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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An infant presented with symptoms of congestive heart failure. Ultrasound examination revealed a dense layer of echoes at the root of the aorta, a large anterior pericardial effusion, and coarse fluttering of the right ventricular wall. The clinical diagnosis of intrapericardial teratoma was confirmed by cineangiography and surgical resection. The pathological examination was consistent with benign teratoma. A postoperative ultrasound examination revealed absence of pericardial effusion and tumor echoes. This appears to be the first echocardiographic report of a pericardial tumor in an infant.
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PMID:Echocardiographic features in a case of intrapericardial teratoma. 9 47

Twenty-one infants and children with ovarian teratomas are reported. Calcification or ossification occurred in 68%, a higher figure than quoted in prior series. Teeth were recognized in 29% of these. A lucent fat-containing mass was appreciated in only two patients. In younger children the tumor was more frequently abdominal rather than pelvic. In two patients the tumor was malignant. A patient with an amputated freely mobile teratoma is reported in detail and the differential diagnosis of mobile abdominal calcifications discussed.
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PMID:Radiographic findings in ovarian teratomas in children. 10 50

Teratomas of the neck are rare in adults. Nine adult patients have been previously reported on in the world literature; six had malignant and three had benign lesions. Most of the lesions were seen as a mass in the neck, but teratoma is rarely considered in the differential diagnosis of neck lesions. A tenth patient, whose case we are presenting, had a supraclavicular sinus mass that was diagnosed at surgical exploration. The tumor was successfully resected and proved to be benign.
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PMID:Benign cervical cystic teratoma. 11 38

We report a third case of an unusual maligant neoplasm of the paranasal sinuses in a 60-year-old woman. Similar cases have been previously reported and called malignant teratoma. In consultation with Ackerman (written communication, February 1976) we propose the term "teratocarcinoma" and believe this is to be a more descriptive term and less likely to be confused with the generic term "teratoma," which is a benign tumor.
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PMID:Teratocarcinoma of the ethmoid sinus: review of literature plus a new case report. 11 30

Connected to testicular germ cell tumors, microcalcifications have been identified by microscopic tissue evaluation, the significance of which has not yet been discussed. Microscopic and radiographic evaluation of histologic slides and paraffin embedded tissue specimens, respectively, of 129 germ cell tumors showed that 46.4% of testes with seminoma and 68.3% of testes with teratoma display microcalcifications as round or roundish psammomatous bodies or irregular-shaped dystrophic calcifications, in teratoma as particles of bone tissue or calcified cartilage. Whereas psammomatous bodies are located within tubules in compressed residual testicular tissue arranged in a shell-like zone around the tumor mass, dystrophic calcifications and bone and cartilage tissues are identified inside the tumor. Often more than 10 microcalcifications per cm2 are present. The diagnostic importance of these findings for clinical use is discussed. Above all, it must be made dependent on a radiographic method which will not be dangerous for testicular tissue.
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PMID:[Microcalcifications in testicular germ cell tumors. Orientating study concerning its diagnostic utilization (author's transl)]. 14 80

The evaluation of total orchiectomy tissue specimens with malignant testicular tumors shows that microcalcifications can be found in a surprisingly high percentage by radiological and histological examinations. Small, often in several groups located calcifications in the parenchyma neighbouring the tumor are typical for seminoma, whereas in teratoma solitary microcalcifications and polymorphic types can also be seen. Microcalcifications are also present in not neoplastic testicular diseases but in a much smaller percentage and with a different type of calcification. The preoperative radiographic examination of testicular tumors of unknown origin seems to be indicated as a non-invasive method able to provide further information about the presence of a malignant germ cell tumor. Regarding the genetic risks of the method, there is hope to avoid other more invasive examinations with their danger of tumor spreading and to enable a radical resection of the primary tumor before its metastic formation by the mean of preoperative orchioradiography.
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PMID:[The diagnostic significance of microcalcifications in testicular tumors (author's transl)]. 15

A patient with a malignant retroperitoneal teratoma that contained Wilms' tumor and renal cell carcinoma is described. The rarity of renal tissue in teratoma, and the possible mode of development of Wilms' tumor and renal cell carcinoma in such a tumor are discussed.
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PMID:Wilms' tumor and renal cell carcinoma in retroperitoneal teratoma. 16 78

