Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Seven cases of tumors of the endodermal sinus are reviewed. This is a highly malignant germinal tumor, arisen from extraembrionary cell differentiation. It is different both biologically and pathologically from sacrocoxigeal teratoma. There are no survivors in these series. All seven patients have been surgically treated chemotherapy has been used in four, and X-ray therapy in two. It is noteworthy that alpha-phetoprotein is present in patients with this type of tumor. This fact can be used both in diagnosis of the tumor and of its recurrence.
 ...
PMID:[Tumors of the endodermal sinus (author's transl)]. 18 50

Seven infants and children with renal tumors underwent nephrectomy and the tumors were cultured to investigate the behavior of their cells. In four children over 1 year of age with histologically typical nephroblastoma in the tumor cells were bizarre and disorderly. In one patient 3 months of age where the histology suggested malignancy the tumor culture showed an orderly growth pattern of spindle cells akin to normal kidney and the patient has had no recurrence for 18 months. In one infant seven months of age the histology was consistent with malignancy and this was confirmed on culture showing bizarre cells similar to those of nephroblastoma. The third infant under 1 year of age had a teratoma on histology and an unusual growth pattern on culture characterised by polyhedral cells with long processes and much overlapping. It is suggested that in infants with kidney tumors, tissue culture be used to help in assessing the malignant potential of the tumor and deciding on adjuvant therapy.
 ...
PMID:Cultural characteristics of mesoblastic nephromas. 19 23

Previous studies on the natural history of neoplasia, utilizing mouse skin as a model, have demonstrated that the process of epidermal carcinogenesis may be separated into at least two different phases. The first of these, termed "initiation," is essentially irreversible; the second phase, that of promotion, may be modulated or reversed by a variety of environmental conditions. More recently, similar stages have been demonstrated for other organ systems during carcinogenesis, in particular that of murine liver. At the same time, investigations of a variety of systems including those in plants, amphibians, and, most recently, in mammals have demonstrated that the initiation process of neoplasia may not be as irreversible as previously considered, but in several of these systems, including those in plants and in the mouse teratoma, the neoplastic process appears to be reversible from its initial stages under appropriate conditions. A proposed scheme is presented which takes into account the reversibility of the process of initiation in the natural history of neoplasia.
 ...
PMID:The stability of events in the natural history of neoplasia. 20 65

From 1962 to 1976, 15 children up to the age of 15 years with malignant neoplasms of the ovary were observed at the Istituto Nazionale Tumori of Milan. 13 patients had a germ cell tumor and 2 a stromal tumor. Natural history and treatment results are reported. Out of 7 patients with dysgerminoma, 3 at stage IA, 2 at stage III retroperitoneal and 1 with recurrent disease are alive and disease free 38+, 20+, 36+, 16+, 23+, 156+ months after the histologic diagnosis; the last case with stage III peritoneal disease died 2 months after the diagnosis. Four children had immature malignant teratoma: 2 patients are alive and disease free 19+ and 51+ months, 1 is alive with disease 20+ months and 1 died 16 months after histologic diagnosis. Two patients with extra-embryonal teratoma died 7 and 12 months after diagnosis. One patient, treated by surgery plus chemotherapy for granulosa cell tumor at stage III, is alive 43+ months later. The child with arrhenoblastoma at stage III treated by surgery plus radiochemotherapy died 6 months after diagnosis. Through a close scrutiny of the literature and by drawing on experience gained in the treatment of the same tumors in adults, a rational approach to the diagnosis and treatment of each childhood ovarian tumor histotype is worked out.
 ...
PMID:Malignant ovarian neoplasms in childhood. 20 95

Radiopaque fluorocarbon (RFC) emulsions were prepared with small particle size and high concentration of the fluorocarbon. When RFC emulsions were injected intravenously in hamsters, rats, and mice with eight types of malignant tumors, the tumors became radiopaque, except in the mice with spontaneous teratoma of the ovaries. Tumors as small as 3 to 4 mm could be defined radiographically using routine x-ray techniques. The tumors remained radiopaque for days to weeks after injection. Light and electron microscopy revealed characteristic fluorocarbon vacuoles primarily in the tumor macrophages. Thus RFC emulsions may be useful in detection of malignant tumors.
 ...
PMID:Tumor imaging with x-rays using macrophage uptake of radiopaque fluorocarbon emulsions. 20 88

