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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Spleen cells from BDIX-rats bearing either GVlAl-tumor (a syngeneic mixed glioma) or NVlAc-tumor (a cloned syngeneic neurinoma of the peripheral nervous system) were cytotoxic to both tumor cells in vitro. However, the tumors displayed individually distinct antigenic specificities by in vivo rejection tests. Their in vitro cross-reactivity disappeared when a particular subpopulation of the spleen cells was used. The procedure of lymphocyte purification included three consecutive steps: treatment with carbonyl iron and magnetism, passage through a nylon wool column, and finally removal of complement receptor-bearing cells present in the colum-excluded population. Cross-reactivity between the syngeneic tumors persisted after the first two steps of lymphocyte purification. In contrast, specific cytotoxic reactions were observed against each individual tumor subsequent to the removal of the remaining C3 receptor-positive but surface Ig-negative cells. While killer cells were present in normal spleen-cell populations, these were almost completely eliminated by passage through the nylon wool column.
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PMID:Spleen-cell reactivity against transplanted neurogenic rat tumors induced by ethylnitrosourea: uncovering of tumor specificity after removal of complement-receptor-bearing lymphocytes. 5 Feb 96

The autopsy of a 68-year-old male who died of cardiac infarction revealed an ep - and intramedullary neurilemmoma of the spinal cord as an associated finding half a year prior to death. The patient had suffered from progressive weakness and sensory disturbances of the lower limbs together with muscular wasting for 6 months. Repeated neurological examinations had led to the diagnosis of an intraspinal space occupation which, however, could not be substantiated by myelography because of its surprisingly small size. The Schwann cell proliferation originated from the adventitia of the epi- and intramedullary vessels of the conus medullaris. The main tumor mass was epi-medullary and extended into the medullary parenchyma via the penetrating vessels forming intramedullary nodules. The special findings in the present case seem to support the hypothesis that intramedullary neurilemmomas originate from the perivascular nerve endings.
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PMID:"Epi-" and intramedullary neurilemmoma of the spinal cord with denervation atrophy in the related skeletal muscles. 5 10

Described is a unique mixed intracerebral tumor composed of schwannoma, piloid astrocytoma, and angiomatous malformation. Review of conventional staining methods for distinguishing glial from connective tissue fibrils reveals that Mallory's phosphotungstic acid-hematoxylin (PTAH) method is less specific than is generally recognized. Knowledge of these pitfalls, combined with use of hematoxylin and eosin stains, and reticulum impregnations are currently most useful in making the distinction by light microscopy. Criteria for malignancy of schwannoma and other mesenchymal tumors should be based on number of mitotic figures and invasiveness rather than on pleomorphiam of cells. Prior knowledge of the location of the tumor may lead to diagnosing some schwannomas as other types of tumor.
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PMID:Brain tumors of mixed tissue origin: staining procedures to distinguish glial from connective tissue. 6 42

Three cases of acoustic neurinoma with parkinsonism and dementia are reported. The characteristics of parkinsonism seen in these cases consisted of the rapid development of symptoms and symmetrical rigidity. In all cases there was a marked enlargement of the ventricular system and transient improvement in their mental states was observed following ventriculoperitoneal shunt or removal of the tumor. In an autopsy case there were no pathological findings in the cerebral cortex, basal ganglia, substantia nigra or pontine nuclei. It was concluded that parkinsonism and dementia in these patients were caused by chronic hydrocephalus due to the acoustic neurinomas.
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PMID:Parkinsonism and dementia with acoustic neurinomas. Report of three cases. 7 63

A case of right sided extradural neurinoma at the level of the foramen magnum is reported which presented as an intramedullary spinal cord syndrome. Ischemia of the anterior spinal artery or of the vertebral artery was considered to be an important pathogenic factor in the production of the neurological syndrome. The outer part of the spinothalamic tract, where sensory fibers carrying pain and thermal sensibility from the sacral segments are situated, escaped ischemia as that part is supplied by penetrating branches of the pial arterial plexus. The discrepancy between the level of neurological deficit (C5) and site of the tumor (C1-2) was due to distant ischemia. The lack of a history of root pain and the rapid recovery following removal of the tumor also favor a vascular origin for the neurological deficit.
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PMID:Intramedullary syndrome due to an extradural neurinoma near the foramen magnum. 7 75

