Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A case of histiocytoma in a 63-year-old woman with general fatigue is described. Ultrasonography and radiological examination revealed a large mass at the retroperitoneum displacing the right kidney to medial anterior abdomen. Exploration of the tumor with right kidney was done via a transperitoneal approach because the tumor had invaded the hilar fat tissue of the right kidney. The total resected weight was 3,200 g. Histological study showed malignant fibrous histiocytoma, storiform-pleomorphic type. Post-operative chemotherapy consisting of cyclophosphamide, vincristine, adriamycin, dimethyl triazeno-imidazole carboxamide (CYVADIC) was performed and the patient is doing well without any evidence of recurrence or metastasis.
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PMID:[Retroperitoneal giant malignant fibrous histiocytoma: report of a case]. 133 4

The present report describes the case of a 57-year-old patient with malignant fibrous histiocytoma of the left atrium operated on for a suspected atrial myxoma. Surgery was performed as radically as possible and included resection of the atrial wall. Clinical investigation and echocardiography performed 29 months after surgery revealed no signs of tumor recurrence. Diagnostic procedures, topography, pathohistology as well as options for therapy are discussed with regard to the latest literature. A radical surgical approach represents the only effective therapeutic measure. Owing to a lack of sufficient experience, there is no additional therapeutic recommendation on hand. Neither radiation nor chemotherapeutic treatment concepts have proved efficient. Echocardiography represents the best examination procedure for both diagnosis and follow-up in patients with cardiac tumor.
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PMID:Malignant fibrous histiocytoma of the heart--case report of a rare left-atrial tumor. 133 28

Malignant fibrous histiocytoma (MFH) of soft tissue is a rare tumor. We present a case of MFH in the bicipital muscle. Local muscle hypertrophy or lesions of the long tendon of the bicipital muscle may be a difficult differential diagnosis. This case is used for outlining advantages of ultrasound, computed tomography and magnetic resonance imaging. In conventional radiography MFH is seen as a soft-tissue tumor sometimes involving the bone. CT is the best way to test bone involvement. Tumor extension will be assessed with great accuracy by means of ultrasonics and magnetic resonance imaging (MRI).
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PMID:[Malignant fibrous histiocytoma: productive use of imaging procedures]. 133 95

On the basis of one personal case, the various clinicopathological features of primary malignant fibrous histiocytoma of the lung are summed up. This tumor, which has a nonspecific radiological appearance, most often appears as a large peripheral pulmonary opacity, for which the prognosis is guarded and the positive diagnosis based on surgical exeresis or biopsy.
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PMID:[Primary malignant fibrous histiocytoma of the lung]. 133 41

Malignant fibrous histiocytoma (MFH) is a soft-tissue tumor of late adult life. This tumor is uncommon in the head and neck region. A case of MFH arising in the auricle is presented with immunohistochemical and electronmicroscopic findings. Histologically the tumor was characterized by numerous spindle cells with abundant eosinophilic cytoplasm and many small capillaries. They were positively stained with vimentin, alpha 1-antitrypsin, and alpha 1-antichymotrypsin. Electronmicroscopically, some tumor cells contained abundant lysosomes and others contained numerous filaments.
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PMID:Malignant fibrous histiocytoma of the auricle: an immunohistochemical and electronmicroscopic study. 133 84

Malignant fibrous histiocytoma is a frequent neoplasm of the soft tissue occurring in patient aged between 5th and 7th decade. Maxillary sinus is an unusual site of origin and few cases have been described in literature. Because of the rarity and its aspecific clinical symptoms, diagnosis is troubled. Moreover, the association of an inflammatory process together with the difficulty to take a representative sample, the histopathological diagnosis is often problematic. The Authors report a case concerning a 30-years-old men treated at National Cancer Institute of Milan. Clinical history, biological behaviour, therapy and prognostic features of the tumor are discussed.
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PMID:[Malignant fibrous histiocytoma of the maxillary sinus]. 133 86

