Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We used aggressive individualized combinations of operation and cyclic actinomycin D therapy and/or irradiation for 12 patients with stage III germinal testis tumors, including 1 seminoma. Eight patients have survived free of tumor for 24 to 83 months. All but 1 survivor had retroperitoneal lymphadenectomy. Five thoracotomies and 4 neck resections were used to manage distant metastic lesions. Cyclic actinomycin D was used in 7 of 8 survivors. The experience with this series and a review of cases in the literature strongly suggest the need to eradicate the most common source of tumor seeding the distant metastatic sites from the retroperitoneal lymphatics. Eradication can best be accomplished by retroperitoneal lymphadenectomy and is indicated even in patients with a complete response to chemotherapy. A general treatment plan is suggested for stage III testis tumors: selective irradiation and chemotherapy for seminoma and an aggressive individualized combination of operation and chemotherapy with irradiation in some instances for non-seminomatous disease.
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PMID:Stage III germinal testis tumors: aggressive approach. 98 97

This is a report of a seventy-three-year-old male found to have a seminomatous tumor of his left testicle. This may represent the oldest reported case of pure seminoma. Men of all ages should have careful palpation of the testicles as part of a physical examination.
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PMID:Seminoma in male aged seventy-three. 99 53

A 30-year-old man who was maintained on immunosuppressants following renal transplantation had seminoma with teratoma of the right testis 3 months postoperatively. The temporal relationship in the development of the tumor in the presence of immunosuppressants strongly suggests the importance of the immunodefense mechanism in the control, development or growth of the neoplasm.
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PMID:Mixed testicular tumor in immunosuppressed patient: case report. 100 66

Characteristic for the germinal cell tumors of the testis is their great variety. Collins and Pugh gave a classification of testis tumors under consideration of the genesis of the tumor and the clinical progressing. The staging should be done according to the TNM-system which is based on the UICC recommendations of 1973. If a tumor is suspected an exploration of the testis must be performed. After definitive histological diagnosis via immediate section for microscopic examination during surgery an enlarged orchiectomy and local lymph node dissection has to be performed. In cases of seminoma a 5-year-survival-rate of 90 to 97 per cent can be achieved by radiation of two fields (4 fields in case metastases are suspected). Because of the radio resistance of the teratoid tumors a retroperitoneal lymph node dissection has to follow the enlarged orchiectomy. With a subtile operating technique all the lymph nodes between diaphragm and aortic bifuraction can be removed in case of operability. Postoperative radiation therapy is only recommended in case of excessive lymph node metastases. By an adjuvant chemotherapy following retroperitoneal lymph node dissection a 5-year-survival-rate of more than 80 per cent can be obtained in cases of teratoid tumors.
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PMID:[Germinal testicular tumors]. 103 17

Serum human chorionic gonadotropin levels were determined in 20 patients with histologically proved seminoma. The test was positive in 2 of the 20 patients and was predictive of non-seminomatous metastasis in each case. Serum human chorionic gonadotropin is a useful tumor marker in detecting and following non-seminomatous metastases in men with pure seminoma of the testis.
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PMID:The seminoma decoy: measurement of serum human chorionic gonadotropin in patients with seminoma. 105 36

In this study, thymoma is defined as a neoplasm of the epithelial-reticular framework cells of the thymus. As in the normal thymus, these cells regularly displayed branching tonofilaments, macuale adherens, elongated processes, and basal lamina. These characteristics proved useful in the differential diagnosis of thymoma from a variety of anterior mediastinal tumors including thymic carcinoid, lymphoma, germinoma (seminoma type), and fibrous mesothelioma. Lymphocytes in the thymomas often showed mitotic activity and a moderate degree of transformation. The significance of this and the gland-like spaces, vacuolated epithelial cells, starry-sky appearance, emperipolesis, and perivascular spaces is discussed.
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PMID:The fine structure of thymoma, with emphasis on its differential diagnosis. A study of ten cases. 108 Sep 57

An initial clinical phase I trial of inosine dialdehyde has been carried out in 40 patients at dose levels of 30-4000 mg/m2 for 5 days given intravenously (iv) monthly. At 1.5 g/m2, noncumulative dose-related toxicity occurred in all patients which consisted of nausea and vomiting, local pain, alterations in coagulation mechanism, elevated partial thromboplastin time, and positive Coombs' test. No dose-limiting leukopenia, thrombocytopenia, anemia, or bleeding occurred; however, depression of the leukocyte and platelet counts, and decreased hemoglobin value were observed. The dose-limiting toxic effect was renal tubular damage with reversible acute renal failure in one of four patients who received 3000 mg/m2 iv for 5 days. Refractory hypercalcemia was controlled in three of three patients without tumor effect. Responses occurred in patients with seminoma, oat cell carcinoma, and melanoma. A starting dose of 2 g/m2 for 3 days monthly is recommended for phase II trials and a trial in lung carcinoma is now being conducted.
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PMID:Clinical phase I trial of inosine dialdehyde (NSC-118994). 110 41

Tumors of the testis are uncommon in childhood comprising only about 2% of all malignant tumors. Twenty-five children with testicular tumors seen in the last 25 yr had 11 orchioblastomas, nine differentiated teratomas, three paratesticular sarcomas, one seminoma, and one dermoid cyst. It must be stressed that, contrary to popular opinion, the prognosis for orchioblastoma is favorable today, eight of the 11 children with this condition have survived for more than 2 yr. Orchiectomy should be followed by rigorous treatment with anticancer chemotherapy for 1 yr. Excision of the para-aortic glands and radiotherapy are not beneficial in prophylaxis. Lymphadenectomy is indicated only if metastases are demonstrated by lymphangiogram. Patients who have survived for more than 2 yr should, in general, be regarded as cured.
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PMID:Testicular tumors in childhood. 111 82

The clinical and morphological features of 7 cases of anaplastic seminoma are reviewed. Although this tumor appears to behave more aggressively than classical seminoma, presenting with earlier metastases, it has the same prognosis when staging is taken into consideration. Radiotherapy remains the treatment of choice.
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PMID:Anaplastic seminoma. 114 5

A large retroperitoneal seminoma in a 42-year-old man is described, which appears to have arisen as a primary tumor at that site. The mechanism for the development of extragonadal germ cell tumors is discussed, and the criteria for their distinction from metastatic occult or regressed testicular neoplasms are re-emphasized. Awareness by clinicians of this entity may save individuals with this neoplasm from unnecessary orchiectomy.
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PMID:Primary retroperitoneal seminoma. Report of a case and review of the literature. 115 22


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