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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We reported the results of hepatic artery ligation (HAL) and infusion (HAI) with chemotherapy in the treatment of 356 patients with nonresectable primary liver cancer (PLC). A comparison of data between the periods 1958-1977 (81 cases) and 1978-1989 (275 cases) revealed that remarkable improvement in survival in the latter period might be attributed to the accurate site of hepatic artery cannulation, long-term infusion with chemotherapy, and combined treatment with subsequent tumor resection. During 1978-1989, the 5-year survival rates of different treatment modalities were 0% in HAL (n = 36) alone, 7.9% in HAI (n = 67) alone, 24.4% in HAL + HAI (n = 112, with subsequent resection in 10 cases), 36.5% in HAL + HAI + radiation (internal and/or external) (n = 60, with subsequent resection in 19 cases). The results indicate that HAL + HAI + combined treatment might provide a hope for the prolongation of survival or even resection in some patients with nonresectable PLC.
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PMID:[Hepatic artery ligation and intrahepatic arterial chemotherapy for nonresectable primary liver cancer]. 165 Jun 84

The importance of chronic hepatitis B virus (HBV) infection in the development of primary liver cancer has been established by epidemiological studies. However, the evidence for a direct role of the virus in liver carcinogenesis is still tentative. In addition, the findings of HBV DNA sequences in HBsAg-negative subjects with liver cancer has been reported, although it is controversial. Here we report the use of the polymerase chain reaction to detect HBV DNA in the serum and liver of HBsAg-negative patients. This technique allows both for the detection and cloning of HBV variants. In addition, the demonstration of HBV DNA and RNA molecules in HCC of HBsAg-negative individuals as determined by standard techniques reinforces the role of HBV in the pathogenesis of this tumor.
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PMID:The detection of hepatitis B virus (HBV) in HBsAG negative individuals with primary liver cancer. 165 Jun 88

Transcatheter arterial chemo-embolization with lipiodol and anticancer agents (LP-TACE) is a highly effective therapeutic method for treating liver cancer. It has been difficult, however, to evaluate how lipiodol, an oil, and anticancer agents dissolved in an aqueous contrast medium are retained in tumors. This paper reports the study on the dynamics of anticancer agents administered in LP-TACE both in vitro and in tumor-bearing animals using emulsions produced by mixing lipiodol and adriamycin (ADM) dissolved in Gd-DTPA. The results were as follows. 1) ADM was dissolved in contrast mediums (60% Urografin and Gd-DTPA) and each solution was emulsified by mixing with lipiodol. The emulsion separated into two distinct layers 5 min. after mixing. From this observation it is guessed that lipiodol and anticancer agents also separate in tumors after administration in LP-TACE. 2) Rabbits with VX2 carcinoma implanted in their lower limbs were treated by chemo-embolization and subjected to serial observations for changes in signals on MRI. The signal intensity markedly increased, persisting until one week after administration, when the tumor was resected. This change may have been owing to Gd-DTPA retained in the tumor, indicating that the anticancer agent is not washed out, even after separating from lipiodol, but is retained in the tumor. 3) When ADM was dissolved in Gd-DTPA and intraarterially infused without being mixed with lipiodol, the intensity of the signal on MRI was the same as that in LP-TACE immediately after the administration, and gradually decreased thereafter. This result indicates earlier washout of the anticancer agent when administered without being combined with lipiodol. Quantitative analysis of the tumor resected one week after the treatment also revealed ADM levels with less than 10% of those in LP-TACE, suggesting the possibility of estimating intratumoral concentration of anticancer agents. This was evaluated on the basis of the signal intensity in the tumor using MRI. 4) A comparison of lipiodol accumulation on CT and signal changes induced by Gd-DTPA on MRI suggested that even after separation from lipiodol, the anticancer agent extends to microvessels in the interior part of the tumor.
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PMID:[Experimental studies on the dynamics of anticancer agents in transcatheter arterial chemo-embolization. Magnetic resonance imaging using emulsions containing lipiodol and Gd-DTPA]. 165 93

From April 1987 to May 1988, right trisegmentectomy was done in 4 primary liver cancer patients under normothermic interruption of porta hepatis. This interruption lasted 22-26 minutes. Two of the 4 cases were associated with mild cirrhosis. No operative complication and mortality occurred. Two patients died of recurrence 5 and 14 months after operation. The other two patients are still alive free of tumor for 14 and 24 months. Detailed technical description and discussion with review of literature are presented.
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PMID:[Right trisegmentectomy for primary liver cancer--a report of 4 cases with review of literature]. 165 89

Anti-tumor activity of cisplatin-capsulated microspheres with ethylcellulose (CDDPmc) was studied in Wistar rat bearing transplantable hepatocellular cancer. Seven days after inoculation into the rat's liver, normal saline, conventional cisplatin, placebo ethylcellulose microsphere and CDDPmc at comparable doses were infused into the proper hepatic artery. The results indicated that the rats treated with CDDPmc had a significantly slower tumor growth, more extensive tumor necrosis and longer survival as compared with the three other groups. It is suggested that the tumoricidal effect of arterial chemoembolization with CDDPmc be superior to arterial chemotherapy or embolization alone in the treatment of liver cancer.
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PMID:[Hepatic arterial infusion of cisplatin microspheres for transplantable hepatocellular carcinoma in rats]. 165 90

