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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Blood catecholamine assays have been used for diagnosis and computerized axial tomography for localization of proved pheochromocytomas in a series of 16 patients. Blood catecholamine assays were obtained in 15 of the patients and were significantly elevated in every instance. Successful localization of the tumor was accomplished by excretory urography in only 40 per cent of the cases, by selective angiography in 84 per cent of the cases and by abdominal computerized axial tomography in 84 per cent of the cases studied. In 4 patients preoperative identification and localization of tumor were correctly determined by computerized axial tomography alone. Data in this series suggest that the diagnosis and localization of pheochromocytoma usually can be accomplished by a simple test and body scan. More elaborate and sometimes hazardous studies should be necessary only in exceptional cases, usually with tumors less than 3 cm. in diameter.
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PMID:A new simplified approach to the diagnosis of pheochromocytoma. 50 7

We describe a case of an asymptomatic patient with a huge left abdominal mass, which at operation was found to be a cystic pheochromocytoma weighing over 3,000 gm. A dignosis of sarcoidosis was established simultaneously, with the discovery of sarcoid granulomas in abdominal nodes and within the tumor mass itself. This is only the second observation of coexistent sarcoidosis and pheochromocytoma, and with the paucity of related literature, we conclude the association is probably fortuitous.
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PMID:Giant pheochromocytoma with sarcoidosis. 51 76

Five cases of pheochromocytoma are described in which sudden death was the form of the initial clinical presentation in almost all of them. After a brief review on the history and the incidence of the tumor within the general population, diverse cases are analyzed from a clinical point of view and in relation to the data appeared in the literature. In the analysis of the symptoms emphasis is placed on the important psychomotor manifestations which are present in the majority of those patients and which causes serious difficulties in the initial diagnosis. All of the patients showed signs of shock at the time of being observed or during the course of this observation, and in the majority of them the presence of acute pulmonary edema was confirmed; facts which we attribute to an initial hypertensive episode associated to a left heart failure. The onset of the crisis in two patients was related to known triggering factors: anesthesia and sulpiride. In other two patients associated conditions were diagnosed: medullary carcinoma of the thyroid gland in one of them, and cystic necrosis of the middle layer of the aorta in the other.
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PMID:[Pheochromocytoma and sudden death (author's transl)]. 52 72

Aberrations in the metabolic pathways of catecholamines in patients with neural crest tumors result in characteristic urinary excretion patterns of their catabolites. Tumors such as pheochromocytoma, neuroblastoma and ganglioneuroma usually defy clinical diagnosis because of their rarity, small size, intraabdominal position and clinical symptoms similar to those of essential hypertension. Quantitative determination of catecholamine metabolites such as vanillylmandelic acid (VMA) and 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG) offers possibilities for reliable confirmation of diagnosis. However, previous techniques for the assessment of catabolite levels suffered from inadequate sensitivity, reproducibility or specificity, which seriously diminished their usefulness as biochemical determinants in the prognosis of these life-threatening tumors. Reported in this paper is the analysis of urinary levels of VMA and MHPG using reversed-phase high-performance liquid chromatography with electrochemical and sectrophotometric detection. We present the excretion patterns showing these metabolites in 15 control subjects, 15 patients with pheochromocytoma and 5 patients with neuroblastoma.
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PMID:Diagnosis of neural crest tumors by reversed-phase high-performance liquid chromatographic determination of urinary catecholamine metabolites. 54 40

When there is a posterior mediastinal mass on a chest X-RAY, a neurogenic tumor is usually evocated. However the occurrence of several other tumors is possible and they should be looked for preoperatively. The literature on the subject is very scarce. We report three cases of uncommon posterior mediastinal tumor. A bronchogenic cyst located between the trachea and the esophagus is described in a two months old girl. The diagnosis is made by tracheoscopy and esophagal contrast study. The anatomic situation explains why even a small tumor induces severe respiratory troubles and requires urgent treatment. An esophageal cyst is described in a 13 year old boy--the mediastinal mass is found incidentally on a routine chest X-RAY because of the risk of complications, the resection of this cyst is required and usually easy when they are intramural. A mediastinal pheochromocytoma is described in a five years old girl. The tumor is discovered during the investigation of a hypertensive syndrome. This location is very uncommon and may be unique or associated with more usual locations. The resection is delicate because of the situation of the tumor in the upper mediastinum. The preoperative angiogram is very helpful in deciding the operative approach.
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PMID:[Rare posterior mediastinal tumors in children (author's transl)]. 54 82