"Second-look" operations were performed in 32 infants and children with initially unresectable or recurrent solid tumors treated with combination chemotherapy and/or irradiation. Tumors were resectable in 26 of 32 cases (81%). These procedures often yielded information affecting staging and treatment. Disease-free survival was achieved in 18 of 32 patients (56%). Mortality was related to progressive disease in seven cases and opportunistic infections due to immunosuppression in three. Four additional patients are alive with evidence of persistent tumor. Second-look procedures were beneficial in patients with Wilms' tumor previously operated upon by a flank approach and in children with bilateral tumors. These procedures were particularly useful in children with stage III localized neuroblastoma and cases of metastatic neuroblastoma that respond to chemotherapy. Second-look operations were also useful in selected cases of rhabdomyosarcoma, teratoma, and Ewing's sarcoma. These observations suggest that combination chemotherapy has increased the use of second-look operations in a variety of less favorable (e.g. initially unresectable or recurrent) pediatric solid tumors.
 ...
PMID:Experience with "second-look" operations in pediatric solid tumors. 20 64

Malignant presacral teratoma is a rare tumor seen predominantly in young female children. The introduction of planned multidisciplinary treatment has improved the outlook for patients with this once dismal disease. Six female children were seen at Memorial Hospital with the diagnosis of malignant presacral teratoma. Five children were age 17 mo to 3 yr and the sixth child was 13 yr old at diagnosis. Presenting symptoms included masses in the buttock or groin, constipation, difficulty voiding, and local pain. Pathological features were varied and complex but three had predominantly endodermal sinus features. One child had the malignant presacral teratoma develop 18 mo after successful resection of a benign sacrosoccygeal teratoma in the newborn period. Treatment varied in the six cases since all were referred after failure of treatment elsewhere. All children had surgery, irradiation, and multiple drug chemotherapy. Four of the six children are surviving disease-free, 3 more than 24 mo off treatment. Evolution of treatment up to the present protocol management is discussed.
 ...
PMID:Malignant presacral teratoma in children. 22 64

In adult patients, testicular tumors consist predominantly of seminoma, embryonal carcinoma, teratoma, choriocarcinoma and mixtures of these. In infants and children, yolk sac tumor and teratoma are the usual tumors; in older age patients, it is predominantly spermatocytic seminoma and malignant lymphoma, although the others may occur as well. Leydig and Sertoli-granulosa cell tumors occur in all ages. The introduction of tumor markers and the capability to demonstrate these in tissue are the most important recent developments. However, there is great need for correlation of histology with these markers and histological demonstration of them.
 ...
PMID:Classification of tumors of testis. 22 62

Sixteen girls with ovarian tumors treated in the years 1970-1975 in the Oncological Department of the National Research Institute of Mother and Child were studied. 6 tumors were benign ( cystis dermoidalis --5 cases, cystadenoma mucinosum --1 case) and 9 tumors were malignant (dysgerminoma--6 cases, teratoma malignum --3 cases and neoplasma malignum epitheliale --1 case). Middle age of girls with ovarian tumors was 11 years. The commonest signs were abdominal pains, abdominal discomfort and presence of tumor in abdomen. Benign tumors were treated surgically by unilateral adnexectomy in 5 cases and bilateral adnexectomy in 1 case. Surgery and radiotherapy were basic treatment in malignant tumors in 6 cases, 3 cases of malignant tumors were treated by surgery, radiotherapy and chemotherapy, one case of malignant teratoma in stage Ia was treated only surgically. 6 girls with malignant tumors survived without evidence of the disease 33 months and longer. The best results were obtained in dysgerminomas even in stage III of disease. In teratoma malignum group survival were obtained only in the stage Ia of the disease.
 ...
PMID:[Ovarian neoplasms in girls treated at the Oncological Clinic of the Mother and Child Institute in Warsaw 1970-1975]. 26 20

A male infant was born with a voluminous left jugal swelling identified by biopsy on the 8th day as a mature benign teratoma. Further investigations were conducted because of mild exophthalmia, including an electro-encephalogram and craniofacial computer tomography. An enormous frontotemporal intracranial extension of the tumor was discovered on the same side. The tumor was completely excised at the age of 1 month by a two-stage operation : neurosurgical followed by maxillofacial eight days later. The postoperative course was uneventful. There was no relapse after one year but because of the consequences of intracranial excision the prognosis was very poor. The authors discuss this case and review those in the published literature in order to describe the diagnosis, treatment, and prognosis of this extremely rare craniofacial teratoma of the newborn.
 ...
PMID:[Hour-glass craniofacial teratoma (author's transl)]. 29 Nov 16


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>