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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In order to estimate end effects of chronic prolonged gammairradiation of dogs, an exposure of 80 animals to irradiation was terminated and they were followed up closely. Out of 80 animals 30 dogs (1st series) were irradiated for 3 years and 50 dogs (II series) for 6 years. The dogs were exposed to irradiation at doses of 21 to 190 rad per year. Out of the total number of animals 22 dogs died. Post-mortem examinations showed neoformations in 13 animals (7 malignant and 12 benign neoformations). The highest number of tumors developed in dogs of the II series (10 out of 11) one-two years after irradiation (6 malignant tumors--malignant pheochromocytoma of adrenals; malignant adenoma of the hypophysis: polymorphocellular sarcoma of the liver; leucomyosarcoma of the uterus; bladder cancer; breast cancer; and 10 benign tumors--pancreatic adenoma; liver angioma; 2 papillary adenomas of the prostate; 3 renal adenomas; lipoma; polyps of the gall-bladder). Animals of the 1st series displayed 3 neoformations (1 malignant tumor--bladder tumor and 2 benign tumorsliver hepatoma and spleen angioma) 4--5 years after irradiation.
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PMID:[Formation of neoplasms in dogs after chronic gamma irradiation at a low-intensity dose]. 64 24

Plasma dopamine beta-hydroxylase (DBY) activity, urinary catecholamine (CA) and vanillylmandelic acid (VMA) were studied pre- and postoperatively in 20 patients with pheochromocytoma. Preoperative plasma DBH activities were distributed widely, ranging from normal to very high; the mean value of DBH as well as urinary CA and VMA was significantly greater than that of normal subjects. Postoperative falls of plasma DBH activity, of urinary CA and of VMA were by 76%, 96% and 83% of the preoperative level, respectively. Significant correlations were observed between postoperative falls of individual DBH activities, urinary VMA and weight of the tumors, whereas there was correlation neither between preoperative DBH activity and urinary CA, nor between the rate of postoperative falls of these respective values. These findings suggest that pheochromocytoma is capable of secreting DBH, and wide variations in the rate of DBH output from these tumors may account for varying capacity of CA biosynthesis in the tumor. Further, it may be concluded that the process of exocytosis plays an important role in the mode of CA secretion by these tumors, although secretion through diffusion may be operating as well.
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PMID:Exocytosis plays an important role in catecholamine secretion from human pheochromocytoma. 64 77

A case in which a pheochromocytoma secreted vasoactive intestinal peptide, causing WDHA syndrome, is reported. The patient, a 43-year-old woman, was seen because of intractable watery diarrhea, hypokalemia and weight loss. She was found to have a mass in the right adrenal area. Preoperatively, vasoactive intestinal peptide levels were elevated, and the diagnosis of WDHA syndrome was entertained. Exploratory laparotomy revealed a tumor of the right adrenal gland, measuring 15 x 15 cm, which was resected. Histologic examination revealed it to be a pheochromocytoma. Postoperatively, vasoactive intestinal peptide returned to normal. The patient had complete remission of symptoms, and has remained well since.
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PMID:WDHA syndrome caused by pheochromocytoma: report of a case. 65 43

As pheochromocytoma sometimes is accompanied by medullary thyroid carcinoma (in the sense of multiple endocrine adonomatosis type II = Sipple-Syndrome), serum calcitonin (CT) was measured by radioimmunoassay in 4 patients with pheochromocytoma. Before extirpation of the adreno-medullary tumor, serum CT was distinctly increased to 3 and 30 ng/ml in 2 of 4 patients, respectively. After removal of the tumor, serum CT was normal in the patients and pentagastrin stimulation produced no exaggerated CT response. In hydrochloric acid extracts from the two corresponding pheochromocytoma tissues, immunoreactive-Calcitonin (IR-CT) was detected, the concentrations amounting 1 and 4 ng/mg wet tissue. These findings suggest that hypercalcitonism in patients with pheochromocytoma cannot always be ascribed to the thyroid, i.e. increased calcitonin levels do not necessarily indicate a medullary carcinoma of this organ.
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PMID:Hypercalcitoninaemia in patients with pheochromocytoma. 67 41

