Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A herpes-type virus that was originally isolated from a cell culture (designated K9V) derived from a tumor biopsy specimen from a patient with Kaposi's sarcoma was partially characterized. The host range of K9V, as determined by the induction of virus-specific cytopathology, synthesis of antigens, and plaque formation, was limited to human cells and particularly to fibroblasts. Immunofluorescence and complement fixation assays confirmed the specificity of the presence of cytomegalovirus (CMV)-type antigens in K9V-infected human fibroblasts. In addition, the density of K9V DNA was consistent with the density of CMV DNA. However, some peculiarities were observed in the K9V strain of CMV. The virus seemed more cell-associated in human fibroblasts than were known laboratory strains: The spread of cytopathology was slow and did not always involve the whole cell sheet, and the total regression of cytopathology with the establishment of a persistent infection was common. Similar characteristics have recently been observed in the Mj strain of CMV, which has been shown to be oncogenic in human fibroblasts.
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PMID:Partial characterization of a herpes-type virus (K9V) derived from Kaposi's sarcoma. 19 73

Pathological, clinical, epidemiological and immunological aspects of a rare tumor, Kaposi's sarcoma, are briefly discussed. The prevalence of the disease in an African population raises questions about genetic and environmental factors in its carcinogenesis. Immunological data indicate a probable viral origin. The clinical patterns seem to be influenced by alterations of the immune defense mechanisms. Most questions about its biological behaviour remain to be answered yet.
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PMID:[Kaposi sarcoma. A short review on a rare disease]. 21 49

Neoplasms of blood and lymph vessels differ from angiectatic and angiokeratotic nevi by real proliferating growth. According to their features of growth and their wall structures, they are classified into three main groups: angiomas, glomangiomas and malignant vascular tumors. Within the angiomas on the one hand, capillary angiomas are classified into: planotuberous and tuberonodous angiomas of childhood and Kasabach-Merritt syndrome, multilocular hemangiomatosis, progressive multiple angiomas, tardive ("senile") angiomas, eruptive angiomas (granulomata pediculata), papular angioplasia, gemmangioma, and benign juvenile hemangioendothelioma. On the other hand, cavernous angiomas, i.e. arterial and venous cavernomas, as well as blue rubberbleb nevus, Mafucci's syndrome, angioleiomyoma, benign juvenile hemangiopericytoma and cavernous lymphangioma, form thick walled structures without involution. Glomangiomas occur as solitary, multiple systematized, and multiple disseminated and familiar forms. Within the group of malignant vascular tumors--Kaposi sarcoma, lymphangiosarcoma in lymphedema, hemangioendothelioma and angioplastic reticulosarcoma, hemangio- or lymphangiosarcoma, angioendotheliomastosis proliferans, rarity and increasing loss of characteristic differentiated structures give rise to difficulties in nosologic classification.
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PMID:[Classification of vascular neoplasms]. 21 13

A report of a case of Kaposi's sarcoma of the vulva is presented. A complete response of the tumor was obtained after 1 treatment cycle using a triple-drug chemotherapy regimen of actinomycin D, vincristine, and 5-(3,3-dimethyl-1-trazeno)imidazole-4-carboxamide (DTIC). Death occurred due to severe erythema multiforme, which was indirectly related to a complication of the chemotherapy.
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PMID:Kaposi's sarcoma of the vulva: a case report and brief review. 49 32

A case of Kaposi's sarcoma in a 60 year-old male was examined histologically and electron microscopically. Multiple hemorrhagic skin lesions were confined within the scalp. The major part of initial skin biopsies exhibited capillary hemangiomatous component, but examination of surgical materials confirmed its nature as hemorrhagic sarcoma. At autopsy, the skin lesions showed various histological pictures ranging from angiomatous or granulomatous to sarcomatous proliferation of spindle-shaped cells. Of intriguing findings were the bone marrow involvement and the pulmonary changes, the former consisting of typical sarcomatous lesion and the latter being characterized by purpuric appearance of the pleura responsible for the terminal pneumohemothorax. Electron microscopically, the tumor cells showed Weibel-Palade granules in the cytoplasm suggesting the endothelial nature. In this article, Japanese autopsy cases of Kaposi's sarcoma so far reported are summarized.
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PMID:Kaposi's sarcoma -- Case report and review of Japanese cases. 55 99