A 36-year-old woman was admitted to our hospital because of general fatigue. The physical and laboratory findings on admission revealed splenomegaly, pancytopenia, hypocoagulopathy, liver hypofunction with a hepaplastin test of 55% and ICG Rmax of 0.6 mg/kg/min. Diagnostic imaging showed a hypoechoic mass 1.5 in diameter a low density area on the CT scan and a faint tumor stain on the AAG in the posterior inferior area of the liver. On a diagnosis of hepatocellular carcinoma with liver cirrhosis and hypersplenism, partial hepatectomy and splenectomy were performed. The resected hepatic specimen revealed a small liver cancer of 1.9 x 1.5 x 1.3 cm with liver cirrhosis. The specimen consisted of a firm rubbery mass. Macroscopically, the tumor appeared oval and was lobulated with a thin capsule. A fibrous scar was observed in the central area. Microscopically, malignant hepatocytes showed various shapes, ranging from polygonal to spindle form, with eosinophilic granular cytoplasm and were surrounded by abundant fibrous stroma. Orcein stain, revealed that these malignant hepatocytes contained many black granules of copper-binding protein. Immunoperoxidase staining for alpha 1-antitrypsin was also positive in the malignant hepatocytes. However, within this lamellar fibrous regions, there were many cords of tumor cells in which nucleoli were absent and abortive biliary differentiation was suggested. Consequently this tumor was diagnosed as an atypical fibrolamellar hepatocellular carcinoma. We think that this case is the 3rd case reported in Japan and the 2nd case in a Japanese person.
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PMID:Fibrolamellar carcinoma of the liver--a case report. 165 47

Hepatitis B virus (HBV) infection was evaluated in serum and liver specimens of eight Italian children with primary liver cancer. All children were negative for HBV markers in serum but four of them showed HBV-DNA sequences and/or HBs antigen expression in the liver. In one case, viral DNA was present in both neoplastic and non-neoplastic tissue, while in one case HBV-DNA was detectable only in nontumoral tissue and in one case only in the tumor area. In these cases, scattered HBsAg was expressed in the cytoplasm of cells in normal part of the liver and in another case neoplastic cells secreted HBsAg in culture. In two cases, the histologic diagnosis was HCC; one case had mixed HPB and one had macrotrabecular HPB. All children were more than 1 year of age. The remaining four children were histologically diagnosed as HPB and were less than 1 year of age. These findings suggest that HBV may be a cofactor for the development of liver cancer also in children of Western countries and that the risk of infection progressively increases with age.
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PMID:Does hepatitis B virus play a role in primary liver cancer in children of Western countries? 166 Dec 2

The relationship between the types of hepatectomy in each stage of hepatoma and the outcome was examined in 222 patients with hepatoma, according to the rules established by Liver Cancer Study Group of Japan. In Stage 1, the survival rate after absolute curative resection was better than that after relative curative resection. In Stage II, the survival after segmentectomy or lobectomy was significantly better than that after subsegmentectomy or less. Tumor recurrence rates in the remaining liver after segmentectomy or lobectomy were significantly lower than that after smaller resections. In Stages III and IV, there was no difference in survival among the various extents of hepatectomy. Incidence and cause of death after hepatectomy were not influenced by the extent of hepatectomy, as far as it was not beyond the preoperatively estimated safety limits. These results indicate the following: 1) In Stage I, absolute curative resection must be carried out. (2) In Stage II, segmentectomy or lobectomy should be applied when feasible. (3) The patients treated with subsegmentectomy or less for Stage II tumor, and the patients with Stage III or Stage IV tumor are at high risk of recurrence, and those patients need adjuvant therapy after hepatectomy.
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PMID:[The significance of extent of resection in the treatment of hepatoma]. 166 9

Twenty-seven liver cancer biopsies (20 hepatocellular carcinomas, 4 metastatic liver cancers and 3 cholangiocellular carcinomas) were obtained using a 21-gauge fine needle biopsy guided by ultrasonography. These cancers were subcutaneously transplanted to the subrenal capsular region of BDF1 mice premedicated with immunosuppressive agents to modulate the host immune reaction. The SRCA was based on the change in tumor size (delta TS) and the tumor growth inhibition rate (TGIR). The transplantation rate of the 27 liver cancer specimens was 85% by delta TS and 67% by TGIR. The efficacy rates of Adriamycin, cis-platinum, and mitomycin were respectively 71%, 58%, and 43% by delta TS, and 73%, 56% and 50% by TGIR. Thus, liver cancer specimens obtained by fine needle biopsy and examined by SRCA had a fairly high transplantation rate, and this method can be useful for patients with inoperable liver cancer, as a general chemosensitivity test for anticancer drugs.
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PMID:Subrenal capsule assay using liver cancer specimens obtained by fine needle biopsy. 166 8

Despite recent advances in hepatic surgery, management of unresectable carcinoma of the liver is still a challenging problem. From September 1988 through March 1989, 10 primary liver cancer patients were treated by hepatic artery embolization (HAE) using lipiodol-adriamycin with or without hepatic artery ligation (HAL). One of them received HAE twice in seven weeks. In two of these patients, following right HAE and HAL, right portal vein embolization (PVE) by catheterization via the ileac vein was performed. Transcatheter portal vein embolization via the ileac vein was simple, easy and safe even it was impossible to expose the hepatic hilum. All patients are alive from 7 to 12 months after operation except one who died of hepatic failure after having survived for 54 days. There was marked alleviation of symptoms and tumor shrinkage was observed in 9 out of 10 patients. HAE and PVE using lipiodol-adriamycin may have the potential of improving the therapeutic effect in patients with hepatocellular carcinoma.
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PMID:[Sequential hepatic artery and portal vein embolization using lipiodol-adriamycin for primary liver cancer]. 166 18


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