Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 47-year old man developed chronic unilateral iridocyclitis with secondary glaucoma, and increased plasma carcinoembryonic antigen levels. The eye was enucleated seven months later, and histopathologic examination revealed a metastatic mucin-producing carcinoembryonic antigen-positive adenocarcinoma. The patient died one year after the initial onset of symptoms. The primary site of the tumor was not proven, but most likely was the gastrointestinal tract.
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PMID:Metastatic adenocarcinoma to the anterior uvea and increased carcinoembryonic antigen levels. 56 33

Antibody-dependent cell-mediated cytotoxicity (ADCC) against human colon carcinoma cells grown in vitro was demonstrated with two specific rabbit anti-carcinoembryonic antigen (cea) antisera. The same antisera did not lyse the colon carcinoma cells in the presence of complement but without lymphocytes. The normal human lymphocytes in the absence of anti-CEA antiserum had a very low cytotoxic activity during the three hours 51Cr release assay used in this study. Two colon carcinoma cell lines, HT-29 and Co-115, expressing CEA on their surface as demonstrated by immunofluorescence, were significantly lysed in the ADCC test, whereas control tumor cell lines, not expressing CEA, were not affected by the anti-CEA sera and the lymphocytes. The specificity of the reaction was further demonstrated by the inhibition of antibody-dependent cell-mediated cytotoxicity after the addition of increasing amounts of purified CEA to the antiserum. The absorption of the anti-CEA antisera was controlled by radioimmunoassay. Absorption of the antisera by normal lung extracts and red cells of different blood groups did not decrease the cytotoxicity.
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PMID:[Antiserums against carcino-embryonic antigen (CEA) can induce a specific lysis of colon carcinoma cells by normal lymphocytes]. 56 64

To demonstrate the presence of specific antigens in the normal and malignant gastric juice the immunological and chemical features of certain antigens with glycoprotein structure from malignant gastric jucice and gastric tumors were studied comparatively with those of antigens obtained from normal gastric juice and gastric tissue. The investigation was carried out in tumor tissue extracts from 7 patients with malignant gastric tumors and in gastric juice from 45 patients with other non-cancerous diseases. From the five fractions obtained, which gave immunoelectrophoretic precipitin lines in the beta and alpha-globulin regions with the antiserum against total normal gastric juice, a single specific was separated by means of successive chromatographies on sephadex G--100 and DEAE-Sephadex -a--50 (eluted in NaCl concentration gradient). This fraction represented 11.1 per cent of the total proteins. None of the five fractions could be identified with carcinoembryonic antigen (value in gastric juice and gastric malignant tumors = 2 to 10 ng per mg lyophilized products).
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PMID:Antigens with glycoprotein structure in the gastric juice. I. Immunological and chemical determinations. 63 6

Serial carcinoembryonic antigen (CEA) measurements were evaluated in a group of 263 patients undergoing systemic chemotherapy for metastatic colorectal carcinoma. Initial CEA levels were not found to be of value in predicting the likelihood of subsequent tumor response. Although a general relation between serial CEA measurements and clinical tumor measurements was noted, these measurements were discordant in a substantial proportion of patients. Tumor measurements as an index of response to therapy were strongly correlated with survival, whereas changes in CEA values and patient survival were not correlated at a statistically significant level. Serial CEA measurements were perhaps of some value in predicting progression of malignant disease, and were roughly comparable to serum alkaline phosphatase assay in assessing response of liver metastasis to chemotherapy. Overall, serial CEA measurements added little to the standard clinical assessment of patients with advanced colorectal carcinoma receiving chemotherapy.
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PMID:Serial plasma carcinoembryonic antigen measurements in the management of metastatic colorectal carcinoma. 64 45

A long-term postoperative carcinoembryonic antigen (CEA) follow-up study is carried out with patients having undergone primary resection of histologically proved adenocarcinomas of the gastrointestinal tract. Up to now, 122 patients who underwent curative resections, as judged from the situs and the results of histologic examinations, were followed up for tumor recurrence by computerized CEA surveillance diagrams and clinical diagnostic methods. In the cases of tumor recurrence the rise of the CEA level preceded a positive clinical diagnosis by a mean of 4 months. On the basis of the CEA time course, we selected 28 patients for second-look surgery. In all cases proof of recurrence of the disease was obtained. A local recurrence correlating with a slow CEA rise was generally resectable, metastases correlating with a rapid CEA rise were only in some cases resectable, provided that second-look surgery was carried out without delay.
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PMID:Carcinoembryonic antigen follow-up and selection of patients for second-look operation in management of gastrointestinal carcinoma. 65 74

