytotoxicity. 31 42

The fourth report of our long-term study concerns 70 cases of primary radiotherapy. The side effects of our radiation technique are minimal and temporary; in over 80% of the cases, potency was not affected. The morphologically demonstrable changes in the tumor tissue, in the original glandular parenchyma, and in the fibromuscular stroma leading to the vessels following high-voltage therapy are described. Three types of progressive patterns, based on the grade of histologic regression, can be determined. In more than half of the cases, with increasing distance from the source of radiation, no tumor or only minimal residual tumor was demonstrable. Sensibility and resistance of carcinoma of the prostate are not dependent upon the grade of differentiation of the tumor. A prognostic statement concerning the success of radiation therapy from initial histologic findings is not possible here. The occurrence of metastases in 18% of the cases following radiation probably resulted from the inexactness of the purely clinical determination of the stage of the tumor. The isolated, local treatment of prostate carcinoma through radiotherapy is justified only after exact determination of the stage of the tumor, i.e., certain exclusion of metastases via a diagnostic lymphadenectomy.
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PMID:[Prostate carcinoma: determination of progression following high-voltage therapy (author's transl)]. 41 Jan 35

Intravesical thio-tepa instillations for 55 patients with superficial transitional cell carcinoma were evaluated prospectively in the treatment of residual disease (therapeutic) and the prevention of recurrence (prophylactic). The over-all response rate to therapeutic thio-tepa was 56 per cent, with toxicity observed in 26 per cent of the cases. Patients with microscopic residual tumor showed better response and less toxicity than those with gross residual tumor. Prophylactic thio-tepa had no effect in lowering recurrence rates. Examination of pre-treatment and post-treatment biopsies showed no worsening of atypia and no correlation between improvement in atypia and gross tumor response. A charcteristic post-treatment thio-tepa effect was observed in non-tumorous urothelium but not in tumor biopsies. The differentiation of such thio-tepa effect cells from pre-malignant atypical cells is discussed.
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PMID:The effect of intravesical thio-tepa on normal and tumor urothelium. 41 37

I-125 seeds in Vicryl suture have been used as a radioactive suture in 24 cases of advanced malignancy of the head and neck. Twelve cases had metastatic carcinoma attached to the internal or common carotid artery. The goal was to excise surgically as much tumor as possible, then implant any residual tumor with this radioactive suture which remains as a permanent implant (half-life of 60 days). This preliminary study shows that use of I-125 impregnated Vicryl suture in this manner appears to produce improved long-term palliation and may increase local cure rates.
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PMID:Radioactive suture in the treatment of head an neck cancer. 43 Dec 40

The use of postoperative irradiation as an adjunctive measure for better control of local and regional disease after a surgical procedure has been used at the Anderson Hospital since approximately 1965. The common clinical setting occurs in those patients in whom, after surgical ablation of the tumor, there are microscopic foci of residual disease at the margins, perineural invasion, histologically a very poorly differentiated carcinoma, dermal lymphatic involvement, multiple nodes in the neck or very large nodes in which the tumor has broken through the nodal capsule and entered the connective tissue. We have been applying this criterion for the treatment of salivary gland malignancies, squamous carcinomas of the hypopharynx and supraglottic larynx, and all sites in the head and neck in which there was extensive cercical nodal metastasis. The results of this therapeutic approach will be reported and discussed.
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PMID:The use of postoperative irradiation--its goals and 1978 attainments. 43 Dec 57

The predictive value of serial levels of carcinoembryonic antigen (CEA) in tumor monitoring was examined in 213 patients with ovarian cancer; each patient had been followed-up at monthly intervals for at least 12 months. CEA was not detectable throughout the period of observation in 35% of the patients. In general. patterns showing a disappearance of CEA or persistently low levels were associated with a good prognosis, whereas those showing a reappearance or highly elevated and rising levels were associated with a poor prognosis. A transient reappearance of CEA was observed in 10 patients; this did not appear to be associated with tumor recurrence or progression. "False positive" results were obtained in 6 patients in whom no tumor has been clinically detectable to date. "False negative" results were obtained in 4 patients with obvious tumor progression. In terms of a good or poor prognosis, the use of CEA levels was highly accurate in patients with minimal or no residual disease (97% and 89%, respectively); the rate fell to 62% in patients with extensive disease. As the clinical significance and limitations become better known, serial CEA levels should contribute substantially to the monitoring of patients with ovarian cancer.
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PMID:Predictive value of serial carcinoembryonic antigen levels in long-term follow-up of ovarian cancer. 45 31

Sixty-four (14.7 percent) of 434 consecutive patients having pulmonary resection for bronchogenic carcinoma were found to have microscopic residual tumor on the cut margins of the resected specimens. These subjects were further subdivided histologically into those with direct extension of the tumor (34 patients), lymphatic permeation (14 patients), clumps of cancer cells in parabronchial tissues (six patients), and the presence of carcinoma in situ change (10 patients). Bronchopleural fistulas developed in eight (12.5 percent) of 64 patients. The operative mortality rate was 15.6 percent, with four of the deaths occurring as the result of bronchopleural fistulas. Thirty-two patients (50 percent) survived 1 year, 21 (32.8 percent) survived 3 years, and 15 (23.4 percent) lived for 5 years or more. The patients with tumor in the submucosal and peribronchial lymphatics had the worst prognosis. 78.6 percent having died within 1 year and the remainder within 3 years. All 5-year survivors were men with squamous cell carcinoma and had relatively small tumors (mean diameter 2.9 cm). No direct relationship between the length of the resected bronchial stump and survival could be established; a short stump did not preclude long survival. The possible factors involved in the relatively high 5 year survival rate in this group of patients and the therapeutic implications of these factors are discussed.
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PMID:Survival with residual tumor on the bronchial margin after resection for bronchogenic carcinoma. 45 24

Measurement of Clq-BA and CEA levels in patients with lung cancer may provide additional information about their clinical status discriminating between disease free patients and those with residual disease. Post-operative determination of Clq-BA and CEA levels may assist in defining patients which have poor prognosis. Preliminary evidence suggests that Clq-BA measurement may provide additional prognostic information in a small group of patients with normal CEA values. Finally, the presence of elevated Clq-BA in tumor bearing patients is of fundamental importance in the biology of cancer as it suggests that there are some tumor associated antigens which provoke the production of antibody in the host with the resultant formation of circulating immune complexes. The definition of the nature of the antigen in these immune complexes awaits further study.
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PMID:Application of tumor marker analysis to patients with lung cancer. 46 52


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