Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

1. Seminoma may occasionally be rapidly growing, aggressive, radioresistant, and chemotherapy-resistant tumor. 2. Alkylating agents have had the greatest number of trials and have produced the best response rates in the management of seminoma, but a wide range of other agents warrants trials. 3. Adjunct chemotherapy is a logical consideration in patients with stage II and stage III seminoma.
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PMID:Chemotherapy of seminoma. 86 94

Tumors may develop in both testes, either concomitantly or sequentially. We herein report 3 cases of bilateral testicular neoplasms. One patient had concomitant seminomas of the testes and another had sequential germ cell tumors separated by an 11-year interval. The third patient is an unusual case in that he had bilateral testicular germ cell tumors diagnosed concomitantly 8 years after irradiation of an extragonadal, histologically proved, seminoma in the mediastinum. Evidence suggests that all 3 sites, each testis and the mediastinum, were primary lesions. Standard methods of therapy should be used in the treatment of malignancies.
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PMID:Multiple germ cell tumors: reports of 3 cases, 1 with 3 primary lesions. 87 48

Two patients with advanced metastatic seminoma were treated with radiation therapy, triple-drug chemotherapy and radical surgical resection. In 1 patient the seminoma was radiation-recurrent and radiation-resistant, while in the second patient the metastatic seminoma encroached upon both kidneys and could not be irradiated initially for fear of bilateral radiation nephritis. Both tumors were reduced in size markedly by the chemotherapy and the residual mass was excised in each instance. One patient was free of the tumor 18 months after treatment, while the other patient had recurrence in a distant area after 16 months. The marked responsiveness of both tumors to triple-drug chemotherapy emphasizes the importance of an aggressive approach to advanced metastatic seminoma, including radiation therapy, chemotherapy and surgery.
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PMID:The response of metastatic retroperitoneal seminoma to chemotherapy. 87 49

Atypical spermatogonia are relatively frequent in the vicinity of testicular teratomas or seminomas. These voluminous cells are seminoma-like, showing broad and clear cytoplasm borders, big nuclei and peculiarly enlarged nucleoli. Atypical spermatogonia usually line the tubules and displace the remaining Sertoli cells towards the middle of the tubules. Recently, such atypical spermatogonia have been described in testicular biopsies performed for fertility disturbances. Two patients showing atypical spermatogonia developed, years later, malignant testicular tumors. Therefore, were checked all of our histological specimens from testicular biopsies over the period 1950-1976 for atypical spermatogonia. They originated from 1935 adult patients in whom biopsy had been performed, in general bilaterally, for fertility disturbances. In fact, atypical spermatogonia were found in the specimens of 9 patients, that is, 0.55%. Five of these patients developed malignant testicular tumours within periods ranging from months to six years, viz. three seminomas, one teratoma and one combined tumor, i.e. a teratoma and seminoma. The remaining four patients with atypical spermatogonia have shown no sign of tumor to date. As the results of our investigation show, atypical spermatogonia in testicular biopsies should not be taken lightly. We therefore strongly advise checks at short intervals on such patients in view of the high risk of their developing malignant testicular tumors.
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PMID:[Atypical spermatogonias as precancerous conditions]. 87 29

A patient with a pure seminoma presented with severe IgG-mediated warm autoimmune hemolytic anemia. Monoclonal IgM-kappa cryoglobulinemia and a biological false positive test for syphilis were also found. Treatment directed at both the seminoma and the hemolysis resulted in the complete disappearance of these antibodies. It is possible that these immunological phenomena occurred in response to the tumor. The occurrence of warm autoimmune hemolytic anemia and monoclonal paraproteinemia in association with solid tumors is reviewed.
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PMID:Transient warm autoimmune hemolytic anemia and cryoglobulinemia associated with seminoma. 90 60

Intratubular seminomas of the testis associated with solid tumors were studied by light and electron microscopy in order to obtain information about the earliest stage of emigration from the tubules and invasion of the interstitial space. Careful examination of numerous sections reveals that at this stage neoplastic cells protrude into evaginations of the tubule covered by basement membrance or directly invade that membrane. At the site of tumor cell emigration, the basement membrane is thickened and multilayered. Tumor cells devoid of basement membrane were found in the interstitium. Their transmigration through the basement membrane was never observed. Subsequent to the migration of seminoma cells the tubules are smaller in diameter and contain only Sertoli cells. From the observations described it is inferred that tumor cells in the interstitial tissue increase in number, form strands and lobules, and finally build up the solid tumor.
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PMID:On the histology of human seminoma: development of the solid tumor from intratubular seminoma cells. 91 48

A review of the experience with 134 consecutive patients with germinal cell testicular neoplasia indicates that definitively accurate staging of the malignancy at presentation is the single most important prognostic factor. Nearly two-thirds of the patients with all types of germinal malignancies survived or died of other causes and the highest survival rates were seen among patients with earlier stages of seminoma. In recent years patients with all types of germinal malignancies of the testis have been treated by radical retroperitoneal lymphadenectomy with enhancement of survivals. Patients with seminoma and non-seminomatous tumors exhibited increased survival rates with node dissection. In 66 consecutive lymphadenectomies the complication rate was less than 14 per cent, with only 1 death related to the operation. Retroperitoneal lymphadenectomy not only affords therapeutic advantage but also provides an opportunity for accurate surgical staging of disease and allows for rational decision relative to additional treatment, radiation therapy or chemotherapy.
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PMID:Germinal malignancies of the testis: experience, management and prognosis. 94 59

Histologically confirmed testicular tumors were diagnosed in 410 dogs from 12 North American veterinary university hospitals and clinics. Three tumor-cell types, Sertoli cell tumor, interstitial cell tumor and seminoma, were about equally represented. Several breeds were identified with high risk for different testicular tumor-cell types. Cytogenetic and immunogenetic studies of these dog families could offer leads applicable to familial testicular cancer in man. The multiplicity of breeds within the series suggests that, as in man, other factors, in addition to hereditary, play a role in etiology. Cryptorchid dogs appear to have a 13.6 times higher risk of testicular tumor than normal dogs. Additionally, male dogs with an inguinal hernia have an increased risk (4.7) of testis tumors. There were no detectable excesses of other urogenital anomalies or urogenital tumors among the series. The Shetland Sheepdog is suggested as an appropriate model for research into the mechanisms responsible for testicular maldescent and tumorigenesis.
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PMID:Canine testicular tumors: epidemiologic features of 410 dogs. 97 90

Testicular tumors in infants and children are rare and most of them are malignant. Embryonal carcinoma is the most common childhood neoplasm, while seminoma is predominantly found in adults. Hemangioma of the testis is an extremely rare tumor, only 2 cases having been reported in infants.
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PMID:Hemangioma of the testis in an infant. 97 33

Three sisters with XY gonadal dysgenesis are presented. All of them have primary amenorrhea and breast development, and in two, a gonadal tumor, seminoma (dysgerminoma) was found. The danger of gonadal neoplasm in XY females with normal female build is emphasized.
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PMID:Familial occurrence of gonadal tumors in XY females with breast development. 98 12


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