Kaposi's sarcoma was diagnosed in a 62 year old female at the last stage of an indefined malignant lymphoma. Clinically and histopathologically, some cutaneous aspects were consistent with mycosis fungoides. However, the histological examination of lymph-nodes led to the diagnosis of Hodgkin's disease, sometimes associated with features of Kaposi's sarcoma. During the past few years, the occurrence of Kaposi's sarcoma in the course of cancers, malignant lymphomas and especially during Hodgkin's disease, has been reported. It has been suggested that immunosuppressive therapy undertaken for the initial tumor could account for a viral carcinogenesis. In this respect, the vascular proliferation observed in Kaposi's sarcoma could be compared with the lymphocyte induced angiogenesis, which occurs during the experimental graft versus host reaction. Therefore, Kaposi's sarcoma could be the result of a tumoral rejection. In the case of our observation, it does not seem possible to diagnose an angio-immunoblastic lymphadenopathy; but it is of interest to note that, in this later disease, histological features of vascular neogenesis have also been reported.
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PMID:[Kaposi's sarcoma and malignant lymphoma. Discussion of this association (author's transl)]. 61 48

From 1975 to 1977 42 patients with advanced solid tumours were treated with imidazole-carboxamide (DTIC). It was applied in 18 cases as monotherapy: in the remaining patients it was administered in combination with other cytostatic agents. Tumour remission was recorded in 4/22 patients with melanoma, 2/2 with Kaposi sarcoma and 2/7 with soft tissue sarcoma. No change in tumour behaviour was recorded in 6/22 melanomas, 2/7 soft tissue sarcomas, 1/7 head and neck tumours and 1/1 thymoma. Side effects of DTIC monotherapy were comparably low. The optimum dosage and frequency of DTIC therapy have not yet been established. Combinations with other cytostatic agents are still being tested.
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PMID:[DTIC in the therapy of solid tumours (author's transl)]. 74 53

In Kaposi's sarcoma (K.S.) the regular metabolism between endothelial cell, extracellular matrix and fibrocyte is disturbed. Thereby the composition of the extracellular matrix change and via a feed-back to the CNS and hormonal system in return changes of endothelial cells and fibrocytes appear. Processing of misinformation sum up in transformation of fibrocytes to tumor cells and destruction of endothelial cells. Initial a widening of the interendothelial borders of the capillary bed seem to be of great importance for the pathogenesis of K.S., because for long time spaces lymphedemas preceed the tumor. With this immunoreactions occur which probably are accompanied by autoimmuno-processes
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PMID:[Light- and electron microscopical investigation on the pathogenesis of Kaposi's sarcoma (author's transl)]. 86 80

Kaposi's sarcoma is a systemic, multicentric and slowly progressing vascular tumor which usually affects the skin. Visceral involvement is common, may follow or precede the cutaneous involvement and rarely, may be the only manifestation of the disease. Gastric sarcomatous lesions are characterized by the presence of multiple submucosal or intraluminal nodules affecting a part or the entire stomach and simulating large gastric rugae. A case of isolated gastric Kaposi's sarcoma affecting the greater curvature of the stomach is presented, illustrated and discussed together with a short review of the pertinent literature.
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PMID:The radiology corner: Kaposi's sarcoma of the stomach. 87 56

There is increasing evidence that the use of hyperthermia alone or in conjunction with other modalities may improve the therapeutic effectiveness of treatment of cancer. The present clinical studies were carried out to evaluate the response of normal and tumor tissues in patients with various cutaneous malignant lesions to repeated courses of hyperthermia alone or in conjunction with radiation therapy. Thirty-six patients with malignant cutaneous lesions (mycosis fungoides, Kaposi sarcoma, malignant melanoma, lymphoma cutis, and other metastatic skin lesions) have been studied. The heating methods used were: 1) temperature regulated water bath immersion; and 2) radiofrequency inductive heating. The normal tissue effects of the combined treatments of radiation and hyperthermia do not appear to be greater than those treated with radiation alone. The initial tumor regression rates were faster in patients treated with radiation plus hyperthermia than in radiation alone, particularly in patients with Kaposi sarcoma and lymphoma cutis. Among ten locally recurrent patients, seven showed significant prolonged benefits achieved by the combined treatments as compared with the radiation therapy alone. Fractionated hyperthermia alone caused significant tumor regression in four out of five patients. Possible mechanisms leading to the improved results from the combined treatments are discussed.
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PMID:Local tumor hyperthermia in combination with radiation therapy. 1. Malignant cutaneous lesions. 88 May 48


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