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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Neck tumors developing from the paraganglion system are best called paragangliomas. They may be described further as to site of origin and as to whether they are functioning or nonfunctioning. Review was made of 116 cases in which operation for paraganglioma was performed at the Mayo Clinic. The diagnosis depends upon demonstration of a lateral neck mass, elimination of other causes, and a tumor blush on angiography. Screening tests should be done to determine whether the tumor is producing epinephrine. Surgical management should be selective, depending upon the location and involvement of surrounding structures, particularly the carotid artery system. A conservative approach is indicated for those patients whose tumor surrounds the carotid vessels, because the risk of complications is greater than the risk of leaving the tumor in the neck. Conservatism is also indicated for patients in the older age group, because of the slow growth of these tumors and the low incidence of malignancy.
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PMID:Paragangliomas of the neck: clinical and pathologic analysis of 116 cases. 86 24

Solitary pulmonary paraganglioma is rare; this is only the eleventh reported case. The tumor grows slowly and may reach a diameter of 9 cm. The treatment includes local resection or lobectomy according to the size and location.
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PMID:Solitary pulmonary paraganglioma: case report and literature review. 91 Nov 3

Six cases of upper intestinal gangliocytic paraganglioma, five in the duodenum and one in the jejunum, are reported. Three histologic patterns, each comparable to patterns in paraganglioma, ganglioneuroma, or carcinoid-islet cell tumor, are mixed in varying proportions. The complex histologic patterns encountered within these tumors reflect the differentiation of pluripotent cells. Although the parent cell is not identified in this study, gangliocytic paragangliomas may arise from cells which normally reside in the mucosal crypts and are presumably derived from cells originating in the neural crest. Three of the six tumors contain stromal amyloid. In one case, studied by electron microscopy, dense-cored cytoplasmic vesicles almost fill some of the tumor cells. Gangliocytic paragangliomas share the features of stromal amyloid and dense-cored vesicles with other neurocrine tumors.
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PMID:Gangliocytic paraganglioma. 92 Aug 68

A case of primary paraganglioma of the lung in a 63-year-old woman is presented. The tumor arose from a segmental pulmonary artery and had typical epithelioid cell nests in a "Zellballen" pattern surrounded by reticulum. An electron microscopic study revealed cytoplasmic neurosecretory granules. As in eight previously reported cases, in the English literature, the tumor was benign. The tumor has occurred in seven women and two men with an age range of 43 to 69 years. All patients were asymptomatic, and the diagnosis has never been made prior to operation.
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PMID:Primary pulmonary paraganglioma: report of a case and review of the literature. 92 69

Glomus intravagale (paraganglioma of the nodose ganglion and/or vagus nerve) is an unusual tumor. There are approximately 45 cases reported in the literature; the authors report four more cases. This tumor may ba associated with other paragangliomas of the head and neck, such as carotid body tumors, and may metastasize to regional lymph nodes, although the histology always appears benign.
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PMID:Glomus intravagale. 92 74

A patient with a most unusual neoplasm of the bladder, a paraganglioma, is presented herein. A combination of episodes of hypertension during or immediately after micturition associated with hematuria is almost pathognomonic of this condition. The patient presented with hematuria only. Less than 7 per cent of all reported cases have a malignant course. The proper treatment appears to be partial cystectomy with wide margins of the affected area, being prepared for wide fluctuations in blood pressure in those patients who have elevated catecholamine levels preoperatively.
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PMID:Paraganglioma of the bladder: report of a case. 111 94

A 63-year-old female had frequent attacks of palpitations with sweating and occasional loss of consciousness for 7 years before admission. These symptoms and documented hypoglycemia (blood glucose: 46 mg/dl) suggested insulinoma, but computed tomography demonstrated a retroperitoneal tumor which was diagnosed as a paraganglioma by histological examination of the resected specimen.
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PMID:Paraganglioma associated with hypoglycemia. 128 35

A 52-year-old female was admitted to our hospital with left anterior chest pain. On physical examination, an elastic hard mass sized in 3.0 x 2.5 cm was palpable at the left suprasternal area. Chest X-ray film showed a large mass shadow in the cervico-thoracic region, and CT films revealed a well-defined mass in the superior mediastinum which was heterogeneously enhanced by contrast medium. Operation was performed under the preoperative diagnosis of thymic tumor extending upwards. At operation, the tumor was located between the trachea and the left subclavian artery in the superior mediastinum displacing these structures and extending to the neck. Resected specimen which was 5.5 x 3.5 x 3.0 cm in size and 42 gm in weight was well encapsulated and highly vascularized. On microscopic findings, the tumor was finally diagnosed as paraganglioma. According to the classification of Glenner and Grimley, it was thought that the tumor originated from subclavian paraganglion in the superior mediastinum. Subclavian paraganglioma had rarely been reported in the literatures. As subclavian paraganglioma, our patient was the first reported case in Japan.
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PMID:[A case of subclavian paraganglioma in the superior mediastinum extending to the neck]. 131 75

Neuroendocrine neoplasms of the larynx have either an epithelial or a neural basis. The former are more numerous and are classified as typical or atypical carcinoids and small cell neuroendocrine carcinomas. Paraganglioma is the sole type of neural neuroendocrine neoplasm. There is a significant worsening of prognosis from typical carcinoid to small cell neuroendocrine carcinoma, with the latter having a dismal 5-year survival rate regardless of therapy. Paragangliomas are the most benign of laryngeal neuroendocrine neoplasms, but their clinical behavior may not be predictable on the basis of their histologic appearance.
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PMID:Neuroendocrine tumors of larynx. 132 30

To our knowledge the case which is reported is the seventh glomus tumor described so far. The mass was located in the ethmoidal cavity and a spreading to the nasal cavity and choana. Firstly, the patient was supposed to have a polyposis naso-sinusal due to the symptom. After being operated (maxillo-ethmoidectomy trans-sinusal technique) the light and electron microscopic descriptions of the mass which was excised, showed the real diagnosis "glomus tumor". The patient stopped coming to the controls one month after the first operation. He did not consult us until eight months later. It was found by TC a recurrence of the tumor. The patient did not complain of any symptoms. He was operated again (external ethmoidectomy technique) and the mass was completely removed. Eventually, the think that it is very important to distinguish the "glomus tumor" (the one which has just been described) from the non-chromaffin paraganglioma or chemodectoma.
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PMID:[A glomus tumor of the nasal fossa and ethmoid sinus]. 132 75


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