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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Renal angiomyolipoma is a rare lesion composed of smooth muscle cells, adipose tissue and abnormal vessels. It is currently classified as a benign, non-epithelial renal tumor. It has a high incidence in patients suffering from tuberous sclerosis but is more frequently found as an isolated renal lesion. Three cases of renal angiomyolipoma, 2 of which underwent perfusion-fixation, were studied by electron microscopy to clarify the cellular composition of this lesion. In the smooth muscle cells abundant accumulation of glycogen was found, whereas the lipocytes disclosed normal ultrastructural features. However, a smaller number of smooth muscle cells also contained lipid, thus simulating an intermediate cell stage between adipose- and smooth muscle cells. The abnormal thickening of the subendothelial spaces contained collagen fibrils in a homogeneous matrix, fibroblast-like cells and non-specific vesicular structures. These findings suggest a secondary vascular damage, i.e. the thickened vessels may not be a primary, integral part of renal angiomyolipoma. Evidence of a common precursor cell of renal angiomyolipoma was not disclosed. It is concluded that renal angiomyolipoma is a hamartoma composed of mature adipose cells and smooth muscle cells displaying different degrees of abnormal differentiation.
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PMID:Renal angiomyolipoma: an ultrastructural investigation of three cases with histogenetic considerations. 322 24

The authors present a case of tumor thrombus in the inferior vena cava produced by angiomyolipoma in a young woman with tuberous sclerosis. Diagnosis was made by computed tomography (CT) by measuring the attenuation values of the tumor thrombus. The values obtained were characteristic of fat, demonstrating that tumoral invasion was the cause of the thrombus. To our knowledge, this is the first description of such an association shown by CT in the literature.
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PMID:CT demonstration of extension of renal angiomyolipoma into the inferior vena cava in a patient with tuberous sclerosis. 332 40

A 47-year-old woman experienced sudden onset of severe left flank pain. By computed tomography (CT) and arteriography, her condition was diagnosed as a ruptured angiomyolipoma of the left kidney. She did not have tuberous sclerosis. Using polyvinyl alcohol foam (Ivalon) particles, immediate embolization of a main artery feeding the tumor--the posterior branch of the left renal artery--was performed. Three months after embolization, intravenous digital subtraction angiography (IVDSA) showed this main feeder was still occluded. This case and others encountered in our review of the literature underscore the usefulness of therapeutic embolization for renal angiomyolipoma.
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PMID:Therapeutic embolization for renal angiomyolipoma: case report and review of the literature. 333 Aug 27

We report the case of a 16-year-old patient with tuberous sclerosis that presented as renal leiomyosarcoma. This is an exceptional form of presentation of this tumor. An angiomyolipoma has to be first suspected in this group of patients. If the diagnosis is not confirmed by the imaging studies, radical surgery is recommended.
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PMID:Renal leiomyosarcoma in a patient with tuberous sclerosis. 337 67

A case of bilateral renal angiomyolipoma is reported. A 21-year-old female visited our hospital with the complaint of severe left flank pain and macroscopic hematuria Bilateral renal mass was suspected from the intravenous pyelography. CT scan revealed bilateral renal angiomyolipoma accompanied by retroperitoneal bleeding. There were no symptoms or signs of tuberous sclerosis. Left partial nephrectomy and right tumor enucleation were performed uneventfully with no recurrence during 4.5 years of follow-up. Several case reports of renal angiomyolipoma have been documented; we sum up these cases with special consideration as to treatment. In the majority of the cases, nephrectomy has been performed after retroperitoneal bleeding. We emphasize that in some cases it is favorable to carry out renal-tissue-conserving operation before the occurrence of the bleeding, because the angiomyolipoma tends to rupture easily.
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PMID:[Bilateral renal angiomyolipoma: report of a case]. 337 95

