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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The chromosomes in 15 cell lines derived from separate tumors induced in rats by ethylnitrosourea (ENU) are described. Thirteen lines were neural (glioma or schwannoma) in origin and type. In 12 of these lines, excess chromosome no. 4 could be demonstrated by Giemsa banding. One to three extra no. 4 chromosomes were seen as numerical or structural abnormalities. Also noted were other changes that were not consistent among lines. The 12 lines produced tumors in newborn rats. The 13th neurogenic line lacked excess chromosome no. 4 and did not produce tumors. The remaining 2 lines were nonneurogenic and lacked excess chromosome no. 4 but produced tumors. Control studies included chromosome analyses of bone marrow preparations from ENU-treated rats with tumors, cell lines from brains of normal rat embryos, and 2 established nonneurogenic rat tumor lines. No excess chromosome no. 4 was seen. These results suggest that nondisjunction and/or rearrangement of chromosome no. 4 is associated with the oncogenic process in neurogenic tumors induced.
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PMID:Excess chromosome no. 4 in ethylnitrosourea-induced neurogenic tumor lines of the rat. 56 44

A neurinoma of the terminal ileum was discussed. It was as large as an infants head and had descended to the lesser pelvis where it became lodged. An intestinal loop became clamped by this mass causing ileus. The mass also compressed theurinary bladder producing dysuria. Even though the neurinoma is quite a rare phenomenon in clinical practice, it deserves attention because of the difficulty with which it can be diagnosed, and because of the complications it can cause; Among them ileus, and hemorrhaging are the most common. Acute peritonitis due to perforation of the infected pseudocysts in the center of the tumor is a significantly rarer phenomenon, and malignant alterations are the rarest complications. As only a few cases of neurinomas of the small intestine have been described in world literature, the authors hope to contribute to a better understanding of this problem.
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PMID:[Neurinoma of the small intestine]. 56 91

We used a new immunocytoadhesion method to test 15 different tumors of the human nervous system to see whether medulloblastomas share tumor-associated surface antigens (TSA) with other tumors. Antisera against medulloblastoma cells were raised in rabbits. One antiserum was adsorbed extensively with tonsil and adenoid cells and with cerebral tissues. Freshly isolated cells from 15 different tumors were first sensitized with the adsorbed antiserum and then rosetted with erythrocytes coated with purified antibody to rabbit immunoglobulin. We found that the antimedulloblastoma antiserum detected TSA on the immunizing medulloblastoma cells and on cells from 2 other medulloblastomas, but apparently not on cells from other tumors (astrocytomas, glioblastomas, neurinoma, meningiomas and craniopharyngioma). In addition, the antiserum probably detected the medulloblastoma TSA on some other tumors (oligodendroglioma, ependymoma and malignant glioma of mixed type).
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PMID:Comparison of tumor-associated surface antigens on cells from medulloblastomas and from other neoplasms of the human nervous system. 56 78

This paper deals with 2 cases of peripheral facial paralysis, due to intratemporal facial neuroma of tympanic (case No. 2) and vertical (case No. 1) segments of the Fallopian canal. The authors present a literature review of the intratemporal facial neuromas with special reference to clinical-surgical and differential diagnostic aspects. It is difficult to detect a Schwannoma of the facial nerve during a peripheral facial paralysis; radiological studies of the mastoid and Fallopian canal are essential for this diagnosis. Treatment of neurinomas of the VIIth nerve is always surgical, the authors emphasize the necessity of an 'en masse' tumor-nerve removal and the use of a nerve graft.
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PMID:Neurinoma of the facial nerve. 57 27

A 23-year-old man had received irradiation for a benign ear problem at the age of 1 year. Twenty year later, a malignant left parotid carcinoma and a right jugular foramen schwannoma developed. Earlier reports in the literature suggest that radiation can induce tumors in the head and neck. The localization of both tumors and the histological features of the parotid tumor suggest that they were radiation-induced.
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PMID:Parotid carcinoma and posterior fossa schwannoma following irradiation. Report of a patient treated in infancy for benign ear disease. 57 93