Analysis of 7 child cases with neurinoma of the acoustic nerve, tumors which are extremely rare in children, showed that they have characteristic clinical features. The disease was manifested at the age of 12--15 years, sometimes against the background of diffuse neurofibromatosis. The mean duration of the disease varied from 5 months to one year. The tumor was marked by rapid growth, medial variant of localization with extension in the oro-caudal direction, and rich blood supply. Hearing diminished rapidly to total deafness, and the loss was usually bilateral. The facial nerve suffered less frequently. The hypertensive-occlusive syndrome was observed with marked stem-cerebellar symptoms and protein-cellular dissociation in the cerebrospinal fluid, which suggests tumor of the cerebellum. Ventriculography with maiodil emulsion and vertebral angiography helped in making a precise diagnosis. Radical removal of the tumor proved very difficult because it was large and intimately connected with the brain stem.
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PMID:[Neurinomas of the auditory nerve in children]. 9 32

Neurilemmomas presenting as primary central bone tumors are extremely rare. Only 21 cases have been reported to have arisen in the jaws; all except for one have occurred in the mandible. The majority of these have been associated with the inferior dental nerve. A case of a central neurilemmoma arising in the anterior mandible is reported. Its probable origin is from one of the alveolar branches of the incisive nerve--an unusual site in the mandible. The radiographic features include expansion of cortical bone, resorption of roots of teeth, the presence of lace-like bony septa and a spotty calcification within the tumor. The treatment and the prognosis are briefly discussed.
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PMID:Central neurilemmoma of the jaws. Review of literature and case report. 10 Apr 43

In this study 4 cases of Schwannoma are reported. The primary localisation of the tumor in the first case was thought to be near the foreamen lacerum with large areas of bone destruction in the base of the skull. Moreover the internal carotid artery was trophic and thinwalled. In the second patient the onset of the disease must have taken place in childhood as a chronic otitis media. Also in this case the tumor was not diagnosed until it reached a considerable size. The primary localisation was the nervus petrosus superficialis major. In the third patient the neurinoma was located in the facial nerve between the two lobes of the parotid gland. In the fourth case a pedunculated neurinoma of the epipharynx was found. Symptomatology, treatment and differential diagnosis of the Schwannoma are discussed.
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PMID:[Schwannoma in otorhinolaryngology]. 12 68

1-Acetoxypropylpropylnitrosamine (1-APPN) was synthesized and its biological effect examined in Syrian hamsters after subcutaneous (s.c.) administration. 1-APPN induced mesenchymal and epithelial neoplasms at the injection sites, as well as epithelial tumors in remote organs. Local neoplasms were a.c. sarcomas, mammary adenocarcinomas and Schwannomas, whereas tumors of the respiratory tract (papillary polyps, papillomas, adenomas, epidermoid carcinomas, and adenocarcinomas) were attributed to a systemic effect as were pancreas duct tumors. Neoplasms which originated in the upper digestive and genital tracts of females (papillomas, epidermoid carcinomas) may be related to a systemic and local effect of 1-APPN.
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PMID:Local and systemic effects of 1-acetoxypropylpropylnitrosamine in Syrian golden hamsters. 14 54

We are discussing a case of neurinoma of the tenth cranial nerve in the area of the base of the skull with endocranial extension in a 51-years-old female patients. The first symptom was hoarseness of the voice, and three years later more cranialnerves were involved (V-VII-X-XI-XII). The existence and the extension of the tumor was verified by radiological examination of the base of the skull, carotic angiography, myelography and scanning; the diagnosis was proved by biopsy. The treatment of choice is the operation because the tumor is radioresistant.
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PMID:[Vagus neurinoma of the basic of the skull and endocranium (author's transl)]. 14 26


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