Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Tumour-specific antibodies directed against membrane antigens were demonstrated by immunofluorescence in three of 45 patients with Wilms' tomour. Antibody capable of collaborating with K cells to kill Wilms' tumour was present in two additional patients. No patient exhibited both membrane immunofluorescence and K-cell collaborating antibody. Of 27 patients with non-renal solid tumours and 52 age-matched controls, none possessed tumour-specific antibody.
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PMID:Tumour-specific antibodies reactive with cell-surface antigens in children with Wilms' tumour. 19 7

Twenty-five Black children with nephroblastoma who were referred to the Paediatric Tumour Clinic during the preceding 4 years, are reviewed. Results indicate that in the case of a locally advanced, fixed, primary tumour, initial surgery, even if it is combined with chemotherapy, may be a factor in the rapid postoperative development of multiple pulmonary metastases. Pre-operative irradiation appeared to be advantageous for these patients. Long-term chemotherapy holds no advantage over short-term chemotherapy.
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PMID:Nephroblastoma in the Black child: a review of treatment in the Johannesburg Paediatric Tumour Clinic. 19 39

In order to evaluate the factors relating to prognosis, a clinico-pathological study was made in 27 patients with Wilms' tumor. Among these 27 cases, 10 survived more than two years after nephrectomy, 16 died within four days up to two years, and one patient could not be followed up. The younger age group and earlier stage of the disease showed more favorable prognosis. The tumor size, location, and number of tumor nodules had no effect on prognosis. Both the lymphatic and capsular invasions were common in the fatal cases. No vascular invasion was seen in any patient that had preoperative radiotherapy. Among the 10 survivors, six patients had received preoperative irradiation, whose tumors revealed a mesoblastic pattern. Polycystic structures were found in two surviving cases. One survivor's tumor contained prominent squamous epithelium. Another case showed predominance of undifferentiated spindle cells. The undifferentiated mesenchymal type with sarcomatous pattern would not always represent unfavorable prognosis. The tumor with mesoblastic pattern after radiotherapy and those with polycystic structure showed low-grade malignancy and maturation of stromal cells and tubules, respectively.
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PMID:Wilms' tumor: evaluation of histological features. 19 80

Cultivated undifferentiated malignant nephroblastoma would produce fibroblastoid zones of growth. The tumor cells differed from normal renal fibroblasts by an abundance of mitochondria; cell boundaries were not distinguished. No differentiations in tumor cells cultures absent in the primary material were noted.
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PMID:[Growth and the cellular transformation of undifferentiated nephroblastoma in tissue culture]. 19 96

The presence of antibody to virus capsid antigen (VCA) of Epstein-Barr virus (EBV) was determined in sera from children with various forms of neoplasia by the indirect immunofluorescence procedure of Henle. Eighty-one sera from children with Wilms tumor, teratoblastoma, reticulosarcoma, neuroblastoma, soft tissue sarcoma, as well as from children with benign tumors were examined. The controls included sera from normal children of the same ages. The test cells synthesizing VCA were suspension cultures of P3HR-1 cells which are one of the clones of Burkitt lymphoma. The studies showed no increase in the content of antibody to EBV in any of the groups of children with tumors as compared with the controls. It was also found that the percentage of EBV infection in various groups of sick and normal children varied from 82 to 100.
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PMID:[Antibodies to Epstein-Barr virus in the sera of children with different neoplasms]. 19 3

