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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Acoustic neuroma has always been reported to accompany neurofibromatosis in patients with enlargement of the internal auditory canal. The authors describe a case in which the internal auditory canal was enlarged but there was no tumor. This may represent a normal variant or a manifestation of the bony dysplasia of neurofibromatosis.
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PMID:Internal auditory canal enlargement in neurofibromatosis without acoustic neuroma. 40 81

The clinical features, macroscopic and radiologic findings and typical histologic alterations in three cases of fibrous dysplasia of ribs are described. In one case the lesion presented as a tumor-like growth of a size unprecedented in previously reported cases. In differentiating this condition from ossifying fibroma, the pattern of distribution of newly formed bone to fibrous connective tissue is shown to be a valuable criterion. In fibrous dysplasia this ratio is constant for any given area, but varies considerably in ossifying fibroma.
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PMID:[Monostotic fibrous dysplasia of the ribs]. 41 Jan

Two cases of ossifying fibroma of long bones are presented. This tumor is confused with monostotic fibrous dysplasia, but can be distinguished by its intracortical location, as demonstrated radiographically, and by its histologic pattern. Distinction from fibrous dysplasia is important since ossifying fibroma of long bone is a more aggressive lesion with different therapeutic implications. It appears that ossifying fibroma and adamantinoma of long bones are somehow related, and that lesions resembling fibrous dysplasia in association with adamantinomas of long bones are actually ossifying fibromas.
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PMID:Ossifying fibroma of long bone: its distinction from fibrous dysplasia and its association with adamantinoma of long bone. 41 32

A comparative study shows high incidence of preclinical cancerous lesions of the uterine cervix in women under thirty years of age. The rate of positive cytology in this age group was the same as in the group of women over thirty (0.3 per cent each). The histological findings revealed intraepithelial lesions like dysplasia and carcinoma in situ in the younger group compared to more advanced lesions like microinvasive cancer in the higher-aged group. The use of colposcopy rendered optical evidence--predominantly in the younger group--of lesions which under long-term observation preceded positive cytology for years as well as the consequent histological proof of dysplasia and preclinical carcinoma. As a result of the given and discussed clinical data in both compared age groups the value of colposcopy is stressed in improving the quality of detection of preclinical neoplasia in the uterine cervix and the necessity of cancer-screening in younger-aged women is emphasized.
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PMID:[Does cancer preventive care on the cervix need to be reformed? Gynecological preventive care and early diagnosis--current knowledge on cervix neoplasms]. 42 93

We have described an unusual case of polyostotic fibrous dysplasia in a 25-year-old white woman who had malignant transformation into a mesenchymal tumor with widespread metastases and features of rhabdomyosarcoma. Masculinization also occurred with high plasma testosterone levels. A mechanism for the development of masculinizing features is discussed.
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PMID:Malignant transformation of polyostotic fibrous dysplasia. 42 32

Twelve patients with vaginal intraepithelial neoplasia received topical therapy with 5% 5-fluorouracil cream. Six patients had carcinoma in situ, 5 had moderate dysplasia, and 1 had mild dysplasia. Five patients responded to 1 treatment course. Six patients required 2, and 1 patient required 3 courses of therapy to respond. Three patients developed recurrent vaginal intraepithelial neoplasia 11-16 months after therapy and were retreated with topical 5-fluorouracil. Vaginal irritation occurred in all patients but was limited to the duration of the treatment course.
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PMID:Topical 5-fluorouracil in the treatment of intraepithelial neoplasia of the vagina. 46 Jul 49

In a five year old boy who had intermittent knee joint swelling, angioma like venous dysplasia of synovial membrane was diagnosed by arthroscopic examination. The arthroscopic diagnosis was the indication for arthrotomy. The suprapatella pouch of the knee joint contained a blue grape like tumor. Angiomalike venous dysplasia of the synovialmembrane can histologically be separated from other angiomas of the inner joint capsule and angiomalike alterations in other joint diseases. Arthroscopy should be performed if within half a year monarticular intermittent joint swelling in childhood can not be diagnosed.
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PMID:[Angioma like dysplasia of synovial membrane with phlebectasia causing palindromic joint swelling in childhood (author's transl)]. 46 32

A case of an adamantinoma of the tibia and fibula is described in a 10-year-old girl who died after 17 years with pulmonary metastasis. For a long time, an exact diagnosis couldn't be made. Histologically the lesion was called chronic osteomyelitis (Brodie's abscess), synovial sarcoma and spindle cell sarcoma. The revision of the histological sections revealed a fibrous dysplasia-like pattern in the first lesion of the tibia with tiny foci of an epitheloid-like pattern. This had could be the key to the right diagnosis, because sometimes adamantinoma of long bones is associated with a fibrous dysplasia-like pattern. The reason for misinterpretation of the histological features is seen in the typical variable histological pattern of this tumor (basaloids, squamoid, spindled and tubular pattern). In this connection is refered to the necessity to correlate the histological feature with the X-ray in making diagnosis in bone pathology.
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PMID:[Differential diagnosis of a metastasizing adamantinoma of the tibia and fibula (author's transl)]. 47 64

By routine histological staining technics and histochemical assays under an appropriate enzymic control the author has studied changes in the basement membranes of the uterine cervix in its precancer and cancer as compared with the normal state. Changes in the basement membranes, revealed morphologically, reflect objectively the status of the epithelium and stroma during the period of tumor origination and growth, and therefore these may serve as a valuable adjunct to the differential microscopic diagnosis of dysplasia, preinvasive cancer and an incipient invasive growth. It is believed that basement membrane neoplasms may develop around mostly differentiated complexes of cancer cells in far-advanced neoplasms and their metastases; this fact is regarded as a tendency to normalization of the relationship between the cancerous tumor parenchyma and stroma with correlations between them being remined even under extremely unfavourable conditions of the tumor growth.
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PMID:[Basement membranes in precancerous conditions and neoplasms of the uterine cervix]. 48 15

A study of the supplementary value of an endocervical swab smear in addition to cervical scraping in the cytological diagnosis of cervical neoplasias is presented. The two sampling techniques were applied to a population with a high prevalence of neoplastic cervical disease. The endocervical swab smear was a useful adjunct in the detection of mild and moderate dysplasia, and a combination of the two sampling methods decreased the false negative rate in the diagnosis of intraepithelial, as well as invasive neoplasia. In the sphere of specific cytological diagnosis cervical scraping was found to be the more accurate method for diagnosing severe dysplasia and carcinoma in situ, while endocervical swab smears were more useful in diagnosing mild and moderate dysplasia. Differences between the results obtained in our study and comparable studies are discussed. It is concluded that the endocervical swab smear is a valuable adjunct to cervical scraping in the diagnosis of malignant cervical disease. It should not, however, be used as the only sampling method as it produces a higher proportion of unsatisfactory smears, and also because the severity of the epithelial lesion is more likely to be underestimated.
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PMID:Evaluation of smears obtained by cervical scraping and an endocervical swab in the diagnosis of neoplastic disease of the uterine cervix. 48 18


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