CT findings of retroperitoneal neoplasma in 50 cases (51 tumors) were reviewed. There were 28 (55%) malignant tumors and 23 (45%) benign ones. MFH and liposarcoma were the most common malignant tumors and neural origin tumors were the most common benign ones. Differentiation is difficult on the basis of CT features alone. Benign tumors were usually smooth and well defined, and malignant ones ill-defined, irregular in shape, heterogenous in density with massive necrosis. The characteristic CT appearance of liposarcoma is the CT attenuation value by fat density. Neural origin tumors are usually located near the spine. They may have thick wall cystic appearance or are dumbbell shaped, showing expansion or extrinsic pressure to the adjacent bone structures. MFH, hemangiopericytoma and other malignant tumors may have marked enhancement after contrast administration. Non-resectability is shown as: 1. big vessels encased by tumor over 90 degrees, 2. adjacent organs or structures invaded by tumor, 3. multiple masses, and 4. huge tumor invading into the pelvis. Local recurrence is common after surgery. Follow-up CT scans every 6 months in a 2 year period is suggested for early detection of recurrence.
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PMID:[Computed tomography of retroperitoneal neoplasms]. 133 88

Lectin binding patterns in ten mouse malignant fibrous histiocytoma (MFH)-like sarcomas containing eosinophilic globule (EG) cells and in granular metrial gland (GMG) cells of mouse placenta were stained with nine lectins (Con A, LCA, WGA, DBA, SBA, e-PHA, PNA, RCA-I and UEA-I) by an avidin-biotin-peroxidase-complex method. EG cells stained strongly with DBA, SBA and PNA which are specific for N-acetyl-D-galactosamine and/or D-galactose. DBA and SBA bound throughout the cytoplasm including the globules; PNA reacted preferentially at the cell surface. There was no evidence that these three lectins were reactive for immature EG cells. WGA, RCA-I and e-PHA also gave a slightly to moderately positive reaction to globules of EG cells. The results indicate that the globules contain abundant O-linked sequences of sugars, but also a few N-linked residues. MFH tumor cells showed a variable degree of binding with Con A, RCA-I, and WGA, but did not react with DBA, SBA and PNA. On the other hand, GMG cells exhibited specific affinities for DBA, SBA and PNA with staining patterns similar to those of EG cells. These findings suggest that EG and GMG cells may be of the same cellular lineage.
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PMID:Eosinophilic globule cells in mouse MFH-like sarcomas: lectin histochemistry. 135 25

Cytokeratin (CK) immunoreactivity in malignant fibrous histiocytoma (MFH) and other selected cases of spindle cell tumors were assessed using two cytokeratin monoclonal antibodies, AE1/AE3 and CAM 5.2. Frozen tissue was used to minimize the effects of fixation on keratin antigenicity; in addition, one block of fixed, paraffin-embedded tissue was tested for comparison. CK immunoreactivity was noted in nine frozen tissue samples (7/20 [35%] MFH, 1/3 schwannomas, 1/3 leiomyosarcomas). In the majority of cases, only rare individual positive cells were seen. Of 19 MFH cases in paraffin-embedded tissue, CK immunoreactivity was noted in three (16%). All 32 cases examined showed vimentin immunoreactivity. MFH must be added to the growing list of mesenchymal tumors exhibiting sporadic CK immunoreactivity. Such reactivity is less frequent in paraffin-embedded tissues. This finding has important implications for tumor diagnosis, particularly in the differential diagnosis of pseudosarcomatous carcinoma. Caution is recommended in the interpretation of CK immunoreactivity, particularly as it relates to speculations regarding histogenesis.
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PMID:Cytokeratin immunoreactivity in malignant fibrous histiocytoma and spindle cell tumors: comparison between frozen and paraffin-embedded tissues. 137 72

We have prepared karyotypes from a malignant fibrous histiocytoma (MFH) of the brain of a 6-year-old girl. Sporadic cases of MFH in the central nervous system have been reported. However, to our knowledge, this is the first central nervous system tumor to be subjected to cytogenetic analysis. The tumor demonstrated a complex karyotype, with a variety of numerical and structural abnormalities. Although no specific cytogenetic abnormality was observed, the karyotype of this case was similar to those reported for adult MFH of soft tissues.
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PMID:Malignant fibrous histiocytoma of the brain in a six-year-old girl. 137 37


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