The evidence that the principles of surgical adjuvant chemotherapy developed in experimental animal systems also apply to a variety of neoplastic diseases in man has been clearly demonstrated. Micrometastatic disease can be eradicated with effective chemotherapy in several diseases. Prolongation of disease-free interval, if not cure, is now possible in diseases in which curative surgery alone or in combination with radiotherapy does not achieve these goals. The previously fatal childhood solid tumors--Wilms', Ewings' sarcoma, embryonal rhabdomyosarcoma--are curable in a high percentage of patients appropriately treated with combinations of surgery, radiotherapy, and chemotherapy. The prolongation of the disease-free interval in osteogenic sarcoma has permitted consideration of entirely new surgical approaches for this tumor in which radical amputation has traditionally been employed. The spectacular results achieved in the treatment of Stage II breast cancer may potentially save hundreds of thousands of lives in the coming decade. Clinically recognizable metastatic disease is rarely curable by any currently available treatment modality. The prolongation of disease-free intervals and production of cures when surgical adjuvant chemotherapy is employed may be partly explained by relatively more circulation, and thus drug delivery to each tumor cell, more favorable cellular kinetics, and a healthier and more immunocompetent host who is better able to withstand drug effects on normal tissues, and to participate in tumor destruction. Cures of certain patients with neoplastic diseases using surgical adjuvant chemotherapy has increased the incentive to learn more about new and old drugs and their effective use alone and in combination. Chemotherapy, in appropriate combinations with surgery, radiotherapy, and immunotherapy, may well be more efficacious in many clinical situations than the traditional use of single-modality treatment. The data presented in this paper relate solid evidence that the possibility of cure in a variety of neoplastic diseases is real.
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PMID:Surgical adjuvant chemotherapy. 19 34

Critical examination of the results of surgical treatment and new surgical techniques have produced changes in the operative treatment of hypernephroid kidney cancer and nephroblastoma. The limits to operative treatment are, first, the local extension and infiltration of the tumor and, second, the grade and degree of metastases. Surgical removal of the hypernephroma seems to have a positive effect on metastasis regression only in the case of bone metastases. Nephrectomy is indicated only in cases with solitary metastases which can be removed at a second operation. The possibility of arterial embolization in renal hemorrhage in inoperable patients is demonstrated. Current aspects of the operative treatment of nephroblastoma are discussed.
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PMID:[The problem of surgical therapy of malignant kidney tumors]. 19 6

The advances in the treatment of the Wilm's tumor have been made both surgically and in the conservative field. Extirpation through a lateral incision has given way to the broad transabdominal exposure. Inoperable tumors are very rare. Cytostatics like actinomycin D and vincristine are already applied intraoperatively. The choice of cytostatic and the duration of cytostatic therapy is adjusted to the intraoperative staging. The Society for Pediatric Oncology has worked out a modified plan of treatment in accordance with the growth of the tumor, in addition irradiation is applied according to the tumor staging. The results are stated as between 60 and 70%, the histology of the tumor and the age of the child, in addition to the growth of the tumor, being especially important.
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PMID:[Advances in the treatment of malignant tumors in childhood: Wilm's tumor as an example (author's transl)]. 19

Three cases of cystic partially differentiated nephroblastoma (CPDN) are presented and ten cases from literature are reviewed. CPDN has been designated by various terms; it is a cystic encapsulated tumor occurring before 2 years of age. Cysts are lined by epithelium; septa of the cysts show a mixture of partially differentiated and undifferentiated metanephrogenic blastema. This histologic feature distinguishes CPDN from multilocular cyst of kidney. In seven cases simple nephrectomy, and in remaining cases nephrectomy with radiation and/or chemotherapy, had been the treatment. The disease-free interval ranged from 5 to 72 months, without reports of recurrence or metastasis. CPDN appears to take a benign course and simple nephrectomy seems to be the treatemtn of choice. However, in view of the possibility of recurrence as shown in rare instances by congenital mesoblastic nephroma, another less aggressive lesion in the spectrum of infantile renal neoplasia, regular follow up is recommended.
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PMID:Cystic partially differentiated nephroblastoma: a clinicopathologic entity in the spectrum of infantile renal neoplasia. 19 44

Seven infants and children with renal tumors underwent nephrectomy and the tumors were cultured to investigate the behavior of their cells. In four children over 1 year of age with histologically typical nephroblastoma in the tumor cells were bizarre and disorderly. In one patient 3 months of age where the histology suggested malignancy the tumor culture showed an orderly growth pattern of spindle cells akin to normal kidney and the patient has had no recurrence for 18 months. In one infant seven months of age the histology was consistent with malignancy and this was confirmed on culture showing bizarre cells similar to those of nephroblastoma. The third infant under 1 year of age had a teratoma on histology and an unusual growth pattern on culture characterised by polyhedral cells with long processes and much overlapping. It is suggested that in infants with kidney tumors, tissue culture be used to help in assessing the malignant potential of the tumor and deciding on adjuvant therapy.
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PMID:Cultural characteristics of mesoblastic nephromas. 19 23


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