A modified CEA-Roche kit was used to determine the pretreatment value of carcinoembryonic antigen (CEA) in patients with intraepithelial neoplasia and invasive squamous cell carcinoma of the cervix. A positive correlation between tumor volume and CEA levels was found in patients with invasive disease, and patients with intraepithelial neoplasia also had elevated levels compared with a reference material of blood donors. Pre- and posttreatment levels were measured in 156 patients with invasive lesions, and a significant response to treatment was seen in 80%. The resutls of this study indicate that any pretreatment level can be of interest in the followup of patients with squamous cell carcinoma of the cervix.
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PMID:Carcinoembryonic antigen levels in patients with squamous cell carcinoma of the cervix. 65

A 58-year-old white male with a history of bronchogenic carcinoma presented with a total retinal detachment overlying a choroidal metastasis. His main tumor burden had been extirpated by pneumonectomy followed by radiation therapy four months prior to admission. With the development of a painful, glaucomatous eye, unresponsive to conventional therapy, enucleation was performed. Histologic examination of the enucleated globe revealed a metastatic tumor to the choroid, consistent with primary bronchogenic carcinoma. Aqueous humor and plasma examination revealed elevated ratios (Aqueous humor:Plasma) of lactate dehydrogenase (LDH) and phosphoglucose isomerase (PGI). Furthermore, subretinal fluid examination demonstrated concentrations of LDH and PGI higher than aqueous humor. While the level of carcinoembryonic antigen (CEA) in the plasma was normal (less than 2.5 ng/ml) following pneumonectomy, it was 121 ng/ml in the subretinal fluid. This would suggest that a choroidal lesion alone, in the absence of a clinically detectable primary tumor, is insufficient to elevate the plasma CEA.
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PMID:Subretinal fluid examination of LDH, PGI, and CEA in a case of metastatic bronchogenic carcinoma of the choroid. 65 94

Medium from primary cultures of human prostatic cells was examined for polyamines and carcinoembryonic antigen. Spermine was elevated in medium from 5 of 17 epithelial cell cultures but was not found to be a specific marker for cultured human prostatic epithelial cells. Carcinoembryonic antigen was elevated in all 27 prostate epithelial-cell culture fluids tested, 24 of which had more than 20 ng. carcinoembryonic antigen per milliliter. Medium from other cultured human cells (prostate fibroblasts, genitourinary tumor and non-tumor cells), as well as control medium, contained less than 1 ng. carcinoembryonic antigen per milliliter. Carcinoembryonic antigen, as measured in this study, is a way to demonstrate the presence of human prostatic epithelial cells in culture.
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PMID:Biochemical markers of cultured human prostatic epithelium. 66 Jul 62

41.5% of 200 newborn infants had levels of carcinoembryonic antigen (CEA) in excess of 2.5 ng/ml in their cord plasma. There was no direct correlation with the maternal CEA level although the frequency of elevated CEA was significantly greater among infants born to mothers with CEA levels greater than 2.5 ng/ml. There was no preponderance of high CEA levels among infants with low birth weights and there was no influence of maternal smoking on a cord CEA level. There was a tendency toward an increased incidence of cancer in families with infants who had elevated CEA levels and a reverse trend was noted with respect to diabetes; however, these associations were not statistically significant. We were unable to define clearly the factors accounting for the persistent elevation of this oncofetal antigen at birth; however, the possible association with susceptibility to the development of neoplasia merits further study.
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PMID:Elevated levels of carcinoembryonic antigen in cord plasma. 66 94

Our patients have demonstrated that serial carcinoembryonic antigen determinations contributed to the detection of recurrent tumor and that shortening the delay between carcinoembryonic antigen elevation and reoperation has resulted in an increase from 27 to 78 per cent in instances of resectable recurrent tumor encountered. If these results continue to be substantiated, the carcinoembryonic antigen assay has made a significant contribution in the control of this disease. Serial carcinoembryonic antigen assays should be performed every two months. All benign inflammatory conditions that cause carcinoembryonic antigen elevations must be searched for, and ruled out, before reoperation is decided upon. The physician must be cognizant not only of the significance of the assay but also of the limitations, and he must rely heavily on his clinical judgment.
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PMID:The use of serial carcinoembryonic antigen determinations to predict recurrence of carcinoma of the colon and the time for a second-look operation. 68 71


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