Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

To determine the true prevalence of vaginal epithelial changes in DES-exposed offspring, the National Cancer Institute funded the DESAD Project, a study designed to follow up these women for 4 years and to determine the prevalence of cancer and various other abnormalities in DES-exposed women. 3339 women have constituted the project study cohort as of 12/31/76. Each woman in the DESAD Project undergoes breast, pelvic and colposcopic examinations, as well as vaginal and cervical cytology. Details of her gynecologic, sexual, and reproductive history are also obtained. 34% of the record review participants had vaginal epithelial changes (this rate is much lower than previously reported); no clear cell adenocarcinoma nor severe dysplasia or carcinoma in situ of either the vagina or cervix had been found in any of the women participants. A multivariate analysis of various factors of participant history and examination findings indicate that timing of onset of exposure to DES; total dosage of DES; duration of DES exposure; and age at initial examination correlated with vaginal epitheliel changes. Vaginal epithelial changes were also found to occur less frequently after 26 years of age. Maternal history (indication for use of DES); maternal age; and exposure to other hormones did not correlate with vaginal epithelial changes. The DESAD Project is currently investigating the changes in vaginal epithelium over time, and is also examining women for any evidence of neoplasia of the lower reproductive tract.
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PMID:Vaginal epithelial changes associated with in utero DES exposure. 52 34

We report a group of neuroid, cutaneous tumors that are usually associated with, or preceded by a melanocytic dysplasia. For this clinicopathologic entity we have chosen the term neurotropic melanoma. The neurotropic melanoma is a cutaneous fibrous tumor whose clinical course is characterized by local infiltration, multiple recurrences, and commonly by metastases. Its microscopic picture is characterized by atypical "neuroma-like" patterns, by poorly defined margins, and by neurotropism. Its early or precursory melanocytic dysplasias include lentigo maligna (actinic or lentigo maligna variant), and a melanoma with borderline cytologic characteristics (minimal deviation variant). A third type is not preceded by a recognizable melanocytic dysplasia: it has "neuroma-like" qualities at its inception (de novo variant). In our 22 cases, the preponderant sites were the head, neck, and lip. The patients were fair-faced, and 18 of the patients were over 40 years old. Seventeen patients had one or more recurrences. Of 16 patients with follow-up, nine died with evidence of disease, five are alive with active disease, and seven are apparently free of disease.
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PMID:Neurotropic melanoma. A variant of desmoplastic melanoma. 53 14

The familial occurrence of retinal dysplasia in five affected male children suggested X-chromosome-linked recessive inheritance. The clinical features were childhood onset, severe visual impairment, head posture, nystagmus, and strabismus. The ophthalmoscopic findings varied in shape and extension; they ranged from retinal folds to dysplastic tissue covering the posterior pole or gliosis with tumor-like protrusion in the vitreous. The marked variability of the retinal findings was paralleled by the visual acuity, which ranged from some vision to blindness. Electroretinograms coordinated well with ophthalmoscopic observations. Of the five mothers, who are the presumed heterozygous carriers, two showed retinal changes.
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PMID:Primary retinal dysplasia transmitted as X-chromosome-linked recessive disorder. 56 35

A painful intracortical and subperiosteal lesion of the fibula with a 14 year follow-up is reported to regress to a painfree state. Infection is favored in the differential diagnosis. Biopsy with histological and radiographical correlation are essential for exclusion of: osteoid osteoma, osteoblastoma, periostitis, glomus tumor, eosinophilic granuloma, enostosis, hemangioma of bone, giant cell tumor, simple cyst, aneurysmal bone cyst, non-ossifying fibroma, polyostotic fibrous dysplasia, hyperparathyroidism, Paget's disease, localized area of avascular necrosis, stress fracture and even metastatic disease.
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PMID:Intracortical and subperiosteal lesion of unknown etiology. 63 98