A hypovascular pheochromocytoma not visualized by nephrotomography or arteriography but demonstrated successfully by computerized axial tomography is described. We propose that this non-invasive test be used alone or in conjunction with other modalities to assist in the localization of this elusive and potentially fatal tumor.
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PMID:Localization of pheochromocytoma by computerized axial tomography. 68 55

Pheochromocytoma is a tumor that characteristically arises in the adrenal medulla. Extra-adrenal tumors make up approximately 10 per cent of all pheochromocytomas, with those occurring in the organ of Zuckerkandl being the most common. Others may occur anywhere along the sympathetic chain, including a number of reported cases in the bladder. A case is reported in which the tumor occurred deep in the presacral pelvic area, retroperitoneal and retrorectal, a so-called Middeldorpf tumor. Its rare presentation and technical demand of its removal underscore the importance of preoperative and intraoperative medical and pharmacologic management.
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PMID:Pheochromocytoma presenting as middeldorpf tumor: case report. 68 56

The PC12 pheochromocytoma line is a clonal line derived from a rat adrenal medullary tumor. PC12 cells grown in vitro have morphologic and cytochemical features in common with normal chromaffin cells in varying stages of development, and with human pheochromocytomas. These features include catecholamine stores demonstrable by formaldehyde-induced fluorescence and argentaffinic secretory granules, measuring 30 to 350 nm. Dark "norepinephrine"- and light "epinephrine"-type granules are both present, despite the absence of epinephrine and of its synthesizing enzyme, phenylethanolamine N-methyltransferase. Addition of nerve growth factor to the culture medium causes the cells to stop dividing and to develop neurite-like processes. Nerve growth factor-treated cells also develop clusters of 30- to 120-nm. granules and of 30- to 70-nm. granular and agranular vesicles, which resemble the granules and vesicles in adrenergic and cholinergic neurons and in neuroblastomas. In the early stages of process formation, formaldehyde-induced fluorescence can be demonstrated both in cell bodies and in processes. In later stages there is a marked diminution of formaldehyde-induced fluorescence in cell bodies and processes and a decreased number of granules in cell bodies, except in occasional cells within large clumps. These residual, fluorescent, granule-containing cells also remain argentaffinic. Alterations of the cell surface and of cytoplasmic filament arrangements also occur in cells treated with nerve growth factor. Further studies of the PC12 line may help to clarify relationships between morphology and function in the developing and mature autonomic nervous system, and the influence of nerve growth factor on these relationships.
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PMID:Morphologic and cytochemical properties of a clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. 68 2

For the first time, to our knowledge, a patient with a functioning pheochromocytoma was subjected to gel foam embolization for physiologic destruction of the tumor. The operation, 24 hours later, provided an uneventful anatomic removal of the infarcted tumor. Observation was considered as a possible alternative to surgical excision. Experience gained may allow testing of the validity of a nonoperative approach in selected cases.
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PMID:Gel foam embolization of a functioning pheochromocytoma. 70 15

An autopsy case of malignant pheochromocytoma arising in the organ of Zuckerkandl is reported, of which distant metastases were found in the liver and lymph nodes. The biochemical and electron microscopic findings from the tumor tissue showed noradrenaline-secreting type. It was revealed that sex ratio in malignant pheochromocytoma was more prominent in the female, and the frequency of extra-adrenal origin was higher in malignant pheochromocytoma than in benign one from comparative study of reported cases of malignant pheochromocytoma.
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PMID:Malignant pheochromocytoma arising in the organ of Zuckerkandl--a clinicopathological study. 73 11

The authors describe one case of paraganglioma of the posterior mediastinum successfully removed after being discovered accidentally in a young male patient who showed no symptoms attributable to the tumor. The latter was a round mass, about 6 cm in diameter, richly vascular, located in the right costomediastinal gutter. Histologically it was a functionally silent paraganglioma originating from the intrathoracic aortosympathetic paraganglia, these being part of the very numerous groups of the paragangliar system distributed segmentally into metamers, particularly in the adrenal medulla. According to the more recent views, chemodectoma or paraganglioma (chromaffine or non-chromaffine, functionally active or silent) and pheochromocytoma (functionally active or silent, adrenal or extra-adrenal) constitute a group of tumors sharing the same tissue matrix, namely paragangliar cells.
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PMID:[Paraganglioma of the posterior mediastinum (author's transl)]. 75 31


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