Only some rare examples of schwannomas localized in the medullary parenchyma are cited in the literature. The first was described by Kernohan in 1933; 9 cases were rapported in the thirty following years. For Brain a few observations about one case were cited by David (1965), Gibson (1966), New (1972) and Ghatak (1975). The authors relate one case of isolated schwannoma in superior vermis. That was a 15 years old young man who had a low evoluting I.C.P. syndrome. The pre-operating neurological investigation revealed a small cerebellar syndrome. The neuroradiological record allowed to localize an expansive median affection in the posterior fossa on a level with the Sylvius aqueduct. The neurosurgical operation allowed to carry off a tumor from the superior vermis; schwannoma tissue was the conclusion of the histological study. The evolution has been good and no cranial nerves were involved. Different theoris about the localisation of Schwann cells in this region are described.
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PMID:[Intracerebellar schwannoma]. 59 87

This study of 25 cases of benign neoplastic involvement of the eighth nerve in man suggests: (1) Eighth nerve auditory dysfunction and minimal structural change in the internal auditory canal are the earliest reliable signs leading to tumor detection. (2) "Early" detection does not mean "small" tumor. (3) Schwannomas tend to grow more slowly in the elderly patient. (4) Compression and displacement of viable axons may be the primary pathophysiology of dysfunction.
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PMID:Clinical correlates of neoplastic involvement of the eight cranial nerve in man. 61 20

A patient with a mobile schwannoma of the cauda equina is described. The wide discrepancy between the myelographic and surgical locations of the tumor is most unusual. Awareness of the possibility of such an extreme degree of motility is important when dealing with cauda equina tumors.
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PMID:Mobile schwannoma of the cauda equina. Case report. 61 15

The results of morphological examinations of 78 heart tumors in BD IX rats induced by methyl- and ethylnitrosourea (MNU, ENU) administered by various routes are described. After repeated intravenous or intraperitoneal injections of MNU heart tumors developed in 39--46% of the treated animals. The following localizations were found: left ventricle--55, right ventricle--7, both ventricles--12, other sites--4. In 51 (65.4%) of 78 cases there were early stages of tumor with a ribbon-like lining of the affected ventricle wall. They consisted of elongated stream-like-arranged tumor cells. Large tumor nodules protruding into the ventricular lumen usually showed considerable features of cellular and nuclear polymorphism. The heart tumors were classified as fibromas or neurinoma-like tumors, fibrosarcomas, and polymorphous sarcomas. Histogenetically, the neoplastic cells are probably derived from fibroblasts and Schwann cells.
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PMID:[Morphology of heart tumors in rats induced by methyl- and ethylnitrosourea]. 62 51

In an attempto to provide preoperative histologic identification of internal auditory canal and cerebellopontine angle tumors, and to attempt to detect small tumors and recurrent tumors, immunologic aspects of acoustic neuroma patients and control subjects were studied. Reactions based upon the interaction of patients' fresh lymphocytes in contact with acoustic neuroma antigens were studied by a leukocyte migration inhibition (LMI) assay and a locally developed refinement, the plasma effect assay. These were performed either preoperatively, postoperative, or both, in 17 patients with surgically confirmed acoustic neuromas and in 24 controls subjects. Preoperative tumor patients had a higher likelihood of having elevated LMI and plasma effect assay values than normals. False positive results were rare and the combination of the LMI and plasma effect assay decreased false negative responses to 20%. Meaningful conclusions must await more extensive testing but it has been demonstrated that tumor associated antigens do exist on the membranes of schwannoma cells and that most patients with an acoustic neuroma mount a cell-mediated immune response against these antigens.
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PMID:Immunologic detection of acoustic neuroma: preliminary report. 64 73


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