A 25-year-old female was admitted for further investigation of the right renal mass, which was noted during evaluation for hepatitis. She had no personal or family history of stigmas of tuberous sclerosis. On physical examination, a movable hard smooth mass of fist size was palpable in the right abdomen. Drip infusion pyelography revealed an elevation of right kidney. Ultrasonography revealed that the abdominal mass had a high amplitude echo area. On CT the mass was heterogeneous with irregular margin and had regions of low attenuation value, suspicious of a tumor with high fat content. An angiogram of the right renal artery revealed a hypervascular tumor showing multiple saccular aneurysms, and absence of arteriovenous shunting. Based on the aforementioned findings, the mass was diagnosed as renal angiomyolipoma. Partial right nephrectomy was performed through an extraperitoneal approach. Pathological diagnosis was a renal angiomyolipoma. Convalescence was uneventful, and the remaining parenchyma of right kidney was working well on drip infusion pyelography three months after operation. The management of renal angiomyolipoma from the conservative point of view is also discussed.
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PMID:[A case of renal angiomyolipoma treated by partial nephrectomy--the management of renal angiomyolipoma from the conservative point of view]. 337 96

Two siblings in a family without a history of phacomatosis or cerebral tumors developed malignant tumors in the posterior fossa at age 28 months and in the left cerebral hemisphere at age 15 months, respectively. Dual ependymal and choroid plexus epithelium differentiation was established by histological, ultrastructural, and immunocytochemical studies. The development of this rare tumor in siblings suggests an inherited predisposition, a common environmental insult, or both.
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PMID:Cerebral malignant tumors with ependymal and choroidal differentiation in two siblings. 338 Feb 85

A case of a renal oncocytoma associated with tuberous sclerosis in a 31-year-old woman is reported. She displayed many characteristic skin features of tuberous sclerosis but no central nervous symptoms. Although she complained of dysmenorrhea and hypermenorrhea, she had no complaints related to the kidney. A left renal tumor was discovered incidentally during preoperative examination for gynecologic disease and left nephrectomy was performed. Histologically, the tumor was shown to be a typical renal oncocytoma. This is supposed to be the first case of renal oncocytoma associated with tuberous sclerosis in Japan.
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PMID:[Renal oncocytoma associated with tuberous sclerosis: report of a case]. 343 96

A case of renal angiomyolipoma originating from polycystic kidney with horseshoe kidney is reported. A 32-year-old woman visited our hospital with the complaint of proteinuria. with computerized tomographic scan and further examinations the patient was diagnosed as having renal angiomyolipoma with tuberous sclerosis. The tumor originated from a polycystic horseshoe kidney. Three weeks later, she complained of right flank pain and was diagnosed with spontaneous rupture of the angiomyolipoma. Right heminephrectomy was performed and histological examination confirmed the preoperative diagnosis. Some discussion is made on the characteristics and treatment of renal angiomyolipoma, and the statistics on renal diseases with tuberous sclerosis in Japan are presented.
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PMID:[A case of angiomyolipoma originating from polycystic kidney with horseshoe kidney]. 343 97

A clinicopathologic study on 16 cases of renal angiomyolipoma is presented. Eleven were women and 5 men. The age ranged from 23 to 80 years with an average of 44.4. The course was from three days to one year. Abdominal mass, pain and hematuria were the main symptoms. Some individual cases were associated with tuberous sclerosis. Spontaneous rupture of the kidney was the principal complication often resulting in shock. The tumor was amenable to resection with a cure rate of 100% without recurrence, metastasis or infiltration of the large renal veins. The prognosis was good. B-type ultrasound and CT scan were helpful in the clinical diagnosis. Of 16 cases, 15 tumors occurred in unilateral kidney, in which the mass was usually located in one pole of the organ. The other tumor involved bilateral kidneys. The tumor was easily misdiagnosed as renal carcinoma by gross examination because of its being relatively large, yellow on the cut surface with hemorrhage and necrosis and often infiltrating tissues surrounding the kidney. Histologically, the tumor consisted of mature blood vessels, smooth muscles and adipose tissues. Sometimes, misdiagnosis of the renal angiomyolipoma with malignant change or angiomyoliposarcoma was made because of the active growth of the smooth muscle and adipose cells. In this paper, special emphasis is put in the discussion of the pathologic features and and causes leading to the misdiagnosis. Basing on long-term follow-up, it is suggested that angiomyolipoma of the kidney be a benign tumor of the hamartomatous nature.
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PMID:[Renal angiomyolipoma--a clinicopathologic study of 16 cases]. 344 64


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