The metastatic transfer of cells from a primary bronchogenic carcinoma to other portions of the lung as a result of mucus embolization and inoculation has been demonstrated. Histologic observations indicate tumor implantation and survival in peripheral bronchioles. In these regions mucosal dysplasia and carcinoma-in-situ changes which characteristically accompany a primary lesion are notably absent. Morphologic changes associated with acute bronchitis and focally denuded bronchial mucosa may be implicated.
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PMID:Transbronchial mucus transfer of bronchogenic carcinoma. 64 53

An unusual hip tumor was seen in a 13-year-old youth following a brief history of discomfort. The osteochondroma was differentiated from dysplasia epiphysealis hemimelica by its location.
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PMID:An unusual location of an esteochondroma. 64 72

Two hundred eight patients with confirmed or suspected diethylstilbestrol exposure were examined colposcopically at two separate medical centers. Cervicovaginal ridges were present in 90 (43.3%) and ectopy was found in 188 (90.4%) of the patients. Evidence of vaginal adenosis was present in 122 (58.6%) of the cases. Seventy-four percent of the patients had abnormal colposcopic findings: 15.4% having columnar epithelium on the surface of the vagina and 66% having abnormal transformation zones (white epithelium, punctation, mosaic). Twenty patients (9.6%) were initially identified histologically as having squamous dysplasia. Subsequent review of the histologic material in these cases could document only two cases of significant squamous dysplasia, both severe, the remainder having immature, atypical metaplasia or possibly very mild dysplasia. This finding emphasizes the problems encountered in histologically differentiating squamous neoplasia from the peculiar metaplasia found in these patients, thereby making it difficult to establish whether these patients are at increased risk for the development of squamous neoplasia.
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PMID:Colposcopic evaluation of DES-exposed progeny at two large medical centers: the squamous neoplasia problem. 66 28

The records of 100 recent urology service patients with bladder neoplasms were evaluated for correlation of cytological findings with clinical and histological diagnoses. At the time of diagnosis 83 patients had synchronous positive biopsies and cytologies, 3 had negative cytologies (even though urothelial cancer was present) and the remaining 14 had abnormal cytologies but clinical examination was negative. Of these 14 patients invasive cancer has been identified subsequently in 11, while 3 have not yet returned for clinical followup. Analysis of the 11 patients in whom cancer was proved eventually reveals 14 distinct periods, ranging from 1 to 37 months, in which cytologies were abnormal and concurrent clinical examinations and histological diagnoses were negative. Ten of these periods preceded tumor recurrence and the other 4 antedated the first occurrence of cancer. A relationship was found between a cytological diagnosis of carcinoma in situ or severe dysplasia and the presence or future appearance of low grade clinical cancer. Cytologies containing overtly malignant cells more commonly were associated with or preceded the appearance of high grade cancers. In these 11 patients the sensitivity of a single spontaneously voided urine specimen was 97 per cent but the sensitivity was 100 per cent when 2 or more specimens were submitted per patient. Bladder barbotages were 100 per cent sensitive.
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PMID:Pre-clinical cytological diagnosis of bladder cancer. 67 5

Urine cytology screening for neoplasm led to the detection of 3 urothelial carcinomas and 1 severe urothelial dysplasia in 98 patients with analgesic-induced papillary necrosis. A further 18 patients had changes suggesting that they were at risk of incurring malignancy in the near future. Routine urine cytology is recommended in all cases of analgesic nephropathy.
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PMID:Urine cytology findings in analgesic nephropathy. 67 20

Extramedullary plasmacytoma is a rare form of plasma cell dyscrasia, in which malignant plasma cell tumors arise outside the bone marrow. The tumor may arise in any part of the body but the vast majority occur in the head and neck, primarily in the nasal cavity, paranasal sinuses, or upper airway. Six patients with extramedullary plasmacytoma are presented and the clinical and radiographic findings are reviewed.
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PMID:Extramedullary plasmacytoma. 67 30


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