Four cases describing the use of enflurane as the main anesthetic during surgical removal of pheochromocytoma (PCC) are presented and the preoperative preparation and intraoperative management of the patients are discussed. Serum levels of epinephrine and norepinephrine were measured in 3 of the reported cases. Intraoperative values were extremely elevated during tumor manipulation, but there was only 1 minor episode of arrhythmias. Criteria for choosing anesthetic agents for surgical removal of PCC are outlined. The authors conclude from their experience and that of others that enflurane is as safe and effective an anesthetic as any now available for PCC excision.
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PMID:Enflurane anesthesia for surgical removal of pheochromocytoma. 55 11

A urinary tract infection with possible septicemia and endocarditis developed in a 36-year-old man. The illness was complicated by pulmonary embolism, thrombocytopenia, hematemesis, hepatic dysfunction, paralytic ileus and accelerated hypertension. The latter finding suggested pheochromocytoma. Treatment with antibiotics and phenoxybenzamine hydrochloride was associated with notable clinical improvement. A chromaffin cell tumor was surgically removed above the lift kidney. Conclusively, a pheochromocytoma may mimic and be present in association with infection.
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PMID:Infection and pheochromocytoma. 57 92

A young woman with hypoplastic right heart syndrome developed a carotid body tumor at age 28. High altitude habitation is known to predispose to hyperplastic and neoplastic carotid bodies; emphysema and congenital cyanotic heart disease have recently been shown to induce hyperplasia of this oxytrophic tissue. Therefore, a link between congenital cyanosis and carotid body tumor is suggested by this patient. Carotid bodies are nonchromaffin paraganglionic analogues of the adrenal medulla. Congenital cyanosis has an association with pheochromocytoma. In the cyanotic milieu carotid body tumor may be a histological analogue of pheochromocytoma.
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PMID:Cyanotic heart disease: "low altitude" risk for carotid body tumor? 62 92

Pheochromocytoma is a tumor derived from chromaffin tissue, which secretes catecholamines. Today, about 90 percent of patients with this tumor are cured by surgical procedures. In 8 to 15 percent of patients with this tumor there is unresectable, recurrent or metastatic disease, which causes significant morbidity and mortality. The natural history of metastatic disease includes long-term survivors; many, however, die early of disseminated disease. The most common site of metastatic lesions is the skeleton. Palliation for these lesions can often be achieved with the use of radiation therapy. Other sites are, in general, less responsive to radiation therapy. Chemotherapy has been used in combination with radiation therapy, but the results generally have been disappointing. Chemotherapy with doxorubicin hydrochloride and cyclophosphamide in combination with radiation therapy has provided good palliation for skeletal disease for about five months, when disease progression was again noted. Further information is needed concerning the optimal chemotherapeutic treatment of this unusual tumor.
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PMID:Treatment of malignant pheochromocytoma. 62 48

A comparison is made between epidemiological features found in a group of 14 patients with familial and nonfamilial pheochromocytomas at M. D. Anderson Hospital and Tumor Institute. The Sipple syndrome (familial) group comprised eitht patients from three different families, and the nonfamilial group consisted of six nonrelated patients. The main differences were noted in the age of onset, sex ratio, bilaterality, malignant behavior, and occurrence of a second nonendocrine primary tumor. An attempt was made by light microscopy to define features that would indicate malignant behavior. No such features could be delineated. Survival time was unrelated to the presence of pheochromocytoma except in operative and investigative procedures.
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PMID:A comparative study of 14 cases of familial and nonfamilial pheochromocytomas. 64 Jun 43


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