The various stages of divergent neuroepithelial differentiation were studied in the solid transplants of a transplantable mouse testicular teratoma (OTT-6050) maintained in both ascitic and solid forms. They included: a) areas of undifferentiated medullary epithelium corresponding to the rare human medulloepithelioma; b) areas of neuroblastic differentiation corresponding to neuroblastoma, with more mature neuronal differentiation corresponding to ganglioneuroma or, when mixed with glial elements, to ganglioglioma; and c) more mature neuroglial areas resembling astrocytoma, oligodendroglioma or ependymoma, as well as more primitive areas corresponding to ependymoblastoma. In tissue culture using collagen-coated coverslips, astrocytic differentiation was found in the outgrowth zone after 15 days, confirmed by immunofluorescence with antibodies to an astroglia-specific protein. In organ culture systems, glial components, including ependymal structures, were preserved in tumor explants, and astrocytic differentiation, as expressed by glial fiber formation, was increased after 4 to 6 weeks in vitro. No neuronal differentiation was demonstrable, however. The neuroepithelial component of this experimental teratoma may provide a model for the study of neoplastic neuroepithelial differentiation.
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PMID:An experimental mouse testicular teratoma as a model for neuroepithelial neoplasia and differentiation. I. Light microscopic and tissue and organ culture observations. 16 76

Prognosis has been poor for patients with retroperitoneal metastases from non-seminomatous testis tumors that are initially unresectable and persist after chemotherapy and irradiation or those that recur after initial lymphadenectomy. Eleven such patients have had re-explorations at our center and are described herein. In 4 patients only histologically benign teratoma and/or fibrosis was found. Therefore, the presence of a retroperitoneal mass in these circumstances does not necessarily mean that malignant tissue was present. The procedure provided an accurate diagnosis in all patients and permitted the elimination or reduction of subsequent chemotherapy or radiation in 4 patients who had no tumor. In addition, 5 of 7 patients with symptoms caused by bulky masses were improved and 3 patients with unresectable disease had radiopaque markers placed to facilitate subsequent radiotherapy. The operation was often difficult because of retroperitoneal adhesions from previous treatment but there was no significant morbidity and no mortality. Nine patients have survived from 6 months to 4 years and 7 have no evidence of disease. Two patients died of recurrent tumor 2 and 9 months after re-exploration. A good prognosis was indicated if the mass found at re-exploration was completely resectable and contained only histologically benign teratoma and/or fibrous tissue. We believe that re-exploration should be considered for selected patients with testis tumors who have 1) a retroperitoneal mass that appears after initial lymphadenectomy and persists after interval chemotherapy or radiation therapy and 2) retroperitoneal metastases that are initially unresectable and persist after subsequent chemotherapy or radiation therapy.
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PMID:Re-exploration for retroperitoneal lymph node metastases from testis tumors. 17 34

The clinical and pathologic features of 30 ovarian mixed germ cell tumors (neoplasms containing combinations of malignant germ cell elements) were studied to determine their behavior and to compare them with pure forms of malignant germ cell tumors. Dysgerminoma was the most common constituent, found in 24 (80%), followed by endodermal sinus tumor in 21 (70%), teratoma in 16 (53%), choriocarcinoma in 6 (20%), and embryonal carcinoma in 5 (16%). The actuarial survival for the entire group was 46%, and for patients with Stage I tumors it was 50%. The most important factors in predicting the prognosis for patients with Stage I disease was the size and the histologic composition of the neoplasm. If more than one-third of a Stage I neoplasm was composed of endodermal sinus tumor, choriocarcinoma, or Grade 3 teratoma, the prognosis was poor, whereas if the tumor contained less than one-third of these components or contained combinations of dysgerminoma, embryonal carcinoma, or Grade 1 or 2 teratoma, the prognosis was excellent. All patients whose neoplasm was less than 10 cm in maximum diameter survived, regardless of the composition of the tumor. Positive pregnancy tests in nonpregnant patients reflected the presence of either frank choriocarcinoma or scattered syncytiotrophoblastic giant cells. The latter did not appear to alter the prognosis. The finding of elevated serum levels of human chorionic gonadotropin (hCG) in 38% of the nonpregnant patients suggested that serial serum assays for hCG might be useful in staging and monitoring the response to treatment in these patients.
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PMID:Malignant mixed germ cell tumors of the ovary. A clinical and pathologic analysis of 30 cases. 18 53


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